CN104274254B - Animal venipuncture administration accurate quantification device - Google Patents

Abstract

The present invention provides an animal venipuncture precise dosing device, said device comprises: a needle part, which includes a needle, a needle protection cover, a needle handle, a needle hose; The three-prong hose, wherein the first port is connected to the first hose of the three-prong hose, the second port is connected to the second hose of the three-prong hose, the third port is connected to the third hose of the three-prong hose, and the first port is used for The needle hose connected to the needle part, the second port and the third port are used to connect the syringe, the second hose and the third hose are provided with flow control pulleys; and two graduated syringes for injecting liquid.

Description

Animal Venipuncture Precise Quantification Device

technical field

The invention relates to a precise quantitative device for venipuncture of animals.

Background technique

When conducting animal experiments or treating animals, venipuncture drug administration or blood collection techniques are often used, usually using a disposable syringe (see Figure 1) for direct drug administration or blood collection. For relatively small animals, such as rats, mice tail veins, rabbit ear veins, etc., due to the small blood vessels, it is difficult to directly use a syringe for venipuncture, which often causes blood vessels to be pierced or the injection needle does not enter. If there is no symptom in this situation, the following consequences will be caused when the medicine is continued: 1. The drug solution leaks (does not enter the blood vessel), which changes the route of administration; 2. The dosage is wrong, causing experimental errors; 3. Waste of precious drugs; 4. Some special drugs will cause experimental animals to be scrapped (such as rat tail margin intravenous injection of doxorubicin for kidney disease model modeling, if the drug does not directly enter the blood vessel and leakage occurs, it will cause The tail of the rat falls off, and it is impossible to inject other drugs through the tail margin vein again, which affects the follow-up experiment) and even affects the parallelism of the entire experiment, resulting in the waste of the entire batch of animal data. It is necessary to re-purchase the entire batch of animals for experiments, which is a serious waste of time and money. . In addition, the injection needle in this method is not easy to fix, and it is easy to fall off, and the toxic agent will pollute the test bench and then affect the safety of the operator.

Contents of the invention

In view of the above problems, the present invention proposes a precise dosing device for venipuncture of animals, said device comprising: a needle part, which includes a needle, a needle protector, a needle handle, and a needle hose; Three-port three-prong hose, where the first port is connected to the first hose of the three-prong hose, the second port is connected to the second hose of the three-prong hose, the third port is connected to the third hose of the three-prong hose, the first The port is used to connect the needle hose of the needle part, the second port and the third port are used to connect the syringe, the second hose and the third hose are provided with flow control pulleys; and two graduated syringes are used to pass through The second port and the third port are filled with liquid.

Through the above technical scheme, it can accurately judge whether the injection needle is located in the blood vessel and then decide whether to continue to push the medicine; it can make the needle easy to fix in the blood vessel, making the whole injection process safer; it can accurately quantify the dosage to make the experiment more accurate, and Avoid drug waste; avoid drug leakage and ensure that the test drug completely enters the blood vessel.

Those skilled in the art will be more aware of the above and other objects, advantages and features of the present invention according to the following detailed description of specific embodiments of the present invention in conjunction with the accompanying drawings.

Description of drawings

Hereinafter, some specific embodiments of the present invention will be described in detail by way of illustration and not limitation with reference to the accompanying drawings. Those skilled in the art will appreciate that the drawings are not necessarily drawn to scale. In the attached picture:

Accompanying drawing 1 is a schematic diagram of venipuncture administration with a disposable syringe in the prior art;

Accompanying drawing 2 is the schematic diagram of the needle portion of the animal venipuncture administration precise quantitative device of the present invention;

Accompanying drawing 3 is the schematic diagram of the three-pronged interface part of the precise dosing device for animal venipuncture drug delivery according to the present invention;

Accompanying drawing 4 is the schematic diagram of the syringe of the precise quantitative device for venipuncture of animals in the present invention.

detailed description

As shown in accompanying drawing 2-4, the device of the present invention is divided into the following several parts: (1) needle head part, comprises needle head, needle head protector, needle handle, needle head hose (similar to scalp needle, but hose is more Needle should be shorter). 2) The three-prong interface part, its main body is a three-section hose connected by a three-prong, with three ports A, B, and C. The A port connected with the first flexible pipe is matched with the needle flexible pipe of the needle part. The second and third hoses connected to the B and C ports each have a flow control pulley. The two ports B and C can be connected with a syringe, especially a disposable syringe, and the ports B and C have sealing caps for easy disassembly. (3) Two disposable syringes with scales A and B matching the B and C terminals respectively. The range can be changed according to need. All connection fittings are pressure connection fittings.

If it is necessary to give multiple medicines, it can be designed as an interface with more forks (more than 3 forks) (referred to as a multi-fork interface in the present invention). This can be used to infuse test animals with multiple drugs over short intervals in one procedure. It can also be used for multiple administrations through multiple forks. For example, if it is necessary to observe the effects of multiple drugs on experimental animals, in the prior art it is necessary to puncture the experimental animals multiple times. Since the puncture time interval is long and difficult to control, this may lead to deviations in the final experimental data due to the puncture time interval. However, the multi-prong interface design of the present invention only needs to puncture the experimental animal once, which avoids the time interval caused by multiple punctures, so that the administration time can be precisely controlled or blood can be drawn accurately. Preferably, in order to prevent blood from clogging the device, an anticoagulant is added to the device.

The method of using this device is as follows:

1. A syringe draws physiological saline and empties the air for later use.

2. Inject the test drug into the syringe B and empty the air for use.

3. The needle hose of the needle part is connected to the A port, open the sealing cap of the B port, connect the A syringe (with physiological saline inside) to the B port, keep the C port sealing cap tight, and connect the B and C ports to the first 2. The flow control pulley on the third hose is opened to the maximum. Push the A syringe to fill the entire three-prong interface and the needle hose with saline, and there will be no air bubbles in the entire device.

4. Hold the needle handle of the needle head, remove the needle protection cap, insert the needle into the animal vein, bend the needle hose or close the pulley adjacent to the B port, and observe whether there is blood back. If there is blood back, keep the needle in the blood vessel. For blood return, continue to search for blood vessels to the best position, and then fix the hose and needle with adhesive tape. (Normal saline solution did not cause damage to the experimental animals or affect the dose of the test drug.)

5. Open the C-end sealing cap, connect the B-syringe (with the test drug inside) to the C-end, close the pulley adjacent to the B-port, open the pulley adjacent to the C-port, and push in the specified volume/dose of the drug according to the scale of the B-syringe ( The volume of medicine pushed in V medicine = the medicine volume V Li required by the test theory + the capacity volume VC of the C-end hose).

6. Close the pulley adjacent to port C, open the pulley adjacent to port B, push the syringe A according to the scale of A, and use normal saline to push all the remaining medicine in the hose into the animal blood vessel (the volume of normal saline pushed into the hose VNS=B end hose The capacity volume VB+the capacity volume VA of the A-end hose+the volume volume V needle of the needle hose), can be pushed in more than the theoretically calculated VNS to ensure that all the liquid medicine enters.

For the convenience of operation, the hoses at all ports can be made with a capacity of 0.1ml or 0.2ml, and different specifications can be prepared according to the size of the animal and the dosage of the drug.

Alternatively, the needle part and the three-fork interface part of the present invention can be directly integrated, so that the time for connecting the needle part and the three-fork interface part during operation can be reduced, and at the same time, the interface between the needle part and the three-fork interface part will be reduced. Potential pollution caused by plugging.

Alternatively, the needle of the needle part of the present invention can be made as an indwelling needle, that is, a needle that stays in the animal body. After each operation is completed, the end of the needle is closed, and the end of the needle is directly connected in the next operation without re-puncturing.

Alternatively, the above three-prong interface parts can be replaced with multi-prong (the number of fork is greater than three) interface parts.

Through the above technical scheme, the operation is simple, drug leakage can be effectively avoided, the success rate of animal experiments can be improved, the pain of animals can be reduced, and a lot of time and money can be saved.

So far, those skilled in the art should appreciate that, although a number of exemplary embodiments of the present invention have been shown and described in detail herein, without departing from the spirit and scope of the present invention, the disclosed embodiments of the present invention can still be used. Many other variations or modifications consistent with the principles of the invention are directly identified or derived from the content. Accordingly, the scope of the present invention should be understood and deemed to cover all such other variations or modifications.

Claims (1)

1. A precise quantitative device for venipuncture of animals, said device comprising: a needle part, which includes a needle, a needle protection cover, a needle handle, and a needle flexible pipe; Hoses where the first port is connected to the first hose of the trifurcated hose, the second port is connected to the second hose of the trifurcated hose, the third port is connected to the third hose of the trifurcated hose, and the first port is used to connect the needle Part of the needle hose, the second port and the third port are used to connect the syringe, the second hose and the third hose are provided with a flow control pulley; and two graduated syringes A syringe and B syringe for passing through The second port and the third port inject liquid, and it is characterized in that, this device operates according to the following steps when in use: Step 1. A syringe draws physiological saline and empties the air for standby; Step 2, inject the test drug into the syringe B, and empty the air for standby; Step 3. Connect the needle hose of the needle part to the first port, open the sealing cap of the second port, connect the A syringe to the second port, keep the sealing cap of the third port tight, and connect the second and third ports The flow control pulleys on the second and third hoses are opened to the maximum, and the syringe A is pushed to fill the entire trident interface and the needle hose with physiological saline, so that there are no air bubbles in the whole device; Step 4. Hold the needle handle of the needle part, remove the needle protective cap, insert the needle into the animal vein, bend the needle hose or close the flow control pulley adjacent to the second port, and observe whether there is blood return. If there is blood return, keep the needle in the In the blood vessel, if there is no blood return, continue to search for the blood vessel to the best position, and then fix the needle hose and needle with tape; Step 5. Open the sealing cap of the third port, connect the second syringe to the third port, close the flow control pulley adjacent to the second port, open the flow control pulley adjacent to the third port, and push in the medicine according to the scale of the second syringe. Injected medicine volume V medicine=needed medicine volume Vli+capacity volume VC of the third flexible tube; Step 6. Close the pulley adjacent to the third port, open the flow control pulley adjacent to the second port, push the syringe A according to the scale of the syringe A, push all the remaining medicine in the hose into the animal blood vessel with normal saline, and push it into the normal saline Volume VNS=containment volume VB of the second hose+containment volume VA of the first hose+containment volume Vneedle of the needle hose.