CN104222117A - Pesticide preparation containing spirotetramat for preventing and treating liriomyza sativae blanchard and bemisia tabaci - Google Patents
Pesticide preparation containing spirotetramat for preventing and treating liriomyza sativae blanchard and bemisia tabaci Download PDFInfo
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- CN104222117A CN104222117A CN201410445355.1A CN201410445355A CN104222117A CN 104222117 A CN104222117 A CN 104222117A CN 201410445355 A CN201410445355 A CN 201410445355A CN 104222117 A CN104222117 A CN 104222117A
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- CN
- China
- Prior art keywords
- spirotetramat
- pesticide preparation
- glycol
- cyromazine
- ether
- Prior art date
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- 239000005931 Spirotetramat Substances 0.000 title claims abstract description 48
- CLSVJBIHYWPGQY-GGYDESQDSA-N spirotetramat Chemical compound CCOC(=O)OC1=C(C=2C(=CC=C(C)C=2)C)C(=O)N[C@@]11CC[C@H](OC)CC1 CLSVJBIHYWPGQY-GGYDESQDSA-N 0.000 title claims abstract description 48
- 238000002360 preparation method Methods 0.000 title claims abstract description 45
- 239000000575 pesticide Substances 0.000 title claims abstract description 38
- 241000254127 Bemisia tabaci Species 0.000 title claims abstract description 23
- 241000594031 Liriomyza sativae Species 0.000 title claims abstract description 18
- 239000005891 Cyromazine Substances 0.000 claims abstract description 43
- LVQDKIWDGQRHTE-UHFFFAOYSA-N cyromazine Chemical compound NC1=NC(N)=NC(NC2CC2)=N1 LVQDKIWDGQRHTE-UHFFFAOYSA-N 0.000 claims abstract description 43
- 229950000775 cyromazine Drugs 0.000 claims abstract description 43
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 33
- 239000000839 emulsion Substances 0.000 claims abstract description 24
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 18
- 239000002671 adjuvant Substances 0.000 claims abstract description 8
- 230000002265 prevention Effects 0.000 claims abstract description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 30
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 30
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 28
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 18
- 239000002904 solvent Substances 0.000 claims description 18
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- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims description 8
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- 229920005682 EO-PO block copolymer Polymers 0.000 claims description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 5
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Landscapes
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Abstract
Description
技术领域technical field
本发明涉及一种控制斑潜蝇、烟粉虱的农药制剂的制备,属于农药制备技术领域。The invention relates to the preparation of a pesticide preparation for controlling Liriomyza sativae and whitefly, and belongs to the technical field of pesticide preparation.
背景技术Background technique
斑潜蝇(Liriomyza spp),属于双翅目潜蝇科害虫。1993年由巴西传入我国,目前全国各地均有发生。其成虫、幼虫均可为害,雌成虫飞翔把植物叶片刺伤,进行取食和产卵,幼虫潜入叶片和叶柄为害,产生不规则蛇形白色虫道,叶绿素被破坏,影响光合作用,受害植株叶片脱落,造成花芽、果实被灼伤,严重的造成毁苗,主要为害黄瓜、番茄、茄子、辣椒、豇豆、蚕豆、大豆、菜豆、西瓜、冬瓜、丝瓜等22个科110多种植物。近几年来随着蔬菜种植面积大幅度增长,蔬菜已成为我国第二大作物,对斑潜蝇的有效防治更引人瞩目,如美洲斑潜蝇对部分化学杀虫剂如某些有机磷类杀虫剂抗药性增长较快。Liriomyza spp is a pest belonging to the Liriomyza family Diptera. It was introduced into my country from Brazil in 1993, and it occurs all over the country at present. Both adults and larvae can cause damage. The female adult flies and stabs the leaves of the plant for feeding and laying eggs. The larvae sneak into the leaves and petioles to cause damage, forming irregular snake-shaped white insect passages, destroying chlorophyll, affecting photosynthesis, and damaging plants. The leaves fall off, causing flower buds and fruits to be burned, and seriously destroying seedlings, mainly damaging more than 110 kinds of plants in 22 families such as cucumbers, tomatoes, eggplants, peppers, cowpeas, broad beans, soybeans, kidney beans, watermelons, wax gourds, and loofahs. In recent years, with the substantial increase in vegetable planting area, vegetables have become the second largest crop in my country, and the effective control of Liriomyza sativus has attracted more attention. Insecticide resistance is growing rapidly.
烟粉虱(Bemisia tabaci(Gennadius))属同翅目粉虱科小粉虱属,自1889年在希腊烟草上被发现至今,已经分布于除南极洲以外的全球所有陆地,寄主植物多达600种,已经成为世界范围内蔬菜、经济作物和园林花卉上的一种重要害虫,危害日益加重。烟粉虱是烟草上的主要害虫之一,它不仅刺吸烟叶汁液,分泌蜜露,诱发煤污病,导致烟叶营养物质直接损失,更重要是传播多种植物病毒,严重影响烟叶的产量和质量,烟粉虱引发病毒病所造成的危害比刺吸所造成的危害要严重的多。烟粉虱大暴发后不久,它所传播的病毒病就会随之大发生。由烟粉虱传播的双生病毒已在多个国家和地区作物上造成毁灭性危害,且有逐年加重的趋势。现在防治烟粉虱的常规药剂主要包括有机磷类(如毒死蜱、乙酰甲胺磷等)、氨基甲酸酯类(如灭多威、丁硫克百威等)、氯化烟酰类(吡虫啉、啶虫脒、烯啶虫胺等)以及昆虫生长调节剂(噻嗪酮、蚊蝇醚)等。由于害虫本身的生物学特性,频繁使用化学杀虫剂以及用药的盲目性,烟粉虱在世界范围内已经对包括烟碱类杀虫剂在内的多种化学农药产生了抗性生物型,因此有必要寻求新型的害虫不易产生抗性的杀虫物质。Bemisia tabaci (Gennadius) belongs to the genus Bemisia tabaci (Gennadius), which has been found in Greek tobacco in 1889 and has been distributed on all lands in the world except Antarctica, with as many as 600 species of host plants. , has become an important pest on vegetables, commercial crops and garden flowers worldwide, and its harm is increasing day by day. Bemisia tabaci is one of the main pests on tobacco. It not only punctures tobacco leaf juice, secretes honeydew, induces soot, and causes direct loss of nutrients in tobacco leaves. More importantly, it spreads a variety of plant viruses, seriously affecting the yield and quality of tobacco leaves. Quality, the harm caused by the virus disease caused by Bemisia tabaci is much more serious than the harm caused by piercing and sucking. Soon after a large outbreak of whitefly, the viral disease it spreads will follow. Geminiviruses transmitted by whiteflies have caused devastating damage to crops in many countries and regions, and there is a trend of increasing year by year. Conventional medicaments for controlling whitefly now mainly include organophosphates (such as chlorpyrifos, acephate, etc.), carbamates (such as methomyl, carbosulfan, etc.), chlorinated nicotinyls (imidacloprid, Acetamiprid, Nitenpyram, etc.) and insect growth regulators (buprofezin, pyriproxyfen), etc. Due to the biological characteristics of the pest itself, the frequent use of chemical pesticides and the blindness of medication, Bemisia tabaci has developed resistant biotypes to various chemical pesticides including neonicotinoids worldwide. Therefore it is necessary to seek novel insecticidal substances that are difficult for pests to develop resistance.
螺虫乙酯(spirotetramat)具有高效广谱,可有效防治各种刺吸式口器害虫,如蚜虫、蓟马、木虱、粉蚧、粉虱和介壳虫等。可应用的主要作物包括,棉花、大豆、柑橘、热带果树、坚果、葡萄、啤酒花、土豆和蔬菜等。研究表明其对重要益虫如瓢虫、食蚜蝇和寄生蜂具有良好的选择性。具有双向内吸传导性能的现代杀虫剂之一。该化合物可以在整个植物体内向上向下移动,抵达叶面和树皮,从而防治如生菜和白菜内叶上,及果树皮上的害虫。这种独特的内吸性能可以保护新生茎、叶和根部,防止害虫的卵和幼虫生长;持效期长。Spirotetramat has high efficiency and broad spectrum, and can effectively control various piercing-sucking mouthpart pests, such as aphids, thrips, psyllids, mealybugs, whiteflies and scale insects. The main crops that can be applied include cotton, soybean, citrus, tropical fruit trees, nuts, grapes, hops, potatoes and vegetables. Studies have shown good selectivity for important beneficial insects such as ladybugs, hoverflies and parasitoid wasps. One of the modern insecticides with two-way systemic conduction properties. The compound can move up and down throughout the plant to reach the foliage and bark, thereby controlling pests such as on the inner leaves of lettuce and cabbage, and on the bark of fruit trees. This unique systemic property protects young stems, leaves and roots from the growth of pest eggs and larvae; long-lasting.
灭蝇胺(cyromazine)是一种昆虫生长调节剂类低毒杀虫剂,有非常强的选择性,主要对双翅目昆虫有活性。其作用机理是使双翅目昆虫幼虫和蛹在形态上发生畸变,成虫羽化不全或受抑制。该药具有触杀和胃毒作用,并有强内吸传导性,持效期较长。灭蝇胺对人、畜无毒副作用,对环境安全。Cyromazine (cyromazine) is an insect growth regulator low-toxicity insecticide with very strong selectivity, mainly active against Diptera insects. Its mechanism of action is to distort the larvae and pupae of Diptera insects in shape, and the adult larvae are incomplete or inhibited. The drug has contact and stomach poisoning effects, and has strong systemic conductivity and a long duration of action. Cyromazine has no toxic and side effects on humans and animals, and is safe to the environment.
但是以上的螺虫乙酯和灭蝇胺的单一制剂在实际使用中遇到了系列的问题。如螺虫乙酯制剂在田间使用中存在生产成本较高;灭蝇胺作为一种化学农药,目前对害虫有较好的防治效果,但是为了提高药剂对害虫的防治效果,农民不断地提高药剂的使用剂量,另外害虫易对药剂产生抗性。However, the above single preparation of spirotetramat and cyromazine encountered a series of problems in actual use. For example, the production cost of spirotetramat preparation is relatively high in field use; cyromazine, as a chemical pesticide, has a good control effect on pests at present, but in order to improve the control effect of pesticides on pests, farmers continue to increase the use of pesticides. In addition, pests are prone to develop resistance to pesticides.
发明内容Contents of the invention
本发明目的是提供一种含有螺虫乙酯的防治斑潜蝇、烟粉虱的农药制剂,该制剂杀虫效率高,对斑潜蝇、烟粉虱有优异的防治效果。The purpose of the present invention is to provide a pesticide preparation containing spirotetramat for controlling Liriomyza and whitefly. The preparation has high insecticidal efficiency and excellent control effect on Liriomyza and whitefly.
本发明的目的是通过以下技术方案实现的,一种含有螺虫乙酯的防治斑潜蝇、烟粉虱的农药制剂,其有效成分为螺虫乙酯和灭蝇胺,螺虫乙酯占所述农药制剂总重量的重量百分比为5.0—30.0%,灭蝇胺占所述农药制剂总重量的重量百分比为5.0—30.0%,其余为辅剂;所述农药制剂为水乳剂或悬浮剂。The object of the present invention is achieved by the following technical scheme, a kind of pesticide preparation containing spirotetramat for preventing and controlling Liriomyza sativae, whitefly, its active ingredient is spirotetramat and cyromazine, spirotetramat accounts for The weight percent of the total weight of the pesticide preparation is 5.0-30.0%, the weight percent of cyromazine in the total weight of the pesticide preparation is 5.0-30.0%, and the rest is adjuvant; the pesticide preparation is an aqueous emulsion or a suspension.
进一步地,所述农药制剂剂型为水乳剂时,辅剂各组分占所述农药制剂总重量的重量百分比分别为:溶剂0.1—60.0%,乳化剂0.1—60%,分散剂0.1—5.0%,抗冻剂0.1—5.0%,水补充至100.0%;Further, when the dosage form of the pesticide preparation is an emulsion in water, the percentages by weight of each component of the adjuvant to the total weight of the pesticide preparation are: 0.1-60.0% of the solvent, 0.1-60% of the emulsifier, and 0.1-5.0% of the dispersant , antifreeze 0.1-5.0%, water added to 100.0%;
所述溶剂选自甲醇、二甲苯、乙二醇、丙二醇、聚乙二醇、N-长链烷基吡咯烷酮中的任意一种或任意两种或两种以上的组合物;The solvent is selected from any one of methanol, xylene, ethylene glycol, propylene glycol, polyethylene glycol, N-long-chain alkylpyrrolidone or any combination of two or more;
所述乳化剂选自环氧乙烷-环氧丙烷嵌段共聚物、烷基聚乙二醇醚、烷基苯基聚乙二醇醚、聚氧乙烯山梨糖醇酐酯、聚氧乙烯脂肪酸酯、2,4,6-三(1-苯乙基)苯酚聚(20)乙二醇磷酸单酯、乙氧化烷基苯醚、乙氧化烷基醚、烷基苯磺酸钙、环氧乙烷-脂肪酸伯胺缩合物中的任意一种或任意两种或两种以上的组合物;The emulsifier is selected from the group consisting of ethylene oxide-propylene oxide block copolymer, alkyl polyglycol ether, alkylphenyl polyglycol ether, polyoxyethylene sorbitan ester, polyoxyethylene fat ester, 2,4,6-tris(1-phenylethyl)phenol poly(20) ethylene glycol phosphate monoester, ethoxylated alkyl phenyl ether, ethoxylated alkyl ether, calcium alkylbenzene sulfonate, cyclic Any one or any combination of two or more of the oxyethane-fatty acid primary amine condensates;
所述分散剂选自聚乙烯醇、阿拉伯胶中的任意一种物质或两种组合物;The dispersant is selected from any one of polyvinyl alcohol, gum arabic, or both compositions;
所述抗冻剂选自乙二醇、丙二醇、丙三醇、聚乙二醇、山梨醇中的任意一种或任意两种或两种以上的组合物。The antifreezing agent is selected from any one of ethylene glycol, propylene glycol, glycerol, polyethylene glycol, and sorbitol, or any combination of two or more of them.
进一步地,所述农药制剂剂型为悬浮剂时,辅剂各组分占所述农药制剂总重量的重量百分比分别为:溶剂0.1—60.0%,乳化剂0.1—60%,稳定剂0.1—5.0%,抗冻剂0.1—5.0%,增稠剂0.1—5.0%,防腐剂0.1—5.0%,用水补充至100.0%;Further, when the dosage form of the pesticide preparation is a suspension concentrate, the percentages by weight of each component of the adjuvant to the total weight of the pesticide preparation are: 0.1-60.0% of solvent, 0.1-60% of emulsifier, and 0.1-5.0% of stabilizer , antifreeze 0.1-5.0%, thickener 0.1-5.0%, preservative 0.1-5.0%, supplemented with water to 100.0%;
所述乳化剂环氧乙烷-环氧丙烷嵌段共聚物、烷基聚乙二醇醚、烷基苯基聚乙二醇醚、聚氧乙烯山梨糖醇酐酯、聚氧乙烯脂肪酸酯、2,4,6-三(1-苯乙基)苯酚聚(20)乙二醇磷酸单酯、乙氧化烷基苯醚、乙氧化烷基醚、烷基苯磺酸钙、环氧乙烷-脂肪酸伯胺缩合物中的任意一种或任意两种或两种以上的组合物;The emulsifier ethylene oxide-propylene oxide block copolymer, alkyl polyglycol ether, alkylphenyl polyglycol ether, polyoxyethylene sorbitan ester, polyoxyethylene fatty acid ester , 2,4,6-tris(1-phenylethyl)phenol poly(20) ethylene glycol phosphate monoester, ethoxylated alkyl phenyl ether, ethoxylated alkyl ether, calcium alkylbenzene sulfonate, ethylene oxide Any one or any combination of two or more of the alkane-fatty acid primary amine condensates;
所述溶剂选自甲苯、二甲苯、乙二醇、丙二醇、聚乙二醇、N-长链烷基吡咯烷酮、甲醇、乙醇、丙醇、丁醇、异丁醇、环己酮、甲乙酮、二甲基甲酰胺、二甲基亚砜中的任意一种或任意两种或两种以上的组合物;The solvent is selected from toluene, xylene, ethylene glycol, propylene glycol, polyethylene glycol, N-long chain alkylpyrrolidone, methanol, ethanol, propanol, butanol, isobutanol, cyclohexanone, methyl ethyl ketone, di Any one or any combination of two or more of methylformamide and dimethyl sulfoxide;
所述增稠剂为聚醋酸乙酯、明胶、聚乙烯醇、丁苯胶乳、阿拉伯胶、海藻酸钠、黄原胶、羧甲基纤维素钠、羧丙基纤维素钠、聚乙二醇、聚氧化乙烯、聚乙烯吡咯烷酮、聚丙烯酰胺、可溶性淀粉、糊精、聚醋酸乙烯脂、萘酚-甲醛树脂中的任意一种或任意两种或两种以上的组合物;Described thickener is polyethyl acetate, gelatin, polyvinyl alcohol, styrene-butadiene latex, gum arabic, sodium alginate, xanthan gum, sodium carboxymethyl cellulose, sodium carboxypropyl cellulose, polyethylene glycol , polyethylene oxide, polyvinylpyrrolidone, polyacrylamide, soluble starch, dextrin, polyvinyl acetate, naphthol-formaldehyde resin, or any combination of two or more of them;
所述稳定剂选自环氧化豆油、环氧化亚麻、油、氨基苯甲酸、焦性没食子酸、对硝基苯甲酸、蓖麻油、苏丹黑、没食子酸丙酯、3-氯-1,2-环氧氯丙烷、丁基缩水甘油醚、苯基缩水甘油醚、聚乙烯基乙二醇二缩水甘油醚、山梨酸醇中的任意一种或任意两种或两种以上的组合物;The stabilizer is selected from epoxidized soybean oil, epoxidized linseed, oil, aminobenzoic acid, pyrogallic acid, p-nitrobenzoic acid, castor oil, Sudan black, propyl gallate, 3-chloro-1, Any one or any combination of two or more of 2-epichlorohydrin, butyl glycidyl ether, phenyl glycidyl ether, polyvinyl glycol diglycidyl ether, and sorbic acid;
所述抗冻剂选自下乙二醇、丙二醇、丙三醇、聚乙二醇、山梨醇中的任意一种或任意两种或两种以上的组合物;The antifreeze agent is selected from any one of butyl glycol, propylene glycol, glycerol, polyethylene glycol, sorbitol or any two or more compositions;
所述防腐剂选自甲醛、苯甲酸钠、异噻唑啉酮中的任意一种或任意两种或三种的组合物。The preservative is selected from any one or any combination of two or three of formaldehyde, sodium benzoate and isothiazolone.
与现有技术相比,本发明具有以下有益效果:Compared with the prior art, the present invention has the following beneficial effects:
第一,本发明的主剂所选用的螺虫乙酯、灭蝇胺均是本领域公知的杀虫剂,并可容易地从市场购得,药剂很容易杀死斑潜蝇、烟粉虱,能够及时大面积有效地控制斑潜蝇、烟粉虱的扩散和传播,所选混配的药剂属于不同作用机制的化合物,混配后增效作用明显,烟粉虱对其不易产生抗药性,并且所选药剂均是低毒或者无毒,对环境选择压力低,价格低廉,在较长时间内均具有良好的防治效果可提高药剂的防治效果,避免单一药剂的杀虫谱窄、持效性不足、防治效果相对不高等弊端,混配后充分发挥药剂的混合增效作用、可以扩大害虫防治谱。The first, the selected spirotetramat and cyromazine of the main agent of the present invention are all insecticides known in the art, and can be purchased from the market easily, and the medicament is easy to kill Liriomyza sativae, Bemisia tabaci , can effectively control the spread and spread of Liriomyza sativae and Bemisia tabaci in a timely and large area. The selected mixed agents belong to compounds with different mechanisms of action. After mixing, the synergistic effect is obvious, and Bemisia tabaci is not easy to develop resistance to them , and the selected pesticides are all low-toxic or non-toxic, have low selection pressure on the environment, are cheap, and have good control effects over a long period of time. This can improve the control effect of the pesticides and avoid the narrow insecticidal spectrum and long-lasting effects of a single pesticide. Insufficient efficacy, relatively low control effect, etc. After mixing, the mixed synergistic effect of the pesticide can be fully exerted, which can expand the spectrum of pest control.
第二,本发明用主剂与辅剂制成水乳剂或悬浮剂,对斑潜蝇、烟粉虱高效、杀灭彻底,药剂对环境污染少,生产成本低,适合于斑潜蝇、烟粉虱的化学防治。Second, the present invention uses a main agent and an auxiliary agent to make an aqueous emulsion or a suspension, which is highly effective and thorough in killing Liriomyza sativae and Bemisia tabaci, and the medicament has less environmental pollution and low production cost, and is suitable for Chemical control of whiteflies.
具体实施方式Detailed ways
下面的实施例是对本发明技术方案进一步说明,但本发明的内容并不局限于此。The following examples further illustrate the technical solution of the present invention, but the content of the present invention is not limited thereto.
实施例1:35.0%螺虫乙酯·灭蝇胺水乳剂组成及制备方法Example 1: Composition and preparation method of 35.0% spirotetramat·cyromazine aqueous emulsion
主剂各有效成分重量百分比(%)为:螺虫乙酯30.0,灭蝇胺5.0;The weight percent (%) of each active ingredient of the main agent is: spirotetramat 30.0, cyromazine 5.0;
辅剂各成分重量百分比(%)为:溶剂,甲醇12.0,N-长链烷基吡咯烷酮10.0;乳化剂,2,4,6-三(1-苯乙基)苯酚聚(20)乙二醇磷酸单酯5.0;分散剂,阿拉伯胶0.5;抗冻剂,丙二醇0.5;水37.0。The weight percentage (%) of each component of the auxiliary agent is: solvent, methanol 12.0, N-long chain alkyl pyrrolidone 10.0; emulsifier, 2,4,6-tris(1-phenylethyl)phenol poly(20) glycol Phosphate monoester 5.0; dispersant, gum arabic 0.5; antifreeze agent, propylene glycol 0.5; water 37.0.
将上述重量比的原料混配后用传统的水乳剂加工方法制成水乳剂。The traditional water emulsion processing method is used to prepare water emulsion after mixing the raw materials in the above weight ratio.
实施例2:35.0%螺虫乙酯·灭蝇胺悬浮剂组成及制备方法Example 2: Composition and preparation method of 35.0% spirotetramat·cyromazine suspension concentrate
主剂各有效成分重量百分比(%)为:螺虫乙酯30.0,灭蝇胺5.0;The weight percent (%) of each active ingredient of the main agent is: spirotetramat 30.0, cyromazine 5.0;
辅剂各成分重量百分比(%)为:乳化剂,聚氧乙烯山梨糖醇酐酯15.0;溶剂,二甲基亚砜2.0,增稠剂,明胶5.0;稳定剂,没食子酸丙酯0.5;抗冻剂,山梨醇0.5;防腐剂,苯甲酸钠0.5;水41.5。The weight percentage (%) of each component of auxiliary agent is: emulsifier, polyoxyethylene sorbitan ester 15.0; Solvent, dimethyl sulfoxide 2.0, thickener, gelatin 5.0; Stabilizer, propyl gallate 0.5; Freezing agent, sorbitol 0.5; preservative, sodium benzoate 0.5; water 41.5.
将上述重量比的原料混配后用传统的悬浮剂加工方法制成悬浮剂。After mixing the raw materials in the above weight ratio, the traditional suspending agent processing method is used to prepare the suspending agent.
实施例3:40.0%螺虫乙酯·灭蝇胺水乳剂组成及制备方法Example 3: Composition and preparation method of 40.0% spirotetramat·cyromazine aqueous emulsion
主剂各有效成分重量百分比(%)为:螺虫乙酯30.0,灭蝇胺10.0;The weight percent (%) of each active ingredient of the main agent is: spirotetramat 30.0, cyromazine 10.0;
辅剂各成分重量百分比(%)为:乳化剂,烷基聚乙二醇醚8.0,乙氧化烷基醚12.0;溶剂,甲醇10.0;分散剂,阿拉伯胶5.0;抗冻剂,丙三醇5.0;水20.0。The weight percent (%) of each component of auxiliary agent is: emulsifier, alkyl polyglycol ether 8.0, ethoxylated alkyl ether 12.0; Solvent, methanol 10.0; Dispersant, gum arabic 5.0; Antifreeze agent, glycerol 5.0 ; Water 20.0.
将上述重量比的原料混配后用传统的水乳剂加工方法制成水乳剂。The traditional water emulsion processing method is used to prepare water emulsion after mixing the raw materials in the above weight ratio.
实施例4:40.0%螺虫乙酯·灭蝇胺悬浮剂组成及制备方法Example 4: Composition and preparation method of 40.0% spirotetramat·cyromazine suspension concentrate
主剂各有效成分重量百分比(%)为:螺虫乙酯30.0,灭蝇胺10.0;The weight percent (%) of each active ingredient of the main agent is: spirotetramat 30.0, cyromazine 10.0;
辅剂各成分重量百分比(%)为:乳化剂,环氧乙烷-环氧丙烷嵌段共聚物15.0;溶剂,甲醇5.0,乙醇5.0;增稠剂,聚乙烯吡咯烷酮1.0,聚乙二醇4.0;抗冻剂,1.0;防腐剂,苯甲酸钠0.5,甲醛0.5;异噻唑啉酮1.0;稳定剂,没食子酸丙酯1.0;水26.0。The weight percent (%) of each component of the auxiliary agent is: emulsifier, ethylene oxide-propylene oxide block copolymer 15.0; solvent, methanol 5.0, ethanol 5.0; thickener, polyvinylpyrrolidone 1.0, polyethylene glycol 4.0 Antifreeze, 1.0; Preservatives, sodium benzoate 0.5, formaldehyde 0.5; Isothiazolinone 1.0; Stabilizer, propyl gallate 1.0;
将上述重量比的原料混配后用传统的悬浮剂加工方法制成悬浮剂。After mixing the raw materials in the above weight ratio, the traditional suspending agent processing method is used to prepare the suspending agent.
实施例5:40.0%螺虫乙酯·灭蝇胺水乳剂组成及制备方法Example 5: Composition and preparation method of 40.0% spirotetramat·cyromazine aqueous emulsion
主剂各有效成分重量百分比(%)为:螺虫乙酯20.0,灭蝇胺20.0;The weight percent (%) of each active ingredient of the main agent is: spirotetramat 20.0, cyromazine 20.0;
辅剂各成分重量百分比(%)为:乳化剂,N-长链烷基吡咯烷酮10.0,乙氧化烷基醚5.0,聚氧乙烯脂肪酸酯5.0;溶剂,异丁醇8.0;分散剂,聚乙烯醇5.0;抗冻剂,山梨醇0.5;水26.5。The weight percentage (%) of each component of the auxiliary agent is: emulsifier, N-long chain alkyl pyrrolidone 10.0, ethoxylated alkyl ether 5.0, polyoxyethylene fatty acid ester 5.0; solvent, isobutanol 8.0; dispersant, polyethylene Alcohol 5.0; antifreeze, sorbitol 0.5; water 26.5.
将上述重量比的原料混配后用传统的水乳剂加工方法制成水乳剂。The traditional water emulsion processing method is used to prepare water emulsion after mixing the raw materials in the above weight ratio.
实施例6:40.0%螺虫乙酯·灭蝇胺悬浮剂组成及制备方法Example 6: Composition and preparation method of 40.0% spirotetramat·cyromazine suspension concentrate
主剂各有效成分重量百分比(%)为:螺虫乙酯20.0,灭蝇胺20.0;The weight percent (%) of each active ingredient of the main agent is: spirotetramat 20.0, cyromazine 20.0;
辅剂各成分重量百分比(%)为:溶剂,丙酮10.0,二甲基甲酰胺5.0;增稠剂,羧丙基纤维素钠2.5,聚乙烯醇2.5;抗冻剂,聚乙二醇5.0;稳定剂,环氧化豆油5.0;防腐剂,甲醛0.5;水29.5。The weight percent (%) of each component of the auxiliary agent is: solvent, acetone 10.0, dimethylformamide 5.0; thickener, sodium carboxypropyl cellulose 2.5, polyvinyl alcohol 2.5; antifreeze agent, polyethylene glycol 5.0; Stabilizer, epoxidized soybean oil 5.0; preservative, formaldehyde 0.5; water 29.5.
将上述重量比的原料混配后用传统的悬浮剂加工方法制成悬浮剂。After mixing the raw materials in the above weight ratio, the traditional suspending agent processing method is used to prepare the suspending agent.
实施例7:40.0%螺虫乙酯·灭蝇胺水乳剂组成及制备方法Example 7: Composition and preparation method of 40.0% spirotetramat·cyromazine aqueous emulsion
主剂各有效成分重量百分比(%)为:螺虫乙酯10.0,灭蝇胺30.0;The weight percent (%) of each active ingredient of the main agent is: spirotetramat 10.0, cyromazine 30.0;
辅剂各成分重量百分比(%)为:溶剂,甲醇5.0;乳化剂,2,4,6-三(1-苯乙基)苯酚聚(20)乙二醇磷酸单酯8.0,烷基苯磺酸钙2.0;分散剂,聚乙烯醇0.5;抗冻剂,乙二醇0.5;水44.0。The weight percent (%) of each component of the auxiliary agent is: solvent, methanol 5.0; emulsifier, 2,4,6-tris(1-phenylethyl)phenol poly(20) ethylene glycol phosphate monoester 8.0, alkylbenzene sulfonate Calcium acid 2.0; dispersant, polyvinyl alcohol 0.5; antifreeze agent, ethylene glycol 0.5; water 44.0.
将上述重量比的原料混配后用传统的水乳剂加工方法制成水乳剂。The traditional water emulsion processing method is used to prepare water emulsion after mixing the raw materials in the above weight ratio.
实施例8:40.0%螺虫乙酯·灭蝇胺悬浮剂组成及制备方法Example 8: Composition and preparation method of 40.0% spirotetramat·cyromazine suspension concentrate
主剂各有效成分重量百分比(%)为:螺虫乙酯10.0,灭蝇胺30.0;The weight percent (%) of each active ingredient of the main agent is: spirotetramat 10.0, cyromazine 30.0;
辅剂各成分重量百分比(%)为:乳化剂,烷基苯磺酸钙10.0;溶剂,乙二醇15.0;增稠剂,明胶5.0;稳定剂,氨基苯甲酸1.0;抗冻剂,乙二醇0.5;丙三醇0.5;防腐剂,异噻唑啉酮3.0,苯甲酸钠2.0;水23.0。The weight percentage (%) of each component of the auxiliary agent is: emulsifier, calcium alkylbenzene sulfonate 10.0; solvent, ethylene glycol 15.0; thickener, gelatin 5.0; stabilizer, aminobenzoic acid 1.0; Alcohol 0.5; Glycerin 0.5; Preservatives, Isothiazolinone 3.0, Sodium Benzoate 2.0; Water 23.0.
将上述重量比的原料混配后用传统的悬浮剂加工方法制成悬浮剂。After mixing the raw materials in the above weight ratio, the traditional suspending agent processing method is used to prepare the suspending agent.
实施例9:35.0%螺虫乙酯·灭蝇胺水乳剂组成及制备方法Example 9: Composition and preparation method of 35.0% spirotetramat·cyromazine aqueous emulsion
主剂各有效成分重量百分比(%)为:螺虫乙酯5.0,灭蝇胺30.0;The weight percent (%) of each active ingredient of the main agent is: spirotetramat 5.0, cyromazine 30.0;
辅剂各成分重量百分比(%)为:溶剂,甲醇10.0,N-长链烷基吡咯烷酮10.0;乳化剂,2,4,6-三(1-苯乙基)苯酚聚(20)乙二醇磷酸单酯0.5;分散剂,聚乙烯醇0.5;抗冻剂,聚乙二醇0.5;水43.5。The weight percent (%) of each component of the auxiliary agent is: solvent, methanol 10.0, N-long chain alkyl pyrrolidone 10.0; emulsifier, 2,4,6-tris(1-phenylethyl)phenol poly(20) glycol Phosphate monoester 0.5; dispersant, polyvinyl alcohol 0.5; antifreeze agent, polyethylene glycol 0.5; water 43.5.
将上述重量比的原料混配后用传统的水乳剂加工方法制成水乳剂。The traditional water emulsion processing method is used to prepare water emulsion after mixing the raw materials in the above weight ratio.
实施例10:35.0%螺虫乙酯·灭蝇胺悬浮剂组成及制备方法Example 10: Composition and preparation method of 35.0% spirotetramat·cyromazine suspension concentrate
主剂各有效成分重量百分比(%)为:螺虫乙酯5.0,灭蝇胺30.0;The weight percent (%) of each active ingredient of the main agent is: spirotetramat 5.0, cyromazine 30.0;
辅剂各成分重量百分比(%)为:乳化剂,烷基苯基聚乙二醇醚12.0;溶剂,异丁醇10.0,甲醇5.0;增稠剂,阿拉伯胶0.5;稳定剂,焦性没食子酸0.5;抗冻剂,丙二醇0.5;防腐剂,苯甲酸钠0.5;水36.0;The weight percentage (%) of each component of the auxiliary agent is: emulsifier, alkylphenyl polyethylene glycol ether 12.0; solvent, isobutanol 10.0, methanol 5.0; thickener, gum arabic 0.5; stabilizer, pyrogallic acid 0.5; antifreeze, propylene glycol 0.5; preservative, sodium benzoate 0.5; water 36.0;
将上述重量比的原料混配后用传统的悬浮剂加工方法制成悬浮剂。After mixing the raw materials in the above weight ratio, the traditional suspending agent processing method is used to prepare the suspending agent.
实施例11:具有杀虫活性的组合物对杀灭斑潜蝇的毒力测定:Embodiment 11: The toxicity determination of the composition with insecticidal activity to killing liriomyza:
以室内长期饲养的美洲斑潜蝇敏感品系为对象,以盆栽土培豆苗为饲养基质,室内温度25℃,试验时以3龄幼虫作材料。采用浸叶法,将供试药剂稀释成5个浓度梯度,将具有存活斑潜蝇幼虫的叶片在药液中浸泡5s,滤纸吸干后叶片置入恒温保湿的培养皿内,48h后检查死亡率。每个处理取10片豆叶,每个处理3次重复,每一重复取用10头幼虫。计算死亡率和校正死亡率,用机率值法求出毒力回归方程和致死中浓度LC50值,共毒系数采用孙云沛法计算。The sensitive strain of Liriomyza sativae that has been reared indoors for a long time was used as the object, and the potted bean seedlings were used as the feeding substrate, and the indoor temperature was 25°C. The 3rd instar larvae were used as the material in the experiment. Using the method of soaking leaves, dilute the test agent into 5 concentration gradients, soak the leaves with the surviving Liriomyza larvae in the liquid for 5 seconds, blot the leaves with filter paper, put them into a constant temperature and moisturizing petri dish, and check for death after 48 hours Rate. 10 bean leaves were taken for each treatment, and each treatment was replicated 3 times, and 10 larvae were used for each repetition. The mortality rate and corrected mortality rate were calculated, the regression equation of toxicity and the LC 50 value of lethal intermediate concentration were obtained by the probability value method, and the co-toxicity coefficient was calculated by Sun Yunpei's method.
共毒系数CTC=100×实际混用的毒力指数/理论混用的毒力指数。Co-toxicity coefficient CTC=100×virulence index of actual mixed use/virulence index of theoretical mixed use.
当共毒系数明显大于100时,表明有增效作用;接近100,表示有相加作用;明显小于100,表明有拮抗作用。测试及计算结果如表1所示:When the co-toxicity coefficient is significantly greater than 100, it indicates that there is a synergistic effect; when it is close to 100, it indicates that there is an additive effect; and when it is significantly less than 100, it indicates that there is an antagonistic effect. The test and calculation results are shown in Table 1:
表1各处理对斑潜蝇的室内毒力测定结果(72h)Table 1 The indoor toxicity test results (72h) of each treatment to Liriomyza sativae
由表1可以看出,螺虫乙酯、灭蝇胺、螺虫乙酯与灭蝇胺各个配比混配对斑潜蝇的有效致死中浓度LC50值按序(6:1、3:1、1:1、1:3和1:6)分别为15.19、22.30、13.14、12.53、11.80、12.29和15.42μg/mL;螺虫乙酯与灭蝇胺各个配比混配的共毒系数按序(6:1、3:1、1:1、1:3和1:6)分别为121.18、131.74、153.18、162.47和135.50。螺虫乙酯与灭蝇胺配比为6:1、3:1、1:1、1:3和1:6具有增效作用,其中配比为1:3时增效作用最明显。As can be seen from Table 1, the LC 50 values of the effective lethal concentration of Liriomyza spp. in the mixed ratios of spirotetramat, cyromazine, spirotetramat and cyromazine are in order (6:1, 3:1 , 1:1, 1:3 and 1:6) are 15.19, 22.30, 13.14, 12.53, 11.80, 12.29 and 15.42 μg/mL respectively; The sequences (6:1, 3:1, 1:1, 1:3, and 1:6) are 121.18, 131.74, 153.18, 162.47, and 135.50, respectively. The ratios of spirotetramat and cyromazine were 6:1, 3:1, 1:1, 1:3 and 1:6, and the synergistic effect was the most obvious when the ratio was 1:3.
实施例12:具有杀虫活性的组合物对杀灭烟粉虱若虫的毒力测定:Example 12: Toxicity determination of insecticidal compositions against whitefly nymphs:
采用叶片浸渍法,将各种药剂稀释成呈等比梯度的5个浓度,从养虫室内摘取含有1~2龄烟粉虱若虫的扶桑叶片若干张,在镜下清除卵和其它虫态,每叶片有烟粉虱1~2龄若虫40~50头左右。将叶片放在药液中浸泡5s后取出、放在室内凉干,在培养皿内垫一层滤纸,将叶片放入培养皿内滤纸上,用湿棉球包住叶柄进行保湿,盖上培养皿盖。试验共30个处理,每个处理设3个重复,用清水浸泡叶片作对照。3d时在显微镜下检查烟粉虱1~2若虫死亡情况(凡虫体干瘪、颜色变枯黄者为死亡)。计算死亡率和校正死亡率,用机率值法求出毒力回归方程和LC50值,共毒系数采用孙云沛法计算。Using the leaf dipping method, dilute various chemicals into 5 concentrations in equal gradients, pick several hibiscus leaves containing 1-2 instar Bemisia tabaci nymphs from the insect culture room, and remove eggs and other insect states under the microscope. , each leaf has about 40-50 1-2 instar nymphs of Bemisia tabaci. Soak the leaves in the liquid medicine for 5 seconds, take them out, put them in the room to dry, put a layer of filter paper in the petri dish, put the leaves on the filter paper in the petri dish, wrap the petiole with wet cotton balls to keep moisture, cover and cultivate Dish cover. A total of 30 treatments were used in the experiment, and each treatment had 3 replicates. The leaves were soaked in water as a control. On the 3rd day, the death of 1 to 2 nymphs of Bemisia tabaci was checked under a microscope (those with shriveled body and withered yellow color were considered dead). The mortality rate and corrected mortality rate were calculated, and the regression equation and LC 50 value of toxicity were obtained by the probability value method. The co-toxicity coefficient was calculated by Sun Yunpei's method.
共毒系数CTC=100×实际混用的毒力指数/理论混用的毒力指数。Co-toxicity coefficient CTC=100×virulence index of actual mixed use/virulence index of theoretical mixed use.
当共毒系数明显大于100时,表明有增效作用;接近100,表示有相加作用;明显小于100,表明有拮抗作用。测试及计算结果如表2所示:When the co-toxicity coefficient is significantly greater than 100, it indicates that there is a synergistic effect; when it is close to 100, it indicates that there is an additive effect; and when it is significantly less than 100, it indicates that there is an antagonistic effect. The test and calculation results are shown in Table 2:
表2各处理对烟粉虱若虫的室内毒力测定结果(72h)Table 2 The indoor toxicity test results (72h) of each treatment to Bemisia tabaci nymphs
由表2可以看出,螺虫乙酯、灭蝇胺、螺虫乙酯与灭蝇胺各个配比混配对烟粉虱若虫的有效致死中浓度LC50值按序(6:1、3:1、1:1、1:3和1:6)分别为11.24、20.15、10.31、9.57、9.76、10.58和12.67μg/mL;螺虫乙酯与灭蝇胺各个配比混配的共毒系数按序(6:1、3:1、1:1、1:3和1:6)分别为116.36、132.06、147.86、159.00和142.85。螺虫乙酯与灭蝇胺配比为6:1、3:1、1:1、1:3和1:6具有增效作用,其中配比为1:3时增效作用最明显。As can be seen from Table 2, spirotetramat, cyromazine, each ratio of spirotetramat and cyromazine are mixed to the effective lethal middle concentration LC50 value of whitefly nymphs in order (6:1, 3: 1, 1:1, 1:3 and 1:6) are 11.24, 20.15, 10.31, 9.57, 9.76, 10.58 and 12.67 μg/mL respectively; In order (6:1, 3:1, 1:1, 1:3, and 1:6) they are 116.36, 132.06, 147.86, 159.00, and 142.85, respectively. The ratios of spirotetramat and cyromazine were 6:1, 3:1, 1:1, 1:3 and 1:6, and the synergistic effect was the most obvious when the ratio was 1:3.
实施例13:混配杀虫剂田间药效试验Embodiment 13: Field efficacy test of mixed insecticide
田间药效试验采用防治蔬菜斑潜蝇,将上述实施例1~例10共10种药剂,稀释相同倍数1000倍,同时设置空白对照和40.0%螺虫乙酯水乳剂、40.0%灭蝇胺水乳剂对照,每处理重复3次。在扬州蒋王蔬菜种植区,寄主植物为黄瓜(盛果期)。小区随机排列,小区面积为20m2。对美洲斑潜蝇的防治于2013年7月,用工农-16喷雾器均匀喷雾,兑水药液50kg/667m2。每小区固定10株,每株固定上部2片展开叶;施药前调查固定叶片上的活虫数,并做标记;施药7天后调查标记内活虫数和新增添活虫数,并逐次做标记。在每一标定叶上的蛀道顶端标定位置,检查蛀道是否超过标定位置,确定幼虫是否存活。按生物统计常规计算方法,计算出虫口减退率。试验结果见表3:The field drug efficacy test adopts the prevention and control of vegetable leafminer, and the above-mentioned examples 1 to 10 are totally 10 kinds of pesticides, and the same multiple is diluted 1000 times, and a blank control and 40.0% spirotetramat water emulsion, 40.0% cyromazine water Emulsion control, each treatment was repeated 3 times. In Yangzhou Jiangwang vegetable planting area, the host plant is cucumber (full fruit period). The plots are arranged randomly, with an area of 20m 2 . The control of Liriomyza sativae was carried out in July 2013, sprayed evenly with Gongnong-16 sprayer, and mixed with water 50kg/667m 2 . Fix 10 plants per plot, and fix 2 expanded leaves on the upper part of each plant; investigate the number of live insects on the fixed leaves before spraying, and mark them; 7 days after spraying, investigate the number of live insects in the mark and the number of newly added live insects, and record them one by one to mark. Mark the position at the top of the borer channel on each marked leaf, check whether the borer channel exceeds the marked position, and determine whether the larvae survive. According to the routine calculation method of biostatistics, the population reduction rate was calculated. The test results are shown in Table 3:
表3各制剂喷雾处理防治斑潜蝇田间药效试验结果Table 3 The results of the field efficacy test of each preparation spray treatment to prevent and control Liriomyza sativae
由表3可以看出:在田间药效试验中,两单剂处理和10个混剂处理组均对斑潜蝇具有良好的防治效果,说明螺虫乙酯与灭蝇胺混配后,制备的各制剂均满足防治斑潜蝇的需要。As can be seen from Table 3: in the field drug efficacy test, two single-dose treatments and 10 mixed-dose treatment groups all have good control effects on Liriomyza sativae, indicating that after spirotetramat and cyromazine are mixed, the prepared All the preparations meet the needs of controlling Liriomyza sativae.
实施例14:混配杀虫剂田间药效试验Embodiment 14: Field efficacy test of mixed insecticides
田间药效试验采用防治蔬菜烟粉虱,将上述实施例1~例10共10种药剂,稀释相同倍数1000倍,同时设置空白对照和40.0%螺虫乙酯水乳剂、40.0%灭蝇胺水乳剂对照,每处理重复3次。试验结果见表4:The field drug efficacy test adopts the prevention and treatment of vegetable Bemisia tabaci. The 10 kinds of pesticides in the above-mentioned Examples 1 to Example 10 are diluted 1000 times at the same multiple. Emulsion control, each treatment was repeated 3 times. The test results are shown in Table 4:
表4各制剂喷雾处理防治烟粉虱田间药效试验结果Table 4 The results of the field efficacy test of each preparation spray treatment to control Bemisia tabaci
由表4可以看出:在田间药效试验中,两单剂处理和10个混剂处理组均对烟粉虱具有良好的防治效果,说明螺虫乙酯与灭蝇胺混配后,制备的各制剂均满足防治烟粉虱的需要。As can be seen from Table 4: in the field drug efficacy test, two single-dose treatments and 10 mixed-dose treatment groups all have good control effects on Bemisia tabaci, indicating that after spirotetramat and cyromazine are mixed, the prepared All the preparations meet the needs of controlling Bemisia tabaci.
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