CN104224412A - Method for preparing intravascular stent upon 3D (three-dimensional) printing technology - Google Patents
Method for preparing intravascular stent upon 3D (three-dimensional) printing technology Download PDFInfo
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- 238000000034 method Methods 0.000 title claims abstract description 34
- 238000007639 printing Methods 0.000 title claims abstract description 22
- 238000005516 engineering process Methods 0.000 title abstract description 8
- 239000000843 powder Substances 0.000 claims abstract description 92
- 239000000463 material Substances 0.000 claims abstract description 56
- 229910001000 nickel titanium Inorganic materials 0.000 claims abstract description 47
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 17
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 17
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000008117 stearic acid Substances 0.000 claims abstract description 17
- 229910001220 stainless steel Inorganic materials 0.000 claims abstract description 12
- 239000010935 stainless steel Substances 0.000 claims abstract description 12
- 238000001816 cooling Methods 0.000 claims abstract description 11
- HZEWFHLRYVTOIW-UHFFFAOYSA-N [Ti].[Ni] Chemical compound [Ti].[Ni] HZEWFHLRYVTOIW-UHFFFAOYSA-N 0.000 claims abstract description 7
- 238000005245 sintering Methods 0.000 claims abstract description 5
- 239000011230 binding agent Substances 0.000 claims description 58
- 238000009413 insulation Methods 0.000 claims description 44
- 239000000758 substrate Substances 0.000 claims description 39
- 229910000831 Steel Inorganic materials 0.000 claims description 35
- 239000010959 steel Substances 0.000 claims description 35
- 239000012188 paraffin wax Substances 0.000 claims description 30
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 22
- 238000010438 heat treatment Methods 0.000 claims description 16
- 230000015572 biosynthetic process Effects 0.000 claims description 11
- 238000000465 moulding Methods 0.000 claims description 11
- 238000000354 decomposition reaction Methods 0.000 claims description 10
- 230000007423 decrease Effects 0.000 claims description 10
- 238000001125 extrusion Methods 0.000 claims description 10
- -1 polypropylene Polymers 0.000 claims description 10
- 238000010146 3D printing Methods 0.000 claims description 9
- 239000004743 Polypropylene Substances 0.000 claims description 8
- 229920001684 low density polyethylene Polymers 0.000 claims description 8
- 239000004702 low-density polyethylene Substances 0.000 claims description 8
- 229920001155 polypropylene Polymers 0.000 claims description 8
- 238000001291 vacuum drying Methods 0.000 claims description 8
- FGBJXOREULPLGL-UHFFFAOYSA-N ethyl cyanoacrylate Chemical compound CCOC(=O)C(=C)C#N FGBJXOREULPLGL-UHFFFAOYSA-N 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
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- 238000005238 degreasing Methods 0.000 abstract 1
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Abstract
The invention discloses a method for preparing an intravascular stent upon the 3D (three-dimensional) printing technology. The method comprises the following steps: firstly establishing a 3D model of the intravascular stent in a computer; inputting data of the established model into corollary equipment of a 3D printer and setting a printing program; bonding a mixed powder material, consisting of stainless steel powder or nickel-titanium powder and stearic acid powder, with a bonder through 3D printing program control to form an intravascular stent blank; performing degreasing, vacuum sintering and cooling treatment on the blank in sequence to obtain the intravascular stent. According to the preparation method, the personalized model can be designed according to the actual requirement of a patient, and the required intravascular stent blank can be rapidly and accurately prepared; the further prepared intravascular stent has a complete surface and has no defects of deformation or cracking and the like; especially, the prepared intravascular stent has no rejection reaction in 24 days in simulated body fluid, is good in biocompatibility and completely meets the medical requirement; the cost for preparing the intravascular stent by a traditional laser cutting method is greatly reduced.
Description
Technical field
The present invention relates to a kind of method preparing endovascular stent based on 3D printing technique, belong to medical apparatus and instruments preparation field.
Background technology
Stent technology is a kind of Micro trauma interventional therapy method, narrow, the inaccessible blood vessel for support human body endogenous cause of ill pathological changes, recover the tubular device of blood circulation, endovascular stent implants the Main Means having become myocardial blood transport reconstruction after acute myocardial infarction at present.Intravascular stent rapidoprint should have corrosion resistance, good with the compatibility of blood vessel wall and blood, and resisting fatigue, can clearly develop under X-ray.The endovascular stent of current extensive use mainly adopts tubing laser cutting parameter to prepare, but this mode cost is high, supporting structure design is limited, be difficult to the intravascular stent realizing complicated shape, and the key performance such as precision, fineness does not reach, thus in Clinical practice, cause the problem such as thrombosis and blocking.Therefore the present invention intends adopting a kind of new method to prepare intravascular stent.
It is a kind of emerging rapid shaping technique that 3D prints (3D Printing) technology.Three-dimensional printing-forming technology adopts precise nozzle according to part section shape, is injected on the powder bed completed in advance by solution, amount of powder is bonded together, Formation cross-section profile.After one deck powder forming completes, repave last layer powder, carry out the bonding of lower one deck powder, so circulation is until workpiece completes, then obtains molded part through post processing.Different from traditional removal materials processing technology, be therefore also called and add manufacture.3D is printed on biological engineering and medical domain has very large development potentiality.But it is generally higher to the requirement of material to prepare medical apparatus and instruments, the material adopting 3D printing shaping to obtain often because the material selected is different, molding time the binding agent selected etc. incorrect and process parameter control is bad, can cause the defects such as the billet surface that obtains is fuzzy, buckling deformation, size distortion, step-like surface, fine structure defect, fragmentation, staggered floor, this is fatal harm for 3D printing technique for the manufacture of medical device.And also having contraction distortion due to product in sintering process, the control of product size precision is more difficult.
Summary of the invention
The object of the invention is to be to provide a kind of fast, precision prepare good biocompatibility, smooth surface smooth, without the method for the endovascular stent of distortion.
The invention provides a kind of method preparing endovascular stent based on 3D printing technique, the method comprises the following steps:
Step (1): modeling
Set up the 3D model of endovascular stent in a computer, and become by described 3D model decomposition thickness to be a series of two-dimensional slice models of 80 ~ 100 μm;
Step (2): batching
Powder body material: be mixed and made into powder body material in 60 ~ 80:40 ~ 20 at 130 DEG C ~ 165 DEG C temperature by volume by powder of stainless steel or NiTi powder and stearic acid powder;
Binding agent: be mixed and made into paraffin wax based binder by paraffin wax, Low Density Polyethylene, polypropylene and stearic acid 65 ~ 75:15 in mass ratio ~ 30:5 ~ 10:1, or make by ethyl α-cyanoacrylate is water-soluble the cyano group binding agent that mass percent concentration is 0.8 ~ 1.2%;
Step (3): 3D prints and prepares base substrate
In the corollary equipment of model data input 3D printer step (1) built up, print routine is set, powder body material in step (2) is sent into the print platform of 3D printer, roll extrusion laying, binding agent in the printhead injecting step (2) of 3D printer is by powder body material Adhesion formation two-dimensional slice, after printing one deck thin slice, controlled print platform to decline 80 ~ 100 μm to carry out the printing of lower one deck thin slice by computer, successively pile up molding, obtain endovascular stent base substrate;
Step (4): come unstuck, sinter
By step (3) gained base substrate successively through defat, vacuum-sintering, cooling post processing, obtain intravascular stent.
The method preparing endovascular stent based on 3D printing technique of the present invention also comprises following preferred version:
In preferred scheme, paraffin wax, Low Density Polyethylene, polypropylene and stearic mass ratio are 68 ~ 72:20 ~ 25:8 ~ 10:1; Most preferably be 70:20:9:1.
In preferred scheme, powder of stainless steel is the spherical 316L stainless steel powder of mean diameter between 5 ~ 20 μm.
In preferred scheme, NiTi powder is the spherical nickel titanium valve of mean diameter between 5 ~ 20 μm.
By regulating the emitted dose of printhead to make the binding agent of injection account for 20 ~ 40% of binding agent and powder body material gross mass in preferred scheme; Most preferably be 30 ~ 35%.
The method preferably preparing rustless steel endovascular stent comprises the following steps:
Step (1): modeling
Set up the 3D model of endovascular stent in a computer, and become by described 3D model decomposition thickness to be a series of two-dimensional slice models of 80 ~ 100 μm;
Step (2): batching
Powder body material: be mixed and made into rustless steel powder body material in 60 ~ 80:40 ~ 20 at 130 DEG C ~ 165 DEG C temperature by volume by the spherical 316L stainless steel powder of mean diameter between 5 ~ 20 μm and stearic acid powder;
Binding agent: be mixed and made into paraffin wax based binder by paraffin wax, Low Density Polyethylene, polypropylene and stearic acid 68 ~ 72:20 in mass ratio ~ 25:8 ~ 10:1;
Step (3): 3D prints and prepares base substrate
In the corollary equipment of model data input 3D printer step (1) built up, print routine is set, rustless steel powder body material in step (2) is sent into the print platform of 3D printer, roll extrusion laying, paraffin wax based binder in the printhead injecting step (2) of 3D printer is by rustless steel powder body material Adhesion formation two-dimensional slice, after printing one deck thin slice, controlled print platform to decline 80 ~ 100 μm to carry out the printing of lower one deck thin slice by computer, successively pile up molding, obtain rustless steel endovascular stent base substrate; Wherein, paraffin wax based binder is 20 ~ 40% of the knot agent of paraffin wax base and rustless steel powder body material gross mass;
Step (4): come unstuck, sinter
After step (3) gained rustless steel endovascular stent base substrate being evaporated into naturally the exsiccation of paraffin wax based binder, remove the rustless steel powder body that described billet surface fails to bond, be placed in stove and carry out temperature programming defat; First be heated to 180 ~ 240 DEG C with the heating rate of 1 ~ 3 DEG C/min from room temperature, insulation 1 ~ 2h, then be warmed up to 300 ~ 350 DEG C further with the heating rate of 1 ~ 5 DEG C/min, insulation 0.5 ~ 1.5h; After defat completes, base substrate is placed in vacuum drying oven, 450 ~ 550 DEG C are heated to the heating rate of 2 ~ 5 DEG C/min, insulation 0.5 ~ 1h, then continue to be warmed up to 800 ~ 900 DEG C with the heating rate of 2 ~ 5 DEG C/min, insulation 1 ~ 1.5h, be warmed up to 1350 ~ 1500 DEG C further again, insulation 1 ~ 2h, then furnace cooling, obtain rustless steel endovascular stent.
The method preferably preparing NiTi endovascular stent comprises the following steps:
Step (1): modeling
Set up the 3D model of endovascular stent in a computer, and become by described 3D model decomposition thickness to be a series of two-dimensional slice models of 80 ~ 100 μm;
Step (2): batching
Powder body material: be mixed and made into NiTi powder body material in 60 ~ 80:40 ~ 20 at 130 DEG C ~ 165 DEG C temperature by volume by the spherical nickel titanium valve of mean diameter between 5 ~ 20 μm and stearic acid powder;
Binding agent: make the cyano group binding agent that mass percent concentration is 0.8 ~ 1.2% by ethyl α-cyanoacrylate is water-soluble;
Step (3): 3D prints and prepares base substrate
In the corollary equipment of model data input 3D printer step (1) built up, print routine is set, NiTi powder body material in step (2) is sent into the print platform of 3D printer, roll extrusion laying, cyano group binding agent in the printhead injecting step (2) of 3D printer is by NiTi powder body material Adhesion formation two-dimensional slice, after printing one deck thin slice, controlled print platform to decline 80 ~ 100 μm to carry out the printing of lower one deck thin slice by computer, successively pile up molding, obtain NiTi endovascular stent base substrate; Wherein, cyano group binding agent is 20 ~ 40% of cyano group binding agent and NiTi powder body material gross mass;
Step (4): come unstuck, sinter
After step (3) gained NiTi endovascular stent base substrate being evaporated into naturally the exsiccation of cyano group binding agent, remove the NiTi powder body that billet surface fails to bond, carry out temperature programming defat being placed in stove, first rise to 400 DEG C with the speed of 1 ~ 5 DEG C/min from room temperature, insulation 30 ~ 60min, 600 ~ 800 DEG C are warming up to further again, insulation 60 ~ 120min with the speed of 0.5 ~ 1.5 DEG C/min; After defat completes, base substrate is placed in vacuum drying oven, rises to 1200 ~ 1250 DEG C with the speed of 10 ~ 15 DEG C/min, insulation 30 ~ 60min, then continue to rise to 2000 ~ 2200 DEG C with the speed of 6 ~ 20 DEG C/min, insulation 120 ~ 240min; Be cooled to 1500 ~ 1600 DEG C with the speed of 10 ~ 20 DEG C afterwards, insulation 30 ~ 60min, then continue to be cooled to 1200 ~ 1250 DEG C with the speed of 12 ~ 20 DEG C, insulation 60 ~ 90min, be cooled to 800 DEG C further with the speed of 10 ~ 20 DEG C again, then furnace cooling, obtain NiTi endovascular stent.
Beneficial effect of the present invention: prepare intravascular stent for laser cutting method in prior art and there is the intravascular stent that cost is high, supporting structure design is limited, be difficult to realize complicated shape, after the metal melting of local, the key performance such as precision, fineness is not reached during cut, affect the biocompatibility of material, in Clinical practice, cause the problem such as thrombosis and blocking.After inventor studies repeatedly, to the selection of material and continuing to optimize of process conditions, finally select and powder of stainless steel or the best binding agent of NiTi powder matching and forming agent, 3D printing technique is successfully used the preparation technology of intravascular stent, print process conditions to 3D to be again optimized, according to the personalized model designed by the actual needs of patient, fast, accurately prepare required perfect endovascular stent base substrate, through defat, after sintering, obtained endovascular stent surface is complete, without distortion, the defects such as cracking, rejection is there is not in 24 days in particularly obtained endovascular stent in simulated body fluid, good biocompatibility, meet medical requirement completely, greatly reduce the cost that conventional laser patterning method prepares endovascular stent.
Accompanying drawing explanation
The endovascular stent figure that [Fig. 1] obtains for embodiment 1.
The A-A view that [Fig. 2] is Fig. 1.
Detailed description of the invention
Following examples are intended to further illustrate content of the present invention, instead of limit the scope of the invention.
Embodiment 1
Step (1): modeling
Set up the 3D model of endovascular stent in a computer, and become by described 3D model decomposition thickness to be a series of two-dimensional slice models of 90 μm;
Step (2): batching
Powder body material: by mean diameter be the spherical 316L stainless steel powder of 8 μm and stearic acid powder by volume 60:40 at 140 DEG C of temperature, be mixed and made into rustless steel powder body material;
Binding agent: by paraffin wax, Low Density Polyethylene, polypropylene and stearic acid in mass ratio 68:23:8:1 be mixed and made into paraffin wax based binder;
Step (3): 3D prints and prepares base substrate
In the corollary equipment of model data input 3D printer step (1) built up, print routine is set, rustless steel powder body material in step (2) is sent into the print platform of 3D printer, roll extrusion laying, paraffin wax based binder in the printhead injecting step (2) of 3D printer is by rustless steel powder body material Adhesion formation two-dimensional slice, after printing one deck thin slice, controlled print platform to decline 90 μm by computer and carry out the printing of lower one deck thin slice, successively pile up molding, obtain rustless steel endovascular stent base substrate; Wherein, paraffin wax based binder is 25% of the knot agent of paraffin wax base and rustless steel powder body material gross mass;
Step (4): come unstuck, sinter
After step (3) gained rustless steel endovascular stent base substrate being evaporated into naturally the exsiccation of paraffin wax based binder, remove the rustless steel powder body that described billet surface fails to bond, be placed in stove and carry out temperature programming defat; First be heated to 180 DEG C with the heating rate of 1 DEG C/min from room temperature, insulation 1.5h, then be warmed up to 300 DEG C further with the heating rate of 2 DEG C/min, insulation 1h; After defat completes, base substrate is placed in vacuum drying oven, is heated to 450 DEG C with the heating rate of 3 DEG C/min, insulation 0.5h, continue to be warmed up to 850 DEG C with the heating rate of 2 DEG C/min again, insulation 1h, then be warmed up to 1350 DEG C further, insulation 2h, then furnace cooling, obtain rustless steel endovascular stent.
Obtained rustless steel endovascular stent surface smoothness is good, and flawless is undeformed.By support after polishing, in the compatibility test carried out in the simulated body fluid purchased and simulate blood, after 24 days, product surface corrosion is not obvious, and acid-base value, the ion concentration change of model fluid are small.
Embodiment 2
Step (1): modeling
Set up the 3D model of endovascular stent in a computer, and become by described 3D model decomposition thickness to be a series of two-dimensional slice models of 100 μm;
Step (2): batching
Powder body material: by mean diameter be the spherical 316L stainless steel powder of 15 μm and stearic acid powder by volume 80:20 at 155 DEG C of temperature, be mixed and made into rustless steel powder body material;
Binding agent: by paraffin wax, Low Density Polyethylene, polypropylene and stearic acid in mass ratio 70:20:9:1 be mixed and made into paraffin wax based binder;
Step (3): 3D prints and prepares base substrate
In the corollary equipment of model data input 3D printer step (1) built up, print routine is set, rustless steel powder body material in step (2) is sent into the print platform of 3D printer, roll extrusion laying, paraffin wax based binder in the printhead injecting step (2) of 3D printer is by rustless steel powder body material Adhesion formation two-dimensional slice, after printing one deck thin slice, controlled print platform to decline 100 μm by computer and carry out the printing of lower one deck thin slice, successively pile up molding, obtain rustless steel endovascular stent base substrate; Wherein, paraffin wax based binder is 35% of the knot agent of paraffin wax base and rustless steel powder body material gross mass;
Step (4): come unstuck, sinter
After step (3) gained rustless steel endovascular stent base substrate being evaporated into naturally the exsiccation of paraffin wax based binder, remove the rustless steel powder body that described billet surface fails to bond, be placed in stove and carry out temperature programming defat; First be heated to 220 DEG C with the heating rate of 2 DEG C/min from room temperature, insulation 1h, then be warmed up to 350 DEG C further with the heating rate of 2 DEG C/min, insulation 1.5h; After defat completes, base substrate is placed in vacuum drying oven, is heated to 550 DEG C with the heating rate of 2 DEG C/min, insulation 1h, continue to be warmed up to 900 DEG C with the heating rate of 2 DEG C/min again, insulation 1h, then be warmed up to 1350 DEG C further, insulation 2h, then furnace cooling, obtain rustless steel endovascular stent.
Obtained rustless steel endovascular stent surface smoothness is good, and flawless is undeformed.By support after polishing, in the compatibility test carried out in the simulated body fluid purchased and simulate blood, the corrosion-free phenomenon of product surface after 24 days, acid-base value, the ion concentration change-detection of model fluid are unchanged.
Embodiment 3
Step (1): modeling
Set up the 3D model of endovascular stent in a computer, and become by described 3D model decomposition thickness to be a series of two-dimensional slice models of 85 μm;
Step (2): batching
Powder body material: by mean diameter be the spherical nickel titanium valve of 10 μm and stearic acid powder by volume 70:30 at 145 DEG C of temperature, be mixed and made into NiTi powder body material;
Binding agent: make the cyano group binding agent that mass percent concentration is 0.8% by ethyl α-cyanoacrylate is water-soluble;
Step (3): 3D prints and prepares base substrate
In the corollary equipment of model data input 3D printer step (1) built up, print routine is set, NiTi powder body material in step (2) is sent into the print platform of 3D printer, roll extrusion laying, cyano group binding agent in the printhead injecting step (2) of 3D printer is by NiTi powder body material Adhesion formation two-dimensional slice, after printing one deck thin slice, controlled print platform to decline 85 μm by computer and carry out the printing of lower one deck thin slice, successively pile up molding, obtain NiTi endovascular stent base substrate; Wherein, cyano group binding agent is 40% of cyano group binding agent and NiTi powder body material gross mass;
Step (4): come unstuck, sinter
After step (3) gained NiTi endovascular stent base substrate being evaporated into naturally the exsiccation of cyano group binding agent, remove the NiTi powder body that billet surface fails to bond, carry out temperature programming defat being placed in stove, first rise to 400 DEG C with the speed of 3 DEG C/min from room temperature, insulation 50min, 650 DEG C are warming up to further again, insulation 70min with the speed of 1 DEG C/min; After defat completes, base substrate is placed in vacuum drying oven, rises to 1200 DEG C with the speed of 10 DEG C/min, insulation 35min, then continue to rise to 2050 DEG C with the speed of 8 DEG C/min, insulation 150min; Be cooled to 1550 DEG C with the speed of 10 DEG C afterwards, insulation 40min, then continue to be cooled to 1200 DEG C with the speed of 12 DEG C, insulation 80min, then be cooled to 800 DEG C further with the speed of 10 DEG C, then furnace cooling, obtain NiTi endovascular stent.
Obtained NiTi endovascular stent surface smoothness is good, and flawless is undeformed.By support after polishing, in the compatibility test carried out in the simulated body fluid purchased and simulate blood, after 24 days, product surface is without obvious corrosion phenomenon, and acid-base value, the ion concentration change of model fluid are small.
Embodiment 4
Step (1): modeling
Set up the 3D model of endovascular stent in a computer, and become by described 3D model decomposition thickness to be a series of two-dimensional slice models of 100 μm;
Step (2): batching
Powder body material: by the spherical nickel titanium valve of mean diameter between 8 μm and stearic acid powder by volume 80:20 at 165 DEG C of temperature, be mixed and made into NiTi powder body material;
Binding agent: make the cyano group binding agent that mass percent concentration is 1.2% by ethyl α-cyanoacrylate is water-soluble;
Step (3): 3D prints and prepares base substrate
In the corollary equipment of model data input 3D printer step (1) built up, print routine is set, NiTi powder body material in step (2) is sent into the print platform of 3D printer, roll extrusion laying, cyano group binding agent in the printhead injecting step (2) of 3D printer is by NiTi powder body material Adhesion formation two-dimensional slice, after printing one deck thin slice, controlled print platform to decline 100 μm by computer and carry out the printing of lower one deck thin slice, successively pile up molding, obtain NiTi endovascular stent base substrate; Wherein, cyano group binding agent is 35% of cyano group binding agent and NiTi powder body material gross mass;
Step (4): come unstuck, sinter
After step (3) gained NiTi endovascular stent base substrate being evaporated into naturally the exsiccation of cyano group binding agent, remove the NiTi powder body that billet surface fails to bond, carry out temperature programming defat being placed in stove, first rise to 400 DEG C with the speed of 3 DEG C/min from room temperature, insulation 45min, 700 DEG C are warming up to further again, insulation 100min with the speed of 1 DEG C/min; After defat completes, base substrate is placed in vacuum drying oven, rises to 1200 DEG C with the speed of 12 DEG C/min, insulation 45min, then continue to rise to 2100 DEG C with the speed of 12 DEG C/min, insulation 180min; Be cooled to 1550 DEG C with the speed of 15 DEG C afterwards, insulation 45min, then continue to be cooled to 1200 DEG C with the speed of 16 DEG C, insulation 75min, then be cooled to 800 DEG C further with the speed of 15 DEG C, then furnace cooling, obtain NiTi endovascular stent.
Obtained NiTi endovascular stent surface smoothness is good, and flawless is undeformed.By support after polishing, in the compatibility test carried out in the simulated body fluid purchased and simulate blood, the corrosion-free phenomenon of product surface after 24 days, acid-base value, the ion concentration change of model fluid are small.
Claims (6)
1. prepare a method for endovascular stent based on 3D printing technique, it is characterized in that, comprise the following steps:
Step (1): modeling
Set up the 3D model of endovascular stent in a computer, and become by described 3D model decomposition thickness to be a series of two-dimensional slice models of 80 ~ 100 μm;
Step (2): batching
Powder body material: be mixed and made into powder body material in 60 ~ 80:40 ~ 20 at 130 DEG C ~ 165 DEG C temperature by volume by powder of stainless steel or NiTi powder and stearic acid powder;
Binding agent: be mixed and made into paraffin wax based binder by paraffin wax, Low Density Polyethylene, polypropylene and stearic acid 65 ~ 75:15 in mass ratio ~ 30:5 ~ 10:1, or make by ethyl α-cyanoacrylate is water-soluble the cyano group binding agent that mass percent concentration is 0.8 ~ 1.2%;
Step (3): 3D prints and prepares base substrate
In the corollary equipment of model data input 3D printer step (1) built up, print routine is set, powder body material in step (2) is sent into the print platform of 3D printer, roll extrusion laying, binding agent in the printhead injecting step (2) of 3D printer is by powder body material Adhesion formation two-dimensional slice, after printing one deck thin slice, controlled print platform to decline 80 ~ 100 μm to carry out the printing of lower one deck thin slice by computer, successively pile up molding, obtain endovascular stent base substrate;
Step (4): come unstuck, sinter
By step (3) gained base substrate successively through defat, vacuum-sintering, cooling post processing, obtain intravascular stent.
2. method according to claim 1, is characterized in that, described paraffin wax, Low Density Polyethylene, polypropylene and stearic mass ratio are 68 ~ 72:20 ~ 25:8 ~ 10:1.
3. method according to claim 1, is characterized in that, described powder of stainless steel is the spherical 316L stainless steel powder of mean diameter between 5 ~ 20 μm; Described NiTi powder is the spherical nickel titanium valve of mean diameter between 5 ~ 20 μm.
4. method according to claim 1, is characterized in that, makes the binding agent of injection account for 20 ~ 40% of binding agent and powder body material gross mass by regulating the emitted dose of printhead.
5. the method according to any one of Claims 1 to 4, is characterized in that, comprises the following steps:
Step (1): modeling
Set up the 3D model of endovascular stent in a computer, and become by described 3D model decomposition thickness to be a series of two-dimensional slice models of 80 ~ 100 μm;
Step (2): batching
Powder body material: be mixed and made into rustless steel powder body material in 60 ~ 80:40 ~ 20 at 130 DEG C ~ 165 DEG C temperature by volume by the spherical 316L stainless steel powder of mean diameter between 5 ~ 20 μm and stearic acid powder;
Binding agent: be mixed and made into paraffin wax based binder by paraffin wax, Low Density Polyethylene, polypropylene and stearic acid 68 ~ 72:20 in mass ratio ~ 25:8 ~ 10:1;
Step (3): 3D prints and prepares base substrate
In the corollary equipment of model data input 3D printer step (1) built up, print routine is set, rustless steel powder body material in step (2) is sent into the print platform of 3D printer, roll extrusion laying, paraffin wax based binder in the printhead injecting step (2) of 3D printer is by rustless steel powder body material Adhesion formation two-dimensional slice, after printing one deck thin slice, controlled print platform to decline 80 ~ 100 μm to carry out the printing of lower one deck thin slice by computer, successively pile up molding, obtain rustless steel endovascular stent base substrate; Wherein, paraffin wax based binder is 20 ~ 40% of the knot agent of paraffin wax base and rustless steel powder body material gross mass;
Step (4): come unstuck, sinter
After step (3) gained rustless steel endovascular stent base substrate being evaporated into naturally the exsiccation of paraffin wax based binder, remove the rustless steel powder body that described billet surface fails to bond, be placed in stove and carry out temperature programming defat; First be heated to 180 ~ 240 DEG C with the heating rate of 1 ~ 3 DEG C/min from room temperature, insulation 1 ~ 2h, then be warmed up to 300 ~ 350 DEG C further with the heating rate of 1 ~ 5 DEG C/min, insulation 0.5 ~ 1.5h; After defat completes, base substrate is placed in vacuum drying oven, 450 ~ 550 DEG C are heated to the heating rate of 2 ~ 5 DEG C/min, insulation 0.5 ~ 1h, then continue to be warmed up to 800 ~ 900 DEG C with the heating rate of 2 ~ 5 DEG C/min, insulation 1 ~ 1.5h, be warmed up to 1350 ~ 1500 DEG C further again, insulation 1 ~ 2h, then furnace cooling, obtain rustless steel endovascular stent.
6. the method according to any one of Claims 1 to 4, is characterized in that, comprises the following steps:
Step (1): modeling
Set up the 3D model of endovascular stent in a computer, and become by described 3D model decomposition thickness to be a series of two-dimensional slice models of 80 ~ 100 μm;
Step (2): batching
Powder body material: be mixed and made into NiTi powder body material in 60 ~ 80:40 ~ 20 at 130 DEG C ~ 165 DEG C temperature by volume by the spherical nickel titanium valve of mean diameter between 5 ~ 20 μm and stearic acid powder;
Binding agent: make the cyano group binding agent that mass percent concentration is 0.8 ~ 1.2% by ethyl α-cyanoacrylate is water-soluble;
Step (3): 3D prints and prepares base substrate
In the corollary equipment of model data input 3D printer step (1) built up, print routine is set, NiTi powder body material in step (2) is sent into the print platform of 3D printer, roll extrusion laying, cyano group binding agent in the printhead injecting step (2) of 3D printer is by NiTi powder body material Adhesion formation two-dimensional slice, after printing one deck thin slice, controlled print platform to decline 80 ~ 100 μm to carry out the printing of lower one deck thin slice by computer, successively pile up molding, obtain NiTi endovascular stent base substrate; Wherein, cyano group binding agent is 20 ~ 40% of cyano group binding agent and NiTi powder body material gross mass;
Step (4): come unstuck, sinter
After step (3) gained NiTi endovascular stent base substrate being evaporated into naturally the exsiccation of cyano group binding agent, remove the NiTi powder body that billet surface fails to bond, carry out temperature programming defat being placed in stove, first rise to 400 DEG C with the speed of 1 ~ 5 DEG C/min from room temperature, insulation 30 ~ 60min, 600 ~ 800 DEG C are warming up to further again, insulation 60 ~ 120min with the speed of 0.5 ~ 1.5 DEG C/min; After defat completes, base substrate is placed in vacuum drying oven, rises to 1200 ~ 1250 DEG C with the speed of 10 ~ 15 DEG C/min, insulation 30 ~ 60min, then continue to rise to 2000 ~ 2200 DEG C with the speed of 6 ~ 20 DEG C/min, insulation 120 ~ 240min; Be cooled to 1500 ~ 1600 DEG C with the speed of 10 ~ 20 DEG C afterwards, insulation 30 ~ 60min, then continue to be cooled to 1200 ~ 1250 DEG C with the speed of 12 ~ 20 DEG C, insulation 60 ~ 90min, be cooled to 800 DEG C further with the speed of 10 ~ 20 DEG C again, then furnace cooling, obtain NiTi endovascular stent.
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