CN104207145A - Vitamin E nano-microemulsion and preparation method thereof - Google Patents
Vitamin E nano-microemulsion and preparation method thereof Download PDFInfo
- Publication number
- CN104207145A CN104207145A CN201410477268.4A CN201410477268A CN104207145A CN 104207145 A CN104207145 A CN 104207145A CN 201410477268 A CN201410477268 A CN 201410477268A CN 104207145 A CN104207145 A CN 104207145A
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- Prior art keywords
- vitamin
- microemulsion
- nano
- tween
- liquid
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title claims abstract description 152
- 229930003427 Vitamin E Natural products 0.000 title claims abstract description 76
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 title claims abstract description 76
- 229940046009 vitamin E Drugs 0.000 title claims abstract description 76
- 235000019165 vitamin E Nutrition 0.000 title claims abstract description 76
- 239000011709 vitamin E Substances 0.000 title claims abstract description 76
- 239000004530 micro-emulsion Substances 0.000 title claims abstract description 58
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 238000000593 microemulsion method Methods 0.000 title description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000007788 liquid Substances 0.000 claims description 29
- CODAYFPFZXWNLD-UHFFFAOYSA-N 2-hydroxypropanoyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(=O)C(C)O CODAYFPFZXWNLD-UHFFFAOYSA-N 0.000 claims description 22
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 22
- 238000010438 heat treatment Methods 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 7
- -1 Tween-65 Chemical compound 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 abstract description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 238000005538 encapsulation Methods 0.000 abstract 1
- YZNWXXJZEDHRKB-UHFFFAOYSA-N octadecyl 2-hydroxypropanoate;sodium Chemical compound [Na].CCCCCCCCCCCCCCCCCCOC(=O)C(C)O YZNWXXJZEDHRKB-UHFFFAOYSA-N 0.000 abstract 1
- 230000010355 oscillation Effects 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 description 7
- 239000004064 cosurfactant Substances 0.000 description 3
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- BBMCTIGTTCKYKF-UHFFFAOYSA-N 1-heptanol Chemical compound CCCCCCCO BBMCTIGTTCKYKF-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 2
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 1
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 description 1
- 239000013504 Triton X-100 Substances 0.000 description 1
- 229920004890 Triton X-100 Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- LIXVMPBOGDCSRM-UHFFFAOYSA-N nonylbenzene Chemical compound CCCCCCCCCC1=CC=CC=C1 LIXVMPBOGDCSRM-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the field of nano-microemulsions, and discloses a vitamin E nano-microemulsion. The vitamin E nano-microemulsion comprises the following components: 5wt%-15wt% of vitamin E, 10wt%-15wt% of Tween-65, 6wt%-12wt% of sodium stearyl lactate, 3wt%-5wt% of Span-80, 4wt%-9wt% of propylene glycol and the balance being water. A preparation method of the vitamin E nano-microemulsion comprises the processes of mixing and implementing vortex oscillation. The prepared vitamin E nano-microemulsion has the characteristics of high content of active ingredients, small grain size, high encapsulation efficiency and the like.
Description
Technical field
The invention belongs to microemulsion field, relate to a kind of nanometer micro-emulsion and preparation method thereof, particularly relate to a kind of nanometer micro-emulsion and method thereof of vitamin E.
Background technology
Microemulsion is thermodynamically stable, isotropic, the transparent dispersion that two kinds of immiscible liquid generate under the effect of surfactant molecule.The low tension system of the high degree of dispersion that microemulsion is made up of by a certain percentage distilled water, oil, surfactant, cosurfactant etc., the character of any one component or the change of amount in component, all can affect formation and the character of microemulsion.The selection of surfactant is the core preparing microemulsion, conventional surfactant is as follows: neopelex, lauryl sodium sulfate, nonionic surface active agent is as Triton X-100 (NPE), Npn (nonyl benzene polyethenoxy ether class surfactant), Tween-40 (60,80), Span-40 (60,80) etc.Except using various surfactant, also cosurfactant will be selected.Conventional cosurfactant has the alcohol of the medium chain such as n-butanol, n-amyl alcohol, n-hexyl alcohol, n-heptanol, n-octyl alcohol, isoamyl alcohol.Vitamin E is a kind of fat-soluble vitamin, needs to be dissolved in the water, and more could be conducive to its absorption in human body.In conventional vitamin E microemulsion, the content of vitamin E is lower usually, and its particle diameter is also comparatively large simultaneously, and envelop rate is also lower, needs the physical and chemical index improving vitamin E microemulsion further.
Summary of the invention
The technical problem solved: vitamin E is as a kind of function factor, need in human body to supplement, but vitamin E is as oil-soluble ingredients, the solubility of itself and water is very low, need that its dissolubility is carried out improvement could effectively absorb, in conventional vitamin E microemulsion, the content of vitamin E is lower, and solvent is more, the object of the invention is to improve the percentage of vitamin E in microemulsion, improve its concentration.
Technical scheme: for the problems referred to above, the invention discloses a kind of vitamin E nano microemulsion and preparation method thereof, and described vitamin E nano microemulsion consists of the following composition:
Vitamin E 5wt%-15wt%,
Tween-65 10wt%-15wt%,
Stearoyl lactate 6wt%-12wt%,
Department class 80 3wt%-5wt%,
Propane diols 4wt%-9wt%,
Surplus is water.
Preferably, described a kind of vitamin E nano microemulsion, consists of the following composition:
Vitamin E 10wt%,
Tween-65 12wt%,
Stearoyl lactate 8wt%,
Department class 80 3wt%,
Propane diols 9wt%,
Surplus is water.
Preferably, described a kind of vitamin E nano microemulsion, average grain diameter is 73nm to 91nm.
Preferably, described a kind of vitamin E nano microemulsion, envelop rate is 84% to 89%.
A preparation method for vitamin E nano microemulsion, the preparation method of described vitamin E nano microemulsion comprises the following steps:
(1) vitamin E, Tween-65, stearoyl lactate, class of department 80 is got, by vitamin E and Tween-65, stearoyl lactate, class of department 80 heating for dissolving, heating-up temperature is 45 DEG C-55 DEG C, carries out eddy oscillating after dissolving with eddy oscillating device, vibration mixes to three kinds of raw materials, is A liquid;
(2) separately getting propane diols soluble in water, mixed by propane diols with water, is B liquid;
(3) also mixed with B liquid by A liquid, carry out eddy oscillating again after mixing, the eddy oscillating time is 10min, vibration terminate after prepare vitamin E nano microemulsion, in microemulsion vitamin E be 5wt%-15wt%, Tween-65 be 10wt%-15wt%,
Stearoyl lactate is 6wt%-12wt%, class of department 80 is 3wt%-5wt%, propane diols is 4wt%-9wt%, surplus is water.
Preferably, the preparation method of described a kind of vitamin E nano microemulsion, comprises the following steps:
(1) vitamin E, Tween-65, stearoyl lactate, class of department 80 is got, by vitamin E and Tween-65, stearoyl lactate, class of department 80 heating for dissolving, heating-up temperature is 45 DEG C-55 DEG C, carries out eddy oscillating after dissolving with eddy oscillating device, vibration mixes to three kinds of raw materials, is A liquid;
(2) separately getting propane diols soluble in water, mixed by propane diols with water, is B liquid;
(3) A liquid is also mixed with B liquid, eddy oscillating is carried out again after mixing, the eddy oscillating time is 10min, prepare vitamin E nano microemulsion after vibration terminates, in microemulsion, vitamin E is 10wt%, Tween-65 is 12wt%, stearoyl lactate is 8wt%, class of department 80 is 3wt%, propane diols is 9wt%, surplus is water.
Beneficial effect: in vitamin E nano microemulsion of the present invention, the content of vitamin E obtains 5wt%-15wt%, effectively raise the concentration of vitamin E in microemulsion, and the microemulsion average grain diameter prepared is at 73nm to 91nm, envelop rate is 84% to 89%, effectively raises vitamin E as the application in the industry of a kind of dietary supplements.
Detailed description of the invention
Embodiment 1
A preparation method for vitamin E nano microemulsion, comprises the following steps:
(1) get that vitamin E is 10g, Tween-65 is 12g, stearoyl lactate is 8g, class of department 80 is 3g, by vitamin E and Tween-65, stearoyl lactate, class of department 80 heating for dissolving, heating-up temperature is 50 DEG C, eddy oscillating is carried out with eddy oscillating device after dissolving, vibration mixes to three kinds of raw materials, is A liquid;
(2) separately getting 9g propane diols to be dissolved in 58g water, mixed by propane diols with water, is B liquid;
(3) also mixed with B liquid by A liquid, carry out eddy oscillating again after mixing, the eddy oscillating time is 10min, prepares vitamin E nano microemulsion after vibration terminates.
The average grain diameter of the vitamin E nano microemulsion of embodiment 1 is 73nm, and envelop rate is 89%.
Embodiment 2
A preparation method for vitamin E nano microemulsion, comprises the following steps:
(1) get that vitamin E is 15g, Tween-65 is 15g, stearoyl lactate is 6g, class of department 80 is 4g, by vitamin E and Tween-65, stearoyl lactate, class of department 80 heating for dissolving, heating-up temperature is 50 DEG C, eddy oscillating is carried out with eddy oscillating device after dissolving, vibration mixes to three kinds of raw materials, is A liquid;
(2) separately getting 7g propane diols to be dissolved in 53g water, mixed by propane diols with water, is B liquid;
(3) also mixed with B liquid by A liquid, carry out eddy oscillating again after mixing, the eddy oscillating time is 10min, prepares vitamin E nano microemulsion after vibration terminates.
The average grain diameter of the vitamin E nano microemulsion of embodiment 2 is 84nm, and envelop rate is 84%.
Embodiment 3
A preparation method for vitamin E nano microemulsion, comprises the following steps:
(1) get that vitamin E is 5g, Tween-65 is 10g, stearoyl lactate is 12g, class of department 80 is 5g, by vitamin E and Tween-65, stearoyl lactate, class of department 80 heating for dissolving, heating-up temperature is 50 DEG C, eddy oscillating is carried out with eddy oscillating device after dissolving, vibration mixes to three kinds of raw materials, is A liquid;
(2) separately getting 4g propane diols to be dissolved in 64g water, mixed by propane diols with water, is B liquid;
(3) also mixed with B liquid by A liquid, carry out eddy oscillating again after mixing, the eddy oscillating time is 10min, prepares vitamin E nano microemulsion after vibration terminates.
The average grain diameter of the vitamin E nano microemulsion of embodiment 3 is 91nm, and envelop rate is 85%.
Claims (6)
1. a vitamin E nano microemulsion, is characterized in that described vitamin E nano microemulsion consists of the following composition:
Vitamin E 5wt%-15wt%,
Tween-65 10wt%-15wt%,
Stearoyl lactate 6wt%-12wt%,
Department class 80 3wt%-5wt%,
Propane diols 4wt%-9wt%,
Surplus is water.
2. a kind of vitamin E nano microemulsion according to claim 1, is characterized in that described vitamin E nano microemulsion consists of the following composition:
Vitamin E 10wt%,
Tween-65 12wt%,
Stearoyl lactate 8wt%,
Department class 80 3wt%,
Propane diols 9wt%,
Surplus is water.
3. a kind of vitamin E nano microemulsion according to claim 1, is characterized in that the average grain diameter of described vitamin E nano microemulsion is 73nm to 91nm.
4. a kind of vitamin E nano microemulsion according to claim 1, is characterized in that the envelop rate of described vitamin E nano microemulsion is 84% to 89%.
5. a preparation method for vitamin E nano microemulsion, is characterized in that the preparation method of described vitamin E nano microemulsion comprises the following steps:
(1) vitamin E, Tween-65, stearoyl lactate, class of department 80 is got, by vitamin E and Tween-65, stearoyl lactate, class of department 80 heating for dissolving, heating-up temperature is 45 DEG C-55 DEG C, carries out eddy oscillating after dissolving with eddy oscillating device, vibration mixes to three kinds of raw materials, is A liquid;
(2) separately getting propane diols soluble in water, mixed by propane diols with water, is B liquid;
(3) also mixed with B liquid by A liquid, carry out eddy oscillating again after mixing, the eddy oscillating time is 10min, vibration terminate after prepare vitamin E nano microemulsion, in microemulsion vitamin E be 5wt%-15wt%, Tween-65 be 10wt%-15wt%,
Stearoyl lactate is 6wt%-12wt%, class of department 80 is 3wt%-5wt%, propane diols is 4wt%-9wt%, surplus is water.
6. the preparation method of a kind of vitamin E nano microemulsion according to claim 5, is characterized in that the preparation method of described vitamin E nano microemulsion comprises the following steps:
(1) vitamin E, Tween-65, stearoyl lactate, class of department 80 is got, by vitamin E and Tween-65, stearoyl lactate, class of department 80 heating for dissolving, heating-up temperature is 45 DEG C-55 DEG C, carries out eddy oscillating after dissolving with eddy oscillating device, vibration mixes to three kinds of raw materials, is A liquid;
(2) separately getting propane diols soluble in water, mixed by propane diols with water, is B liquid;
(3) A liquid is also mixed with B liquid, eddy oscillating is carried out again after mixing, the eddy oscillating time is 10min, prepare vitamin E nano microemulsion after vibration terminates, in microemulsion, vitamin E is 10wt%, Tween-65 is 12wt%, stearoyl lactate is 8wt%, class of department 80 is 3wt%, propane diols is 9wt%, surplus is water.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410477268.4A CN104207145B (en) | 2014-09-18 | 2014-09-18 | A kind of vitamin E nano microemulsion and preparation method thereof |
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| CN201410477268.4A CN104207145B (en) | 2014-09-18 | 2014-09-18 | A kind of vitamin E nano microemulsion and preparation method thereof |
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| CN104207145A true CN104207145A (en) | 2014-12-17 |
| CN104207145B CN104207145B (en) | 2016-04-06 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168129A (en) * | 2015-07-29 | 2015-12-23 | 山东迅达康生物科技有限公司 | Vitamin E nanoemulsion and preparation method thereof |
| CN106031705A (en) * | 2016-05-13 | 2016-10-19 | 陕西科技大学 | High-content stable prinsepia utilis royle oil microemulsion and preparation method thereof |
| CN106389152A (en) * | 2016-08-24 | 2017-02-15 | 登封市科创商务咨询有限公司 | Vitamin E nourishing and skin-care lotion |
| CN107375210A (en) * | 2017-08-17 | 2017-11-24 | 武汉轻工大学 | A kind of preparation method of watermiscible vitamin E nanoemulsions |
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| CN1546016A (en) * | 2003-12-04 | 2004-11-17 | 东南大学 | Nanometer preparation of natural vitamin E and its preparation |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168129A (en) * | 2015-07-29 | 2015-12-23 | 山东迅达康生物科技有限公司 | Vitamin E nanoemulsion and preparation method thereof |
| CN105168129B (en) * | 2015-07-29 | 2018-02-23 | 山东迅达康生物科技有限公司 | A kind of vitamin E nano-emulsion and preparation method thereof |
| CN106031705A (en) * | 2016-05-13 | 2016-10-19 | 陕西科技大学 | High-content stable prinsepia utilis royle oil microemulsion and preparation method thereof |
| CN106031705B (en) * | 2016-05-13 | 2019-02-22 | 陕西科技大学 | A kind of high-content stable type prinsepia utilis royle oil microemulsion and preparation method thereof |
| CN106389152A (en) * | 2016-08-24 | 2017-02-15 | 登封市科创商务咨询有限公司 | Vitamin E nourishing and skin-care lotion |
| CN107375210A (en) * | 2017-08-17 | 2017-11-24 | 武汉轻工大学 | A kind of preparation method of watermiscible vitamin E nanoemulsions |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104207145B (en) | 2016-04-06 |
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