CN104161721A - Snake king medicine for treating dermatopathy and preparation method thereof - Google Patents

Abstract

The invention discloses a snake king medicine for treating dermatopathy and a preparation method thereof, the snake king medicine comprises the following components by weight percentage: 2-5% of monostearin, 5-8% of glycerin, 5-7% of Vaseline, 0.1-0.3% of ethyl ester, 0.2-0.3% of methyl esters, 3-5% of stearic acid, 3-5% of octadecanol, 1-2% of silicone oil, 1-3% of borneol, 0.6-0.8% of azone, 1-3% of peregal and 65-80% of purifying water. The provided snake king medicine is a white emulsifiable paste, and has the characteristics of no foreign impurity, no peculiar smell, special smell, fine paste body and lubrication. The provided snake king medicine is used for treating cutaneous pruritus, ringworm of the body, tinea cruris, manus and tinea pedis, acne, psoriasis and various dermatitis dermatopathy, The snake king medicine is externally applied medicine, and has the advantages of safety, no stimulation and no side effect.

Description

A kind of dermopathic snake king's medicament and preparation method thereof that is used for the treatment of

Technical field

The present invention relates to a kind of dermopathic snake king's medicament and preparation method thereof that is used for the treatment of.

Background technology

Dermatosis is the disease of relevant skin, is one of the commonly encountered diseases that has a strong impact on people ' s health, frequently-occurring disease, as leprosy, scabies, mycosis, bacterial skin infections etc.Dermatosis is that skin (comprising hair and first) is subject to after the impact of internal and external factor, and its form, 26S Proteasome Structure and Function all change, and produces pathological process, and produces accordingly various clinical priority performances.How low weight dermopathic sickness rate is very high,, often not unhealthful, even can threat to life but minority is heavier.

Skin is possessing the Physiological protection function of almost Perfect: as barrier action, sensation, regulate body temperature, Absorption, secretion and Excretion etc., safeguarding the health of body, playing very important effect.

The invention provides the medicine for external use of a kind of effect treatment multiple dermatosis remarkable, easy to use.Especially for dermatosiss such as treatment skin pruritus, tinea corporis, tinea cruris, tinea manus and pedis, acne, psoriasis, various dermatitis, can reach the object of radical cure, and have no side effect after long-term application.

Summary of the invention

The object of the present invention is to provide a kind of preparation method that is used for the treatment of dermopathic snake king's medicament.

To achieve these goals, technical scheme of the present invention is: be a kind ofly used for the treatment of dermopathic snake king's medicament, its primary raw material comprises monoglyceride, glycerol, vaseline, ethyl ester, methyl ester, stearic acid, octadecanol, silicone oil, Borneolum Syntheticum, azone, peregal and purified water; Percentage by weight between each raw material is: monoglyceride: 2%～5%; Glycerol: 5%～8%; Vaseline: 5%～7%; Ethyl ester: 0.1%～0.3%; Methyl ester: 0.2%～0.3%; Stearic acid: 3%～5%; Octadecanol: 3%～5%; Silicone oil: 1%～2%; Borneolum Syntheticum: 1%～3%; Azone: 0.6%～0.8%; Peregal: 1%～3%; Purified water: 65%～80%.

A preparation method that is used for the treatment of dermopathic snake king's medicament, its preparation technology comprises the steps:

(1) by the weight percentage between each raw material, be: monoglyceride: 2%～5%; Glycerol: 5%～8%; Vaseline: 5%～7%; Ethyl ester: 0.1%～0.3%; Methyl ester: 0.2%～0.3%; Stearic acid: 3%～5%; Octadecanol: 3%～5%; Silicone oil: 1%～2%; Borneolum Syntheticum: 1%～3%; Azone: 0.6%～0.8%; Peregal: 1%～3%; Purified water: 65%～80% measures monoglyceride, glycerol, vaseline, ethyl ester, methyl ester, stearic acid, octadecanol, silicone oil, Borneolum Syntheticum, azone, peregal and purified water raw material for standby;

(2) monoglyceride measuring, vaseline, ethyl ester, methyl ester, stearic acid, octadecanol and silicone oil raw material stirring are mixed, be heated to 85 ℃, at 85 ℃, continuous heating stirs 40～45min;

(3) glycerol measuring, peregal and purified water are uniformly mixed, at 85 ℃, continuous heating stirs 40～50min;

(4) product step (2) and (3) being obtained mixes, after stirring, and cool to room temperature;

(5) azone measuring and Borneolum Syntheticum are joined in the product that step (4) obtains, are stirred to evenly, both product.

The beneficial effect of the embodiment of the present invention is:

Preparation method of the present invention is simple, and effect is remarkable, easy to use.Its raw material comprises: monoglyceride, glycerol, vaseline, ethyl ester, methyl ester, stearic acid, octadecanol, silicone oil, Borneolum Syntheticum, azone, peregal and purified water.Wherein single glycerol is used as emulsifying agent in medical unguentum, makes mastic fine and smooth, lubricious; Glycerol: achromatism and clarity thick liquid, odorless can absorb moisture and reach skin moisturizing from air; Azone: azone is colourless to micro-yellow liquid, odorless, tasteless, the penetrating agent of smearing, massaging as external used medicine; Peregal: there is good wet performance, and there is good emulsifying, dispersion, the performance such as clean; Borneolum Syntheticum is translucent crystalline solid, and color is white in color to light taupe brown, abnormal smells from the patient delicate fragrance, and acrid in the mouth is cool, has volatility, and easily volatilization, has that pain relieving is anticorrosion, bacteriostasis, can be used for neuralgia and antiinflammatory.Provided by the invention a kind of to treat dermopathic snake king's medicament be white emulsifiable paste, without exogenous impurity, free from extraneous odour, has the distinctive abnormal smells from the patient of this product, and mastic is fine and smooth, lubricious.This product is medicine for external use, safe and non-stimulating property, has no side effect.

Using method: be directly applied in affected part, every day two to three times.

The scope of application: suppress tinea corporis, tinea manus and pedis, the crowds such as skin pruritus that eczema etc. cause; This product is for by antibacterial, the various inflammation that fungal infection causes, and psoriasis, tinea capitis, scabies, tinea pedis (beriberi) tinea versicolor, tinea versicolor tinea etc. has obvious rehabilitation effect; Be applicable to skin eczema, herpes zoster, seborrheic dermatitis, the infection such as urticaria.

Points for attention:

1, only external, is sure not to take orally;

2, skin injury place is cautious use of;

3, child must use under adult's Assistance And Instruction;

4, allergy sufferers forbidding.

The specific embodiment

Below in conjunction with specific embodiment, the present invention is described in detail, but content of the present invention is not only confined to the following examples.

Embodiment 1:

Be used for the treatment of dermopathic snake king's medicament, take that to prepare 100 grams of snake king's medicaments be example, the concrete preparation method of described snake king's medicament is:

(1) measure monoglyceride: 3 grams; Glycerol: 6 grams; Vaseline: 6 grams; Ethyl ester: 0.2 gram; Methyl ester: 0.2 gram; Stearic acid: 4 grams; Octadecanol: 4 grams; Silicone oil: 1.5 grams; Borneolum Syntheticum: 2 grams; Azone: 0.7 gram; Peregal: 2 grams; Purified water: 70.4 grams of raw materials, standby.

(2) monoglyceride measuring, vaseline, ethyl ester, methyl ester, stearic acid, octadecanol and silicone oil raw material stirring are mixed, be heated to 85 ℃, at 85 ℃, continuous heating stirs 40min;

(3) glycerol measuring, peregal and purified water are uniformly mixed, at 85 ℃, continuous heating stirs 40～50min;

(4) product step (2) and (3) being obtained mixes, after stirring, and cool to room temperature;

(5) azone measuring and Borneolum Syntheticum are joined in the product that step (4) obtains, are stirred to evenly, both product.

Embodiment 2:

Be used for the treatment of dermopathic snake king's medicament, take that to prepare 100 grams of snake king's medicaments be example, the concrete preparation method of described snake king's medicament is:

(1) measure monoglyceride: 2 grams; Glycerol: 8 grams; Vaseline: 7 grams; Ethyl ester: 0.3 gram; Methyl ester: 0.2 gram; Stearic acid: 3 grams; Octadecanol: 3 grams; Silicone oil: 2 grams; Borneolum Syntheticum: 3 grams; Azone: 0.8 gram; Peregal: 3 grams; Purified water: 80.4 grams of raw materials, standby.

(2) monoglyceride measuring, vaseline, ethyl ester, methyl ester, stearic acid, octadecanol and silicone oil raw material stirring are mixed, be heated to 85 ℃, at 85 ℃, continuous heating stirs 45min;

(3) glycerol measuring, peregal and purified water are uniformly mixed, at 85 ℃, continuous heating stirs 40～50min;

(4) product step (2) and (3) being obtained mixes, after stirring, and cool to room temperature;

(5) azone measuring and Borneolum Syntheticum are joined in the product that step (4) obtains, are stirred to evenly, both product.

Monoglyceride: 2%～5%; Glycerol: 5%～8%; Vaseline: 5%～7%; Ethyl ester: 0.1%～0.3%; Methyl ester: 0.2%～0.3%; Stearic acid: 3%～5%; Octadecanol: 3%～5%; Silicone oil: 1%～2%; Borneolum Syntheticum: 1%～3%; Azone: 0.6%～0.8%; Peregal: 1%～3%; Purified water: 65%～80%.

Embodiment 3:

Be used for the treatment of dermopathic snake king's medicament, take that to prepare 100 grams of snake king's medicaments be example, the concrete preparation method of described snake king's medicament is:

(1) measure monoglyceride: 5 grams; Glycerol: 5 grams; Vaseline: 5 grams; Ethyl ester: 0.1 gram; Methyl ester: 0.3 gram; Stearic acid: 5 grams; Octadecanol: 5 grams; Silicone oil: 1 gram; Borneolum Syntheticum: 1 gram; Azone: 0.6 gram; Peregal: 1 gram; Purified water: 65 grams of raw materials, standby.

(2) monoglyceride measuring, vaseline, ethyl ester, methyl ester, stearic acid, octadecanol and silicone oil raw material stirring are mixed, be heated to 85 ℃, at 85 ℃, continuous heating stirs 42min;

(3) glycerol measuring, peregal and purified water are uniformly mixed, at 85 ℃, continuous heating stirs 40～50min;

(4) product step (2) and (3) being obtained mixes, after stirring, and cool to room temperature;

(5) azone measuring and Borneolum Syntheticum are joined in the product that step (4) obtains, are stirred to evenly, both product.

Clinical trial:

A kind ofly be used for the treatment of dermopathic snake king's medicament for treating skin disease clinical observation by above-described embodiment 1 is prepared:

Clinical case one:

Select 100 cases, male's case 52 people wherein, women's case 48 people, in age 18-40 year, are divided into two groups by random packet way, every group of 50 people, matched group is slight and moderate patient controls with roxithromycin capsules vitaminize B6, and severe patient adds metronidazole, and external Benzagel and tretinoin cream, test group is carried out coating with medicament of the present invention according to described requirement, treat 28 days afterwards concrete therapeutic effect as following table:

From table, therapeutic effect of the present invention is significantly better than the curative effect of existing Therapeutic Method, and its difference is very remarkable.

Clinical case two:

With the present invention, treat neurodermatitis and PIYANPING contrast situation: select 40 cases, male's case 20 people wherein, women's case 20 people, age 25-50 year, by random packet way, be divided into two groups, every group of 20 people, matched group employing is smeared PIYANPING and is treated, test group is used according to described requirement with medicament of the present invention, treat 28 days afterwards specifically therapeutic effect as following table:

From table, therapeutic effect of the present invention is significantly better than the curative effect of PIYANPING, and its difference is very remarkable.

Curative effect judging standard: recovery from illness: symptom and sign disappears; Take a turn for the better: symptom and sign is clearly better; Invalid: symptom and sign is without improvement.

Clinical case three:

With the present invention, treat comedo and fiery furuncle: select 100 cases, male's case 45 people wherein, women's case 55 people, age 25-40 year, with medicament of the present invention, according to described requirement, use, treat after one week and have 82 example recoveries from illness, remaining 18 example treatments were all cured after the course for the treatment of.

From table, the present invention treats acne and fiery furuncle, and the good results are evident, and effective percentage reaches 100%.

Claims (2)

1. one kind is used for the treatment of dermopathic snake king's medicament, it is characterized in that: the dermopathic snake king's medicament of described treatment primary raw material comprises monoglyceride, glycerol, vaseline, ethyl ester, methyl ester, stearic acid, octadecanol, silicone oil, Borneolum Syntheticum, azone, peregal and purified water, its percentage by weight:

。

2. a method of preparing the dermopathic snake king's medicament for the treatment of claimed in claim 1, is characterized in that comprising following steps:

(1) by the weight percentage between each raw material, be: monoglyceride: 2%-5%; Glycerol: 5%-8%; Vaseline: 5%-7%; Ethyl ester: 0.1%-0.3%; Methyl ester: 0.2%-0.3%; Stearic acid: 3%-5%; Octadecanol: 3%-5%; Silicone oil: 1%-2%; Borneolum Syntheticum: 1%-3%; Azone: 0.6%-0.8%; Peregal: 1%-3%; Purified water: 65%-80% measures monoglyceride, glycerol, vaseline, ethyl ester, methyl ester, stearic acid, octadecanol, silicone oil, Borneolum Syntheticum, azone, peregal and purified water raw material, standby;

(2) monoglyceride measuring, vaseline, ethyl ester, methyl ester, stearic acid, octadecanol and silicone oil raw material stirring are mixed, be heated to 85 ℃, at 85 ℃, continuous heating stirs 40～45min;

(3) glycerol measuring, peregal and purified water are uniformly mixed, at 85 ℃, continuous heating stirs 40～50min;

(4) product step (2) and (3) being obtained mixes, after stirring, and cool to room temperature;

(5) azone measuring and Borneolum Syntheticum are joined in the product that step (4) obtains, are stirred to evenly, both product snake king medicament.