CN1041698A - Embedding-type cancer treating instrument with microwave radiation - Google Patents
Embedding-type cancer treating instrument with microwave radiation Download PDFInfo
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- CN1041698A CN1041698A CN 88109737 CN88109737A CN1041698A CN 1041698 A CN1041698 A CN 1041698A CN 88109737 CN88109737 CN 88109737 CN 88109737 A CN88109737 A CN 88109737A CN 1041698 A CN1041698 A CN 1041698A
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Abstract
The present invention is a kind of embedding-type cancer treating instrument with microwave radiation, comprises a power splitter that is connected on the microwave source, and power splitter is with the microwave power five equilibrium and become a plurality of branch roads and be transferred on the irradiator with the branch road same number.For the different needs that adapts to tumor size clinically and with the input power coupling, the length of irradiator and different, the direct implant into body interstitial laser photocoagulation of the outfan of irradiator is inner or on every side.At microwave source and be heated a thermocouple temperature measurement pin is arranged between tissue, the temperature of continuous monitoring heat tissue, and the size of regulating microwave source output energy automatically.
The present invention can once heat fast 3-6 minute high temperature 80-100 ℃ solidify cancerous protuberance, be applicable to deep liver (lung) cancer and other internal organs the part cancer.
Description
The present invention relates to a kind of implanted microwave irradiation therapy device.
The microwave radiation cancer-curing method is mainly used in localized hyperthermia and solidifies the human body cancerous protuberance, and underwent operative is excised or do not excised then, all can reach the purpose of controlling cancer, and minimum to the damage of its normal surrounding tissue.The device of realizing the microwave radiation cancer-curing method clinically has three kinds of forms: the one, and external radiant heating device; The 2nd, utilize human body natural's pipeline (as rectum, esophagus, vagina etc.) plug-in type radiant heating device; The 3rd, directly implant cancerous protuberance inside or ambient radiation heater.The latter is used for the treatment of deep tissue liver (lung) cancer and other internal organs part cancerous protuberances, and effect is more obvious.
United States Patent (USP) (patent No. is US4,712,559, DEC.15,1987) has proposed the diathermanous cancer system that controls of a kind of implanted electromagnetic wave.It comprises an electromagnet source, and a power splitter is connected on the source, is used for transmission, distribute energy.Be provided with attenuator and phase-shifter in the power splitter, place the power and the Energy distribution of irradiator in the insulated conduit in order to control, conduit is used in the implant into body cancerous protuberance or around it, catheter tip is equipped with electromagnetic energy coupling metallic rod and the thermistor (temperature) sensor that adds heavy caliber, and the heating state of electromagnetic energy and mensuration conduit irradiator surrounding tissue is provided.Whole system is controlled power, temperature and heating figure on demand automatically by a centre data processor between source of being connected and the power splitter.The diathermanous cancer system that controls of this implanted electromagnetic wave can control, regulate, observe radiant power and heating-up temperature easily, but still has following some deficiency:
(1) complex structure, the cost height;
(2) thermometric needs to carry out under cut-off condition, and wave frequency is chosen in about 100,000,000, and heat time heating time is long;
(3) irradiator has a changeover portion to be in the insufficient state of heating, is difficult to heat the bulk tumor;
(4) adopt the electric capacity mode of heating, relatively poor to the uniformity of tissue heating.
At above-mentioned situation, the invention provides a kind of novel embedding-type cancer treating instrument with microwave radiation.This machine has saved attenuator and the phase-shifter in data processor of the prior art, balance converter and the power splitter, and changeover portion in the irradiator and inductance coupling element.Make it simple in structure, clinical result of use is also more obvious.
The present invention is achieved in that and selects the microwave source that frequency is 2450 ± 25 megahertzes that the output continuous wave power can be regulated artificially or by the temperature information of thermocouple feedback automatically in 0-700 watt.The power of microwave source output directly is transferred on the power splitter through coaxial cable, and power splitter is made of n-1 coaxial threeway, and it is divided into a plurality of branch roads with energy and is transported to 2
nOn the individual irradiator (n=1,2,3,4.... is variable),, make it be transferred to the basic impartial and coupling of power on each irradiator again through regulating the structure and the length of irradiator.The structure of irradiator and length are divided into two big classes: a class is the coaxial inner conductor tap of length 3-5cm; Another kind of is the above cylindricality helix of length 5cm.Polytetrafluorethylecoatings coatings or conduit are arranged on conductor tap and the helix, and each irradiator can be distinguished in the local cancerous protuberance of implant into body or on every side, when connecting microwave source, can be warmed up to 80-100 ℃ at 3-6 minute and solidify the cancer piece, to reach the purpose of controlling cancer.The present invention is connected a thermocouple temperature measurement pin at microwave source with being heated between the tissue, be used for the continuous monitoring tissue temperature, and will feed back to from the temperature information that tissue records the microwave source, automatically the size of control output microwave energy.
The present invention has following characteristics:
1. power splitter adopts a plurality of coaxial three way cock, regulates length, the structure of irradiator in addition, the power of each irradiator is equated, and adopt the radiation mode heating, and is not only simple in structure, and radiation effect is even.
2. adopt the microwave source of 2450 ± 25 megahertzes, can once solidify the cancer piece by quick high-temp.
3. irradiator adopts coaxial inner conductor tap and the direct implanting tissue of cylindricality helix, and is not only simple for production, and reduced energy consumption.
Fig. 1, structure block chart of the present invention.
Fig. 2, the structural representation of power splitter.
Fig. 3, the structure chart of coaxial inner conductor tap irradiator.
Fig. 4, the structure chart of cylindricality helix irradiator.
Among Fig. 1,1 is microwave source, and 2 is coaxial cable, and 3 is power splitter, and 4 is irradiator, and 5 is the thermocouple temperature measurement pin, and 6 expressions are heated tissue.
Among Fig. 2,7-28 represents the joint of symmetric one group of coaxial threeway in the power splitter, and A is total input of microwave source.
Among Fig. 3,29 are coaxial fitting, and 30 is coaxial cable, and 31 is polytetrafluoroethylene floor, and 32 expression tissues add the thermocoagulation figure, and 33 is the conductor tap.
Among Fig. 4,34 is coaxial fitting, and 35 is coaxial line, and 36 is insulating coating, and 37 is coaxial inner conductor, and 38 is helix, and 39 expression tissues add the thermocoagulation figure.
In conjunction with the accompanying drawings and embodiments design of the present invention is further described:
1. the selection of microwave source: the frequency of cancer therapy machine is selected, and is mainly decided by the microwave heating degree of depth.According to microwave theory, the penetration depth of microwave in medium is relevant with microwave frequency f with the electrical parameter of medium (DIELECTRIC CONSTANT and electrical conductivity δ).For stripped liver (lung) tissue, when the f=2450 megahertz, penetration depth d ≈ 1.7cm; As the f=915 megahertz, d ≈ 3cm then.Frequency reduces, and penetration depth also can increase.Based on this, when adopting external exposure with micro-wave therapeutic than deep tumor in the prior art, the frequency of selecting for use lower (it is following to be generally 100 megahertzes), repeatedly heat repeatedly (heating 43-45 ℃) at every turn.As adopt the implanted method, and can be owing to underfrequency, heat penetration is too wide, may cause the damage of cancer piece normal surrounding tissue too many, especially unfavorable to visceral cancer.Clinical practice proves, f of the present invention selects 2450 ± 25 megahertz micro-wave therapeutic liver (lung) cancers for use, when solidification temperature is 80-100 ℃, during 3-6 minute heat time heating time, discovery has no significant change apart from the morphology and the various enzyme of irradiator center 2cm liver (lung) tissue in addition, shows the damage of liver (lung) tissue minimum.
2. power splitter.For the microwave energy with microwave source output is distributed to 2
nOn the individual irradiator, must use power splitter, and require power splitter will bear about 600 watts power.Power splitter of the present invention utilizes n-1 coaxial three way cock, through a series of adjustment, can realize substantially that the power of each branch road equates, meets clinical instructions for use.
Fig. 2 is 16 ramose sketch maps that are made of 15 three way cock, and A is total input, becomes 16 tunnel branches after 15 coaxial threeways, and each branch's seam connects an irradiator.In order to realize to each road branch mean allocation power, must with irradiator and coaxial cable length combined debugging.Adjustment method is as follows:
The length that earlier will be mixes up monopole (or helix) irradiator of coupling with coaxial line is made minor alteration (this moment, the matching status of single irradiator changed very little), makes slightly capacitive of its input reactance, this irradiator is connected on 7 ends of Fig. 2.Use above-mentioned similar approach, change the length of second irradiator slightly, make its input reactance slightly be perception, this irradiator is connected on 8 ends.As regulate appropriately, can obtain input reactance at 9 ends of threeway and slightly be capacitive, and standing-wave ratio is still less than 2.Utilize similar approach, can debug two irradiators that are connected on 13,14 ends and slightly be perception at threeway 12 ends, standing-wave ratio is less than 2.As long as capacitive and inductive reactance value that 9,12 ends are presented are appropriate, can obtain better coupling (require standing-wave ratio ρ＜2, reactance slightly is capacitive) at another threeway 15 ends.Can debug out 19,20,25,26 ends of threeway with same manner, make at 18 ends also to obtain to mate preferably (require standing-wave ratio less than 2, reactance slightly is perception).When adjusting is appropriate, can obtain matching status preferably at 28 ends equally.Utilize above-mentioned same quadrat method, can obtain standing-wave ratio＜2.5 at the A end at last, and each branch's power division is more even.Just because of above-mentioned reason, so the length of 16 irradiators is not exclusively the same, each irradiator can be in variation in the ± 0.5cm scope.
3. implanted irradiator.Clinical instructions for use, the diameter of implanted irradiator is little, and in order to adapt to the size of different tumors, requires effective heated length of irradiator also different.The present invention has designed two class irradiators.One class selects for use the coaxial inner conductor tap to make (Fig. 3).Getting the irradiator diameter is 0.1-1.5mm, when effectively heated length is 3-5cm, can realize coupling, standing-wave ratio＜1.6 with coaxial line.The serious adhesion of irradiator and tissue when adding thermocoagulation in order to overcome is at conductor tap surface attachment one deck PTFE medium.The add thermocoagulation figure of this class irradiator in liver (lung) tissue is similar to rotating cone.
The telescopic helix of another kind of radiation metal v-belt politef is made, helix by coaxial inner conductor at vertex feed, the other end unsettled (Fig. 4).The length of getting irradiator is 5-7cm, and diameter is 2.5-3.0mm, when the number of turns is the 80-90 circle, can realize coupling with coaxial line, and standing-wave ratio is less than 1.6.
Above-mentioned two class radiators do not need matching element, determine by the radiator self structure, make radiator structure simple.
Claims (5)
1, embedding-type cancer treating instrument with microwave radiation, comprise a power divider (3) that is connected on the microwave source (1), its effect is to distribute and transmission of power to irradiator (4), place irradiator (4) in the conduit to be used in the implant into body interstitial laser photocoagulation or on every side, when microwave when power splitter feeds irradiator, can reach the purpose that adds the thermocoagulation cancerous protuberance, it is characterized in that the microwave source output frequency is 2450 ± 25 megahertzes, power is adjustable continuously in 0-700 watt, directly be transferred on the power splitter through coaxial cable (2), power splitter is made of n-1 coaxial threeway (7)-(28), and power splitter is divided into 2 with microwave energy
nRoad branch, and be transferred on 2 corresponding irradiators, it is 3-5cm that irradiator has designed length, diameter is that coaxial inner conductor tap and the length of 1.0-1.5mm is 5-7cm, diameter is that 2.5-3.0mm helix two classes are uneven in length and variform irradiator, is complementary and adapts to the different needs of clinical treatment cancer size to realize output with power splitter.
2, the described cancer therapy machine of claim 1 is characterized in that 2
nIndividual irradiator, n=1,2,3,4 ... variable.
3, the described cancer therapy machine of claim 1, the output that it is characterized in that microwave source is regulated in 0-700 watt continuously artificially, perhaps the temperature information that is recorded from be heated tissue by the thermocouple temperature measurement pin feeds back in the microwave source, regulates the size of output automatically.
4, claim 1 or 2 described cancer therapy machines is characterized in that outside tap of irradiator coaxial inner conductor and the cylindricality helix teflon insulation coating and teflon insulation conduit being arranged.
5, the described cancer therapy machine of claim 1 is characterized in that it is 3-6 minute that interstitial laser photocoagulation is added the thermal-radiating time, and temperature 80-100 ℃ once solidifies the cancer piece.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88109737 CN1041698A (en) | 1988-10-14 | 1988-10-14 | Embedding-type cancer treating instrument with microwave radiation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88109737 CN1041698A (en) | 1988-10-14 | 1988-10-14 | Embedding-type cancer treating instrument with microwave radiation |
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| CN1041698A true CN1041698A (en) | 1990-05-02 |
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| CN 88109737 Pending CN1041698A (en) | 1988-10-14 | 1988-10-14 | Embedding-type cancer treating instrument with microwave radiation |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5571154A (en) * | 1993-07-19 | 1996-11-05 | Hunan University | Microwave deep-diathermy apparatus |
| CN1037746C (en) * | 1993-09-29 | 1998-03-18 | 北京华光医疗电子设备有限公司 | Computer micro-wave instrument for treatment of milk gland disease |
| CN1082419C (en) * | 1998-03-11 | 2002-04-10 | 安善泰 | Compressing method and equipment for raising hardness and strength of wood |
| CN1303938C (en) * | 2001-11-14 | 2007-03-14 | 光谱治疗公司 | Therapy and diagnosis system and method with distributor for distribution of radiation |
| WO2008151469A1 (en) * | 2007-06-15 | 2008-12-18 | Changxue Ren | Heating device and method using a pseudo-uniform electromagnetic field |
| CN101282600B (en) * | 2007-04-06 | 2010-09-15 | 财团法人食品工业发展研究所 | Continuous microwave heating apparatus |
| CN102969554A (en) * | 2011-09-01 | 2013-03-13 | 亚树科技股份有限公司 | Radio-frequency (RF) power distribution device |
| WO2019192347A1 (en) * | 2018-04-04 | 2019-10-10 | 西安大医集团有限公司 | Microwave power control device and method, and radiotherapy equipment |
| CN113058161A (en) * | 2021-04-29 | 2021-07-02 | 广西善缘健康管理有限公司 | Microwave therapeutic instrument |
-
1988
- 1988-10-14 CN CN 88109737 patent/CN1041698A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5571154A (en) * | 1993-07-19 | 1996-11-05 | Hunan University | Microwave deep-diathermy apparatus |
| CN1037746C (en) * | 1993-09-29 | 1998-03-18 | 北京华光医疗电子设备有限公司 | Computer micro-wave instrument for treatment of milk gland disease |
| CN1082419C (en) * | 1998-03-11 | 2002-04-10 | 安善泰 | Compressing method and equipment for raising hardness and strength of wood |
| CN1303938C (en) * | 2001-11-14 | 2007-03-14 | 光谱治疗公司 | Therapy and diagnosis system and method with distributor for distribution of radiation |
| CN101282600B (en) * | 2007-04-06 | 2010-09-15 | 财团法人食品工业发展研究所 | Continuous microwave heating apparatus |
| WO2008151469A1 (en) * | 2007-06-15 | 2008-12-18 | Changxue Ren | Heating device and method using a pseudo-uniform electromagnetic field |
| CN102969554A (en) * | 2011-09-01 | 2013-03-13 | 亚树科技股份有限公司 | Radio-frequency (RF) power distribution device |
| WO2019192347A1 (en) * | 2018-04-04 | 2019-10-10 | 西安大医集团有限公司 | Microwave power control device and method, and radiotherapy equipment |
| US11679280B2 (en) | 2018-04-04 | 2023-06-20 | Our United Corporation | Microwave power control device and method, and radiotherapy equipment |
| CN113058161A (en) * | 2021-04-29 | 2021-07-02 | 广西善缘健康管理有限公司 | Microwave therapeutic instrument |
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