CN104055827A - Gynostemma pentaphyllum wall-broken preparation - Google Patents
Gynostemma pentaphyllum wall-broken preparation Download PDFInfo
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- CN104055827A CN104055827A CN201310090050.9A CN201310090050A CN104055827A CN 104055827 A CN104055827 A CN 104055827A CN 201310090050 A CN201310090050 A CN 201310090050A CN 104055827 A CN104055827 A CN 104055827A
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Abstract
The invention relates to the technical field of Chinese medicine preparations, and in particular relates to a gynostemma pentaphyllum wall-broken preparation. The gynostemma pentaphyllum wall-broken preparation is prepared as follows: crushing gynostemma pentaphyllum into super-fine powder, then granulating by use of an ethanol-water wet method, extruding for forming at a certain rotating speed and drying, and the prepared gynostemma pentaphyllum wall-broken preparation is high in bioavailability, strong in stability, and good in disintegration.
Description
Technical field
The present invention relates to tcm field, more specifically, relate to a kind of Herb Gynostemmae Pentaphylli breaking cellular wall preparation.
Background technology
Superfine communication technique is the new technique developing rapidly in recent years.Effective ingredient in Chinese crude drug is distributed in cell mostly, and conventional decoction pieces can only make part effective ingredient discharge while decoction, utilization rate of active components 10-30%; And employing wall breaking pulverization technology; as the prepared slices of Chinese crude drugs being crushed to 300 order left and right; cell wall breaking rate will reach 86.7%; improve the stripping of effective ingredient in medical material; greatly strengthen its drug effect; utilization rate of active components, more than 90%, reaches and reduces medical material use amount and protection herb resource, also can improve the mass penalty drug effect of medicine simultaneously.But current main superfine powder technology still rests on the stage that traditional Chinese medicine powder is broken to ultra-fine powder.Because micropowder granulocyte sporoderm-broken rate increases, exist breaking cellular wall powder surface area to increase, out-of-shape, mobility, bad dispersibility, be easy to moisture absorption, the inherent characteristicses such as poor stability, by its granulation, the stability that improves product, preparation prepared by the present invention has well solved the problem of above existence, reaches the utilization of medical material and use to maximize.
At present, for there being following technical barrier in breaking cellular wall preparation and pelletization thereof: (1), although the utilization rate of current breaking cellular wall preparation Chinese medicine ingredients is high, breaking cellular wall powder body is easy to oxidized, and stability is not high, and drug effect is easily lost; (2) product that existing herbal species obtains by soft material granulation is difficult to ensure yield, disintegrative and stability simultaneously; (3) some herbal species is not suitable for adopting breaking cellular wall powder body-soft material granulation method to make preparation, as Fructus Lycii, Radix Achyranthis Bidentatae and so on; And the present invention is by the groping of great many of experiments, and the herbal species of suitable breaking cellular wall powder body-soft material granulation method is screened, and find out the condition of each step.
Herb Gynostemmae Pentaphylli, another name Pentapanax, gynostemma pentaphyllum makino, Herb Gynostemmae Pentaphylli, Herba Gynostemmatis, Herb Gynostemmae Pentaphylli, Herba Adonidis, lucky star grass, Radix Rhodiolae, the sweet bitter edible plant are climing, south Radix Ginseng, Herba Gynostemmatis, raw, the Herba Gynostemmatis that lands, for the dry aerial parts of cucurbitaceous plant Herb Gynostemmae Pentaphylli Gynostemma pentaphyllum (Thunb.) Makino, there is effect of tonify deficiency, heat clearing away, removing toxic substances, it is clinical that to be usually used in body void weak, nephrasthenia emission, leukopenia, hyperlipemia, viral hepatitis, the diseases such as chronic gastroenteritis and chronic tracheitis.Its main effective ingredient includes polysaccharide, flavonoid, saponins and microelement kind.Adopt traditional decocting method, easily destroy on the one hand a part of thermal sensitivity composition, effective ingredient decocts not exclusively on the other hand, causes the loss of effective ingredient.How to make all effective ingredient make full use of? Herb Gynostemmae Pentaphylli is prepared into Herb Gynostemmae Pentaphylli superfine powder by the present invention, make Herb Gynostemmae Pentaphylli plant cell wall breaking, intracellular matter flows out, the utilization rate that has greatly improved effective ingredient has solved an above-mentioned difficult problem, but simultaneously due to the increase of powder specific-surface area detection, produce and be easy to the moisture absorption, oxidation, rotten etc. shortcoming.The present invention on the basis that is prepared into superfine powder, then to its transformation for further processing, effectively to overcome these unfavorable factors, thereby the therapeutic effect of maximized performance medicine.
Summary of the invention
Technical problem to be solved by this invention is, in order to overcome Herb Gynostemmae Pentaphylli breaking cellular wall powder body above shortcomings, to provide a kind of Herb Gynostemmae Pentaphylli breaking cellular wall preparation.
Above-mentioned technical problem of the present invention is achieved by the following technical programs:
A kind of Herb Gynostemmae Pentaphylli breaking cellular wall preparation provided by the invention, adopt following technical scheme: Herb Gynostemmae Pentaphylli is carried out to wall breaking pulverization and obtain superfine powder, add ethanol-water solution fully to mix, make soft material, further extruding obtains wet grain again, the dry Herb Gynostemmae Pentaphylli breaking cellular wall preparation that obtains; In described superfine powder 90% or above grain diameter be less than or equal to 40 μ m.The superfine powder adopting in the present invention program, 90% grain diameter is preferably the powder body of 40 μ m, taking 35 ~ 40 μ m as many (can be for example 35,36,37,38,39 or 40 μ m).But what those skilled in the art can know understanding is that these embodiment can not be served as restriction of the present invention, as long as particle diameter is less than or equal to 40 μ m and all can realizes the present invention.
Preferably, the sporoderm-broken rate of described superfine powder is 80 ~ 95%.
Herb Gynostemmae Pentaphylli breaking cellular wall preparation prepared by the present invention, can make consumer in the time taking without decoction, by can make with warm boiled water effective ingredient utilization maximize.
Herb Gynostemmae Pentaphylli first can be crushed to 100 orders, more further carry out micronizing, make in superfine powder 90% or the grain diameter of above (such as being 90%, 91%, 92%, 93%, 94% or 95%) be less than or equal to 40 μ m.
The present invention adopts ethanol-water solution to carry out wet granulation, and its outstanding advantage is without any need for other additives, can make superfine powder of the present invention by follow-up granulation, dry, becomes Herb Gynostemmae Pentaphylli preparation granules.But in this process, should adopt the ethanol-water solution of which kind of concentration, and proportioning between this solution and superfine powder, all to need the strict parameter of controlling, to make the characteristic applicable to Herb Gynostemmae Pentaphylli superfine powder such as humidity, solid content, viscosity of soft material, making between superfine powder to have effective adhesive; Further by the setting of specific squeezing parameter, soft material extruding is become to density, sizeable Herb Gynostemmae Pentaphylli granular preparation, makes its density/loft suitable, thus dry become finished product after, even if be positioned in air at room temperature, also can prevent the Oxidation of air.And, the finished product obtaining, in the time using warm boiled water, superfine powder can comparatively promptly scatter, and makes effective ingredient dissolve rapidly and fully and spread, and improves utilization rate of active components.
The present invention, by repeatedly groping, has finally chosen following scheme:
When wet granulation, in the ethanol-water solution adopting, the mass fraction of ethanol is 20% ~ 95%; Preferably, the mass fraction of ethanol is 50 ﹪～90 ﹪, is more preferably 55 ﹪～85 ﹪.In the time that ethanol mass fraction is 20% ~ 29%, superfine powder is 1 ︰ 0.5 ~ 0.55 with ethanol-water solution than by weight, is preferably 1 ︰ 0.5; In the time that ethanol mass fraction is 30% ~ 39%, superfine powder is 1 ︰ 0.5 ~ 0.6 with ethanol-water solution than by weight, is preferably 1 ︰ 0.55; In the time that ethanol mass fraction is 40% ~ 49%, superfine powder is 1 ︰ 0.5 ~ 0.8 with ethanol-water solution than by weight, is preferably 1 ︰ 0.6 ~ 0.8; In the time that ethanol mass fraction is 60% ~ 69%, superfine powder is 1 ︰ 0.5 ~ 1.1 with ethanol-water solution than by weight, is preferably 1 ︰ 0.8 ~ 1.0; In the time that ethanol mass fraction is 70% ~ 79%, superfine powder is 1 ︰ 0.5 ~ 1.3 with ethanol-water solution than by weight, is preferably 1 ︰ 0.8 ~ 1.2, in the time that ethanol mass fraction is 80% ~ 95%, superfine powder is 1 ︰ 0.5 ~ 1.5 with ethanol-water solution than by weight, is preferably 1 ︰ 1.0 ~ 1.5.
In the time that soft material extruding is become to wet grain, be preferably controlled at following condition: adopt prepackage 10 order～30 eye mesh screens, extruding dynamics 0.05Mpa～1Mpa, rotating speed 50r/min～100r/min; Preferably, extruding dynamics 0.2Mpa～0.3Mpa, rotating speed 80r/min～90r/min.
The wet grain particle diameter of extruding gained is 10 order ~ 30 orders, and when dry, baking temperature is 45 DEG C ~ 75 DEG C, and be 0.5h ~ 2.5h drying time.
The bulk density of the Herb Gynostemmae Pentaphylli breaking cellular wall preparation obtaining is 0.21g/ml～0.51g/ml.
Compared with prior art, the present invention has following beneficial effect:
(1) the Herb Gynostemmae Pentaphylli preparation obtaining by method of the present invention, its utilization rate of active components improves greatly, and utilization rate is close to 100%;
(2) the present invention is by groping to obtain suitable wet granulation technology, make pelletization except the adding of alcohol-water, do not introduce other any additives, can obtain the soft material of solid content, modest viscosity, successfully to push granulating technique, the Chinese medicinal granule stability forming is strong, is difficult for collapsing rotten in storage and transportation;
(3) extruding condition of the present invention has been groped suitable rotating speed and extruding force, make thus stickiness, Herb Gynostemmae Pentaphylli granular preparation that density is moderate, in obtaining finished product stability strong (being difficult for moisture absorption), take in process and make again its easy disintegrate disperse, be convenient to warm boiled water.
Detailed description of the invention
In order more clearly to understand technology contents of the present invention, describe in detail especially exemplified by following examples, but embodiments of the present invention are not limited to this.
Embodiment 1
Get the clean medical material of Herb Gynostemmae Pentaphylli, after the coarse powder of coarse pulverization to 100 order left and right, be broken in superfine powder through superfine powder the powder body that 90% grain diameter is less than or equal to 40 μ m, add ethanol-water solution (ethanol mass fraction is 20%) wet method soft material processed, solution and superfine powder addition are than 0.5 ︰ 1(by weight), after mixing, through pre-installing 10 mesh sieves, select extruding rotating speed 50r/min, extruding dynamics 1MPa wet granular processed, in wet granular transposition heated-air circulation oven, sets 75 DEG C of baking temperatures, dry 2.5h, to dry, obtains Herb Gynostemmae Pentaphylli breaking cellular wall preparation after granulate screening.
remarks: full marks are in 10.
Embodiment 2
Get the clean medical material of Herb Gynostemmae Pentaphylli, after the coarse powder of coarse pulverization to 100 order left and right, be broken in superfine powder through superfine powder the powder body that 90% grain diameter is less than or equal to 40 μ m, add ethanol-water solution (ethanol mass fraction is 30%) wet method soft material processed, solution and superfine powder addition are than 0.6 ︰ 1(by weight), after mixing, through pre-installing 10 mesh sieves, select extruding rotating speed 55r/min, extruding dynamics 0.9MPa wet granular processed, in wet granular transposition vacuum microwave drying case, sets 45 DEG C of baking temperatures, dry 0.75h, to dry, obtains Herb Gynostemmae Pentaphylli breaking cellular wall preparation after granulate screening.
remarks: full marks are in 10.
Embodiment 3
Get the clean medical material of Herb Gynostemmae Pentaphylli, after the coarse powder of coarse pulverization to 100 order left and right, be broken in superfine powder through superfine powder the powder body that 90% grain diameter is less than or equal to 40 μ m, add ethanol-water solution (ethanol mass fraction is 95%) wet method soft material processed, solution and superfine powder addition are than 1.5 ︰ 1(by weight), after mixing, through pre-installing 30 mesh sieves, select extruding rotating speed 90r/min, extruding dynamics 0.1MPa wet granular processed, in wet granular transposition heated-air circulation oven, sets 75 DEG C of baking temperatures, dry 2.0h, to dry, obtains Herb Gynostemmae Pentaphylli breaking cellular wall preparation after granulate screening.
remarks: full marks are in 10.
Embodiment 4
Get the clean medical material of Herb Gynostemmae Pentaphylli, after the coarse powder of coarse pulverization to 100 order left and right, be broken in superfine powder through superfine powder the powder body that 90% grain diameter is less than or equal to 40 μ m, add ethanol-water solution (ethanol mass fraction is 90%) wet method soft material processed, solution and superfine powder addition are than 1.4 ︰ 1(by weight), after mixing, through pre-installing 30 mesh sieves, select extruding rotating speed 85r/min, extruding dynamics 0.75MPa wet granular processed, in wet granular transposition vacuum microwave drying case, sets 50 DEG C of baking temperatures, dry 0.5h, to dry, obtains Herb Gynostemmae Pentaphylli breaking cellular wall preparation after granulate screening.
remarks: full marks are in 10.
Embodiment 5
Get the clean medical material of Herb Gynostemmae Pentaphylli, after the coarse powder of coarse pulverization to 100 order left and right, be ground in superfine powder through micronizing the powder body that 90% grain diameter is less than or equal to 40 μ m, add ethanol-water solution (second mass fraction is 45%) wet method soft material processed, solution and superfine powder addition are than 0.8 ︰ 1(by weight), after mixing, through pre-installing 20 mesh sieves, select extruding rotating speed 70r/min, extruding dynamics 0.4MPa wet granular processed, in wet granular transposition heated-air circulation air box, sets 70 DEG C of baking temperatures, dry 2.0h, to dry, obtains Herb Gynostemmae Pentaphylli breaking cellular wall preparation after granulate screening.
remarks: full marks are in 10.
Embodiment 6
Get the clean medical material of Herb Gynostemmae Pentaphylli, after the coarse powder of coarse pulverization to 100 order left and right, be ground in superfine powder through micronizing the powder body that 90% grain diameter is less than or equal to 40 μ m, the solution wet method soft material processed that the mass fraction that adds ethanol-water solution is 75%, solution and superfine powder addition are than 1.2 ︰ 1(by weight), after mixing, through pre-installing 30 mesh sieves, select extruding rotating speed 65r/min, extruding dynamics 0.6MPa wet granular processed, adopts airpillow-dry, sets 75 DEG C of dry inlet temperature, dry 1.0h, to dry, obtains Herb Gynostemmae Pentaphylli breaking cellular wall preparation after granulate screening.
remarks: full marks are in 10.
Embodiment 7
Get the clean medical material of Herb Gynostemmae Pentaphylli, after the coarse powder of coarse pulverization to 100 order left and right, be ground in superfine powder through micronizing the powder body that 90% grain diameter is less than or equal to 40 μ m, add ethanol-water solution (second mass fraction is 65%) wet method soft material processed, solution and superfine powder addition are than 1.0 ︰ 1(by weight), after mixing, through pre-installing 20 mesh sieves, select extruding rotating speed 80r/min, extruding dynamics 0.25MPa wet granular processed, in wet granular transposition heated-air circulation air box, sets 70 DEG C of baking temperatures, dry 2.0h, to dry, obtains Herb Gynostemmae Pentaphylli breaking cellular wall preparation after granulate screening.
Remarks: full marks are in 10.
Embodiment 8
Get the clean medical material of Herb Gynostemmae Pentaphylli, after the coarse powder of coarse pulverization to 100 order left and right, be ground in superfine powder through micronizing the powder body that 90% grain diameter is less than or equal to 40 μ m, add ethanol-water solution (second mass fraction is 50%) wet method soft material processed, solution and superfine powder addition are than 0.9 ︰ 1(by weight), after mixing, through pre-installing 20 mesh sieves, select extruding rotating speed 85r/min, extruding dynamics 0.85MPa wet granular processed, in wet granular transposition heated-air circulation air box, sets 70 DEG C of baking temperatures, dry 2.0h, to dry, obtains Herb Gynostemmae Pentaphylli breaking cellular wall preparation after granulate screening.
remarks: full marks are in 10.
Embodiment 9
Get the clean medical material of Herb Gynostemmae Pentaphylli, after the coarse powder of coarse pulverization to 100 order left and right, be broken in superfine powder through superfine powder the powder body that 90% grain diameter is less than or equal to 40 μ m, add ethanol-water solution (ethanol mass fraction is 45%) wet method soft material processed, solution and superfine powder addition are than 0.9 ︰ 1(by weight), after mixing, through pre-installing 10 mesh sieves, select extruding rotating speed 60r/min, extruding dynamics 1MPa wet granular processed, in wet granular transposition vacuum microwave drying case, sets 45 DEG C of baking temperatures, dry 0.75h, to dry, obtains Herb Gynostemmae Pentaphylli breaking cellular wall preparation after granulate screening.
remarks: full marks are in 10.
Embodiment 10
Get the clean medical material of Herb Gynostemmae Pentaphylli, after the coarse powder of coarse pulverization to 100 order left and right, be broken in superfine powder through superfine powder the powder body that 90% grain diameter is less than or equal to 40 μ m, add ethanol-water solution (ethanol mass fraction is 95%) wet method soft material processed, solution and superfine powder addition are than 1.5 ︰ 1(by weight), after mixing, through pre-installing 30 mesh sieves, select extruding rotating speed 60r/min, extruding dynamics 0.5MPa wet granular processed, in wet granular transposition vacuum microwave drying case, sets 50 DEG C of baking temperatures, dry 0.5h, to dry, obtains Herb Gynostemmae Pentaphylli breaking cellular wall preparation after granulate screening.
remarks: full marks are in 10.
Embodiment 11
Get the clean medical material of Herb Gynostemmae Pentaphylli, after the coarse powder of coarse pulverization to 100 order left and right, be broken in superfine powder through superfine powder the powder body that 90% grain diameter is less than or equal to 40 μ m, add ethanol-water solution (ethanol mass fraction is 65%) wet method soft material processed, solution and superfine powder addition are than 1.2 ︰ 1(by weight), after mixing, through pre-installing 30 mesh sieves, select extruding rotating speed 80r/min, extruding dynamics 0.3MPa wet granular processed, in wet granular transposition heated-air circulation oven, sets 85 DEG C of baking temperatures, dry 2.5h, to dry, obtains Herb Gynostemmae Pentaphylli breaking cellular wall preparation after granulate screening.
remarks: full marks are in 10.
Embodiment 12
Get the clean medical material of Herb Gynostemmae Pentaphylli, after the coarse powder of coarse pulverization to 100 order left and right, be ground in superfine powder through micronizing the powder body that 90% grain diameter is less than or equal to 40 μ m, add ethanol-water solution (second mass fraction is 75%) wet method soft material processed, solution and superfine powder addition are than 1.0 ︰ 1(by weight), after mixing, through pre-installing 20 mesh sieves, select extruding rotating speed 65r/min, extruding dynamics 0.6MPa wet granular processed, in wet granular transposition heated-air circulation air box, sets 70 DEG C of baking temperatures, dry 2.0h, to dry, obtains Herb Gynostemmae Pentaphylli breaking cellular wall preparation after granulate screening.
Remarks: full marks are in 10.
Embodiment 13
Get the clean medical material of Herb Gynostemmae Pentaphylli, after the coarse powder of coarse pulverization to 100 order left and right, be broken in superfine powder through superfine powder the powder body that 90% grain diameter is less than or equal to 40 μ m, add ethanol-water solution (ethanol mass fraction is 65%) wet method soft material processed, solution and superfine powder addition are than 1.0 ︰ 1(by weight), after mixing, through pre-installing 30 mesh sieves, select extruding rotating speed 45r/min, extruding dynamics 0.04MPa wet granular processed, in wet granular transposition vacuum microwave drying case, sets 50 DEG C of baking temperatures, dry 0.5h, to dry, obtains Herb Gynostemmae Pentaphylli breaking cellular wall preparation after granulate screening.
Remarks: full marks are in 10.
Embodiment 14
Get the clean medical material of Herb Gynostemmae Pentaphylli, after the coarse powder of coarse pulverization to 100 order left and right, be broken in superfine powder through superfine powder the powder body that 90% grain diameter is less than or equal to 40 μ m, add ethanol-water solution (ethanol mass fraction is 70%) wet method soft material processed, solution and superfine powder addition are than 1.0 ︰ 1(by weight), after mixing, through pre-installing 30 mesh sieves, select extruding rotating speed 110r/min, extruding dynamics 1.1MPa wet granular processed, in wet granular transposition heated-air circulation oven, sets 75 DEG C of baking temperatures, dry 2.5h, to dry, obtains Herb Gynostemmae Pentaphylli breaking cellular wall preparation after granulate screening.
Remarks: full marks are in 10.
Embodiment 15
Get 1 ~ 8 lower finished product of embodiment by end product quality standard test, result all meets regulation requirement under the relevant dosage form item of Chinese Pharmacopoeia, and result is as shown in table 1.
Clothes made of brocade step is by conventional to 1 ~ 8 lower Herb Gynostemmae Pentaphylli breaking cellular wall preparation of embodiment and Herb Gynostemmae Pentaphylli superfine powder, Herb Gynostemmae Pentaphylli routine decoction pieces, using character, moisture and water extraction as evaluation index, three is placed on 40 DEG C ± 2 DEG C of temperature after all adopting sealed plastic bag encapsulation, places 1 month, 2 months, 3 months each preparation stabilities of post-evaluation under the condition of relative humidity 75% ± 5%.Result is as shown in table 2 below:
The above results shows, the Herb Gynostemmae Pentaphylli breaking cellular wall preparation that the present invention prepares all lower than the blue ultrafine powder of thigh and the Herb Gynostemmae Pentaphylli prepared slices of Chinese crude drugs, illustrates that the Herb Gynostemmae Pentaphylli preparation described in this law is difficult for moisture absorption in moisture wherein of each time period.From extract content, illustrate that the stability of Herb Gynostemmae Pentaphylli breaking cellular wall preparation of the present invention is all better than strand blue ultrafine powder and the Herb Gynostemmae Pentaphylli prepared slices of Chinese crude drugs.
Claims (9)
1. a Herb Gynostemmae Pentaphylli breaking cellular wall preparation, is characterized in that, Herb Gynostemmae Pentaphylli is carried out to wall breaking pulverization and obtain superfine powder, adds ethanol-water solution soft material processed, more further extruding obtains wet grain, the dry Herb Gynostemmae Pentaphylli breaking cellular wall preparation that obtains; In described superfine powder 90% or above grain diameter be less than or equal to 40 μ m.
2. Herb Gynostemmae Pentaphylli breaking cellular wall preparation according to claim 1, is characterized in that, in described ethanol-water solution, the mass fraction of ethanol is 20%～95%.
3. Herb Gynostemmae Pentaphylli breaking cellular wall preparation according to claim 1, is characterized in that, described superfine powder and ethanol-water solution mass ratio are 1:0.5～1.5.
4. Herb Gynostemmae Pentaphylli breaking cellular wall preparation according to claim 1, is characterized in that, in the time that ethanol mass fraction is 20% ~ 29%, superfine powder is 1:0.5 ~ 0.55 with ethanol-water solution than by weight; In the time that ethanol mass fraction is 30% ~ 39%, superfine powder is 1:0.5 ~ 0.6 with ethanol-water solution than by weight; In the time that ethanol mass fraction is 40% ~ 49%, superfine powder is 1:0.5 ~ 0.8 with ethanol-water solution than by weight; In the time that ethanol mass fraction is 60% ~ 69%, superfine powder is 1:0.5 ~ 1.1 with ethanol-water solution than by weight; In the time that ethanol mass fraction is 70% ~ 79%, superfine powder is 1:0.5 ~ 1.3 with ethanol-water solution than by weight, and in the time that ethanol mass fraction is 80% ~ 95%, superfine powder is 1:1.0 ~ 1.5 with ethanol-water solution than by weight.
5. Herb Gynostemmae Pentaphylli breaking cellular wall preparation according to claim 4, is characterized in that, in the time that ethanol mass fraction is 20% ~ 29%, superfine powder is 1:0.5 with ethanol-water solution than by weight; In the time that ethanol mass fraction is 30% ~ 39%, superfine powder is 1:0.55 with ethanol-water solution than by weight; In the time that ethanol mass fraction is 40% ~ 49%, superfine powder is 1:0.6 ~ 0.8 with ethanol-water solution than by weight; In the time that ethanol mass fraction is 60% ~ 69%, superfine powder is 1:0.8 ~ 1.0 with ethanol-water solution than by weight; In the time that ethanol mass fraction is 70% ~ 79%, superfine powder is 1:0.8 ~ 1.2 with ethanol-water solution than by weight, and in the time that ethanol mass fraction is 80% ~ 95%, superfine powder is 1:1.0 ~ 1.5 with ethanol-water solution than by weight.
6. Herb Gynostemmae Pentaphylli breaking cellular wall preparation according to claim 1, is characterized in that, the density of described Herb Gynostemmae Pentaphylli breaking cellular wall preparation is 0.21g/ml～0.51g/ml.
7. Herb Gynostemmae Pentaphylli breaking cellular wall preparation according to claim 1, is characterized in that, described extruding condition is: wet granulation: prepackage sieve number is 10 order～30 orders, extruding dynamics 0.05Mpa～1Mpa, rotating speed 50r/min～100r/min.
8. Herb Gynostemmae Pentaphylli breaking cellular wall preparation according to claim 7, is characterized in that, described extruding condition is: wet granulation: extruding dynamics 0.2Mpa～0.3Mpa, rotating speed 80r/min～90r/min.
9. Herb Gynostemmae Pentaphylli breaking cellular wall preparation according to claim 1, is characterized in that, the wet grain particle diameter of extruding gained is 20 order～40 orders, and when dry, baking temperature is 45 DEG C ~ 75 DEG C, and be 0.5h ~ 2.5h drying time.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310090050.9A CN104055827A (en) | 2013-03-20 | 2013-03-20 | Gynostemma pentaphyllum wall-broken preparation |
| HK15101632.5A HK1201172A1 (en) | 2013-03-20 | 2015-02-13 | A preparation of ultra-fine granulated powder of gynostemmatis pentaphylli herba |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310090050.9A CN104055827A (en) | 2013-03-20 | 2013-03-20 | Gynostemma pentaphyllum wall-broken preparation |
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Citations (2)
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| CN1357318A (en) * | 2000-12-06 | 2002-07-10 | 杨孟君 | Prepn process, product and use of nano Chinese medicine pieces |
| CN102302680A (en) * | 2011-09-16 | 2012-01-04 | 蔡光先 | Processing method capable of reserving all components of dendrobium officinale |
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2013
- 2013-03-20 CN CN201310090050.9A patent/CN104055827A/en active Pending
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2015
- 2015-02-13 HK HK15101632.5A patent/HK1201172A1/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1357318A (en) * | 2000-12-06 | 2002-07-10 | 杨孟君 | Prepn process, product and use of nano Chinese medicine pieces |
| CN102302680A (en) * | 2011-09-16 | 2012-01-04 | 蔡光先 | Processing method capable of reserving all components of dendrobium officinale |
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| 邓美林: "超微粉碎对绞股蓝总皂苷提取工艺的影响", 《食品工业》 * |
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