CN104000049A - Composite preventing and treating lamb dysentery and application thereof - Google Patents
Composite preventing and treating lamb dysentery and application thereof Download PDFInfo
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Abstract
The invention discloses a composite preventing and treating lamb dysentery and application thereof. The composite comprises, by weight, 100-150 parts of plant leaves, 80-120 parts of dandelions, 100-160 parts of garlic skin, 30-60 parts of valerian, 40-80 parts of phytase and 80-150 IU of B vitamins. The composite can be manufactured into feed additives and external sterilization liquid. The composite integrates Chinese herbal medicine and bacterial preparations, is simple in preparing method, low in raw material price, safe and harmless, improves taste through matching of the raw materials, stimulates appetite of lambs, increases immunity of the lambs and has good prevention and treatment functions on lamb dysentery.
Description
Technical field
The present invention relates to a kind of composition of preventing and treating lamb dysentery, be specifically related to a kind of lamb special use, can prevent and treat feed addictive or the lamb dysentery external medicinal liquid of lamb dysentery.
Background technology
The current extensive use due to antibiotics, particularly in recent years because vast plant, head of a household's phase are used antibacterials in a large number or unreasonably, cause many antibody-resistant bacterium to produce stronger drug resistance, thereby make curable some diseases originally become the disease that intractable is difficult to healing, or control repeatly and send out repeatly, dosage is increasing, curative effect worse and worse, cause the production performance of animal to decline, expenses for medicine is high, and plant's economic benefit is declined.Along with the increase of drug dose, medicament residue is on the rise, and has affected the people's health and the foreign exchange earning of animal products simultaneously.Particularly in feeding process, due to the abusing of additive, unordered, cause animal products security incident more and more to receive people's concern, by the caused livestock and poultry of food pollution and product security incident, also risen one after another, take melamine, tonyred, clenbuterol hydrochloride still to exist so far as the impact that typical case causes market.The people that make of above food safety affair recognize, feed safety is exactly food security, more and more high to the cry of feed addictive.
Current developed country has turned to the emphasis of additive invention the exploitation invention and application of the novel fodder additive of high-quality, efficient, safety, low dosage.Develop livestock and poultry compound nuisance free feed supplement product, significant for animal products upgrading.That compound nuisance free feed supplement refers to is pollution-free, noresidue, anti-disease, somatotrophic natural additive, and it comprises three layers of meaning: the one, to livestock and poultry nonhazardous effect; The 2nd, noresidue in animal products, to human health without damaging effect; The 3rd, the effect of farm animal excrement environmentally safe.Compound nuisance free feed supplement mainly comprises: Chinese herbal and crude drugs preparations, probiotics, chemical probiotic, enzyme preparation etc.China starts extensively invention exploitation Chinese herb feed additive product in late 1980s, makes some progress, and is widely used in herding production.According to incompletely statistics, successively oneself has more than 200 to plant Chinese herbal medicine for additive of livestock and poultry.Chinese herbal and crude drugs preparations, as green additive, has the features such as natural sex, security, noresidue and medicine source popularity.Itself just contains rich in protein, vitamin and mineral element some Chinese herbal medicine, has drug effect and nutrition dual-use function concurrently.Long-term use can improve animal production performance, improve carcass quality and meat.
Lamb dysentery is caused by multiple pathogenic microorganisms, is mainly wherein Escherichia coli, C.perfringens, salmonella, rotavirus, bovine diarrhea virus etc.Lamb dysentery is common disease and the frequently-occurring disease of lamb, and ill lamb can show lassitude, there is no appetite, diarrhoea, the phenomenon of becoming thin gradually.The lamb dysentery incidence of disease is high, early stage lamb dysentery particularly, and the incidence of disease is high, and indivedual sheep field incidence of disease accounts for 60%～80% of lamb, to sheep husbandry, brings huge economic loss.But because pathological change is slight, sometimes there is no obvious clinical symptoms, often by people, ignored.And lamb dysentery common antibiotics treatment clinically, due to irrational prolonged application antibiotic, makes antibody-resistant bacterium more and more, thereby bring difficulty for clinical treatment.Also can cause medicine residual in vivo simultaneously, and affect food hygiene, harm people ' s health.
In addition, the having a low resistance of lamb, stomach are fragile, to the applicable ability of medicine not as adult goat, therefore should be more prudent when treatment.If add the feed addictive with relevant resistant effect when feeding, can greatly reduce the incidence of lamb dysentery, reduce the loss.
Summary of the invention
The invention provides a kind of composition of preventing and treating lamb dysentery, said composition is carried out combination by Chinese herbal medicine and microorganism formulation, safe and harmless, and improved mouthfeel by material matching, promoted lamb appetite, strengthened lamb resistance, lamb dysentery has been had to good preventive and therapeutic effect.
The present invention also provides take feed addictive and the external application sterilized solution that above-mentioned composition is raw material.During as feed addictive, can directly add feeding in lamb feed, during as external application sterilized solution, can directly act on lamb anus place, all can play the effect that prevents and treats lamb dysentery.
The present invention also provides the preparation method of this external application sterilized solution.
Find under study for action, the main cause of lamb dysentery is that lamb early growth and development is rapid, be badly in need of nutrition, but its digestive function has certain limit, thereby easily produces diarrhoea.For this reason, inventor, according to animal nutrition, Animal physiology and feed addictive feature, is studied prescription, contains invigorating the spleen and regulate the flow of vital energy, promote digestion, the composition absorbing in prescription, can strengthen lamb digestive function, pre-anti-diarrhea; Contain in addition clearing heat and detoxicating, antipathogenic composition, when dysentery occurs, play timely the effect for the treatment of.
The present invention is achieved by the following measures:
Prevent and treat a composition for lamb dysentery, it is characterized in that comprising the bulk drug of following weight portion: leaves of plants 100-150 part, dandelion 80-120 part, Cortex Bulbus Allii 100-160 part, valerian 30-60 part, phytase 40-80 part, B family vitamin 80-150IU.
The present composition has screened that medicine source is abundant, cheap, the raw material of drug residue free, uses for reference pilot production simultaneously and assists, and adjusts each raw material magnitude relation, makes additive reach remarkably productive, the target that taste is suitable.
In above-mentioned composition, preferably include the bulk drug of following weight portion: 120 parts of leaves of plants, 100 parts of dandelions, 150 parts of Cortex Bulbus Alliis, 50 parts of valerians, 50 parts of phytases, B family vitamin 100IU.
In the present invention formula, that leaves of plants, dandelion have is clearing heat and detoxicating, anti-inflammation, dispersing swelling and dissipating binds, Huoxue San " what, clearing and activating the channels and collaterals effect; The effect that Cortex Bulbus Allii has restraining and sterilizing bacteria, stops dysentery stomach invigorating, improves feed local flavor, improves immunity; Valerian has the effect calm, antibacterial, pain relieving of calming the nerves; Phytase is as microorganism formulation, can improve the effect of above Chinese herbal medicine with B family vitamin, and the aid digestion absorption of stomach invigorating, can improve abilities of digestive and absorption and the non-specific immunity of lamb.All material coordinate there is clearing heat and detoxicating, bacteriostasis antibiosis, the effect of the calmness of releiving, stomach invigorating, aid digestion absorption.
On the basis of above-mentioned formula, the present composition can also add sodium bicarbonate, jerusalem artichoke, caraway root.Appropriate sodium bicarbonate can strengthen lamb appetite, promote lamb growth; Jerusalem artichoke energy clearing heat for detumescence, the Bifidobacterium that Effective multiplication is useful to animal, improves immunity, but that consumption will be controlled is proper, otherwise can affect mouthfeel; Caraway root mouthfeel delicious and crisp, can improve feed local flavor, promotes lamb appetite, can also urge digestion.
Add after sodium bicarbonate, jerusalem artichoke, caraway root, the new composite formula forming is (weight portion): leaves of plants 100-150 part, dandelion 80-120 part, Cortex Bulbus Allii 100-160 part, valerian 30-60 part, phytase 40-80 part, B family vitamin 80-150IU, sodium bicarbonate 1-3 part, jerusalem artichoke 40-60 part, caraway root 80-120 part.Preferred: 120 parts of leaves of plants, 100 parts of dandelions, 150 parts of Cortex Bulbus Alliis, 50 parts of valerians, 50 parts of phytases, B family vitamin 100IU, 2 parts, sodium bicarbonate, 50 parts of jerusalem artichokes, 100 parts of caraway roots.
In above-mentioned composition, described leaves of plants is through the light salt brine of 0.5wt%, to soak the mixture of fresh leaf of Broussonetia papyrifera(L.) Vent, grape leaf and the sweet potato leaves of drying after 4-6h.Wherein, the mass ratio of leaf of Broussonetia papyrifera(L.) Vent, sweet potato leaves, grape leaf is 10:3-5:0.5-1, preferably 10:4:0.7.
Take compound composition of the present invention as raw material, can make feed addictive, can make external application sterilized solution again, the two can be used in conjunction with in preventing and treating lamb dysentery, be in lamb feed, to add the ability that feed addictive of the present invention increases its appetite, digestion resistance against diseases and treatment dysentery, external application sterilized solution injected to lamb anus simultaneously, make drug ingedient direct onset in part, work along both lines, effect is better.The present composition is during as feed addictive, and the addition in feed is 0.5-1%.
When the present composition is made feed addictive, by pulverizing after each raw material drying, mixing, cross 60 mesh sieves.
When the present composition is made external application sterilized solution, can adopt following methods to make: raw material to be pulverized, crossed 60 mesh sieves, boiling twice, decocts 20～30min for the first time, decocts for the second time 20min, merge decoction liquor, be concentrated into 1 gram of every milliliter contained, obtain external application sterilized solution.
Inventor, through the invention tackling key problem more than 3 years, has obtained formula of the present invention.In research, carried out great many of experiments, experimental result shows, in formula, single raw material is all undesirable to the fungistatic effect of dysentery, the fungistatic effect that raw material proportioning difference shows is also different, after only all raw materials being coordinated by proper proportion with magnitude relation according to the present invention, could greatly improve fungistatic effect, reach the object that be even better than conventional ablastins identical with conventional antibiotic bacteriostasis, better for animal body anaphase effect, this has fully shown the profound meaning of " medicine has the speciality of individual character, and there is gregarious magical effect side ".Meanwhile, said composition mainly adds in feed and uses with the form of feed addictive, when considering fungistatic effect, also needs to consider the acceptance level of lamb to this feed addictive.In optimum formula of the present invention, by the collocation of raw material consumption, not only make its fungistatic effect outstanding, also make the taste of additive better, after adding, can better promote lamb appetite, promote Lamb Growth.
The present invention has the following advantages:
1, the present invention is from Chinese veterinarian is theoretical, Animal nutrition is theoretical, animal physiological theory, in conjunction with clinical practice, Chinese herbal medicine and microorganism formulation are applied to lamb cultivation aspect, solved because of long-term a large amount of medicament residue that antibiotic cause and the various disadvantages such as generation of antibody-resistant bacterium used.
The composition of the present invention's formula all has good bacteriostasis in body in vitro, not only can treat lamb lamb dysentery, and be better than conventional antibiotic, having solved feed addictive in the past can only be as problem for health care, particularly the interior administration of anus can be given full play to the local action of prescription, has improved cure rate.Meanwhile, the present invention uses and can also improve mouthfeel as additive, increases lamb appetite, promotes Lamb Growth.
Preparation method of the present invention is simple, the raw material of selecting is wide material sources, cheap all, having some is all directly to have abandoned as rubbish at ordinary times, these raw materials are turned waste into wealth in the present invention, realized their value, prevented from wasting and avoided again rubbish to abandon brought environmental pollution, there is good economic and social benefit.
The specific embodiment
Below by specific embodiment and related experiment, further explain the present invention, prove advantage of the present invention simultaneously, following content should not play to protection scope of the present invention the effect of restriction.If no special instructions, following raw material medicaments is weight portion.
The present invention's phytase used and B family vitamin all can have been bought from market.
embodiment 1
The composition material medicine composition of preventing and treating lamb dysentery is: 120 parts of leaves of plants, 100 parts of dandelions, 150 parts of Cortex Bulbus Alliis, 50 parts of valerians, 50 parts of phytases, B family vitamin 100IU.Described leaves of plants is that mass ratio is the mixture of leaf of Broussonetia papyrifera(L.) Vent, grape leaf and the sweet potato leaves of 10:4:0.7, leaves of plants is processed through following before use: the light salt brine of the mixture of fresh leaf of Broussonetia papyrifera(L.) Vent, grape leaf and sweet potato leaves being put into concentration 0.5wt%, after soaking 5h, normal temperature dries, and the leaves of plants after drying adds in formula the raw material as composition.
By the following method above-mentioned composition is made to feed addictive: by said ratio, take each bulk drug, pulverize, cross 60 mesh sieves, put into vertical mixer and mix, dress plastic bag sealing is standby, every bag of 500g packing.
By the following method above-mentioned composition is made to external application sterilized solution: by said ratio, take each bulk drug, pulverize, cross 60 mesh sieves, put into vertical mixer and mix, dress plastic bag sealing is standby; Get said mixture, add water boil 20～30min, elimination liquid, then boiling 20min filtration, by twice liquid Hybrid Heating, be concentrated into 1 gram of every milliliter contained, and by above-mentioned liquid bottling, autoclaving is standby.
embodiment 2
The composition material medicine composition of preventing and treating lamb dysentery is: 100 parts of leaves of plants, 120 parts of dandelions, 100 parts of Cortex Bulbus Alliis, 60 parts of valerians, 40 parts of phytases, B family vitamin 150IU.Described leaves of plants is that mass ratio is the mixture of leaf of Broussonetia papyrifera(L.) Vent, grape leaf and the sweet potato leaves of 10:3:1, leaves of plants is processed through following before use: the light salt brine of the mixture of fresh leaf of Broussonetia papyrifera(L.) Vent, grape leaf and sweet potato leaves being put into concentration 0.5wt%, after soaking 5h, dry, the leaves of plants after drying adds in formula the raw material as composition.
According to the method for embodiment 1, said composition is made respectively to feed addictive and external application sterilized solution.
embodiment 3
The composition material medicine composition of preventing and treating lamb dysentery is: 150 parts of leaves of plants, 80 parts of dandelions, 160 parts of Cortex Bulbus Alliis, 30 parts of valerians, 80 parts of phytases, B family vitamin 80IU.Described leaves of plants is that mass ratio is the mixture of leaf of Broussonetia papyrifera(L.) Vent, grape leaf and the sweet potato leaves of 10:5:0.5, leaves of plants is processed through following before use: the light salt brine of the mixture of fresh leaf of Broussonetia papyrifera(L.) Vent, grape leaf and sweet potato leaves being put into concentration 0.5wt%, after soaking 5h, dry, the leaves of plants after drying adds in formula the raw material as composition.
According to the method for embodiment 1, said composition is made respectively to feed addictive and external application sterilized solution.
embodiment 4
The composition material medicine composition of preventing and treating lamb dysentery is: the composition material medicine composition of preventing and treating lamb dysentery is: 120 parts of leaves of plants, 100 parts of dandelions, 150 parts of Cortex Bulbus Alliis, 50 parts of valerians, 50 parts of phytases, B family vitamin 100IU, 2 parts, sodium bicarbonate, 50 parts of jerusalem artichokes, 100 parts of caraway roots.Described leaves of plants is that mass ratio is the mixture of leaf of Broussonetia papyrifera(L.) Vent, grape leaf and the sweet potato leaves of 10:4:0.7, leaves of plants is processed through following before use: the light salt brine of the mixture of fresh leaf of Broussonetia papyrifera(L.) Vent, grape leaf and sweet potato leaves being put into concentration 0.5wt%, after soaking 5h, dry, the leaves of plants after drying adds in formula the raw material as composition.
According to the method for embodiment 1, said composition is made respectively to feed addictive and external application sterilized solution.
embodiment 5
The composition material medicine composition of preventing and treating lamb dysentery is: 100 parts of leaves of plants, 120 parts of dandelions, 100 parts of Cortex Bulbus Alliis, 60 parts of valerians, 40 parts of phytases, B family vitamin 150IU, 1 part, sodium bicarbonate, 60 parts of jerusalem artichokes, 80 parts of caraway roots.Described leaves of plants is that mass ratio is the mixture of leaf of Broussonetia papyrifera(L.) Vent, grape leaf and the sweet potato leaves of 10:3:1, leaves of plants is processed through following before use: the light salt brine of the mixture of fresh leaf of Broussonetia papyrifera(L.) Vent, grape leaf and sweet potato leaves being put into concentration 0.5wt%, after soaking 5h, dry, the leaves of plants after drying adds in formula the raw material as composition.
According to the method for embodiment 1, said composition is made respectively to feed addictive and external application sterilized solution.
embodiment 6
The composition material medicine composition of preventing and treating lamb dysentery is: 150 parts of leaves of plants, 80 parts of dandelions, 160 parts of Cortex Bulbus Alliis, 30 parts of valerians, 80 parts of phytases, B family vitamin 80IU, 3 parts, sodium bicarbonate, 40 parts of jerusalem artichokes, 120 parts of caraway roots.Described leaves of plants is that mass ratio is the mixture of leaf of Broussonetia papyrifera(L.) Vent, grape leaf and the sweet potato leaves of 10:5:0.5, leaves of plants is processed through following before use: the light salt brine of the mixture of fresh leaf of Broussonetia papyrifera(L.) Vent, grape leaf and sweet potato leaves being put into concentration 0.5wt%, after soaking 5h, dry, the leaves of plants after drying adds in formula the raw material as composition.
comparative example
The composition material medicine composition of preventing and treating lamb dysentery is: 120 parts of sweet potato leaves, 100 parts of dandelions, 150 parts of Cortex Bulbus Alliis, 50 parts of phytases, B family vitamin 100IU.Described sweet potato leaves is fresh sweet potato leaves, processes before use through following: fresh sweet potato leaves is put into the light salt brine of concentration 0.5wt%, after immersion 5h, normal temperature dries, and after drying, adds in formula as raw material.
According to the method for embodiment 1, above-mentioned formula is made respectively to feed addictive and external application sterilized solution.
below by the advantage of the present invention of the results show in research process.
one, the research to the preventive and therapeutic effect of lamb dysentery
1, lamb dysentery is prevented and treated test among a small circle
1.1 test drug
The feed addictive that the embodiment of the present invention 1,2,4,5 is made or external application sterilized solution: commodity scorching health by name is precious;
The feed addictive that reference examples of the present invention is made or external application sterilized solution;
Ciprofloxacin injection: produced by Co., Ltd of Qilu Pharmaceutical Factory, specification 100ml:0.2g, is purchased from Linyi City pharmaceuticals.
1.2 experimental animal
Test is provided by great Feng mutton sheep field, Linyi and Linyi field, prosperous sheep field with lamb.
1.3 test method
1.3.1 recessive lamb dysentery test: the conventional scatoscopy of diagnosis, choose 70 of the lambs of the recessive lamb dysentery positive, be divided at random 7 groups, the 1st group is not medication control group, and the 2nd group is embodiment 1 feed addictive group, and the 3rd group is embodiment 2 feed addictive groups, the 4th group is embodiment 4 feed addictive groups, the 5th group is embodiment 5 feed addictive groups, and the 6th group is comparative example feed addictive group, and the 7th group is Ciprofloxacin Lactate group.It is basically identical that duration of test is raised condition.
Feed addictive using method is: feed additive powder agent prepared by each embodiment and comparative example adds in feed and carries out feeding according to 1% addition, and every lamb of additive once a day, is used in conjunction 6 days.
Ciprofloxacin Lactate using method: extracting lactic acid ciprofloxacin injection 50ml, ill lamb afterbody is around cleaned, through conduit, inject anus, after administration, with hand, pinch anus jog for several times, so that liquid spreads and guarantees and no longer flows out, every lamb once a day, is used in conjunction 6 days.
1.3.2 clinical type lamb dysentery test: clinical type lamb dysentery mainly causes obvious lamb diarrhea, poor appetite, the clinical symptoms such as anus redness, choose 50 of the obvious ill lambs of clinical symptoms, be divided at random 5 groups, the 1st group is embodiment 1 feed addictive+external application sterilized solution group, the 2nd group is the alone feed addictive group of embodiment 1, the 3rd group is embodiment 2 feed addictives+external application sterilized solution group, the 4th group is embodiment 4 feed addictives+external application sterilized solution group, the 5th group is embodiment 5 feed addictives+external application sterilized solution group, the 6th group is comparative example feed addictive+external application sterilized solution group, the 7th group is Ciprofloxacin Lactate group.Duration of test is strengthened feeding and management, and it is basically identical that duration of test is raised condition.
Feed addictive+external application sterilized solution using method is: feed additive powder agent prepared by each embodiment adds in feed and carries out feeding according to 1% addition, and every lamb of additive once a day, is used in conjunction 6 days; Ill lamb afterbody is cleaned, with sterilized solution, 100ml injects anus through conduit simultaneously, after administration, with hand, pinches anus jog for several times, so that liquid spreads and guarantees, no longer flows out, and every lamb once a day, is used in conjunction 4 days.
Ciprofloxacin Lactate using method is the same, once a day, is used in conjunction 4 days.
In above-mentioned process of the test, observe, record treatment situation, carry out diagnositc decision.
1.4 efficacy determination
1.4.1 recessive lamb dysentery efficacy determination: cure: treatment is by being diagnosed as feminine gender; Effective: treatment is by test diagnosis, and its positive findings reduces by one more than "+"; Invalid: treatment is by test diagnosis, unchanged before its positive findings and treatment, even increase the weight of or transfer clinical type lamb dysentery to.
1.4.2 clinical type lamb dysentery efficacy determination: cure: the red and swollen heating of its anus, afterbody diarrhea are obviously, degradation clinical symptoms disappear completely under appetite; Effective: its clinical symptoms substantially disappear or are clearly better; Invalid: its clinical symptoms continue to worsen.
result
1.5.1 the result for the treatment of of recessive lamb dysentery is in Table 1.
According to the observation in experimentation and experimental result, see, control group without improvement, and has an example to transfer clinical type lamb dysentery on the 4th day in test the sick sheep of duration of test; Diagnosis after the test of various embodiments of the present invention group, its positive findings has reduction in various degree, and wherein the result for the treatment of of embodiment 4 is best, and efficient and cure rate all reaches 100%.Ciprofloxacin Lactate is to the cure rate of recessive lamb dysentery and efficient not ideal enough, and cure rate is 30%, and efficient is 50%, and comparative example is also not ideal enough to the therapeutic action of recessive lamb dysentery, and cure rate is 30%, and efficient is 60%, and invalid is 40%.From result, the embodiment of the present invention each group and the comparison of Ciprofloxacin Lactate group, significant difference (P < 0.05), illustrates that formula of the present invention has good therapeutic action to recessive lamb dysentery, and the selection of raw material of the present invention and raw material consumption all has considerable influence to treatment results.As coordinating anus medication, result for the treatment of is by even more ideal.
1.5.2 the result for the treatment of of clinical type lamb dysentery is in Table 2.
As can be seen from the above results, the present invention's for oral administration mode of administration in anus that coordinates of filling a prescription has good therapeutic action to clinical type lamb dysentery, the best results of embodiment 4 wherein, cure rate and efficiently all reach 100%.And Ciprofloxacin Lactate is also not ideal enough to the therapeutic action of clinical type lamb dysentery, cure rate is 40%, and efficient is 60%, invalid is 40%, and comparative example is also not ideal enough to the therapeutic action of clinical type lamb dysentery, and cure rate is 40%, efficient is 70%, and invalid is 30%.From result, the embodiment of the present invention each group and the comparison of Ciprofloxacin Lactate group, significant difference (P < 0.05), illustrates that formula of the present invention also has good therapeutic action to clinical type lamb dysentery.In addition, the selection of raw material of the present invention and raw material consumption all has considerable influence to treatment results.
lamb dysentery is prevented and treated test on a large scale
For further the research present composition is as the effect of feed addictive, in March, 2012, in Yimeng, large red Yang Chang makees the scorching health treasured of the present invention to the clinical expanding test of lamb.
2.1 test drug
The embodiment of the present invention 1, embodiment 4: commodity scorching health by name is precious;
The feed addictive that comparative example is made.
2.2 test method
Test is provided by the large red Yang Chang in Yimeng with lamb.Select 4 groups of lambs 200 minutes lactation, wherein the scorching health of the 1st group 50 embodiment 1 that feed is continuously precious 30 days, precious 30 days of the scorching health of the 2nd group 50 embodiment 4 that feed continuously, the 3rd group 50 the comparative example feed addictives 30 days of feeding continuously, the 4th group (control group) 50 feeding patternses with front 3 groups identical, feeding feed stuff additive not just.
The Feeding way of the 1st group, the 2nd group and the 3rd group is: get respectively the feed additive powder agent of embodiment 1,4 and comparative example formula, then they are evenly sneaked in feed and fed respectively, additive addition is 1%.Be used in conjunction 1 month.
2.3, result
Feed continuously after one month, each is organized lamb dysentery a situation arises and sees the following form 3.
Evidence, the group of usually feeding obviously raises than the scorching health treasured group dysentery incidence of feeding, and this explanation additive of the present invention can comparatively effectively suppress the generation of lamb dysentery.In addition, by the contrast of the embodiment of the present invention and comparative example, can find out, the feed addictive effect of embodiment is better.
two, product of the present invention is promoted the research of Lamb Growth and resistance against diseases
1, experimental animal
The large pier village school of the Linyi City Lanshan District white sand Bu Zhen tail Han Yangchang of take is subjects, chooses the cold lamb sheep of 120 3 little tails of monthly age, is divided into 4 groups, 30 every group.
2, test method
The 1st group according to 1% addition, and the embodiment of the present invention of feeding every day 1 feed addictive, is used in conjunction 60 days; The 2nd group according to 1% addition, and the embodiment of the present invention of feeding every day 4 feed addictives, are used in conjunction 60 days; The 3rd group according to 1% addition, and the comparative example feed addictive of the present invention of feeding every day, is used in conjunction 60 days; The 4th group is not added additive of the present invention, according to normally feeding; In process of the test, other each raising condition is all consistent, 4 groups of sheep of inspection record every day upgrowth situation only.After feeding 60 days, weigh.
3, result of the test
Feed after 60 days, each organizes lamb diarrhoea and growing state sees the following form 4.
Through evidence, the embodiment of the present invention 1 and 4 additive all have better prevention effect to the cold lamb sheep diarrhea of little tail, and also can promote the appetite of lamb simultaneously and grow, and more effective than comparative example, wherein the effect of the additive of embodiment 4 is optimum.
By above experiment, can find out, prescription of the present invention is simple, cheap, given full play to the characteristic of the bidirectional modulation body of Chinese herbal medicine and probiotics, all components matching application have improved the nospecific immunity function of body, strengthened the premunition of lamb, the aspects such as lamb epidemic disease resistivity, promotion Lamb Growth have all been had to comparatively ideal effect.As additive, to treatment lamb dysentery, therapeutic action is better than Ciprofloxacin Lactate to the present composition, has good promotion prospect.
Claims (9)
1. prevent and treat a composition for lamb dysentery, it is characterized in that comprising the bulk drug of following weight portion: leaves of plants 100-150 part, dandelion 80-120 part, Cortex Bulbus Allii 100-160 part, valerian 30-60 part, phytase 40-80 part, B family vitamin 80-150IU.
2. composition according to claim 1, is characterized in that comprising the bulk drug of following weight portion: 120 parts of leaves of plants, 100 parts of dandelions, 150 parts of Cortex Bulbus Alliis, 50 parts of valerians, 50 parts of phytases, B family vitamin 100IU.
3. composition according to claim 1, is characterized in that also comprising the bulk drug of following weight portion: sodium bicarbonate 1-3 part, jerusalem artichoke 40-60 part, caraway root 80-120 part.
4. composition according to claim 3, is characterized in that also comprising the bulk drug of following weight portion: 2 parts, sodium bicarbonate, 50 parts of jerusalem artichokes, 100 parts of caraway roots.
5. according to the composition described in any one in claim 1-4, it is characterized in that: described leaves of plants is through the light salt brine of 0.5wt%, to soak the mixture of fresh leaf of Broussonetia papyrifera(L.) Vent, grape leaf and the sweet potato leaves of drying after 4-6h.
6. according to the composition described in any one in claim 1-5, it is characterized in that: the mass ratio of leaf of Broussonetia papyrifera(L.) Vent, sweet potato leaves, grape leaf is 10:3-5:0.5-1, preferably 10:4:0.7.
7. a feed addictive of preventing and treating lamb dysentery, is characterized in that: the composition of preventing and treating lamb dysentery described in any one in claim 1-6 of take is raw material.
8. an external application sterilized solution of preventing and treating lamb dysentery, is characterized in that: the composition of preventing and treating lamb dysentery described in any one in claim 1-6 of take is raw material.
9. a preparation method who prevents and treats the external application sterilized solution of lamb dysentery claimed in claim 8, it is characterized in that: raw material is pulverized, cross 60 mesh sieves, twice of boiling, decoct for the first time 20～30min, decoct for the second time 20min, merge decoction liquor, be concentrated into 1 gram of every milliliter contained, obtain external application sterilized solution.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104225551A (en) * | 2014-09-26 | 2014-12-24 | 施瑞客（天津）生物技术有限公司 | Traditional Chinese medicine oral liquid for treating lamb dysentery and preparation method thereof |
| CN105194579A (en) * | 2015-11-09 | 2015-12-30 | 马英臣 | Medicament for preventing and treating lamb dysentery |
| CN105412860A (en) * | 2015-11-26 | 2016-03-23 | 全椒县同创养羊专业合作社 | Oral solution for preventing and treating weak and limp symptom of lambs and preparation method thereof |
| CN105412761A (en) * | 2015-11-26 | 2016-03-23 | 全椒县同创养羊专业合作社 | Oral solution for preventing and treating lamb dysentery and preparation method thereof |
| CN105475645A (en) * | 2016-01-18 | 2016-04-13 | 肖华 | Ecological and health sheep feed additive |
| CN114343061A (en) * | 2022-01-13 | 2022-04-15 | 山东益得来生物科技有限公司 | Composition for improving bone and meat quality of livestock and poultry |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104225551A (en) * | 2014-09-26 | 2014-12-24 | 施瑞客（天津）生物技术有限公司 | Traditional Chinese medicine oral liquid for treating lamb dysentery and preparation method thereof |
| CN105194579A (en) * | 2015-11-09 | 2015-12-30 | 马英臣 | Medicament for preventing and treating lamb dysentery |
| CN105412860A (en) * | 2015-11-26 | 2016-03-23 | 全椒县同创养羊专业合作社 | Oral solution for preventing and treating weak and limp symptom of lambs and preparation method thereof |
| CN105412761A (en) * | 2015-11-26 | 2016-03-23 | 全椒县同创养羊专业合作社 | Oral solution for preventing and treating lamb dysentery and preparation method thereof |
| CN105475645A (en) * | 2016-01-18 | 2016-04-13 | 肖华 | Ecological and health sheep feed additive |
| CN114343061A (en) * | 2022-01-13 | 2022-04-15 | 山东益得来生物科技有限公司 | Composition for improving bone and meat quality of livestock and poultry |
| CN114343061B (en) * | 2022-01-13 | 2023-07-25 | 山东益得来生物科技有限公司 | Composition for improving quality of livestock and poultry bone and meat |
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