CL2023000605A1 - Desimetrización de diol mediante sustitución aromática nucleófila - Google Patents
Desimetrización de diol mediante sustitución aromática nucleófilaInfo
- Publication number
- CL2023000605A1 CL2023000605A1 CL2023000605A CL2023000605A CL2023000605A1 CL 2023000605 A1 CL2023000605 A1 CL 2023000605A1 CL 2023000605 A CL2023000605 A CL 2023000605A CL 2023000605 A CL2023000605 A CL 2023000605A CL 2023000605 A1 CL2023000605 A1 CL 2023000605A1
- Authority
- CL
- Chile
- Prior art keywords
- desymmetrization
- diol
- aromatic substitution
- nucleophilic aromatic
- via nucleophilic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Se proporcionan en la presente procesos para sintetizar inhibidores de Mcl-1 y productos intermedios tales como el compuesto Y que pueden usarse para prepararlos, donde el R1 variable es tal como se define en la presente. En particular, se proporcionan en la presente procesos para sintetizar el compuesto A1, y sales o solvatos del mismo, el compuesto A2, y sales y solvatos del mismo, y el compuesto A3 y sales y solvatos del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063074241P | 2020-09-03 | 2020-09-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2023000605A1 true CL2023000605A1 (es) | 2023-08-11 |
Family
ID=77924515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2023000605A CL2023000605A1 (es) | 2020-09-03 | 2023-03-02 | Desimetrización de diol mediante sustitución aromática nucleófila |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230365588A1 (es) |
| EP (1) | EP4208467A1 (es) |
| JP (1) | JP7627747B2 (es) |
| KR (1) | KR20230058694A (es) |
| CN (1) | CN116249705A (es) |
| AU (1) | AU2021337589A1 (es) |
| CA (1) | CA3193132A1 (es) |
| CL (1) | CL2023000605A1 (es) |
| IL (1) | IL300977A (es) |
| MX (1) | MX2023002691A (es) |
| WO (1) | WO2022051317A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT4065567T (pt) | 2019-11-26 | 2024-11-08 | Gilead Sciences Inc | Processos e intermediários para a preparação de inibidores de mcl1 |
| JP2023550612A (ja) * | 2020-11-19 | 2023-12-04 | ギリアード サイエンシーズ， インコーポレイテッド | 大環状ｍｃｌ１阻害剤を調製するための方法及び中間体 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003240681B2 (en) | 2002-05-29 | 2008-10-09 | F. Hoffmann-La Roche Ag | N-acylaminobenzene derivatives as selective monoamine oxidase B inhibitors |
| ES2714314T3 (es) | 2012-04-12 | 2019-05-28 | Xenon Pharmaceuticals Inc | Síntesis asimétrica para compuestos de espiro-oxindol útiles como agentes terapéuticos |
| CA2782774A1 (en) | 2012-07-06 | 2014-01-06 | Pharmascience Inc. | Protein kinase inhibitors |
| JO3474B1 (ar) * | 2014-08-29 | 2020-07-05 | Amgen Inc | مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1 |
| JP6453507B2 (ja) | 2017-03-30 | 2019-01-16 | アムジエン・インコーポレーテツド | Ｍｃｌ−１タンパク質を阻害する化合物 |
| TWI831829B (zh) | 2018-09-12 | 2024-02-11 | 美商建南德克公司 | 苯氧基-吡啶基-嘧啶化合物及使用方法 |
| PE20211871A1 (es) | 2018-11-22 | 2021-09-21 | Qilu Regor Therapeutics Inc | Agonistas de glp-1r y usos de los mismos |
| WO2020147802A1 (en) | 2019-01-18 | 2020-07-23 | Ascentage Pharma (Suzhou) Co., Ltd. | Macrocyclic spiroethers as mcl-1 inhibitors |
-
2021
- 2021-09-01 WO PCT/US2021/048588 patent/WO2022051317A1/en active Application Filing
- 2021-09-01 MX MX2023002691A patent/MX2023002691A/es unknown
- 2021-09-01 JP JP2023513981A patent/JP7627747B2/ja active Active
- 2021-09-01 CA CA3193132A patent/CA3193132A1/en active Pending
- 2021-09-01 AU AU2021337589A patent/AU2021337589A1/en active Pending
- 2021-09-01 IL IL300977A patent/IL300977A/en unknown
- 2021-09-01 CN CN202180065223.4A patent/CN116249705A/zh active Pending
- 2021-09-01 US US18/024,716 patent/US20230365588A1/en active Pending
- 2021-09-01 KR KR1020237010991A patent/KR20230058694A/ko active Pending
- 2021-09-01 EP EP21778303.4A patent/EP4208467A1/en active Pending
-
2023
- 2023-03-02 CL CL2023000605A patent/CL2023000605A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL300977A (en) | 2023-04-01 |
| WO2022051317A1 (en) | 2022-03-10 |
| JP2023540083A (ja) | 2023-09-21 |
| EP4208467A1 (en) | 2023-07-12 |
| MX2023002691A (es) | 2023-05-03 |
| JP7627747B2 (ja) | 2025-02-06 |
| US20230365588A1 (en) | 2023-11-16 |
| AU2021337589A1 (en) | 2023-03-30 |
| KR20230058694A (ko) | 2023-05-03 |
| CN116249705A (zh) | 2023-06-09 |
| CA3193132A1 (en) | 2022-03-10 |
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