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CL2017001511A1 - Derivados de piperidina como inhibidores de hdac1/2. - Google Patents

Derivados de piperidina como inhibidores de hdac1/2.

Info

Publication number
CL2017001511A1
CL2017001511A1 CL2017001511A CL2017001511A CL2017001511A1 CL 2017001511 A1 CL2017001511 A1 CL 2017001511A1 CL 2017001511 A CL2017001511 A CL 2017001511A CL 2017001511 A CL2017001511 A CL 2017001511A CL 2017001511 A1 CL2017001511 A1 CL 2017001511A1
Authority
CL
Chile
Prior art keywords
hdac1
inhibitors
piperidine derivatives
myelodisplasic
hemoglobinopatia
Prior art date
Application number
CL2017001511A
Other languages
English (en)
Inventor
Duzer John H Van
Ralph Mazitschek
Original Assignee
Acetylon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acetylon Pharmaceuticals Inc filed Critical Acetylon Pharmaceuticals Inc
Publication of CL2017001511A1 publication Critical patent/CL2017001511A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

<p>COMPUESTOS DERIVADOS DE PIPERIDINA, COMO INHIBIDORES DE HDAC1/2; COMPOSICION FARMACEUTICA QUE LOS COMPRENDE, UTIL PARA EL TRATAMIENTO DE SINDROME MIELODISPLASICO, HEMOGLOBINOPATIA, CANCER DE PULMON, DE COLON, DE MAMA, NEUROBLASTOMAS, LEUCEMIA O LINFOMA, ENTRE OTRAS ENFERMEDADES.</p>
CL2017001511A 2014-12-12 2017-06-13 Derivados de piperidina como inhibidores de hdac1/2. CL2017001511A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462091221P 2014-12-12 2014-12-12
US201562238931P 2015-10-08 2015-10-08

Publications (1)

Publication Number Publication Date
CL2017001511A1 true CL2017001511A1 (es) 2018-02-16

Family

ID=56108272

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017001511A CL2017001511A1 (es) 2014-12-12 2017-06-13 Derivados de piperidina como inhibidores de hdac1/2.

Country Status (17)

Country Link
US (6) US9790180B2 (es)
EP (2) EP3292113B1 (es)
JP (1) JP6693957B2 (es)
KR (1) KR20170095964A (es)
CN (1) CN107835810A (es)
AU (2) AU2015360270B9 (es)
BR (1) BR112017012504A2 (es)
CA (1) CA2970500C (es)
CL (1) CL2017001511A1 (es)
EA (1) EA035120B1 (es)
ES (1) ES2816641T3 (es)
HK (1) HK1251566A1 (es)
IL (1) IL252828A0 (es)
MX (2) MX2017007623A (es)
PH (1) PH12017501095A1 (es)
SG (1) SG11201704759QA (es)
WO (1) WO2016094824A1 (es)

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US10196363B2 (en) 2014-12-12 2019-02-05 Japan Tobacco Inc. Dihydropyrimidin-2-one compounds and medical use thereof

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US9145412B2 (en) 2012-11-02 2015-09-29 Acetylon Pharmaceuticals, Inc. Selective HDAC1 and HDAC2 inhibitors
JP6626437B2 (ja) 2013-10-08 2019-12-25 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． ヒストンデアセチラーゼ阻害剤とＨｅｒ２阻害剤またはＰＩ３Ｋ阻害剤のいずれかの組み合わせ
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JP6693957B2 (ja) * 2014-12-12 2020-05-13 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． Ｈｄａｃ１／２阻害剤としてのピペリジン誘導体
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JP6816036B2 (ja) 2015-06-08 2021-01-20 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． ヒストン脱アセチル化阻害剤の結晶形態
ES2929032T3 (es) 2016-08-08 2022-11-24 Acetylon Pharmaceuticals Inc Combinaciones farmacéuticas de inhibidores de histona desacetilasa 6 y anticuerpos inhibidores de CD20 y usos de los mismos
MX2020008982A (es) 2018-02-28 2020-09-28 Japan Tobacco Inc Compuestos de 4-metildihidropirimidinona y su uso farmaceutico.
CN110372572A (zh) * 2019-08-23 2019-10-25 苏州汉德创宏生化科技有限公司 一种4,4-二氟哌啶-1-甲酰氯的合成方法
WO2024030659A1 (en) 2022-08-05 2024-02-08 Tango Therapeutics, Inc. An hdac inhibitor for treating cancer with a modified stk11 activity or expression
WO2024167423A1 (en) 2023-02-07 2024-08-15 Captor Therapeutics S.A. Gspt1 degrader compounds

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10196363B2 (en) 2014-12-12 2019-02-05 Japan Tobacco Inc. Dihydropyrimidin-2-one compounds and medical use thereof

Also Published As

Publication number Publication date
WO2016094824A1 (en) 2016-06-16
US10239837B2 (en) 2019-03-26
EA035120B1 (ru) 2020-04-29
EP3292113B1 (en) 2020-07-08
MX2017007623A (es) 2018-09-26
US20180022702A1 (en) 2018-01-25
US10968180B2 (en) 2021-04-06
US20160168093A1 (en) 2016-06-16
EA201791259A1 (ru) 2017-11-30
US9790180B2 (en) 2017-10-17
EP3292113A1 (en) 2018-03-14
HK1251566A1 (zh) 2019-02-01
JP6693957B2 (ja) 2020-05-13
AU2015360270B2 (en) 2019-11-28
KR20170095964A (ko) 2017-08-23
MX2020002487A (es) 2020-07-13
EP3725787B1 (en) 2023-11-29
IL252828A0 (en) 2017-08-31
BR112017012504A2 (pt) 2018-01-09
CA2970500A1 (en) 2016-06-16
AU2015360270B9 (en) 2019-12-05
US20210179559A1 (en) 2021-06-17
EP3725787A1 (en) 2020-10-21
AU2015360270A1 (en) 2017-07-13
PH12017501095A1 (en) 2017-10-18
US20170369441A1 (en) 2017-12-28
US20230348389A1 (en) 2023-11-02
US10358421B2 (en) 2019-07-23
US20190359569A1 (en) 2019-11-28
JP2018502841A (ja) 2018-02-01
EP3292113A4 (en) 2018-07-04
SG11201704759QA (en) 2017-07-28
ES2816641T3 (es) 2021-04-05
AU2020200846A1 (en) 2020-02-27
CN107835810A (zh) 2018-03-23
CA2970500C (en) 2023-08-29
US11702389B2 (en) 2023-07-18

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