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CL2017000069A1 - Derivado de hidantoina. - Google Patents

Derivado de hidantoina.

Info

Publication number
CL2017000069A1
CL2017000069A1 CL2017000069A CL2017000069A CL2017000069A1 CL 2017000069 A1 CL2017000069 A1 CL 2017000069A1 CL 2017000069 A CL2017000069 A CL 2017000069A CL 2017000069 A CL2017000069 A CL 2017000069A CL 2017000069 A1 CL2017000069 A1 CL 2017000069A1
Authority
CL
Chile
Prior art keywords
hydantoin derivative
written
page
formula
acceptable salts
Prior art date
Application number
CL2017000069A
Other languages
English (en)
Inventor
Tatsuya Tamura
Yoshikazu Nishimura
Toru Esaki
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of CL2017000069A1 publication Critical patent/CL2017000069A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)

Abstract

<p>LA PRESENTE INVENCIÓN PROPORCIONA COMPUESTOS REPRESENTADOS POR LA FÓRMULA (1) QUE SE MUESTRA A CONTINUACIÓN Y SUS SALES FARMACOLÓGICAMENTE ACEPTABLES:</p> <p>* incluir figura de estructura de hoja resumen (pag 3), escrito 11-01-2017</p> <p>EN DONDE RL, R2, R3, Y R4 SON COMO SE DEFINEN EN LAS REIVINDICACIONES.</p>
CL2017000069A 2012-12-10 2017-01-11 Derivado de hidantoina. CL2017000069A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2012269178 2012-12-10

Publications (1)

Publication Number Publication Date
CL2017000069A1 true CL2017000069A1 (es) 2017-08-25

Family

ID=50934349

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2015001391A CL2015001391A1 (es) 2012-12-10 2015-05-22 Compuestos derivados de hidantoina, análogo de pth; composicion farmaceutica; metodo para la prevencion o el tratamieno de osteoporosis,fracturas, hipocondroplasia; y su uso para la produccion de un agente movilizador de celulas madre o un agente para prevenir o tratar osteoporosis, entre otras
CL2017000069A CL2017000069A1 (es) 2012-12-10 2017-01-11 Derivado de hidantoina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2015001391A CL2015001391A1 (es) 2012-12-10 2015-05-22 Compuestos derivados de hidantoina, análogo de pth; composicion farmaceutica; metodo para la prevencion o el tratamieno de osteoporosis,fracturas, hipocondroplasia; y su uso para la produccion de un agente movilizador de celulas madre o un agente para prevenir o tratar osteoporosis, entre otras

Country Status (35)

Country Link
US (5) US9428505B2 (es)
EP (1) EP2930176B1 (es)
JP (1) JP5951799B2 (es)
KR (1) KR102168738B1 (es)
CN (1) CN104854106B (es)
AU (1) AU2013358167B2 (es)
BR (1) BR112015012411B1 (es)
CA (1) CA2892621C (es)
CL (2) CL2015001391A1 (es)
CR (1) CR20150272A (es)
DK (1) DK2930176T3 (es)
ES (1) ES2663797T3 (es)
HK (1) HK1209735A1 (es)
HR (1) HRP20180647T1 (es)
HU (1) HUE037530T2 (es)
IL (1) IL238277B (es)
LT (1) LT2930176T (es)
MA (1) MA38250B1 (es)
MX (1) MX2015007309A (es)
MY (1) MY178583A (es)
NO (1) NO2930176T3 (es)
NZ (1) NZ707946A (es)
PE (1) PE20151295A1 (es)
PH (1) PH12015501146B1 (es)
PL (1) PL2930176T3 (es)
PT (1) PT2930176T (es)
RS (1) RS57190B1 (es)
RU (1) RU2678984C2 (es)
SA (1) SA515360528B1 (es)
SG (1) SG11201504204XA (es)
SI (1) SI2930176T1 (es)
TW (1) TWI615394B (es)
UA (1) UA115072C2 (es)
WO (1) WO2014092061A1 (es)
ZA (1) ZA201503597B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI496782B (zh) 2009-04-28 2015-08-21 Chugai Pharmaceutical Co Ltd Spiro haloperidone derivatives
NZ707946A (en) * 2012-12-10 2019-11-29 Chugai Pharmaceutical Co Ltd Hydantoin derivative
WO2015189901A1 (ja) * 2014-06-09 2015-12-17 中外製薬株式会社 ヒダントイン誘導体含有医薬組成物
MX2021001063A (es) * 2018-07-30 2021-04-12 Chugai Pharmaceutical Co Ltd Dispersion solida de derivado de hidantoina.
CN110464002A (zh) * 2019-09-12 2019-11-19 西南石油大学 一种天然冰粉的制备方法及其应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1135470A (ja) * 1997-07-23 1999-02-09 Teijin Ltd ビタミンｄ３誘導体を含有する副甲状腺ホルモン産生促進剤
DK1137640T3 (da) 1998-12-11 2006-02-06 Hoffmann La Roche Cykliske hydrazinderivater som TNF-alfa-inhibitorer
US7004593B2 (en) * 2002-06-06 2006-02-28 Donnelly Corporation Interior rearview mirror system with compass
EP1321141A4 (en) 2000-08-30 2004-02-18 Teijin Ltd INHIBITORS OF PARATHORMONE PRODUCTION CONTAINING VITAMIN D3 DERIVATIVES
EP1332146A2 (en) * 2000-10-26 2003-08-06 Pfizer Products Inc. Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
SE0100902D0 (sv) 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
AR038658A1 (es) 2001-06-15 2005-01-26 Novartis Ag Derivados de 4-aril-2(1h) quinazolinona y 4-aril-quinazolina 2-sustituidas, un proceso para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la preparacion de un medicamento
US20070123548A1 (en) * 2004-02-11 2007-05-31 Cowan David J Pth agonists
EP1713815A4 (en) * 2004-02-11 2009-03-11 Smithkline Beecham Corp PTH AGONISTS
AU2005294448B2 (en) 2004-10-07 2011-07-14 Merck Sharp & Dohme Corp. CGRP receptor antagonists
WO2007135417A1 (en) 2006-05-19 2007-11-29 James Black Foundation Benzotriazepinone derivatives
WO2007149873A2 (en) 2006-06-20 2007-12-27 Wyeth Kv1.5 potassium channel inhibitors
CA2689560A1 (en) 2007-06-07 2008-12-11 F.Hoffmann-La Roche Ag Prolinamide derivatives as nk3 antagonists
AU2008334629B2 (en) 2007-12-10 2012-04-12 Novartis Ag Organic compounds
US7981904B2 (en) 2008-03-20 2011-07-19 Takeda Pharmaceutical Company Limited Acetyl CoA carboxylase inhibitors
US8513193B2 (en) 2008-10-13 2013-08-20 University Of Rochester Protecting and repairing cartilage and musculoskeletal soft tissues
TWI496782B (zh) 2009-04-28 2015-08-21 Chugai Pharmaceutical Co Ltd Spiro haloperidone derivatives
NZ707946A (en) * 2012-12-10 2019-11-29 Chugai Pharmaceutical Co Ltd Hydantoin derivative
WO2015189901A1 (ja) * 2014-06-09 2015-12-17 中外製薬株式会社 ヒダントイン誘導体含有医薬組成物

Also Published As

Publication number Publication date
BR112015012411A2 (pt) 2017-07-11
NO2930176T3 (es) 2018-07-07
AU2013358167A1 (en) 2015-04-09
IL238277B (en) 2018-01-31
BR112015012411B1 (pt) 2021-10-05
HK1209735A1 (en) 2016-04-08
US9428505B2 (en) 2016-08-30
SA515360528B1 (ar) 2018-05-24
HRP20180647T1 (hr) 2018-06-01
CA2892621A1 (en) 2014-06-19
RU2678984C2 (ru) 2019-02-05
UA115072C2 (uk) 2017-09-11
SI2930176T1 (en) 2018-06-29
EP2930176A4 (en) 2016-06-01
PE20151295A1 (es) 2015-10-10
ES2663797T3 (es) 2018-04-17
US20220162208A1 (en) 2022-05-26
WO2014092061A1 (ja) 2014-06-19
MA38250B1 (fr) 2017-10-31
MY178583A (en) 2020-10-16
KR102168738B1 (ko) 2020-10-22
RS57190B1 (sr) 2018-07-31
EP2930176A1 (en) 2015-10-14
CN104854106A (zh) 2015-08-19
EP2930176B1 (en) 2018-02-07
PH12015501146A1 (en) 2015-08-10
TW201439092A (zh) 2014-10-16
IL238277A0 (en) 2015-06-30
PL2930176T3 (pl) 2018-07-31
TWI615394B (zh) 2018-02-21
KR20150092275A (ko) 2015-08-12
MX2015007309A (es) 2015-09-10
NZ707946A (en) 2019-11-29
DK2930176T3 (en) 2018-03-19
CL2015001391A1 (es) 2015-07-31
ZA201503597B (en) 2016-09-28
JPWO2014092061A1 (ja) 2017-01-12
MA38250A1 (fr) 2017-02-28
SG11201504204XA (en) 2015-07-30
CR20150272A (es) 2015-07-09
US20210024524A1 (en) 2021-01-28
PH12015501146B1 (en) 2015-08-10
JP5951799B2 (ja) 2016-07-13
CN104854106B (zh) 2017-07-04
CA2892621C (en) 2021-02-16
AU2013358167B2 (en) 2017-09-14
US20180237436A1 (en) 2018-08-23
US20150274727A1 (en) 2015-10-01
US20160326175A1 (en) 2016-11-10
HUE037530T2 (hu) 2018-09-28
RU2015127624A (ru) 2017-01-16
LT2930176T (lt) 2018-04-10
PT2930176T (pt) 2018-04-03

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