CL2016003346A1 - Anticuerpos anti-tau humanizados - Google Patents
Anticuerpos anti-tau humanizadosInfo
- Publication number
- CL2016003346A1 CL2016003346A1 CL2016003346A CL2016003346A CL2016003346A1 CL 2016003346 A1 CL2016003346 A1 CL 2016003346A1 CL 2016003346 A CL2016003346 A CL 2016003346A CL 2016003346 A CL2016003346 A CL 2016003346A CL 2016003346 A1 CL2016003346 A1 CL 2016003346A1
- Authority
- CL
- Chile
- Prior art keywords
- tauopathy
- treat
- prevent
- humanized anti
- fragment
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Mycology (AREA)
- Optics & Photonics (AREA)
Abstract
<p>UN ANTICUERPO AISLADO O FRAGMENTO DE UNIÓN A ANTÍGENO QUE SE UNE ESPECÍFICAMENTE A TAU, EN DONDE EL ANTICUERPO O FRAGMENTO COMPRENDE UNA REGIÓN VARIABLE DE CADENA PESADA (VH) Y UNA REGIÓN VARIABLE DE CADENA LIVIANA (VL) QUE TIENE LAS SECUENCIAS DE AMINOÁCIDOS DETALLADAS EN LA PRESENTE. TAMBIÉN SE PROVEEN MÉTODOS PARA PREVENIR O TRATAR UNA TAUOPATÍA EN UN SUJETO, QUE COMPRENDE ADMINISTRAR A UN HUMANO QUE LA REQUIERE UNA TERAPIA PARA UNA TAUOPATÍA CON UNO A MÁS ANTICUERPOS O FRAGMENTOS COMO SE DESCRIBE EN LA PRESENTE, EN DONDE LOS ANTICUERPOS O FRAGMENTO DE UNIÓN A ANTÍGENO SE ADMINISTRAN BAJO CONDICIONES Y EN UNA CANTIDAD EFICAZ PARA PREVENIR O TRATAR LA TAUOPATÍA.</p>
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462018436P | 2014-06-27 | 2014-06-27 | |
| US201462080903P | 2014-11-17 | 2014-11-17 | |
| US201562170036P | 2015-06-02 | 2015-06-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2016003346A1 true CL2016003346A1 (es) | 2017-07-21 |
Family
ID=54938957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2016003346A CL2016003346A1 (es) | 2014-06-27 | 2016-12-27 | Anticuerpos anti-tau humanizados |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US9957317B2 (es) |
| EP (1) | EP3182987B1 (es) |
| JP (3) | JP6626892B2 (es) |
| KR (1) | KR102431596B1 (es) |
| CN (1) | CN106659759B (es) |
| AU (2) | AU2015279643B2 (es) |
| BR (1) | BR112016030686A2 (es) |
| CA (2) | CA3094638A1 (es) |
| CL (1) | CL2016003346A1 (es) |
| CR (1) | CR20170026A (es) |
| DO (1) | DOP2016000335A (es) |
| EC (1) | ECSP17005649A (es) |
| ES (1) | ES2959528T3 (es) |
| IL (3) | IL249734B (es) |
| MA (1) | MA40229A (es) |
| MX (2) | MX2017000205A (es) |
| MY (1) | MY184540A (es) |
| NZ (1) | NZ727919A (es) |
| PE (1) | PE20170665A1 (es) |
| PH (2) | PH12016502608A1 (es) |
| RU (1) | RU2743152C2 (es) |
| SG (2) | SG11201610862VA (es) |
| TW (3) | TWI664190B (es) |
| UA (1) | UA122771C2 (es) |
| UY (1) | UY36194A (es) |
| WO (1) | WO2015200806A2 (es) |
| ZA (1) | ZA201608875B (es) |
Families Citing this family (37)
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| EP3838921A3 (en) | 2012-07-03 | 2021-09-01 | Washington University | Antibodies to tau |
| CA2902026C (en) | 2013-03-13 | 2023-08-29 | Prothena Biosciences Limited | Tau immunotherapy |
| TWI664190B (zh) | 2014-06-27 | 2019-07-01 | 美商Ｃ２Ｎ醫療診斷有限責任公司 | 人類化抗－ｔａｕ抗體 |
| JP6793134B2 (ja) | 2015-06-05 | 2020-12-02 | ジェネンテック， インコーポレイテッド | 抗ｔａｕ抗体及び使用方法 |
| US20200030445A1 (en) * | 2015-06-12 | 2020-01-30 | C2N Diagnostics, Llc | Stable formulations of humanized anti-tau antibody |
| PL3445785T3 (pl) | 2016-04-18 | 2022-10-17 | Faron Pharmaceuticals Oy | Humanizowane przeciwciała anty-clever-1 i ich zastosowanie |
| CN109219615B (zh) | 2016-05-02 | 2022-12-09 | 普罗塞纳生物科学有限公司 | 识别tau的抗体 |
| SG11201809331RA (en) | 2016-05-02 | 2018-11-29 | Prothena Biosciences Ltd | Antibodies recognizing tau |
| CN109415432B (zh) | 2016-05-02 | 2022-07-08 | 普罗塞纳生物科学有限公司 | Tau免疫疗法 |
| US10570196B2 (en) * | 2016-07-20 | 2020-02-25 | Anahit Ghochikyan | Humanized anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies |
| EP3509636A4 (en) * | 2016-09-10 | 2020-12-16 | Yeda Research and Development Co. Ltd | REDUCTION IN QUANTITIES OR ACTIVITY OF SYSTEMIC REGULATORY T CELLS FOR THE TREATMENT OF CNS ILLNESS AND INJURY |
| CN110036033B (zh) | 2016-09-27 | 2023-12-08 | 森罗治疗公司 | 嵌合吞噬受体分子 |
| CA3044679A1 (en) | 2016-12-07 | 2018-06-14 | Genentech, Inc. | Anti-tau antibodies and methods of use |
| WO2018106776A2 (en) | 2016-12-07 | 2018-06-14 | Genentech, Inc. | Anti-tau antibodies and methods of use |
| EP3583123A1 (en) | 2017-02-17 | 2019-12-25 | Denali Therapeutics Inc. | Anti-tau antibodies and methods of use thereof |
| JOP20180014A1 (ar) * | 2017-02-27 | 2019-01-30 | Teijin Pharma Ltd | جسم مضاد متوافق مع البشر لعلاج أو الوقاية من الاضطرابات الإدراكية، وعملية لإنتاجه، وعامل لعلاج أو الوقاية من الاضطرابات الإدراكية باستخدامه |
| SG10201911225WA (en) | 2017-03-28 | 2020-01-30 | Genentech Inc | Methods of treating neurodegenerative diseases |
| BR112019022906A2 (pt) | 2017-05-02 | 2020-05-26 | Prothena Biosciences Limited | Anticorpos que reconhecem tau |
| CN111386284B (zh) | 2017-09-26 | 2024-08-30 | 森罗治疗公司 | 嵌合吞噬受体分子和使用方法 |
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| US20210015865A1 (en) | 2018-03-28 | 2021-01-21 | Cero Therapeutics, Inc. | Chimeric engulfment receptors and uses thereof for neurodegenerative diseases |
| AU2019312831A1 (en) | 2018-08-01 | 2021-02-18 | Centre National De La Recherche Scientifique - Cnrs - | Anti-BTN3a antibodies and their use in treating cancer or infectious disorders |
| JP2022524588A (ja) | 2019-03-03 | 2022-05-09 | プロセナ バイオサイエンシーズ リミテッド | タウ認識抗体 |
| EP3946605A1 (en) * | 2019-04-05 | 2022-02-09 | Tauc3 Biologics Limited | Anti-tauc3 antibodies and uses thereof |
| JP2022541539A (ja) * | 2019-07-15 | 2022-09-26 | アデル，インコーポレーテッド | 抗タウ抗体およびその使用 |
| JP7181438B2 (ja) | 2019-08-06 | 2022-11-30 | アプリノイア セラピューティクス リミテッド | 病理学的タウ種に結合する抗体及びその使用 |
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| AU2022332303A1 (en) | 2021-08-27 | 2024-02-01 | Genentech, Inc. | Methods of treating tau pathologies |
| EP4405680A1 (en) | 2021-09-20 | 2024-07-31 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for improving the efficacy of hdac inhibitor therapy and predicting the response to treatment with hdac inhibitor |
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