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CL2016002267A1 - Ureas asimétricas p-sustituidas y usos médicos de las mismas - Google Patents

Ureas asimétricas p-sustituidas y usos médicos de las mismas

Info

Publication number
CL2016002267A1
CL2016002267A1 CL2016002267A CL2016002267A CL2016002267A1 CL 2016002267 A1 CL2016002267 A1 CL 2016002267A1 CL 2016002267 A CL2016002267 A CL 2016002267A CL 2016002267 A CL2016002267 A CL 2016002267A CL 2016002267 A1 CL2016002267 A1 CL 2016002267A1
Authority
CL
Chile
Prior art keywords
asymmetric
medical uses
substituted areas
substituted
areas
Prior art date
Application number
CL2016002267A
Other languages
English (en)
Inventor
Claudio Giuliano
Rubio Silvina Garcia
Antoine Daina
Angelo Guainazzi
Claudio Pietra
Original Assignee
Helsinn Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52706292&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2016002267(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Helsinn Healthcare Sa filed Critical Helsinn Healthcare Sa
Publication of CL2016002267A1 publication Critical patent/CL2016002267A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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Abstract

<p>Se describen compuestos, composiciones y métodos para la prevención y/o tratamiento de enfermedades que son mediadas patofisiológicamente por el receptor de ghrelina. Los compuestos tienen la Fórmula general I o sales farmacéuticamente aceptables de los mismos.</p>
CL2016002267A 2014-03-07 2016-09-07 Ureas asimétricas p-sustituidas y usos médicos de las mismas CL2016002267A1 (es)

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EP3542799A1 (en) 2018-03-22 2019-09-25 Helsinn Healthcare SA New centrally-active ghrelin agonist and medical uses thereof
EP4186893A1 (en) * 2020-07-22 2023-05-31 Geneora Pharma (Shijiazhuang) Co., Ltd. 5-ht2a receptor inhibitor or inverse agonist, preparation method therefor, and application thereof
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NZ720467A (en) 2021-04-30
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PH12016501483B1 (en) 2016-08-22
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DOP2016000161A (es) 2016-10-16
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