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CL2016001023A1 - Compuesto n-(1-(4-(2-(4-cloro-2,6-dimetilpirimidin-5-il)etil)piperidin-1-il)-1-oxopropan-2-il)ciclopropanocarboxamida, estereoisomero, inhibidores de grelina o-aciltransferasa (goat); composición farmaceutica; y uso para reducir la ganancia de peso y para tratar la diabetes tipo 2. - Google Patents

Compuesto n-(1-(4-(2-(4-cloro-2,6-dimetilpirimidin-5-il)etil)piperidin-1-il)-1-oxopropan-2-il)ciclopropanocarboxamida, estereoisomero, inhibidores de grelina o-aciltransferasa (goat); composición farmaceutica; y uso para reducir la ganancia de peso y para tratar la diabetes tipo 2.

Info

Publication number
CL2016001023A1
CL2016001023A1 CL2016001023A CL2016001023A CL2016001023A1 CL 2016001023 A1 CL2016001023 A1 CL 2016001023A1 CL 2016001023 A CL2016001023 A CL 2016001023A CL 2016001023 A CL2016001023 A CL 2016001023A CL 2016001023 A1 CL2016001023 A1 CL 2016001023A1
Authority
CL
Chile
Prior art keywords
dimethylpyrimidin
oxopropan
cyclopropanecarboxamide
ghrelin
acyltransferase
Prior art date
Application number
CL2016001023A
Other languages
English (en)
Inventor
Grau Maria Angeles Martinez
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CL2016001023A1 publication Critical patent/CL2016001023A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuesto N-(1-(4-(2-(4-cloro-2,6-dimetilpirimidin-5-il)etil)piperidin-1-il)-1-oxopropan-2-il)ciclopropanocarboxamida, su enantiómero, inhibidor de grelina o-aciltransferasa (GOAT); composición farmacéutica y uso para reducir la ganancia de peso y para tratar la diabetes tipo 2
CL2016001023A 2013-11-14 2016-04-29 Compuesto n-(1-(4-(2-(4-cloro-2,6-dimetilpirimidin-5-il)etil)piperidin-1-il)-1-oxopropan-2-il)ciclopropanocarboxamida, estereoisomero, inhibidores de grelina o-aciltransferasa (goat); composición farmaceutica; y uso para reducir la ganancia de peso y para tratar la diabetes tipo 2. CL2016001023A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13382460 2013-11-14

Publications (1)

Publication Number Publication Date
CL2016001023A1 true CL2016001023A1 (es) 2016-11-18

Family

ID=49622771

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016001023A CL2016001023A1 (es) 2013-11-14 2016-04-29 Compuesto n-(1-(4-(2-(4-cloro-2,6-dimetilpirimidin-5-il)etil)piperidin-1-il)-1-oxopropan-2-il)ciclopropanocarboxamida, estereoisomero, inhibidores de grelina o-aciltransferasa (goat); composición farmaceutica; y uso para reducir la ganancia de peso y para tratar la diabetes tipo 2.

Country Status (40)

Country Link
US (1) US9035051B1 (es)
EP (1) EP3068775B1 (es)
JP (1) JP6159484B2 (es)
KR (1) KR101739243B1 (es)
CN (1) CN105636948B (es)
AP (1) AP2016009189A0 (es)
AR (1) AR098274A1 (es)
AU (1) AU2014348967B2 (es)
BR (1) BR112016009488B1 (es)
CA (1) CA2926224C (es)
CL (1) CL2016001023A1 (es)
CR (1) CR20160184A (es)
CY (1) CY1119489T1 (es)
DK (1) DK3068775T3 (es)
DO (1) DOP2016000070A (es)
EA (1) EA028550B1 (es)
ES (1) ES2647790T3 (es)
HK (1) HK1222860A1 (es)
HR (1) HRP20171648T1 (es)
HU (1) HUE035590T2 (es)
IL (1) IL244856A (es)
JO (1) JO3302B1 (es)
LT (1) LT3068775T (es)
MA (1) MA39025B1 (es)
ME (1) ME02841B (es)
MX (1) MX2016006223A (es)
NO (1) NO3068775T3 (es)
NZ (1) NZ718373A (es)
PE (1) PE20160609A1 (es)
PH (1) PH12016500895A1 (es)
PL (1) PL3068775T3 (es)
PT (1) PT3068775T (es)
RS (1) RS56533B1 (es)
SG (1) SG11201602953YA (es)
SI (1) SI3068775T1 (es)
TN (1) TN2016000145A1 (es)
TW (1) TWI538677B (es)
UA (1) UA118034C2 (es)
WO (1) WO2015073281A1 (es)
ZA (1) ZA201602202B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR104672A1 (es) * 2015-04-15 2017-08-09 Lilly Co Eli Inhibidores de grelina o-aciltransferasa
AR104673A1 (es) * 2015-04-15 2017-08-09 Lilly Co Eli Inhibidores de grelina o-aciltransferasa
DK3494120T3 (da) 2016-08-05 2021-05-31 Boehringer Ingelheim Int Oxadiazolopyridinderivater til anvendelse som ghrelin-o-acyl-transferase-(goat)-inhibitorer
CN106478519B (zh) * 2016-10-10 2018-12-11 上海再启生物技术有限公司 一种2-甲基-4-氨基-6-氯嘧啶的制备方法
MA51774A (fr) * 2018-02-02 2021-05-12 Boehringer Ingelheim Int Dérivés de triazolopyrimidine destinés à être utilisés en tant qu'inhibiteurs de la ghréline o-acyltransférase (goat)
EP3746449B1 (en) 2018-02-02 2022-03-30 Boehringer Ingelheim International GmbH Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors
JP7015396B2 (ja) * 2018-02-02 2022-02-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング グレリンｏ－アシルトランスフェラーゼ（ｇｏａｔ）阻害剤としての、ベンジル－、（ピリジン－３－イル）メチル－または（ピリジン－４－イル）メチル置換オキサジアゾロピリジン誘導体
EA202091804A1 (ru) 2018-02-02 2020-12-24 Бёрингер Ингельхайм Интернациональ Гмбх Гетероциклил-замещенные оксадиазолопиридиновые производные для применения в качестве ингибиторов грелин-о-ацилтрансферазы (goat)
CN108774221A (zh) * 2018-05-30 2018-11-09 王丽萍 一种goat抑制剂及其在肥胖和糖尿病中的应用
CN108516971A (zh) * 2018-05-30 2018-09-11 王丽萍 一种苯并[b]噻吩类化合物及其在肥胖和糖尿病中的应用
CN108558849A (zh) * 2018-05-30 2018-09-21 王丽萍 一种苯并[b]噻吩类化合物及其在肥胖和糖尿病中的应用
CN108610337A (zh) * 2018-05-30 2018-10-02 王丽萍 一种苯并[b]噻吩类化合物及其在肥胖和糖尿病中的应用
CN108558852A (zh) * 2018-05-30 2018-09-21 王丽萍 一种goat抑制剂及其在肥胖和糖尿病中的应用
CN115884974B (zh) 2020-05-22 2024-09-17 勃林格殷格翰国际有限公司 制备烷基7-氨基-5-甲基-[1,2,5]噁二唑并[3,4-b]吡啶羧酸酯的方法
JP2023526353A (ja) 2020-05-22 2023-06-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング アルキル７－アミノ－５－メチル－［１，２，５］オキサジアゾロ［３，４－ｂ］ピリジンカルボキシレートの連続製造方法

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CA2403686C (en) * 2000-03-23 2010-01-26 Merck & Co., Inc. Substituted piperidines as melanocortin receptor agonists
US20060233788A1 (en) 2003-09-05 2006-10-19 Heiman Mark L Anti-ghrelin antibodies
WO2006019577A1 (en) 2004-07-14 2006-02-23 Eli Lilly And Company Anti-ghrelin antibodies
JP2008520204A (ja) 2004-11-15 2008-06-19 イーライ リリー アンド カンパニー 非アシル化グレリン抗体及びその治療への使用
US7525238B2 (en) 2005-01-26 2009-04-28 Kistler Holding Ag Ground insulated piezoelectric sensor for the measurement of acceleration or pressure
EP1856154A1 (en) 2005-02-23 2007-11-21 Eli Lilly And Company Humanized anti-ghrelin antibodies
WO2006124490A2 (en) * 2005-05-17 2006-11-23 Schering Corporation Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia
CN101175759A (zh) * 2005-05-17 2008-05-07 先灵公司 作为治疗血脂异常的烟酸受体激动剂的杂环化合物
US20070213359A1 (en) * 2005-12-30 2007-09-13 Acadia Pharmaceuticals Inc. Bicyclic-nitrogen compounds as modulators of ghrelin receptor and uses thereof
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AR091516A1 (es) * 2012-06-22 2015-02-11 Actelion Pharmaceuticals Ltd Derivados de 1-[m-carboxamido(hetero)aril-metil]-heterociclil-carboxamida

Also Published As

Publication number Publication date
EP3068775A1 (en) 2016-09-21
SI3068775T1 (sl) 2017-10-30
KR20160068926A (ko) 2016-06-15
WO2015073281A1 (en) 2015-05-21
IL244856A0 (en) 2016-05-31
PH12016500895B1 (en) 2016-06-20
CN105636948B (zh) 2017-10-24
EP3068775B1 (en) 2017-09-06
PH12016500895A1 (en) 2016-06-20
DOP2016000070A (es) 2016-05-30
ES2647790T3 (es) 2017-12-26
SG11201602953YA (en) 2016-05-30
BR112016009488B1 (pt) 2021-01-19
TWI538677B (zh) 2016-06-21
NZ718373A (en) 2017-12-22
KR101739243B1 (ko) 2017-05-23
RS56533B1 (sr) 2018-02-28
HK1222860A1 (zh) 2017-07-14
MX2016006223A (es) 2016-08-08
PE20160609A1 (es) 2016-07-03
AU2014348967A1 (en) 2016-04-28
JP2016537371A (ja) 2016-12-01
EA028550B1 (ru) 2017-11-30
CA2926224A1 (en) 2015-05-21
US9035051B1 (en) 2015-05-19
MA39025B1 (fr) 2018-05-31
ME02841B (me) 2018-01-20
EA201690764A1 (ru) 2016-07-29
CR20160184A (es) 2016-06-17
TW201529073A (zh) 2015-08-01
HUE035590T2 (en) 2018-05-28
CY1119489T1 (el) 2018-03-07
DK3068775T3 (en) 2017-10-23
AP2016009189A0 (en) 2016-05-31
JO3302B1 (ar) 2018-09-16
US20150133474A1 (en) 2015-05-14
LT3068775T (lt) 2017-11-27
PT3068775T (pt) 2017-11-20
UA118034C2 (uk) 2018-11-12
TN2016000145A1 (en) 2017-10-06
AU2014348967B2 (en) 2017-05-04
NO3068775T3 (es) 2018-02-03
HRP20171648T1 (hr) 2017-12-15
IL244856A (en) 2017-07-31
PL3068775T3 (pl) 2018-01-31
MA39025A1 (fr) 2017-05-31
ZA201602202B (en) 2019-10-30
AR098274A1 (es) 2016-05-18
CA2926224C (en) 2017-05-02
JP6159484B2 (ja) 2017-07-05
BR112016009488A8 (pt) 2018-01-30
CN105636948A (zh) 2016-06-01

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