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CL2016000597A1 - Derivados de desoxino jirimicina y sus métodos de uso. - Google Patents

Derivados de desoxino jirimicina y sus métodos de uso.

Info

Publication number
CL2016000597A1
CL2016000597A1 CL2016000597A CL2016000597A CL2016000597A1 CL 2016000597 A1 CL2016000597 A1 CL 2016000597A1 CL 2016000597 A CL2016000597 A CL 2016000597A CL 2016000597 A CL2016000597 A CL 2016000597A CL 2016000597 A1 CL2016000597 A1 CL 2016000597A1
Authority
CL
Chile
Prior art keywords
jirimicina
deoxino
derivatives
methods
deoxinojirimicine
Prior art date
Application number
CL2016000597A
Other languages
English (en)
Inventor
Urban Ramstedt
Raju Penmasta
Hitesh Batra
Tam Nguyen
Original Assignee
Emergent Virology Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emergent Virology Llc filed Critical Emergent Virology Llc
Publication of CL2016000597A1 publication Critical patent/CL2016000597A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

<p>COMPUESTOS DERIVADOS DE DESOXINOJIRIMICINA N-SUSTITUIDA; COMPOSIICION FARMACEUTICA; Y SU USO PARA EL TRATAMIENTO DEL DENGUE Y LA INFLUENZA TIPO A</p>
CL2016000597A 2013-09-16 2016-03-14 Derivados de desoxino jirimicina y sus métodos de uso. CL2016000597A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361878286P 2013-09-16 2013-09-16

Publications (1)

Publication Number Publication Date
CL2016000597A1 true CL2016000597A1 (es) 2017-02-24

Family

ID=52666528

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016000597A CL2016000597A1 (es) 2013-09-16 2016-03-14 Derivados de desoxino jirimicina y sus métodos de uso.

Country Status (18)

Country Link
US (1) US10144727B2 (es)
EP (1) EP3046558B1 (es)
JP (1) JP6456393B2 (es)
KR (1) KR20160055916A (es)
CN (1) CN105636589B (es)
AP (1) AP2016009125A0 (es)
AU (1) AU2014318488B2 (es)
BR (1) BR112016005417A8 (es)
CA (1) CA2924026C (es)
CL (1) CL2016000597A1 (es)
CR (1) CR20160178A (es)
HK (1) HK1222129A1 (es)
IL (1) IL244446A0 (es)
MX (1) MX2016003323A (es)
PH (1) PH12016500465A1 (es)
RU (1) RU2702133C2 (es)
SG (1) SG11201601646YA (es)
WO (1) WO2015039010A2 (es)

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* Cited by examiner, † Cited by third party
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EP3094615A4 (en) 2014-01-13 2017-11-08 P2 Science, Inc. Terpene-derived acids and esters and methods for preparing and using same
WO2015196019A1 (en) 2014-06-20 2015-12-23 P2 Science, Inc. Film ozonolysis in a tubular or multitubular reactor
WO2016022803A2 (en) * 2014-08-06 2016-02-11 P2 Science, Inc. Fragrances from the esters of fatty acids
BR112017008898B1 (pt) 2014-11-05 2022-11-29 Emergent Virology Llc Compostos de iminoaçúcares, suas composições farmacêuticas e usos dos mesmos para tratar doenças virais
WO2017201030A1 (en) * 2016-05-16 2017-11-23 Emergent Virology Llc Methods of treating viral infection
WO2017201052A1 (en) * 2016-05-16 2017-11-23 Emergent Virology Llc Methods of treating zika virus infection
CA3026192A1 (en) 2016-06-21 2017-12-28 P2 Science, Inc. Flow-through reactors for the continuous quenching of peroxide mixtures and methods comprising the same
WO2018053289A1 (en) 2016-09-16 2018-03-22 P2 Science, Inc. Uses of vanadium to oxidize aldehydes and ozonides
CN111904959A (zh) * 2020-08-21 2020-11-10 牡丹江医学院 α-L-岩藻糖苷酶抑制剂在制备治疗小儿肺炎的药物中的用途

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DE2834122A1 (de) 1978-08-03 1980-02-14 Bayer Ag Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose
DE2853573A1 (de) 1978-12-12 1980-07-03 Bayer Ag Herstellung von n-substituierten derivaten des l-desoxynojirimycins
DE3007078A1 (de) * 1980-02-26 1981-09-10 Bayer Ag, 5090 Leverkusen Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung
DE3038901A1 (de) 1980-10-15 1982-05-06 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins
DE3611841A1 (de) 1986-04-09 1987-10-15 Bayer Ag Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten
US5043273A (en) 1989-08-17 1991-08-27 Monsanto Company Phosphorylated glycosidase inhibitor prodrugs
US5103008A (en) 1989-08-17 1992-04-07 Monsanto Company Compound, N-butyl-deoxynojirimycin-6-phosphate
US4994572A (en) 1989-10-12 1991-02-19 Monsanto Company Synthesis of nojirimycin derivatives
US5200523A (en) 1990-10-10 1993-04-06 Monsanto Company Synthesis of nojirimycin derivatives
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US20030100532A1 (en) 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
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JP5575246B2 (ja) 2009-09-04 2014-08-20 ユナイテッド セラピューティクス コーポレイション ポックスウイルス感染の治療方法
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Also Published As

Publication number Publication date
PH12016500465B1 (en) 2016-05-16
BR112016005417A8 (pt) 2020-02-18
RU2016111704A3 (es) 2018-06-09
EP3046558A4 (en) 2017-06-07
AP2016009125A0 (en) 2016-04-30
US20160221993A1 (en) 2016-08-04
WO2015039010A2 (en) 2015-03-19
CN105636589A (zh) 2016-06-01
KR20160055916A (ko) 2016-05-18
AU2014318488A1 (en) 2016-04-21
PH12016500465A1 (en) 2016-05-16
CA2924026A1 (en) 2015-03-19
IL244446A0 (en) 2016-04-21
US10144727B2 (en) 2018-12-04
EP3046558A2 (en) 2016-07-27
WO2015039010A3 (en) 2015-05-07
MX2016003323A (es) 2016-08-12
AU2014318488A2 (en) 2016-04-28
SG11201601646YA (en) 2016-04-28
RU2016111704A (ru) 2017-10-23
JP2016530332A (ja) 2016-09-29
CR20160178A (es) 2016-08-08
JP6456393B2 (ja) 2019-01-23
CA2924026C (en) 2021-12-28
HK1222129A1 (zh) 2017-06-23
RU2702133C2 (ru) 2019-10-04
EP3046558B1 (en) 2019-08-14
AU2014318488B2 (en) 2019-03-07
CN105636589B (zh) 2019-07-23

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