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CL2015001916A1 - Derivados de pirimidona y su uso en el tratamiento, mejora o prevención de una enfermedad viral. - Google Patents

Derivados de pirimidona y su uso en el tratamiento, mejora o prevención de una enfermedad viral.

Info

Publication number
CL2015001916A1
CL2015001916A1 CL2015001916A CL2015001916A CL2015001916A1 CL 2015001916 A1 CL2015001916 A1 CL 2015001916A1 CL 2015001916 A CL2015001916 A CL 2015001916A CL 2015001916 A CL2015001916 A CL 2015001916A CL 2015001916 A1 CL2015001916 A1 CL 2015001916A1
Authority
CL
Chile
Prior art keywords
prevention
improvement
treatment
viral disease
pyrimidone derivatives
Prior art date
Application number
CL2015001916A
Other languages
English (en)
Inventor
Zhuming Zhang
Achyutharao Sidduri
Andrea Wolkerstorfer
Oliver Szolar
Norbert Handler
Helmut Buschmann
Stephen Cusack
Mark Smith
Sung-Sau So
Ronald Charles Hawley
Original Assignee
Hoffmann La Roche
Savira Pharmaceuticals Gmbh
European Molecular Biology Lab Embl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50070507&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2015001916(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche, Savira Pharmaceuticals Gmbh, European Molecular Biology Lab Embl filed Critical Hoffmann La Roche
Publication of CL2015001916A1 publication Critical patent/CL2015001916A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPUESTOS DERIVADOS DE PIRAZINOPIRIMIDONA; COMPOSICION FARMACEUTICA QUE LOS COMPRENDE; Y SU USO PARA EL TRATAMIENTO, MEJORA O PREVENCION DE UNA ENFERMEDAD VIRAL CAUSADA POR HERPESVIRIDAE, FILOVIRIDAE, PARAMYXOVIRIDAE, ORTHOMYXOVIRIDAE, ENTRE OTROS.
CL2015001916A 2013-01-08 2015-07-06 Derivados de pirimidona y su uso en el tratamiento, mejora o prevención de una enfermedad viral. CL2015001916A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361750017P 2013-01-08 2013-01-08

Publications (1)

Publication Number Publication Date
CL2015001916A1 true CL2015001916A1 (es) 2016-01-22

Family

ID=50070507

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015001916A CL2015001916A1 (es) 2013-01-08 2015-07-06 Derivados de pirimidona y su uso en el tratamiento, mejora o prevención de una enfermedad viral.

Country Status (21)

Country Link
US (1) US9045486B2 (es)
EP (1) EP2943495B1 (es)
JP (1) JP2016518305A (es)
KR (1) KR20150103285A (es)
CN (1) CN104918942A (es)
AR (1) AR094378A1 (es)
AU (1) AU2014204889A1 (es)
BR (1) BR112015012693A2 (es)
CA (1) CA2894642A1 (es)
CL (1) CL2015001916A1 (es)
CR (1) CR20150337A (es)
EA (1) EA201591291A1 (es)
HK (2) HK1211286A1 (es)
IL (1) IL239656A0 (es)
MA (1) MA38323B1 (es)
MX (1) MX2015008293A (es)
PE (1) PE20151722A1 (es)
PH (1) PH12015501517A1 (es)
SG (1) SG11201503946UA (es)
TW (1) TW201443053A (es)
WO (1) WO2014108406A1 (es)

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GB201300304D0 (en) 2013-01-08 2013-02-20 Kalvista Pharmaceuticals Ltd Benzylamine derivatives
TWI636047B (zh) 2013-08-14 2018-09-21 英商卡爾維斯塔製藥有限公司 雜環衍生物
KR102468319B1 (ko) 2013-09-12 2022-11-16 얀센 바이오파마, 인코퍼레이트. 아자-피리돈 화합물 및 이의 용도
GB201421085D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd New enzyme inhibitors
GB201421083D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd Enzyme inhibitors
MX2017011655A (es) 2015-03-11 2018-04-30 Alios Biopharma Inc Compuestos de aza-piridona y usos de estos.
HRP20230215T1 (hr) 2015-04-28 2023-04-14 Shionogi & Co., Ltd. Supstituirani policiklički derivati piridona i njihov predlijek
DK3428170T3 (da) 2015-04-28 2021-03-01 Shionogi & Co Anti-influenza polycyklisk pyridonderivat og prodrug deraf
US9988390B2 (en) 2015-10-30 2018-06-05 F. Hoffmann-La Roche Ag Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
PE20181516A1 (es) 2015-12-15 2018-09-21 Shionogi & Co Medicamento para tratar la gripe caracterizado por combinar un inhibidor de endonucleasa dependiente de cap y un farmaco antigripal
WO2017109088A1 (en) 2015-12-23 2017-06-29 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
JP6918819B2 (ja) * 2016-03-08 2021-08-11 ノバルティス アーゲー オルトミクソウイルス感染の処置に有用な三環式化合物
WO2017158147A1 (en) 2016-03-18 2017-09-21 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
WO2017158151A1 (en) 2016-03-18 2017-09-21 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
JP6961963B2 (ja) * 2016-04-01 2021-11-05 三菱ケミカル株式会社 フルフラールの製造方法
JP6957518B2 (ja) * 2016-05-20 2021-11-02 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 感染症の治療のための酸素、硫黄および窒素リンカーを有する新規ピラジン化合物
SG10201913616UA (en) 2016-05-31 2020-03-30 Kalvista Pharmaceuticals Ltd Pyrazole derivatives as plasma kallikrein inhibitors
GB201609603D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
GB201609607D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
EP4458348A2 (en) 2016-08-10 2024-11-06 Shionogi & Co., Ltd Pharmaceutical compositions containing substituted polycyclic pyridone derivatives and prodrug thereof
JOP20170169A1 (ar) 2016-08-29 2019-01-30 Novartis Ag مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو
MX2020005168A (es) 2017-11-29 2020-08-20 Kalvista Pharmaceuticals Ltd Formas de dosificacion que contienen un inhibidor calicreina de plasma.
GB201719881D0 (en) 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of plasma kallikrein inhibitor and salts thereof
US11629149B2 (en) 2018-02-28 2023-04-18 Novartis Ag 10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1′,2′:4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza
EP4010333A1 (en) 2019-08-09 2022-06-15 Kalvista Pharmaceuticals Limited Plasma kallikrein inhibitors
US20240228495A1 (en) * 2020-03-25 2024-07-11 Sri International Tricyclic Inhibitors of Influenza Virus Endonuclease
EP4074317A1 (en) 2021-04-14 2022-10-19 Bayer AG Phosphorus derivatives as novel sos1 inhibitors
WO2024061300A1 (en) * 2022-09-22 2024-03-28 Insilico Medicine Ip Limited Inhibitors of trex1 and uses thereof
US20240199558A1 (en) 2022-10-19 2024-06-20 Astrazeneca Ab 2,4,6-trisubstituted 1,3,5-triazines as modulators of cx3cr1

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US5475109A (en) 1994-10-17 1995-12-12 Merck & Co., Inc. Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease
JP2007528379A (ja) * 2004-03-09 2007-10-11 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー Ｈｉｖインテグラーゼ阻害薬
US7550463B2 (en) 2004-09-15 2009-06-23 Shionogi & Co., Ltd. Carbamoylpyridone derivatives having inhibitory activity against HIV integrase
WO2006125048A2 (en) 2005-05-16 2006-11-23 Gilead Sciences, Inc. Hiv-integrase inhibitor compounds
US20080076740A1 (en) 2005-07-27 2008-03-27 Gilead Sciences, Inc. Antiviral compounds
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TWI518084B (zh) 2009-03-26 2016-01-21 鹽野義製藥股份有限公司 哌喃酮與吡啶酮衍生物之製造方法
WO2010147068A1 (ja) 2009-06-15 2010-12-23 塩野義製薬株式会社 置換された多環性カルバモイルピリドン誘導体
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Also Published As

Publication number Publication date
BR112015012693A2 (pt) 2017-07-11
WO2014108406A1 (en) 2014-07-17
HK1211286A1 (en) 2016-05-20
CR20150337A (es) 2015-11-02
MX2015008293A (es) 2016-06-02
CA2894642A1 (en) 2014-07-17
HK1212686A1 (zh) 2016-06-17
MA38323A1 (fr) 2017-02-28
TW201443053A (zh) 2014-11-16
KR20150103285A (ko) 2015-09-09
US20140194431A1 (en) 2014-07-10
SG11201503946UA (en) 2015-09-29
CN104918942A (zh) 2015-09-16
MA38323B1 (fr) 2018-05-31
PE20151722A1 (es) 2015-11-19
EA201591291A1 (ru) 2015-12-30
PH12015501517A1 (en) 2015-11-09
EP2943495B1 (en) 2016-12-28
US9045486B2 (en) 2015-06-02
EP2943495A1 (en) 2015-11-18
AR094378A1 (es) 2015-07-29
AU2014204889A1 (en) 2015-06-11
JP2016518305A (ja) 2016-06-23
IL239656A0 (en) 2015-08-31

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