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CL2015000544A1 - Una composicion farmaceutica que comprende regorafenib y al menos un excipiente farmaceuticamente aceptable, en el que la composicion esta recubierta por un recubrimiento que comprende un polimero basado en alcohol polivinilico; y su procedimiento de preparacion. - Google Patents

Una composicion farmaceutica que comprende regorafenib y al menos un excipiente farmaceuticamente aceptable, en el que la composicion esta recubierta por un recubrimiento que comprende un polimero basado en alcohol polivinilico; y su procedimiento de preparacion.

Info

Publication number
CL2015000544A1
CL2015000544A1 CL2015000544A CL2015000544A CL2015000544A1 CL 2015000544 A1 CL2015000544 A1 CL 2015000544A1 CL 2015000544 A CL2015000544 A CL 2015000544A CL 2015000544 A CL2015000544 A CL 2015000544A CL 2015000544 A1 CL2015000544 A1 CL 2015000544A1
Authority
CL
Chile
Prior art keywords
composition
regorafenib
coated
coating
pharmaceutically acceptable
Prior art date
Application number
CL2015000544A
Other languages
English (en)
Inventor
Dr Susanne Skrabs
Dr Adrian Funke
Dr Mayk Kresse
Dr Ulrich Oberdieck
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46963450&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2015000544(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of CL2015000544A1 publication Critical patent/CL2015000544A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CL2015000544A 2012-09-06 2015-03-05 Una composicion farmaceutica que comprende regorafenib y al menos un excipiente farmaceuticamente aceptable, en el que la composicion esta recubierta por un recubrimiento que comprende un polimero basado en alcohol polivinilico; y su procedimiento de preparacion. CL2015000544A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12183331 2012-09-06

Publications (1)

Publication Number Publication Date
CL2015000544A1 true CL2015000544A1 (es) 2015-08-21

Family

ID=46963450

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015000544A CL2015000544A1 (es) 2012-09-06 2015-03-05 Una composicion farmaceutica que comprende regorafenib y al menos un excipiente farmaceuticamente aceptable, en el que la composicion esta recubierta por un recubrimiento que comprende un polimero basado en alcohol polivinilico; y su procedimiento de preparacion.

Country Status (43)

Country Link
US (1) US20140065212A1 (es)
EP (2) EP3243508A1 (es)
JP (1) JP6445436B2 (es)
KR (1) KR102162036B1 (es)
CN (5) CN104902878A (es)
AP (1) AP2015008292A0 (es)
AR (1) AR092439A1 (es)
AU (1) AU2013312531B2 (es)
BR (1) BR112015004936B1 (es)
CA (1) CA2883767C (es)
CL (1) CL2015000544A1 (es)
CO (1) CO7310528A2 (es)
CR (1) CR20150114A (es)
CU (1) CU24244B1 (es)
CY (1) CY1118839T1 (es)
DK (1) DK2892507T3 (es)
EA (1) EA027685B1 (es)
ES (1) ES2623205T3 (es)
GT (1) GT201500053A (es)
HK (1) HK1214170A1 (es)
HR (1) HRP20170620T1 (es)
HU (1) HUE032758T2 (es)
IL (1) IL237350B (es)
IN (1) IN2015DN01673A (es)
JO (1) JO3479B1 (es)
LT (1) LT2892507T (es)
MA (1) MA37888B1 (es)
MX (1) MX359922B (es)
MY (1) MY176135A (es)
NZ (1) NZ705578A (es)
PE (1) PE20151005A1 (es)
PH (1) PH12015500460B1 (es)
PL (1) PL2892507T3 (es)
PT (1) PT2892507T (es)
RS (1) RS56019B1 (es)
SA (1) SA515360113B1 (es)
SG (1) SG11201501683WA (es)
SI (1) SI2892507T1 (es)
TW (1) TWI640329B (es)
UA (1) UA115994C2 (es)
UY (1) UY35006A (es)
WO (1) WO2014039677A1 (es)
ZA (1) ZA201501394B (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR081060A1 (es) 2010-04-15 2012-06-06 Bayer Schering Pharma Ag Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida
DK3043778T3 (da) * 2013-09-13 2017-11-27 Bayer Pharma AG Farmaceutiske sammensætninger, der indeholder refametinib
CN104586808B (zh) * 2014-12-27 2017-08-18 北京元延医药科技股份有限公司 抗肿瘤药物组合物
CN105136956A (zh) * 2015-09-11 2015-12-09 江苏嘉逸医药有限公司 一种快速测定瑞戈非尼含量的方法
CN105267167A (zh) * 2015-09-11 2016-01-27 江苏嘉逸医药有限公司 一种瑞戈非尼口服固体药物组合物的制备方法
CN106880607A (zh) * 2015-12-15 2017-06-23 北大方正集团有限公司 一种含有瑞戈非尼的口腔崩解片及其制备方法
CN106880615A (zh) * 2015-12-15 2017-06-23 北大方正集团有限公司 一种瑞戈非尼的口服固体制剂及其制备方法
CN105496975B (zh) * 2015-12-17 2019-01-04 河南润弘制药股份有限公司 一种瑞戈非尼片剂及其制备方法
CN106913527A (zh) * 2015-12-28 2017-07-04 江苏先声药业有限公司 一种瑞戈非尼速释微丸及其制备方法
CN105879049B (zh) * 2016-05-13 2019-03-26 浙江大学 一种瑞戈非尼与β-环糊精的包合物及其制备方法
CN107661296A (zh) * 2016-07-27 2018-02-06 江苏先声药业有限公司 一种瑞戈非尼固体分散体及其制备方法
FI3630112T3 (fi) 2017-06-02 2024-05-02 Bayer Healthcare Llc Regorafenibin ja nivolumabin yhdistelmä syövän hoidossa
WO2020010058A1 (en) * 2018-07-06 2020-01-09 Agios Pharmaceuticals, Inc. Ivosidenib forms and pharmaceutical compositions
CN111053751A (zh) * 2018-10-16 2020-04-24 正大天晴药业集团股份有限公司 瑞戈非尼的缓释片剂及其制备方法
TWI799599B (zh) * 2019-06-06 2023-04-21 華納國際生物科技股份有限公司 醫藥或保健品自乳化固體分散組成物
EP3861989A1 (en) 2020-02-07 2021-08-11 Bayer Aktiengesellschaft Pharmaceutical composition containing regorafenib and a stabilizing agent
CN112587485A (zh) * 2021-01-08 2021-04-02 湖南南新制药股份有限公司 一种药物固体分散体及其制备方法
CN113018274A (zh) * 2021-03-10 2021-06-25 药源生物科技（启东）有限公司 一种含羟丙甲纤维素的药物组合物及其制备方法
WO2024191389A1 (en) * 2023-03-10 2024-09-19 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi A pharmaceutical composition of regorafenib

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100544717C (zh) * 2002-09-20 2009-09-30 华生制药公司 含有双胍和噻唑烷二酮衍生物的药物剂型
CN1265793C (zh) * 2002-11-18 2006-07-26 杭州容立医药科技有限公司 左西替利嗪伪麻黄碱复方口服制剂及制备方法
AU2004259760B9 (en) * 2003-07-23 2011-02-03 Bayer Healthcare Llc Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
MY191349A (en) * 2004-08-27 2022-06-17 Bayer Pharmaceuticals Corp New pharmaceutical compositions for the treatment of hyper-proliferative disorders
WO2007068381A1 (en) * 2005-12-15 2007-06-21 Bayer Healthcare Ag Diaryl ureas for treating inflammatory skin, eye and/or ear diseases
AR062927A1 (es) * 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
WO2008044111A1 (en) * 2006-10-13 2008-04-17 Pfizer Products Inc. Pharmaceutical formulation tablet
EA200970552A1 (ru) * 2006-12-07 2009-10-30 Эли Лилли Энд Компани Изделие с празугрелом
WO2009054550A1 (en) * 2007-10-25 2009-04-30 Bayer Yakuhin, Ltd. Nifedipine-containing press coated tablet and method of preparing the same
AR081060A1 (es) 2010-04-15 2012-06-06 Bayer Schering Pharma Ag Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida
RU2602911C2 (ru) * 2011-05-20 2016-11-20 Астразенека Юкей Лимитед Фармацевтическая композиция, содержащая кальциевую соль розувастатина

Also Published As

Publication number Publication date
WO2014039677A1 (en) 2014-03-13
EP2892507B1 (en) 2017-02-01
PL2892507T3 (pl) 2017-09-29
AU2013312531A1 (en) 2015-03-12
CO7310528A2 (es) 2015-06-30
US20140065212A1 (en) 2014-03-06
UA115994C2 (uk) 2018-01-25
AU2013312531B2 (en) 2017-10-19
CY1118839T1 (el) 2018-01-10
SG11201501683WA (en) 2015-04-29
HRP20170620T1 (hr) 2017-06-30
BR112015004936A2 (pt) 2017-07-04
HK1214170A1 (zh) 2016-07-22
MY176135A (en) 2020-07-24
CA2883767C (en) 2018-11-13
EA201590520A1 (ru) 2015-10-30
IL237350B (en) 2020-11-30
UY35006A (es) 2014-03-31
BR112015004936B1 (pt) 2022-12-06
LT2892507T (lt) 2017-06-12
PT2892507T (pt) 2017-05-02
TW201414510A (zh) 2014-04-16
MX359922B (es) 2018-10-16
KR20150048872A (ko) 2015-05-07
JP6445436B2 (ja) 2018-12-26
MA37888B1 (fr) 2019-08-30
AR092439A1 (es) 2015-04-22
JO3479B1 (ar) 2020-07-05
IL237350A0 (en) 2015-04-30
CR20150114A (es) 2015-05-11
CU24244B1 (es) 2017-02-02
NZ705578A (en) 2017-10-27
JP2015527395A (ja) 2015-09-17
AP2015008292A0 (en) 2015-02-28
ZA201501394B (en) 2016-07-27
DK2892507T3 (en) 2017-05-01
CN111249247A (zh) 2020-06-09
RS56019B1 (sr) 2017-09-29
KR102162036B1 (ko) 2020-10-07
CA2883767A1 (en) 2014-03-13
TWI640329B (zh) 2018-11-11
ES2623205T3 (es) 2017-07-10
CU20150020A7 (es) 2015-05-28
MX2015002815A (es) 2015-05-15
PH12015500460A1 (en) 2015-04-20
MA37888A1 (fr) 2018-07-31
IN2015DN01673A (es) 2015-07-03
PH12015500460B1 (en) 2015-04-20
SI2892507T1 (sl) 2017-08-31
PE20151005A1 (es) 2015-06-27
CN116392485A (zh) 2023-07-07
CN104902878A (zh) 2015-09-09
EA027685B1 (ru) 2017-08-31
CN116392484A (zh) 2023-07-07
CN116392598A (zh) 2023-07-07
GT201500053A (es) 2015-10-12
SA515360113B1 (ar) 2016-08-10
HUE032758T2 (en) 2017-10-30
EP2892507A1 (en) 2015-07-15
EP3243508A1 (en) 2017-11-15

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