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CL2014003242A1 - Compuestos de pirazol sustituidos como antagonistas del receptor del acido lisofosfatidico (lpar); usos contra la fibrosis pulmonar. - Google Patents

Compuestos de pirazol sustituidos como antagonistas del receptor del acido lisofosfatidico (lpar); usos contra la fibrosis pulmonar.

Info

Publication number
CL2014003242A1
CL2014003242A1 CL2014003242A CL2014003242A CL2014003242A1 CL 2014003242 A1 CL2014003242 A1 CL 2014003242A1 CL 2014003242 A CL2014003242 A CL 2014003242A CL 2014003242 A CL2014003242 A CL 2014003242A CL 2014003242 A1 CL2014003242 A1 CL 2014003242A1
Authority
CL
Chile
Prior art keywords
lpar
receptor antagonists
pulmonary fibrosis
acid receptor
lysophosphatidic acid
Prior art date
Application number
CL2014003242A
Other languages
English (en)
Inventor
Stephen Deems Gabriel
Yimin Qian
Matthew Michael Hamilton
Achyutharao Sidduri
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48656033&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2014003242(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2014003242A1 publication Critical patent/CL2014003242A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38Nitrogen atoms
    • C07D231/40Acylated on said nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00Drug, bio-affecting and body treating compositions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CL2014003242A 2012-06-20 2014-11-28 Compuestos de pirazol sustituidos como antagonistas del receptor del acido lisofosfatidico (lpar); usos contra la fibrosis pulmonar. CL2014003242A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261661958P 2012-06-20 2012-06-20

Publications (1)

Publication Number Publication Date
CL2014003242A1 true CL2014003242A1 (es) 2015-03-20

Family

ID=48656033

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014003242A CL2014003242A1 (es) 2012-06-20 2014-11-28 Compuestos de pirazol sustituidos como antagonistas del receptor del acido lisofosfatidico (lpar); usos contra la fibrosis pulmonar.

Country Status (22)

Country Link
US (1) US20150259295A1 (es)
EP (1) EP2864294A1 (es)
JP (1) JP2015520201A (es)
KR (1) KR20150011003A (es)
CN (1) CN104411690A (es)
AU (1) AU2013279510A1 (es)
BR (1) BR112014031108A2 (es)
CA (1) CA2869602A1 (es)
CL (1) CL2014003242A1 (es)
CO (1) CO7160077A2 (es)
CR (1) CR20140516A (es)
EA (1) EA201492283A1 (es)
HK (1) HK1206341A1 (es)
IL (1) IL236091A0 (es)
IN (1) IN2014DN09347A (es)
MA (1) MA37765A1 (es)
MX (1) MX2014014105A (es)
PE (1) PE20142445A1 (es)
PH (1) PH12014502364A1 (es)
SG (1) SG11201407229UA (es)
UA (1) UA109867C2 (es)
WO (1) WO2013189862A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104066729A (zh) 2011-08-15 2014-09-24 英特穆恩公司 溶血磷脂酸受体拮抗剂
ES2855173T3 (es) 2013-03-15 2021-09-23 Epigen Biosciences Inc Compuestos heterocíclicos útiles para el tratamiento de una enfermedad
EP3162801B1 (en) 2014-06-27 2020-07-22 UBE Industries, Ltd. Salt of halogen-substituted heterocyclic compound
MX2020005874A (es) * 2017-12-19 2020-08-13 Bristol Myers Squibb Co Acidos carbamoil ciclohexilicos n-enlazados a pirazol como antagonistas de receptores del acido lisofosfatidico (lpa).
CN111434655A (zh) * 2019-01-15 2020-07-21 武汉朗来科技发展有限公司 溶血磷脂酸受体拮抗剂及其制备方法
JP7431961B2 (ja) 2019-11-15 2024-02-15 ギリアード サイエンシーズ, インコーポレイテッド Lpa受容体アンタゴニストとしてのトリアゾールカルバメートピリジルスルホンアミド及びその使用
TWI843503B (zh) 2020-06-03 2024-05-21 美商基利科學股份有限公司 Lpa受體拮抗劑及其用途
KR20230019880A (ko) 2020-06-03 2023-02-09 길리애드 사이언시즈, 인코포레이티드 Lpa 수용체 길항제 및 이의 용도
AU2022273631A1 (en) 2021-05-11 2023-11-02 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
KR20240115978A (ko) 2021-12-08 2024-07-26 길리애드 사이언시즈, 인코포레이티드 Lpa 수용체 길항제 및 이의 용도

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005063241A1 (ja) * 2003-12-26 2005-07-14 Ono Pharmaceutical Co., Ltd. ミトコンドリアベンゾジアゼピン受容体介在性疾患の予防および/または治療剤
TW200827346A (en) 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
US20090036425A1 (en) 2007-08-02 2009-02-05 Pfizer Inc Substituted bicyclolactam compounds
GB2466121B (en) * 2008-12-15 2010-12-08 Amira Pharmaceuticals Inc Antagonists of lysophosphatidic acid receptors
GB2470833B (en) * 2009-06-03 2011-06-01 Amira Pharmaceuticals Inc Polycyclic antagonists of lysophosphatidic acid receptors
US8592402B2 (en) * 2009-08-04 2013-11-26 Amira Pharmaceuticals, Inc. Compounds as lysophosphatidic acid receptor antagonists
JP2014508111A (ja) * 2010-12-07 2014-04-03 アミラ ファーマシューティカルス,インコーポレーテッド リゾフォスファチジン酸受容体アンタゴニスト、その線維症の治療における使用
WO2012138648A1 (en) * 2011-04-06 2012-10-11 Irm Llc Compositions and methods for modulating lpa receptors
CN104066729A (zh) * 2011-08-15 2014-09-24 英特穆恩公司 溶血磷脂酸受体拮抗剂

Also Published As

Publication number Publication date
EP2864294A1 (en) 2015-04-29
IL236091A0 (en) 2015-02-01
WO2013189862A1 (en) 2013-12-27
MX2014014105A (es) 2015-03-05
US20150259295A1 (en) 2015-09-17
UA109867C2 (ru) 2015-10-12
IN2014DN09347A (es) 2015-07-17
MA37765A1 (fr) 2017-04-28
SG11201407229UA (en) 2014-12-30
JP2015520201A (ja) 2015-07-16
EA201492283A1 (ru) 2015-04-30
PE20142445A1 (es) 2015-01-28
PH12014502364A1 (en) 2015-01-12
AU2013279510A1 (en) 2014-10-16
BR112014031108A2 (pt) 2017-06-27
CR20140516A (es) 2014-12-01
CO7160077A2 (es) 2015-01-15
HK1206341A1 (en) 2016-01-08
KR20150011003A (ko) 2015-01-29
CA2869602A1 (en) 2013-12-27
CN104411690A (zh) 2015-03-11

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