[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

CL2012002095A1 - Biparatopic binding polypeptide comprising a first individual variable domain of immunoglobulin (ig) that specifically binds to a first epitope of the β-amyloid peptide (ßa) and a second variable domain of ig that specifically binds to a second epitope of ßa, where said ßa epitopes are not identical; nucleic acid encoding it; vector; host cell; pharmaceutical composition; Preparation method; and its use in the treatment and / or prevention of ßa deposits - Google Patents

Biparatopic binding polypeptide comprising a first individual variable domain of immunoglobulin (ig) that specifically binds to a first epitope of the β-amyloid peptide (ßa) and a second variable domain of ig that specifically binds to a second epitope of ßa, where said ßa epitopes are not identical; nucleic acid encoding it; vector; host cell; pharmaceutical composition; Preparation method; and its use in the treatment and / or prevention of ßa deposits

Info

Publication number
CL2012002095A1
CL2012002095A1 CL2012002095A CL2012002095A CL2012002095A1 CL 2012002095 A1 CL2012002095 A1 CL 2012002095A1 CL 2012002095 A CL2012002095 A CL 2012002095A CL 2012002095 A CL2012002095 A CL 2012002095A CL 2012002095 A1 CL2012002095 A1 CL 2012002095A1
Authority
CL
Chile
Prior art keywords
epitope
variable domain
specifically binds
epitopes
immunoglobulin
Prior art date
Application number
CL2012002095A
Other languages
Spanish (es)
Inventor
Ciosssek Cornelia Dorner
Stefan Hoerer
Lothar Kussmaul
Martin Lenter
Katharina Zimmermann
Gerald Beste
Toon Laeremans
Pascal Merchiers
Jo Vercammen
John E Park
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2012002095A1 publication Critical patent/CL2012002095A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Polipéptido de unión biparatópico que comprende un primer dominio variable individual de inmunoglobulina (Ig) que se une específicamente a un primer epítopo del péptido ß-amiloide (ßA) y un segundo dominio variable de Ig que se une específicamente a un segundo epítopo del ßA, donde dichos epítopos del ßA no son idénticos; ácido nucleico que lo codifica; vector; célula hospedera; composición farmacéutica; método de preparación; y su uso en el tratamiento y/o prevención de depósitos del ßa.Biparatopic binding polypeptide comprising a first individual variable domain of immunoglobulin (Ig) that specifically binds to a first epitope of the β-amyloid peptide (ßA) and a second variable domain of Ig that specifically binds to a second epitope of ßA, where said ßA epitopes are not identical; nucleic acid encoding it; vector; host cell; pharmaceutical composition; Preparation method; and its use in the treatment and / or prevention of ßa deposits.

CL2012002095A 2010-03-03 2012-07-27 Biparatopic binding polypeptide comprising a first individual variable domain of immunoglobulin (ig) that specifically binds to a first epitope of the β-amyloid peptide (ßa) and a second variable domain of ig that specifically binds to a second epitope of ßa, where said ßa epitopes are not identical; nucleic acid encoding it; vector; host cell; pharmaceutical composition; Preparation method; and its use in the treatment and / or prevention of ßa deposits CL2012002095A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10155339 2010-03-03

Publications (1)

Publication Number Publication Date
CL2012002095A1 true CL2012002095A1 (en) 2012-10-19

Family

ID=42227600

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012002095A CL2012002095A1 (en) 2010-03-03 2012-07-27 Biparatopic binding polypeptide comprising a first individual variable domain of immunoglobulin (ig) that specifically binds to a first epitope of the β-amyloid peptide (ßa) and a second variable domain of ig that specifically binds to a second epitope of ßa, where said ßa epitopes are not identical; nucleic acid encoding it; vector; host cell; pharmaceutical composition; Preparation method; and its use in the treatment and / or prevention of ßa deposits

Country Status (24)

Country Link
US (3) US8337845B2 (en)
EP (1) EP2542579A1 (en)
JP (2) JP5826194B2 (en)
KR (1) KR20130010114A (en)
CN (1) CN102781962B (en)
AP (1) AP2012006359A0 (en)
AR (1) AR080446A1 (en)
AU (1) AU2011222980B2 (en)
BR (1) BR112012022102A2 (en)
CA (1) CA2788275A1 (en)
CL (1) CL2012002095A1 (en)
CO (1) CO6592094A2 (en)
EA (1) EA201201227A1 (en)
EC (1) ECSP12012184A (en)
HK (1) HK1175184A1 (en)
MA (1) MA34025B1 (en)
MX (1) MX2012009460A (en)
NZ (1) NZ601117A (en)
PE (1) PE20130527A1 (en)
SG (1) SG183369A1 (en)
TN (1) TN2012000434A1 (en)
TW (1) TW201144437A (en)
UY (1) UY33253A (en)
WO (1) WO2011107507A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR080446A1 (en) 2010-03-03 2012-04-11 Boehringer Ingelheim Int UNION TO A-BETA POLYPEPTIDES (AMYLOID BETA)
EP2621953B1 (en) 2010-09-30 2017-04-05 Ablynx N.V. Biological materials related to c-met
US11644471B2 (en) * 2010-09-30 2023-05-09 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
PT2723769T (en) 2011-06-23 2017-04-04 Ablynx Nv Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
AU2012271974B2 (en) 2011-06-23 2017-01-12 Ablynx Nv Serum albumin binding proteins
US9346884B2 (en) 2011-09-30 2016-05-24 Ablynx N.V. Biological materials related to c-Met
NZ626620A (en) * 2012-01-10 2016-07-29 Biogen Ma Inc Enhancement of transport of therapeutic molecules across the blood brain barrier
WO2015006337A2 (en) 2013-07-08 2015-01-15 Nanjingjinsirui Science & Technology Biology Corporation Compositions and methods for increasing protein half-life in a serum
WO2015173325A2 (en) 2014-05-16 2015-11-19 Ablynx Nv Improved immunoglobulin variable domains
CA2966397A1 (en) * 2014-11-03 2016-05-12 Merck Patent Gmbh Methods for generating bispecific shark variable antibody domains and use thereof
US20170335324A1 (en) 2014-11-12 2017-11-23 The General Hospital Corporation Methods for treating neurodegenerative diseases
CN104558172A (en) * 2015-01-04 2015-04-29 东南大学 Single-domain heavy-chain nanobody for amyloid-beta and application of single-domain heavy-chain nanobody
US10961299B2 (en) 2015-02-06 2021-03-30 University Of Maryland, Baltimore Tetra-specific, octameric binding agents and antibodies against Clostridium difficile toxin A and toxin B for treatment of C. difficile infection
WO2016172855A1 (en) * 2015-04-28 2016-11-03 深圳翰宇药业股份有限公司 High performance liquid chromatography method for polypeptide mixtures
AR106949A1 (en) 2015-12-04 2018-03-07 Boehringer Ingelheim Int BIPARATOPIC POLIPEPTIDES THAT ANTAGONIZE WNT SIGNALING IN TUMOR CELLS
KR102717656B1 (en) 2017-05-31 2024-10-14 베링거 인겔하임 인터내셔날 게엠베하 Polypeptides that antagonize WNT signaling in tumor cells
CA3070253A1 (en) * 2017-07-19 2019-01-24 Vib Vzw Serum albumin binding agents
JP7266611B2 (en) * 2018-02-26 2023-04-28 アブリンクス・エヌ・フェー Improved nucleotide sequences encoding peptide linkers
EP3836966A4 (en) * 2018-08-17 2022-06-08 Ab Studio Inc. Catabodies and methods of use thereof
JP2022509372A (en) * 2018-10-29 2022-01-20 バイオジェン・エムエイ・インコーポレイテッド Humanized and stabilized FC5 variant for promoting blood-brain barrier transport
CN111334480B (en) * 2020-05-18 2020-09-01 苏州仁端生物医药科技有限公司 Hybridoma cell strain secreting anti-Abeta 1-42 monoclonal antibody and application thereof
US20220049009A1 (en) 2020-07-23 2022-02-17 Othair Prothena Limited Anti-Abeta Antibodies
CN113686235B (en) * 2021-08-16 2022-09-16 中国科学院力学研究所 Method for estimating protein conformation morphology characteristics based on nanopore via hole current
WO2024133935A1 (en) 2022-12-23 2024-06-27 Ablynx Nv Protein-based conjugation carriers
US20240368250A1 (en) 2023-02-17 2024-11-07 Ablynx N.V. Polypeptides binding to the neonatal fc receptor

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1621554E (en) 1992-08-21 2009-07-13 Univ Bruxelles Immunoglobulins devoid of light chains
EP0739981A1 (en) 1995-04-25 1996-10-30 Vrije Universiteit Brussel Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
US6329516B1 (en) 1997-04-28 2001-12-11 Fmc Corporation Lepidopteran GABA-gated chloride channels
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
CA2405550A1 (en) 2000-04-12 2001-10-25 Human Genome Sciences, Inc. Albumin fusion proteins
CA2441903C (en) 2000-05-26 2012-07-31 National Research Council Of Canada Single-domain brain-targeting antibody fragments derived from llama antibodies
PE20020574A1 (en) 2000-12-06 2002-07-02 Wyeth Corp HUMANIZED ANTIBODIES THAT RECOGNIZE THE AMYLOID PEPTIDE BETA
ATE477280T1 (en) 2001-06-28 2010-08-15 Domantis Ltd DOUBLE-SPECIFIC LIGAND AND USE THEREOF
JP4123856B2 (en) 2001-07-31 2008-07-23 日油株式会社 Bio-related substance modifier and method for producing polyoxyalkylene derivative
WO2003059934A2 (en) 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin fusion proteins
AR038568A1 (en) 2002-02-20 2005-01-19 Hoffmann La Roche ANTI-A BETA ANTIBODIES AND ITS USE
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
FR2846667B1 (en) 2002-11-06 2004-12-31 Pasteur Institut VARIABLE FRAGMENTS OF SINGLE-CHAIN CAMELIDE ANTIBODIES DIRECTED AGAINST BETA-AMYLOID PEPTIDE 1-42 AND THEIR APPLICATIONS FOR DIAGNOSIS AND TREATMENT OF NEUROAGREGATIVE DISEASES
AU2003283137B8 (en) 2002-11-08 2010-07-29 Ablynx N.V. Camelidae antibodies against immunoglobulin E and use thereof for the treatment of allergic disorders
WO2004041862A2 (en) 2002-11-08 2004-05-21 Ablynx N.V. Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
US7432330B2 (en) 2002-12-31 2008-10-07 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
EP2390270A1 (en) * 2003-01-10 2011-11-30 Ablynx N.V. Therapeutic polypeptides, homologues thereof, fragments thereof and for use in modulating platelet-mediated aggregation
TWI306458B (en) 2003-05-30 2009-02-21 Elan Pharma Int Ltd Humanized antibodies that recognize beta amyloid peptide
DE602004017726D1 (en) 2003-06-30 2008-12-24 Domantis Ltd Pegylated single-domain antibodies (dAb)
PT1687338E (en) 2003-11-07 2011-01-20 Ablynx Nv Camelidae single domain antibodies vhh directed against epidermal growth factor receptor and uses thereof
DK2336147T3 (en) 2003-12-17 2014-06-10 Wyeth Llc BETA-IMMUNOGEN-PEPTIDE CARRIER CONJUGATES AND PROCEDURES FOR PRODUCING THEREOF
RU2007117752A (en) 2004-10-13 2008-11-20 Аблинкс Н.В. (Be) NANOTELES (NANOBODIES TM) AGAINST BETA-AMYLOID AND POLYPEPTIDES CONTAINING BETA-AMYLOID FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES, SUCH AS AN ALZHEIMER'S DISEASE
CN101076543A (en) * 2004-10-13 2007-11-21 阿布林克斯公司 Single domain camelide anti-amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenerative neural diseases such as alzheimer's disease
WO2006066089A1 (en) 2004-12-15 2006-06-22 Neuralab Limited Humanized amyloid beta antibodies for use in improving cognition
JP2008524247A (en) 2004-12-15 2008-07-10 エラン ファーマ インターナショナル リミテッド Amyloid beta antibody for use in cognitive improvement
TW200636066A (en) 2004-12-15 2006-10-16 Elan Pharm Inc Humanized antibodies that recognize beta amyloid peptide
EP1841455A1 (en) 2005-01-24 2007-10-10 Amgen Inc. Humanized anti-amyloid antibody
GT200600031A (en) 2005-01-28 2006-08-29 ANTI-BETA ANTIBODY FORMULATION
MY148086A (en) 2005-04-29 2013-02-28 Rinat Neuroscience Corp Antibodies directed against amyloid-beta peptide and methods using same
EP2949668B1 (en) 2005-05-18 2019-08-14 Ablynx N.V. Improved nanobodies tm against tumor necrosis factor-alpha
TR201815552T4 (en) * 2005-05-20 2018-11-21 Ablynx Nv Improved nanoantibodies (TM) for the treatment of aggregation-related diseases.
WO2007024715A2 (en) * 2005-08-19 2007-03-01 Abbott Laboratories Dual variable domain immunoglobin and uses thereof
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
US20100323905A1 (en) 2005-09-23 2010-12-23 Academisch Ziekenhuis Leiden Vhh for the Diagnosis, Prevention and Treatment of Diseases Associated with Protein Aggregates
EP1959996A2 (en) 2005-12-12 2008-08-27 AC Immune S.A. Monoclonal antibody
NO346105B1 (en) 2005-12-12 2022-02-21 E Hoffmann La Roche Ag AMYLOID-BETA-4 ANTIBODIES WITH GLYCOSYLATED ASPARAGIN IN THE VARIABLE REGION
KR101263294B1 (en) 2006-03-30 2013-06-04 글락소 그룹 리미티드 Antibodies against amyloid-beta peptide
EP2468770B1 (en) 2006-07-14 2017-12-20 AC Immune S.A. Humanized antibody against amyloid beta.
EP2057191A1 (en) 2006-08-18 2009-05-13 Ablynx N.V. Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling
AU2007328900A1 (en) 2006-12-05 2008-06-12 Ablynx N.V. Peptides capable of binding to serum proteins
JP2010512356A (en) 2006-12-11 2010-04-22 エフ．ホフマン−ラ ロシュ アーゲー Parenteral Abeta antibody preparation
US8907065B2 (en) * 2006-12-15 2014-12-09 Ablynx N.V. Polypeptides that modulate the interaction between cells of the immune system
LT2842967T (en) 2007-01-18 2017-02-27 Eli Lilly And Company Pegylated amyloid beta fab
EP1978035A1 (en) 2007-04-05 2008-10-08 Hans-Knöll-Institut Leibniz-Institut für Naturstoff-Forschung Anti-amyloid antibodies and their use in diagnosis and therapy of amyloid diseases
KR20120125601A (en) 2007-05-24 2012-11-16 아블린쓰 엔.브이. Amino acid sequences directed against rank-l and polypeptides comprising the same for the treatment of bone diseases and disorders
US20090175847A1 (en) 2007-05-30 2009-07-09 Abbott Laboratories Humanized antibodies to ab (20-42) globulomer and uses thereof
WO2008156622A1 (en) 2007-06-12 2008-12-24 Ac Immune S.A. Humanized antibodies to amyloid beta
CA2690434C (en) 2007-06-12 2018-05-22 Ac Immune S.A. Monoclonal anti beta amyloid antibody
EP2009445A1 (en) 2007-06-29 2008-12-31 Institut Pasteur Use of a camelid single-domain antibody for detecting an oligomeric form of an amyloid beta peptide and its applications
EP2008666A1 (en) * 2007-06-29 2008-12-31 Institut Pasteur Use of VHH antibodies for the preparation of peptide vectors for delivering a substance of interest and their applications
JO3076B1 (en) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap Immunotherapy regimes dependent on apoe status
AP2957A (en) 2007-10-29 2014-08-31 Inst Nat Sante Rech Med New antibodies specific of the Beta-amyloid peptides and their uses as diagnostic agents or drugs
EP2215123A1 (en) * 2007-11-27 2010-08-11 Ablynx N.V. Immunoglobulin constructs
US20110091462A1 (en) 2008-03-05 2011-04-21 Ablynx N.V. Novel antigen binding dimer-complexes, methods of making and uses thereof
EP2268668A1 (en) 2008-04-17 2011-01-05 Ablynx N.V. Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same
TW201006485A (en) 2008-06-03 2010-02-16 Abbott Lab Dual variable domain immunoglobulins and uses thereof
AR080446A1 (en) 2010-03-03 2012-04-11 Boehringer Ingelheim Int UNION TO A-BETA POLYPEPTIDES (AMYLOID BETA)

Also Published As

Publication number Publication date
NZ601117A (en) 2014-06-27
TW201144437A (en) 2011-12-16
US20140030275A1 (en) 2014-01-30
US9211330B2 (en) 2015-12-15
CO6592094A2 (en) 2013-01-02
PE20130527A1 (en) 2013-05-09
JP2015180691A (en) 2015-10-15
UY33253A (en) 2011-09-30
HK1175184A1 (en) 2013-06-28
MX2012009460A (en) 2012-09-12
JP2013520974A (en) 2013-06-10
ECSP12012184A (en) 2012-10-30
BR112012022102A2 (en) 2017-01-10
WO2011107507A1 (en) 2011-09-09
EP2542579A1 (en) 2013-01-09
AU2011222980B2 (en) 2016-08-11
US8614308B2 (en) 2013-12-24
CN102781962B (en) 2014-12-10
AR080446A1 (en) 2012-04-11
US20120058118A1 (en) 2012-03-08
AP2012006359A0 (en) 2012-08-31
TN2012000434A1 (en) 2014-01-30
JP5826194B2 (en) 2015-12-02
CA2788275A1 (en) 2011-09-09
US8337845B2 (en) 2012-12-25
MA34025B1 (en) 2013-02-01
EA201201227A1 (en) 2013-04-30
CN102781962A (en) 2012-11-14
AU2011222980A1 (en) 2012-08-02
SG183369A1 (en) 2012-09-27
KR20130010114A (en) 2013-01-25
US20130017209A1 (en) 2013-01-17

Similar Documents

Publication Publication Date Title
CL2012002095A1 (en) Biparatopic binding polypeptide comprising a first individual variable domain of immunoglobulin (ig) that specifically binds to a first epitope of the β-amyloid peptide (ßa) and a second variable domain of ig that specifically binds to a second epitope of ßa, where said ßa epitopes are not identical; nucleic acid encoding it; vector; host cell; pharmaceutical composition; Preparation method; and its use in the treatment and / or prevention of ßa deposits
CO2018000877A2 (en) Bispecific antibody constructs that bind dll3 and cd3
EA202091710A1 (en) ANTIBODIES AGAINST CD73 AND METHODS OF THEIR USE
EA201791134A1 (en) POLYPEPTIDES OF THE CHEMICAL FACTOR VIII AND THEIR APPLICATION
PH12018502113A1 (en) Chimeric receptors and methods of use thereof
CO2018000882A2 (en) Antibody constructs for flt3 and cd3
CO2018000887A2 (en) Bispecific antibody constructs that bind to egfrviii and cd3
CO2018000976A2 (en) Antibody constructs for cd70 and cd3
EA201791057A1 (en) ANTIGENSBELTING MOLECULES CONTAINING THERMAL LIGAND OF TNF FAMILIES
JOP20170028B1 (en) Bispecific t cell engaging antibody constructs
EA201892193A1 (en) CHEMICAL RECEPTORS TO FLT3 AND METHODS OF THEIR APPLICATION
EA201891366A1 (en) HUMANIZED ANTIBODIES AGAINST CD73
EA201400568A1 (en) ALBUMINS CONNECTING ANTIBODIES AND THEIR CONNECTING FRAGMENTS
PE20180480A1 (en) FACTOR XI ANTIBODIES AND METHODS OF USE
MX2022007774A (en) Altered april binding antibodies.
NZ761188A (en) Antibody molecules to tim-3 and uses thereof
BR112017003582A2 (en) antibodies, compositions and uses
NZ731571A (en) T cell receptors
AR095611A1 (en) ANTIBODIES THAT JOIN THE RECEPTOR OF THE ACTIVATOR POLYPEPTIDE OF THE HUMAN PITUITARY CYCLASS TYPE I (HPAC1)
EA201792245A1 (en) BIOCONJUGATES AND THEIR APPLICATIONS
IN2014DN10288A (en)
EA201400964A1 (en) CX3CR1-BONDING POLYPEPTIDES
AR082518A1 (en) ANTIBODIES AGAINST IL-18R1 AND USES OF THE SAME
EA201792466A1 (en) ANTIBODIES AGAINST FcRn
NZ629553A (en) Anti-big-endothelin-1 (big-et-1) antibodies and uses thereof