CL2011002185A1 - Compuestos n,n-dimetil-5-(2-metil-6-((5-metilpirazin-2-il)-carbamoil)benzofuran-4-iloxi)pirimidin-2-carboxamida y sus sales; composicion farmaceutica que los comprende; y su uso como activadores de la glucoquinasa para tratar la obesidad y para tratar o retrasar la progresion o el comienzo de la diabetes de tipo 2 y trastornos relacionados. - Google Patents
Compuestos n,n-dimetil-5-(2-metil-6-((5-metilpirazin-2-il)-carbamoil)benzofuran-4-iloxi)pirimidin-2-carboxamida y sus sales; composicion farmaceutica que los comprende; y su uso como activadores de la glucoquinasa para tratar la obesidad y para tratar o retrasar la progresion o el comienzo de la diabetes de tipo 2 y trastornos relacionados.Info
- Publication number
- CL2011002185A1 CL2011002185A1 CL2011002185A CL2011002185A CL2011002185A1 CL 2011002185 A1 CL2011002185 A1 CL 2011002185A1 CL 2011002185 A CL2011002185 A CL 2011002185A CL 2011002185 A CL2011002185 A CL 2011002185A CL 2011002185 A1 CL2011002185 A1 CL 2011002185A1
- Authority
- CL
- Chile
- Prior art keywords
- treat
- benzofuran
- pyrimidin
- carboxamide
- progression
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
UN COMPUESTO QUE ES N, N-DIMETIL-5-(2-METIL-6-((5-METILPIRAZIN-2-IL)-CARBAMOIL)BENZOFURAN-4-ILOXI)PIRIMIDIN-2-CARBOXAMIDA O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, COMPOSICION FARMACEUTICA QUE LOS COMPRENDE, Y SU USO COMO ACTIVADOR DE LA GLUCOQUINASA PARA TRATAR LA OBESIDAD,Y PARA TRATAR O RETRASAR LA PROGRESION O EL COMIENZO DE LA DIABETES DE TIPO 2 Y TRASTORNOS RELACIONADOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15909909P | 2009-03-11 | 2009-03-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2011002185A1 true CL2011002185A1 (es) | 2012-02-03 |
Family
ID=42124287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2011002185A CL2011002185A1 (es) | 2009-03-11 | 2011-09-05 | Compuestos n,n-dimetil-5-(2-metil-6-((5-metilpirazin-2-il)-carbamoil)benzofuran-4-iloxi)pirimidin-2-carboxamida y sus sales; composicion farmaceutica que los comprende; y su uso como activadores de la glucoquinasa para tratar la obesidad y para tratar o retrasar la progresion o el comienzo de la diabetes de tipo 2 y trastornos relacionados. |
Country Status (38)
| Country | Link |
|---|---|
| US (2) | US8455496B2 (es) |
| EP (2) | EP2604604A1 (es) |
| JP (1) | JP5086480B2 (es) |
| KR (1) | KR101295937B1 (es) |
| CN (1) | CN102388038B (es) |
| AP (1) | AP3179A (es) |
| AR (1) | AR075729A1 (es) |
| AU (1) | AU2010222589B2 (es) |
| BR (1) | BRPI1013246B1 (es) |
| CA (1) | CA2754681C (es) |
| CL (1) | CL2011002185A1 (es) |
| CO (1) | CO6430427A2 (es) |
| CR (1) | CR20110467A (es) |
| CU (1) | CU24036B1 (es) |
| DK (1) | DK2406253T3 (es) |
| DO (1) | DOP2011000279A (es) |
| EA (1) | EA018894B1 (es) |
| EC (1) | ECSP11011306A (es) |
| ES (1) | ES2427279T3 (es) |
| GE (1) | GEP20156239B (es) |
| HK (1) | HK1164281A1 (es) |
| HR (1) | HRP20130661T1 (es) |
| IL (1) | IL214942A (es) |
| MA (1) | MA33119B1 (es) |
| MY (1) | MY151246A (es) |
| NI (1) | NI201100166A (es) |
| NZ (1) | NZ595024A (es) |
| PE (1) | PE20120668A1 (es) |
| PL (1) | PL2406253T3 (es) |
| PT (1) | PT2406253E (es) |
| RS (1) | RS52903B (es) |
| SI (1) | SI2406253T1 (es) |
| TN (1) | TN2011000454A1 (es) |
| TW (1) | TWI383981B (es) |
| UA (1) | UA99882C2 (es) |
| UY (1) | UY32480A (es) |
| WO (1) | WO2010103437A1 (es) |
| ZA (1) | ZA201106632B (es) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2547679E (pt) | 2010-03-19 | 2016-01-27 | Pfizer | Derivados de 2,3-di-hidro-1h-indeno-1-il-2,7-diazaspiro[3.6]nonano e sua utilização como antagonistas ou agonistas inversos do receptor de grelina |
| HUE025078T2 (en) | 2010-10-29 | 2016-01-28 | Pfizer | N1 / N2-lactam-acetyl-CoA carboxylase inhibitors |
| KR101567659B1 (ko) | 2011-04-22 | 2015-11-09 | 화이자 인코포레이티드 | 아세틸-CoA 카복실라아제 억제제로 사용하기 위한 피라졸로스피로케톤 유도체 |
| JP2014520879A (ja) | 2011-07-15 | 2014-08-25 | ファイザー・インク | Ｇｐｒ１１９調節因子 |
| WO2013014569A1 (en) | 2011-07-22 | 2013-01-31 | Pfizer Inc. | Quinolinyl glucagon receptor modulators |
| WO2013030713A1 (en) | 2011-08-31 | 2013-03-07 | Pfizer Inc. | Hexahydropyrano [3,4-d][1,3] thiazin-2-amine compounds |
| MD20140044A2 (ro) | 2011-11-11 | 2014-08-31 | Pfizer Inc. | 2-Tiopirimidinone şi utilizarea lor pentru tratamentul afecţiunilor cardiovasculare |
| WO2013150416A1 (en) | 2012-04-06 | 2013-10-10 | Pfizer Inc. | Diacylglycerol acyltransferase 2 inhibitors |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| ES2585262T3 (es) | 2012-05-04 | 2016-10-04 | Pfizer Inc | Compuestos heterocíclicos de hexahidropiran[3,4-d][1,3]tiazin-2-amina sustituidos como inhibidores de PPA, BACE1 y BACE2 |
| US9260455B2 (en) | 2012-09-20 | 2016-02-16 | Pfizer Inc. | Alkyl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds |
| EP2931731A1 (en) | 2012-12-11 | 2015-10-21 | Pfizer Inc. | Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1 |
| CA2893333C (en) | 2012-12-19 | 2017-10-24 | Pfizer Inc. | Carbocyclic-and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds |
| JP2016507551A (ja) | 2013-02-13 | 2016-03-10 | ファイザー・インク | ヘテロアリール置換ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物 |
| US9233981B1 (en) | 2013-02-15 | 2016-01-12 | Pfizer Inc. | Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds |
| JP6348582B2 (ja) | 2013-10-09 | 2018-06-27 | ファイザー・インク | プロスタグランジンｅｐ３受容体の拮抗薬 |
| PL3119757T3 (pl) | 2014-03-17 | 2018-09-28 | Pfizer Inc. | Inhibitory diacyloglicerolo acylotransferazy 2 do stosowania w leczeniu zaburzeń metabolicznych i związanych |
| EP3126330B1 (en) | 2014-04-04 | 2019-02-27 | Pfizer Inc | Bicyclic-fused heteroaryl or aryl compounds and their use as irak4 inhibitors |
| WO2015155626A1 (en) | 2014-04-10 | 2015-10-15 | Pfizer Inc. | 2-AMINO-6-METHYL-4,4a,5,6-TETRAHYDROPYRANO[3,4-d][1,3]THIAZIN-8a(8H)-YL-1,3-THIAZOL-4-YL AMIDES |
| CN104387348A (zh) * | 2014-10-27 | 2015-03-04 | 湖南华腾制药有限公司 | 一种苯并呋喃衍生物的制备方法 |
| WO2016092413A1 (en) | 2014-12-10 | 2016-06-16 | Pfizer Inc. | Indole and indazole compounds that activate ampk |
| EP3237401B1 (en) | 2014-12-22 | 2019-03-06 | Pfizer Inc | Antagonists of prostaglandin ep3 receptor |
| US10231951B2 (en) | 2015-03-03 | 2019-03-19 | Saniona A/S | Tesofensine, beta blocker combination formulation |
| PE20180503A1 (es) | 2015-05-05 | 2018-03-09 | Pfizer | 2-tiopirimidinonas |
| WO2016193844A1 (en) | 2015-05-29 | 2016-12-08 | Pfizer Inc. | Novel heterocyclic compounds as inhibitors of vanin-1 enzyme |
| SG10201912333PA (en) | 2015-06-17 | 2020-02-27 | Pfizer | Tricyclic compounds and their use as phosphodiesterase inhibitors |
| WO2016203335A1 (en) | 2015-06-18 | 2016-12-22 | Pfizer Inc. | Novel pyrido[2,3-b]pyrazinones as bet-family bromodomain inhibitors |
| BR112018002071A2 (pt) | 2015-08-13 | 2018-09-18 | Pfizer | compostos heteroarílicos ou arílicos fundidos bicíclicos |
| KR102029124B1 (ko) | 2015-08-27 | 2019-10-07 | 화이자 인코포레이티드 | Irak4 조정제로서의 비시클릭-융합된 헤테로아릴 또는 아릴 화합물 |
| WO2017037567A1 (en) | 2015-09-03 | 2017-03-09 | Pfizer Inc. | Regulators of frataxin |
| WO2017051303A1 (en) | 2015-09-24 | 2017-03-30 | Pfizer Inc. | Tetrahydropyrano[3,4-d][1,3]oxazin derivatives and their use as bace inhibitors |
| WO2017051294A1 (en) | 2015-09-24 | 2017-03-30 | Pfizer Inc. | N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl] amides useful as bace inhibitors |
| EP3353183A1 (en) | 2015-09-24 | 2018-08-01 | Pfizer Inc | N-[2-(2-amino-6,6-disubstituted-4, 4a, 5, 6-tetrahydropyrano [3,4-d][1,3]thiazin-8a (8h)-yl) -1, 3-thiazol-4-yl]amides |
| WO2017115205A1 (en) | 2015-12-29 | 2017-07-06 | Pfizer Inc. | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors |
| SG11201811161YA (en) | 2016-07-14 | 2019-01-30 | Pfizer | Novel pyrimidine carboxamides as inhibitors of vanin-1 enzyme |
| AR109179A1 (es) | 2016-08-19 | 2018-11-07 | Pfizer | Inhibidores de diacilglicerol aciltransferasa 2 |
| GB201714777D0 (en) | 2017-09-14 | 2017-11-01 | Univ London Queen Mary | Agent |
| WO2019133445A1 (en) | 2017-12-28 | 2019-07-04 | Inception Ibd, Inc. | Aminothiazoles as inhibitors of vanin-1 |
| KR102695126B1 (ko) * | 2018-05-31 | 2024-08-16 | 후아 메디슨 (상하이) 엘티디. | 글루코키나제 활성화제 및 sglt-2 억제제를 포함하는 약제학적 병용물, 조성물, 및 병용 제제, 및 이의 제조방법 및 용도 |
| BR112021003039A2 (pt) | 2018-08-31 | 2021-05-18 | Pfizer Inc. | combinações para o tratamento de nash/nafld e doenças relacionadas |
| US20210338776A1 (en) * | 2018-09-06 | 2021-11-04 | Yale University | Treatments against mosquito-borne viruses based on mosquito salivary gland proteins |
| WO2020102575A1 (en) | 2018-11-16 | 2020-05-22 | Inception Ibd, Inc. | Heterocyclic aminothiazoles and uses thereof |
| WO2020234726A1 (en) | 2019-05-20 | 2020-11-26 | Pfizer Inc. | Combinations comprising benzodioxol as glp-1r agonists for use in the treatment of nash/nafld and related diseases |
| WO2020261144A1 (en) | 2019-06-28 | 2020-12-30 | Pfizer Inc. | 5-(thiophen-2-yl)-1h-tetrazole derivatives as bckdk inhibitors useful for treating various diseases |
| TW202115086A (zh) | 2019-06-28 | 2021-04-16 | 美商輝瑞大藥廠 | Bckdk抑制劑 |
| TWI771766B (zh) | 2019-10-04 | 2022-07-21 | 美商輝瑞股份有限公司 | 二醯基甘油醯基轉移酶２ 抑制劑 |
| IL295281A (en) | 2020-02-07 | 2022-10-01 | Gasherbrum Bio Inc | Heterocyclic glp-1 agonists |
| JP2022058085A (ja) | 2020-02-24 | 2022-04-11 | ファイザー・インク | ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ |
| IL298891A (en) | 2020-06-09 | 2023-02-01 | Pfizer | Melanocortin 4 antagonists and use of preparations containing them |
| WO2023026180A1 (en) | 2021-08-26 | 2023-03-02 | Pfizer Inc. | Amorphous form of (s)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-n-(tetrahydrofuran-3- yl)pyrimidine-5-carboxamide |
| MX2024006739A (es) | 2021-12-01 | 2024-06-19 | Pfizer | Derivados de acido 3-fenil-1-benzotiofeno-2-carboxilico como inhibidores de alfa cetoacido deshidrogenasa quinasa de cadena ramificada para el tratamiento de diabetes, enfermedad renal, esteatohepatitis no alcoholica (nash) e insuficiencia cardiaca. |
| WO2023105387A1 (en) | 2021-12-06 | 2023-06-15 | Pfizer Inc. | Melanocortin 4 receptor antagonists and uses thereof |
| WO2023169456A1 (en) | 2022-03-09 | 2023-09-14 | Gasherbrum Bio , Inc. | Heterocyclic glp-1 agonists |
| WO2023198140A1 (en) | 2022-04-14 | 2023-10-19 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| WO2024075051A1 (en) | 2022-10-07 | 2024-04-11 | Pfizer Inc. | Hsd17b13 inhibitors and/or degraders |
| WO2024084360A1 (en) | 2022-10-18 | 2024-04-25 | Pfizer Inc. | Patatin-like phospholipase domain-containing protein 3 (pnpla3) modifiers |
| WO2024118524A1 (en) | 2022-11-28 | 2024-06-06 | Cerevel Therapeutics, Llc | Azaindole compounds and their use as phosphodiesterase inhibitors |
| WO2024125602A1 (en) | 2022-12-15 | 2024-06-20 | Gasherbrum Bio, Inc. | Salts and solid forms of a compound having glp-1 agonist activity |
| WO2024127297A1 (en) | 2022-12-16 | 2024-06-20 | Pfizer Inc. | 3-fluoro-4-hydroxybenzmide-containing inhibitors and/or degraders and uses thereof |
| WO2024214038A1 (en) | 2023-04-14 | 2024-10-17 | Pfizer Inc. | Glucose-dependent insulinotropic polypeptide receptor antagonists and uses thereof |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5795984A (en) | 1980-12-05 | 1982-06-15 | Tanabe Seiyaku Co Ltd | Pyridinecarboxamide derivative and its preparation |
| US5399564A (en) | 1991-09-03 | 1995-03-21 | Dowelanco | N-(4-pyridyl or 4-quinolinyl) arylacetamide and 4-(aralkoxy or aralkylamino) pyridine pesticides |
| AU662997B2 (en) | 1992-07-03 | 1995-09-21 | Ihara Chemical Industry Co. Ltd. | Condensed heterocyclic derivative and weedkiller |
| JP4146894B2 (ja) | 1994-07-22 | 2008-09-10 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | ジヒドロベンゾフラン |
| DE4434637A1 (de) | 1994-09-28 | 1996-04-04 | Hoechst Schering Agrevo Gmbh | Substituierte Pyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide |
| KR100232341B1 (ko) | 1994-10-13 | 2000-07-01 | 디. 제이. 우드 | 류코트리엔 b4(ltb4) 길항물질로서의 벤조피란 및 벤조-축합된 화합물 |
| NZ285154A (en) | 1994-10-13 | 1998-11-25 | Pfizer | Optionally heterocyclically substituted benzopyran and benzo-fused derivatives, preparation and use as leukotriene antagonists |
| DE19603576A1 (de) | 1996-02-01 | 1997-08-07 | Bayer Ag | Acylierte 4-Amino und 4-Hydrazinopyrimidine |
| ES2193376T3 (es) | 1996-05-20 | 2003-11-01 | Darwin Discovery Ltd | Carboxamidas de benzofurano y sus utilizaciones terapeuticas. |
| DK0923568T5 (da) | 1996-08-19 | 2003-11-03 | Altana Pharma Ag | Hidtil ukendte benzofuran-4-carboxamider |
| CN1290266A (zh) | 1998-02-09 | 2001-04-04 | 达尔文发现有限公司 | 苯并呋喃－4－甲酰胺和其治疗用途 |
| PL350050A1 (en) | 1999-01-22 | 2002-10-21 | Elan Pharm Inc | Acyl derivatives which treat vla-4 related disorders |
| SE9901573D0 (sv) | 1999-05-03 | 1999-05-03 | Astra Ab | New compounds |
| US6777446B2 (en) | 2000-09-05 | 2004-08-17 | Tularik, Inc. | FXR modulators |
| JP2004536023A (ja) | 2000-11-20 | 2004-12-02 | ブリストル−マイヤーズ スクイブ カンパニー | ａＰ２インヒビターとしてのピリドン誘導体 |
| CA2429642C (en) | 2000-12-06 | 2007-11-20 | F. Hoffmann-La Roche Ag | Fused heteroaromatic glucokinase activators |
| EP1354882A1 (en) | 2000-12-27 | 2003-10-22 | Kyowa Hakko Kogyo Co., Ltd. | Dipeptidyl peptidase iv inhibitor |
| SK286917B6 (sk) | 2001-02-28 | 2009-07-06 | Merck & Co., Inc. | 4-Substituované N-acylované deriváty piperidínu, farmaceutický prípravok s ich obsahom a ich použitie |
| JPWO2002100833A1 (ja) | 2001-06-12 | 2004-09-24 | 住友製薬株式会社 | Ｒｈｏキナーゼ阻害剤 |
| SE0102300D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
| MXPA04003758A (es) | 2001-10-22 | 2005-06-20 | Univ New York State Res Found | Inhibidores de proteina - cinasas y proteina-fosfatasas, metodos para disenarlos y metodos para usarlos. |
| ES2334990T3 (es) | 2002-02-14 | 2010-03-18 | Pharmacia Corporation | Piridinonas sustituidas como moduladores de p38 map quinasa. |
| CN100357283C (zh) | 2002-04-02 | 2007-12-26 | 中国科学院上海药物研究所 | 一类甲硫氨酰氨肽酶抑制剂 |
| MXPA04010780A (es) | 2002-05-03 | 2005-03-07 | Warner Lambert Co | Antagonistas de bombesina. |
| BR0311707A (pt) | 2002-06-13 | 2005-03-15 | Du Pont | Composto, composição e método de controle de pelo menos uma praga invertebrada |
| JP4302967B2 (ja) * | 2002-11-18 | 2009-07-29 | パイオニア株式会社 | 楽曲検索方法、楽曲検索装置及び楽曲検索プログラム |
| GB0226930D0 (en) * | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| EP1433778A1 (en) | 2002-12-23 | 2004-06-30 | Jerini AG | Use of nitriles as rotamase inhibitors |
| JP4621198B2 (ja) | 2003-02-11 | 2011-01-26 | プロシディオン・リミテッド | トリ（シクロ）置換アミドグルコキナーゼ活性化化合物 |
| NZ540791A (en) | 2003-02-13 | 2009-09-25 | Banyu Pharma Co Ltd | Novel 2-pyridinecarboxamide derivatives |
| CN100378094C (zh) * | 2003-02-13 | 2008-04-02 | 万有制药株式会社 | 2-吡啶甲酰胺衍生物 |
| CL2004000303A1 (es) | 2003-02-20 | 2005-04-08 | Tibotec Pharm Ltd | Compuestos derivados de pirimidinas y triazinas; proceso de preparacion; composicion farmaceutica; y su uso para inhibir la replicacion del vih. |
| MXPA05009059A (es) | 2003-02-26 | 2005-10-19 | Banyu Pharma Co Ltd | Derivados de heteroarilcarbamoilbenceno. |
| JP2007523873A (ja) | 2003-07-15 | 2007-08-23 | スミスクライン・ビーチャム・コーポレイション | 新規化合物 |
| DE602004030017D1 (de) | 2003-08-01 | 2010-12-23 | Chugai Pharmaceutical Co Ltd | Heterocyclische verbindungen als nützliche malonyl-coa decarboxylase-hemmer |
| NL1026826C2 (nl) | 2003-08-13 | 2007-01-04 | Pharmacia Corp | Gesubstitueerde pyridinonen. |
| EP1532980A1 (en) | 2003-11-24 | 2005-05-25 | Novo Nordisk A/S | N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes |
| SE0303480D0 (sv) | 2003-12-19 | 2003-12-19 | Biovitrum Ab | Benzofuranes |
| PT1735322E (pt) | 2004-04-02 | 2012-01-12 | Novartis Ag | Derivados de sulfonamido-tiazolopiridina como activadores de glucoquinase úteis para o tratamento de diabetes de tipo 2 |
| CA2568056A1 (en) | 2004-05-25 | 2005-12-08 | Pfizer Products Inc. | Tetraazabenzo[e]azulene derivatives and analogs thereof |
| AU2005267884B2 (en) | 2004-07-29 | 2011-04-21 | Merck Sharp & Dohme Corp. | Potassium channel inhibitors |
| JP2008511659A (ja) | 2004-09-01 | 2008-04-17 | ライジェル ファーマシューティカルズ， インコーポレイテッド | ２，４−ピリミジンジアミン化合物の合成 |
| GB0420719D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| SE0403006D0 (sv) | 2004-12-09 | 2004-12-09 | Biovitrum Ab | New compounds |
| ES2306275T3 (es) | 2004-12-21 | 2008-11-01 | F. Hoffmann-La Roche Ag | Derivados de cromano y sus usos como ligandos dde receptores 5-ht. |
| JP4167218B2 (ja) | 2004-12-22 | 2008-10-15 | 株式会社メタル建材 | 薄板用タッピンねじ |
| PA8660701A1 (es) | 2005-02-04 | 2006-09-22 | Pfizer Prod Inc | Agonistas de pyy y sus usos |
| TW200700392A (en) | 2005-03-16 | 2007-01-01 | Astrazeneca Ab | Novel compounds |
| CA2601983A1 (en) | 2005-04-06 | 2006-10-12 | Astrazeneca Ab | Substituted heterocycles and their use as chk1, pdk1 and pak inhibitors |
| US7754717B2 (en) | 2005-08-15 | 2010-07-13 | Amgen Inc. | Bis-aryl amide compounds and methods of use |
| KR20080040046A (ko) | 2005-08-31 | 2008-05-07 | 아스텔라스세이야쿠 가부시키가이샤 | 티아졸 유도체 |
| JP2009013065A (ja) * | 2005-10-14 | 2009-01-22 | Astellas Pharma Inc | 縮合へテロ環化合物 |
| WO2007058580A1 (en) | 2005-11-15 | 2007-05-24 | Astrazeneca Ab | Novel 2-aminopyrimidinone derivatives and their use |
| US8034822B2 (en) | 2006-03-08 | 2011-10-11 | Takeda San Diego, Inc. | Glucokinase activators |
| WO2007117995A2 (en) | 2006-03-30 | 2007-10-18 | Takeda San Diego, Inc. | Kinase inhibitors |
| US7842713B2 (en) | 2006-04-20 | 2010-11-30 | Pfizer Inc | Fused phenyl amido heterocyclic compounds |
| ES2487967T3 (es) * | 2006-04-20 | 2014-08-25 | Pfizer Products Inc. | Compuestos amido heterocíclicos condensados con fenilo para la prevención y el tratamiento de enfermedades mediadas por la glucoquinasa |
| US8163779B2 (en) | 2006-12-20 | 2012-04-24 | Takeda San Diego, Inc. | Glucokinase activators |
| JP2010138073A (ja) | 2007-03-30 | 2010-06-24 | Taisho Pharmaceutical Co Ltd | ピコリン酸アミド化合物 |
| CN101679365A (zh) | 2007-06-08 | 2010-03-24 | 艾德维纳斯医疗私人有限公司 | 作为葡萄糖激酶激活剂的新型吡咯-2-甲酰胺衍生物、它们的制造方法和药学应用 |
| EP2389374A1 (en) | 2009-01-20 | 2011-11-30 | Pfizer Inc. | Substituted pyrazinone amides |
-
2010
- 2010-03-04 SI SI201030278T patent/SI2406253T1/sl unknown
- 2010-03-04 PE PE2011001580A patent/PE20120668A1/es not_active Application Discontinuation
- 2010-03-04 MY MYPI2011004231 patent/MY151246A/en unknown
- 2010-03-04 AU AU2010222589A patent/AU2010222589B2/en not_active Ceased
- 2010-03-04 GE GEAP201313280A patent/GEP20156239B/en unknown
- 2010-03-04 CN CN201080016137.6A patent/CN102388038B/zh active Active
- 2010-03-04 UA UAA201110834A patent/UA99882C2/uk unknown
- 2010-03-04 EP EP13158856.8A patent/EP2604604A1/en not_active Withdrawn
- 2010-03-04 PL PL10708644T patent/PL2406253T3/pl unknown
- 2010-03-04 JP JP2011553571A patent/JP5086480B2/ja not_active Expired - Fee Related
- 2010-03-04 NZ NZ595024A patent/NZ595024A/xx not_active IP Right Cessation
- 2010-03-04 PT PT107086449T patent/PT2406253E/pt unknown
- 2010-03-04 ES ES10708644T patent/ES2427279T3/es active Active
- 2010-03-04 RS RS20130355A patent/RS52903B/en unknown
- 2010-03-04 MA MA34164A patent/MA33119B1/fr unknown
- 2010-03-04 KR KR1020117023630A patent/KR101295937B1/ko active IP Right Grant
- 2010-03-04 EP EP10708644.9A patent/EP2406253B1/en active Active
- 2010-03-04 EA EA201190158A patent/EA018894B1/ru not_active IP Right Cessation
- 2010-03-04 WO PCT/IB2010/050943 patent/WO2010103437A1/en active Application Filing
- 2010-03-04 BR BRPI1013246-5A patent/BRPI1013246B1/pt not_active IP Right Cessation
- 2010-03-04 DK DK10708644.9T patent/DK2406253T3/da active
- 2010-03-04 CA CA2754681A patent/CA2754681C/en not_active Expired - Fee Related
- 2010-03-04 AP AP2011005882A patent/AP3179A/xx active
- 2010-03-09 UY UY0001032480A patent/UY32480A/es not_active Application Discontinuation
- 2010-03-10 TW TW099106974A patent/TWI383981B/zh active
- 2010-03-10 US US12/720,724 patent/US8455496B2/en active Active
- 2010-03-10 AR ARP100100715A patent/AR075729A1/es unknown
-
2011
- 2011-08-31 CR CR20110467A patent/CR20110467A/es unknown
- 2011-09-01 IL IL214942A patent/IL214942A/en active IP Right Grant
- 2011-09-02 NI NI201100166A patent/NI201100166A/es unknown
- 2011-09-02 CU CU2011000168A patent/CU24036B1/es active IP Right Grant
- 2011-09-05 CL CL2011002185A patent/CL2011002185A1/es unknown
- 2011-09-06 EC EC2011011306A patent/ECSP11011306A/es unknown
- 2011-09-08 DO DO2011000279A patent/DOP2011000279A/es unknown
- 2011-09-08 TN TN2011000454A patent/TN2011000454A1/fr unknown
- 2011-09-09 ZA ZA2011/06632A patent/ZA201106632B/en unknown
- 2011-09-12 CO CO11117871A patent/CO6430427A2/es active IP Right Grant
-
2012
- 2012-05-10 HK HK12104609.1A patent/HK1164281A1/xx unknown
-
2013
- 2013-05-22 US US13/899,851 patent/US8735396B2/en active Active
- 2013-07-11 HR HRP20130661AT patent/HRP20130661T1/hr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2011002185A1 (es) | Compuestos n,n-dimetil-5-(2-metil-6-((5-metilpirazin-2-il)-carbamoil)benzofuran-4-iloxi)pirimidin-2-carboxamida y sus sales; composicion farmaceutica que los comprende; y su uso como activadores de la glucoquinasa para tratar la obesidad y para tratar o retrasar la progresion o el comienzo de la diabetes de tipo 2 y trastornos relacionados. | |
| PE20191474A1 (es) | Compuestos de amino-triazolopiridina y su uso en el tratamiento del cancer | |
| CL2008000198A1 (es) | Compuestos derivados de azacicloalcanos, inhibidores de estearoil-coenzima a delta-9; composicion farmaceutica; y uso para el tratamiento de enfermedades tales como diabetes tipo 2, trastorno de lipidos, obesidad y aterosclerosis. | |
| CO7111284A2 (es) | Nucleósidos de espirooxetano de uracilo | |
| CL2008003690A1 (es) | Compuestos derivados de amonobenzamida; composicion farmceutica que comprende los compuestos; y uso para controlar parasitos. | |
| UY32629A (es) | Compuestos antivirales, composiciones y uso para la manufactura de un medicamento para el tratamiento de trastornos asociados con hepatitis c. | |
| GT201400147A (es) | Pirimidinas y triazinas fusionadas sustituidas y su uso | |
| CL2016001790A1 (es) | Compuestos derivados y composiciones de n-azaspirocicloalcano n-heteroaril sustituido para inhibir la actividad de shp2. | |
| CL2012000921A1 (es) | Compuestos derivados de espiropiperidina-metilbenciloxifenil, activadores del receptor rpg-40; composicion farmaceutica que los comprende; y uso del compuesto para tratar diabetes. | |
| SV2011003903A (es) | Aminotetrahidropiranos como inhibidores de dipeptidil peptidasa iv para el tratamiento o prevencion de diabetes | |
| UY33921A (es) | Oxazinopteridinas y oxazinoptiridinonas n-sustituidas | |
| GT201200250A (es) | Ariltriazolonas ligadas a bisarilo y su uso | |
| CL2008000669A1 (es) | Compuestos derivados de tiazolidindionas n alquiladas, moduladores del receptor alfa relacionados con estrogenos; composicion farmaceutica; y su uso para tratar enfermedades relacionadas con los huesos, cancer, sindrome metabolicos, entre otras. | |
| UY33735A (es) | Compuestos antivirales | |
| NI201400070A (es) | Compuestos de benzaldehído sustituidos y métodos para su uso en incrementar la oxigenación del tejido. | |
| PA8770101A1 (es) | Amidas de 4-aril-1,4-dihidro-1, 6-naftiridina sustituidas y su uso | |
| UY29839A1 (es) | Ácidos fenoxiaceticos sustituidos, composiciones farmacéuticas conteniéndolos, procesos para su preparación y aplicaciones. | |
| ECSP067021A (es) | Compuestos y composiciones como moduladores del receptor activado por proliferador de peroxisoma (ppar) | |
| CL2017000432A1 (es) | Inhibidores espirocíclicos de catepsina c | |
| CL2016003329A1 (es) | Derivados de indano e indolina y el uso de los mismos como activadores de la guanilato ciclasa soluble | |
| UY31228A1 (es) | Ariloxazoles sustituidos y su uso | |
| CL2008002295A1 (es) | Compuestos derivados de tiazolida sustituidos con alquilsulfonilos; composicion farmaceutica; y uso para el tratamiento de la hepatitis c. | |
| UY31863A (es) | Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar | |
| CL2011000544A1 (es) | Compuestos derivados de benzamida n sustituida por heterociclo, ligandos de los receptores cannabinoides; composicion farmaceutica; y su uso para tratar el dolor, entre otras enfermedades. | |
| CL2008002093A1 (es) | Compuestos derivados de piperazinona y tiadiazinona, antagonistas de los receptores ccr2, ccr3 y ccr5; proceso de preparacion de estos; composicion farmaceutica que los comprende; uso para tratar enfermedades como, artritis reumatoide, isquemia, asma, entre otras. |