CL2008000647A1 - Compuestos derivados de indazol; composicion farmaceutica; yuso en el tratamiento de enfermedades tales como dolor, trastornos inflamatorios cronicos, trastornos del snc, entre otros. - Google Patents
Compuestos derivados de indazol; composicion farmaceutica; yuso en el tratamiento de enfermedades tales como dolor, trastornos inflamatorios cronicos, trastornos del snc, entre otros.Info
- Publication number
- CL2008000647A1 CL2008000647A1 CL2008000647A CL2008000647A CL2008000647A1 CL 2008000647 A1 CL2008000647 A1 CL 2008000647A1 CL 2008000647 A CL2008000647 A CL 2008000647A CL 2008000647 A CL2008000647 A CL 2008000647A CL 2008000647 A1 CL2008000647 A1 CL 2008000647A1
- Authority
- CL
- Chile
- Prior art keywords
- disorders
- indazole
- pain
- diseases
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos derivados de indazol; composición farmacéutica; y uso en el tratamiento de enfermedades, tales como, dolor, trastornos inflamatorios crónicos, trastornos del SNC, entre otros.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0704407.6A GB0704407D0 (en) | 2007-03-07 | 2007-03-07 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2008000647A1 true CL2008000647A1 (es) | 2009-01-02 |
Family
ID=37988543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2008000647A CL2008000647A1 (es) | 2007-03-07 | 2008-03-04 | Compuestos derivados de indazol; composicion farmaceutica; yuso en el tratamiento de enfermedades tales como dolor, trastornos inflamatorios cronicos, trastornos del snc, entre otros. |
Country Status (16)
Country | Link |
---|---|
US (1) | US7960563B2 (es) |
EP (1) | EP2118068A1 (es) |
JP (1) | JP2010520259A (es) |
KR (1) | KR20090118998A (es) |
CN (1) | CN101679288A (es) |
AR (1) | AR065605A1 (es) |
AU (1) | AU2008223850A1 (es) |
BR (1) | BRPI0808464A2 (es) |
CA (1) | CA2680109A1 (es) |
CL (1) | CL2008000647A1 (es) |
EA (1) | EA200970835A1 (es) |
GB (1) | GB0704407D0 (es) |
MX (1) | MX2009009581A (es) |
PE (1) | PE20081878A1 (es) |
TW (1) | TW200848025A (es) |
WO (1) | WO2008107455A1 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
AU2008297877C1 (en) | 2007-09-14 | 2013-11-07 | Addex Pharma S.A. | 1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones |
NZ584152A (en) | 2007-09-14 | 2011-11-25 | Ortho Mcneil Janssen Pharm | 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones |
ES2356032T3 (es) | 2007-09-14 | 2011-04-04 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | 4-fenil-3,4,5,6-tetrahidro-2h,1'h-[1,4']bipiridinil-2'-onas 1,3'-disustituidas. |
CA2704436C (en) | 2007-11-14 | 2016-01-05 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
GB0803017D0 (en) | 2008-02-19 | 2008-03-26 | Glaxo Group Ltd | Compounds |
JP5547194B2 (ja) | 2008-09-02 | 2014-07-09 | ジャンセン ファーマシューティカルズ, インコーポレイテッド. | 代謝型グルタミン酸受容体の調節因子としての3−アザビシクロ[3.1.0]ヘキシル誘導体 |
RU2517181C2 (ru) | 2008-10-16 | 2014-05-27 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов |
CN102232074B (zh) | 2008-11-28 | 2014-12-03 | 奥梅-杨森制药有限公司 | 作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物 |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
BRPI1010831A2 (pt) | 2009-05-12 | 2016-04-05 | Addex Pharmaceuticals Sa | derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2 |
MY161325A (en) | 2009-05-12 | 2017-04-14 | Janssen Pharmaceuticals Inc | 1, 2, 4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
GB2483736B (en) | 2010-09-16 | 2012-08-29 | Aragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
ES2552455T3 (es) | 2010-11-08 | 2015-11-30 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
ES2552879T3 (es) | 2010-11-08 | 2015-12-02 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
WO2012062751A1 (en) | 2010-11-08 | 2012-05-18 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
NZ630124A (en) | 2012-03-20 | 2016-01-29 | Seragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
KR20200126026A (ko) | 2014-01-21 | 2020-11-05 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
EP3431106B1 (en) | 2014-01-21 | 2020-12-30 | Janssen Pharmaceutica NV | Combinations comprising positive allosteric modulators of metabotropic glutamatergic receptor subtype 2 and their use |
AU2019274580B2 (en) * | 2018-05-23 | 2024-11-07 | The Board Of Trustees Of The University Of Illinois | Estrogen receptor beta ligands for the prevention and treatment of multiple sclerosis (MS) and other demyelinating, inflammatory and neurodegenerative diseases |
CN110483403A (zh) * | 2019-09-02 | 2019-11-22 | 南通大学 | 一种5-溴-4-甲氧基-1h-吲唑的合成方法 |
JP2023504623A (ja) * | 2019-12-04 | 2023-02-06 | アーカス バイオサイエンシーズ,インコーポレーテッド | Hif-2アルファの阻害剤 |
WO2021188769A1 (en) | 2020-03-19 | 2021-09-23 | Arcus Biosciences, Inc. | Tetralin and tetrahydroquinoline compounds as inhibitors of hif-2alpha |
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CA2131625A1 (en) * | 1992-03-09 | 1993-09-16 | Donald R. James | Novel arylindazoles and their use as herbicides |
DE4236105A1 (de) | 1992-10-26 | 1994-04-28 | Hoechst Ag | Arylboronsäuren als Vorprodukte zur Herstellung von Komponenten von Flüssigkristallmischungen |
US5474995A (en) | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
JPH0770078A (ja) * | 1993-07-08 | 1995-03-14 | Fuji Photo Film Co Ltd | インダゾールの製造方法 |
US5466823A (en) | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
CA2212836C (en) | 1995-02-13 | 2003-08-12 | G.D. Searle & Co. | Substituted isoxazoles for the treatment of inflammation |
US5633272A (en) | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
CA2201098C (en) | 1995-09-08 | 2001-03-27 | George G.J.M. Kuiper | Orphan receptor |
UA57002C2 (uk) | 1995-10-13 | 2003-06-16 | Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. | Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування |
JP3382624B2 (ja) | 1996-04-12 | 2003-03-04 | ジー.ディー.サール アンド カンパニー | Cox―2阻害剤のプロドラッグとしての置換ベンゼンスルホンアミド誘導体 |
PL187848B1 (pl) | 1996-07-18 | 2004-10-29 | Merck Frosst Canada Inc | Podstawione pirydyny, kompozycja farmaceutyczna, podstawione pirydyny jako selektywne inhibitory cyklooksygenazy-2 oraz zastosowanie podstawionych pirydyn |
CO4960662A1 (es) | 1997-08-28 | 2000-09-25 | Novartis Ag | Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados |
SK283922B6 (sk) | 1997-09-05 | 2004-05-04 | Glaxo Group Limited | 2,3-Diarylpyrazolo[1,5-b]pyridazínové zlúčeniny, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie |
US6407261B1 (en) * | 1998-04-17 | 2002-06-18 | Eli Lilly And Company | Process for preparing 4-hdyroxy indole, indazole and carbazole compounds |
CZ20011556A3 (cs) | 1998-11-03 | 2001-11-14 | Glaxo Group Limited | Pyrazolopyridinové deriváty |
US6025683A (en) | 1998-12-23 | 2000-02-15 | Stryker Corporation | Motor control circuit for regulating a D.C. motor |
JP2002538157A (ja) | 1999-02-27 | 2002-11-12 | グラクソ グループ リミテッド | ピラゾロピリジン |
GB0003224D0 (en) | 2000-02-11 | 2000-04-05 | Glaxo Group Ltd | Chemical compounds |
GB0021494D0 (en) | 2000-09-01 | 2000-10-18 | Glaxo Group Ltd | Chemical comkpounds |
EP1403255A4 (en) * | 2001-06-12 | 2005-04-06 | Sumitomo Pharma | INHIBITORS OF RHO KINASE |
KR101160698B1 (ko) * | 2003-06-27 | 2012-06-28 | 아사히 가세이 가부시키가이샤 | 세포 분화 억제제, 이것을 이용하는 세포 배양 방법, 배양 배지 및 배양된 세포주 |
EP1647549A1 (en) | 2004-10-14 | 2006-04-19 | Laboratoire Theramex | Indazoles, benzisoxazoles and benzisothiazoles as estrogenic agents |
TW200815361A (en) | 2005-10-20 | 2008-04-01 | Astrazeneca Ab | Chemical compounds |
-
2007
- 2007-03-07 GB GBGB0704407.6A patent/GB0704407D0/en not_active Ceased
-
2008
- 2008-03-04 CL CL2008000647A patent/CL2008000647A1/es unknown
- 2008-03-05 CN CN200880015045A patent/CN101679288A/zh active Pending
- 2008-03-05 MX MX2009009581A patent/MX2009009581A/es unknown
- 2008-03-05 PE PE2008000434A patent/PE20081878A1/es not_active Application Discontinuation
- 2008-03-05 EP EP08717414A patent/EP2118068A1/en not_active Withdrawn
- 2008-03-05 JP JP2009552198A patent/JP2010520259A/ja not_active Withdrawn
- 2008-03-05 BR BRPI0808464-5A patent/BRPI0808464A2/pt not_active IP Right Cessation
- 2008-03-05 US US12/529,561 patent/US7960563B2/en not_active Expired - Fee Related
- 2008-03-05 AR ARP080100911A patent/AR065605A1/es unknown
- 2008-03-05 KR KR1020097020816A patent/KR20090118998A/ko not_active Application Discontinuation
- 2008-03-05 EA EA200970835A patent/EA200970835A1/ru unknown
- 2008-03-05 TW TW097107583A patent/TW200848025A/zh unknown
- 2008-03-05 WO PCT/EP2008/052664 patent/WO2008107455A1/en active Application Filing
- 2008-03-05 CA CA002680109A patent/CA2680109A1/en not_active Abandoned
- 2008-03-05 AU AU2008223850A patent/AU2008223850A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US7960563B2 (en) | 2011-06-14 |
WO2008107455A1 (en) | 2008-09-12 |
KR20090118998A (ko) | 2009-11-18 |
AR065605A1 (es) | 2009-06-17 |
EA200970835A1 (ru) | 2010-04-30 |
TW200848025A (en) | 2008-12-16 |
CA2680109A1 (en) | 2008-09-12 |
US20100087502A1 (en) | 2010-04-08 |
PE20081878A1 (es) | 2009-03-05 |
JP2010520259A (ja) | 2010-06-10 |
BRPI0808464A2 (pt) | 2014-07-15 |
GB0704407D0 (en) | 2007-04-18 |
MX2009009581A (es) | 2009-09-16 |
EP2118068A1 (en) | 2009-11-18 |
CN101679288A (zh) | 2010-03-24 |
AU2008223850A1 (en) | 2008-09-12 |
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