[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

CL2004000366A1 - USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA. - Google Patents

USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA.

Info

Publication number
CL2004000366A1
CL2004000366A1 CL200400366A CL2004000366A CL2004000366A1 CL 2004000366 A1 CL2004000366 A1 CL 2004000366A1 CL 200400366 A CL200400366 A CL 200400366A CL 2004000366 A CL2004000366 A CL 2004000366A CL 2004000366 A1 CL2004000366 A1 CL 2004000366A1
Authority
CL
Chile
Prior art keywords
quinasa
combination
cardiovascular
neuropatia
insotunatio
Prior art date
Application number
CL200400366A
Other languages
English (en)
Inventor
E Rudolph Ricardo Rocha Os Amy
Original Assignee
Pharmacia Corp Sa Organizada B
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp Sa Organizada B filed Critical Pharmacia Corp Sa Organizada B
Publication of CL2004000366A1 publication Critical patent/CL2004000366A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

USO DE UN INHIBIDOR QUINASA p38 (POR EJEMPLO, UN INHIBIDOR DE QUINASA p38 D EPIRAZOL SUSTITUIDO) Y UNA COMBINACION DE UN INHIBIDOR DE QUINASA p38 CON UN INHIBIDOR DE ENZIMA CONVERTIDORA DE ANGIOTENSINA (ACE) UTILES PARA PREPARAR UN MEDICAMENTO PARA TRATAR UNA CONDICION CARDIOVASCULAR, ES DECIR, HIPERTENSION O FALLA CARDIACA O UNA CONDICION ASOCIADA CON UNA CONDICION CARDIOVASCULAR. COMPRENDE TAMBIEN COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LAS ANTEDICHAS COMBINACIONES.
CL200400366A 2003-02-26 2004-02-25 USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA. CL2004000366A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45052903P 2003-02-26 2003-02-26

Publications (1)

Publication Number Publication Date
CL2004000366A1 true CL2004000366A1 (es) 2005-01-07

Family

ID=32927663

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200400366A CL2004000366A1 (es) 2003-02-26 2004-02-25 USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA.

Country Status (4)

Country Link
US (2) US20050203072A1 (es)
CL (1) CL2004000366A1 (es)
TW (2) TW200500361A (es)
WO (2) WO2004075852A2 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6979686B1 (en) * 2001-12-07 2005-12-27 Pharmacia Corporation Substituted pyrazoles as p38 kinase inhibitors
CA2550283A1 (en) * 2003-12-19 2005-07-07 Pharmacia Corporation Crystalline form of 2-{4-[3-(4-chloro-2-fluorophenyl)-4-pyrimidin-4-yl-1h-pyrazol-5-yl]piperidin-1-yl}-2-oxoethanol
GB0405381D0 (en) * 2004-03-10 2004-04-21 Univ Wales Medicine A method and means for treating heart failure
DE602005010714D1 (de) * 2004-08-12 2008-12-11 Pfizer Der p38-map-kinase
EP2208496A1 (en) * 2004-08-25 2010-07-21 Essentialis, Inc. Pharmaceutical formulations of potassium ATP channel openers and uses thereof
WO2006118914A2 (en) * 2005-04-29 2006-11-09 Children's Medical Center Corporation Methods of increasing proliferation of adult mammalian cardiomyocytes through p38 map kinase inhibition
CN103172592B (zh) 2006-01-05 2016-01-06 伊森舍丽斯有限公司 钾atp 通道开放剂的盐及其用途
AU2012203517B2 (en) * 2006-01-05 2014-04-24 Essentialis, Inc. Salts of potassium ATP channel openers and uses thereof
KR20080083046A (ko) 2006-01-31 2008-09-12 에프. 호프만-라 로슈 아게 7h-피리도[3,4-d]피리미딘-8-온, 이의 제조 및 단백질키나아제 억제제로서의 용도
US9090604B2 (en) 2006-07-27 2015-07-28 E I Du Pont De Nemours And Company Fungicidal azocyclic amides
WO2008013622A2 (en) * 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Fungicidal azocyclic amides
WO2008060871A1 (en) * 2006-11-10 2008-05-22 Mayo Foundation For Medical Education And Research Biomarkers for chronic vascular dysfunction
JP2010528662A (ja) * 2007-06-05 2010-08-26 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイト T細胞サイトカイン誘導表面分子およびその使用
US20080318909A1 (en) * 2007-06-14 2008-12-25 Sparagna Genevieve C Use Of Linoleic Compounds Against Heart Failure
FR2917975B1 (fr) * 2007-06-26 2009-10-16 Ceva Sante Animale Sa Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains
AU2008272923A1 (en) * 2007-07-02 2009-01-08 Essentialis, Inc. Salts of potassium ATP channel openers and uses thereof
EA201070143A1 (ru) * 2007-07-13 2010-08-30 Аддекс Фарма С.А. Новые гетероароматические производные и их использование в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов
FR2921063B1 (fr) * 2007-09-13 2009-12-11 Sod Conseils Rech Applic Ligands des recepteurs cannabinoides
US20090270356A1 (en) * 2008-04-28 2009-10-29 Ceva Sante Animale Sa Compositions and treatments of heart failure in non-human mammal animals
GB0908193D0 (en) 2009-05-13 2009-06-24 Albright Patents Treatment of disease state
CA2816448A1 (en) 2009-05-20 2010-11-25 Heart Metabolics Limited Treatment of heart failure with normal ejection fraction
UY36680A (es) 2015-05-19 2016-12-30 Glaxosmithkline Ip Dev Ltd Amidas heterocíclicas como inhibidores de quinasa
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
US10286036B2 (en) 2017-05-12 2019-05-14 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
WO2018224037A1 (zh) * 2017-06-09 2018-12-13 南京明德新药研发股份有限公司 作为at2r受体拮抗剂的羧酸衍生物

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1054655B (it) * 1975-08-27 1981-11-30 Lepetit Spa Derivati condensati del l isochinolina
US4105776A (en) * 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives
JPS559058A (en) * 1978-07-06 1980-01-22 Dainippon Pharmaceut Co Ltd 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative
US4175127A (en) * 1978-09-27 1979-11-20 Smithkline Corporation Pyridyl substituted 2,3-dihydroimidazo[2,1-b]thiazoles
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4470972A (en) * 1981-04-28 1984-09-11 Schering Corporation 7-Carboxyalkylaminoacyl-1,4-dithia-7-azaspiro[4.4]-nonane-8-carboxylic acids
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4337201A (en) * 1980-12-04 1982-06-29 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4623304A (en) * 1981-12-08 1986-11-18 Sanyo Electric Co., Ltd. Hermetically sealed rotary compressor
IE55867B1 (en) * 1981-12-29 1991-02-14 Hoechst Ag New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
US4555502A (en) * 1982-09-30 1985-11-26 Merck & Co., Inc. Aminoacyl-containing dipeptide derivatives useful as antihypertensives
JPS6058233B2 (ja) * 1982-05-24 1985-12-19 田辺製薬株式会社 2−オキソイミダゾリジン誘導体及びその製法
US4452790A (en) * 1982-06-23 1984-06-05 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4699905A (en) * 1984-04-10 1987-10-13 Sankyo Company, Limited Perhydrothiazepine derivatives, their preparation and their therapeutic use
SE8801423D0 (sv) * 1988-04-18 1988-04-18 Dominator Ab Pneumatisk ventil for styrning av i synnerhet tryckluftdrivna membranpumpar
US5656644A (en) * 1994-07-20 1997-08-12 Smithkline Beecham Corporation Pyridyl imidazoles
IL104369A0 (en) * 1992-01-13 1993-05-13 Smithkline Beecham Corp Novel compounds and compositions
US5670527A (en) * 1993-07-16 1997-09-23 Smithkline Beecham Corporation Pyridyl imidazole compounds and compositions
US5593992A (en) * 1993-07-16 1997-01-14 Smithkline Beecham Corporation Compounds
US5593991A (en) * 1993-07-16 1997-01-14 Adams; Jerry L. Imidazole compounds, use and process of making
US5599984A (en) * 1994-01-21 1997-02-04 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions
TW440562B (en) * 1994-05-20 2001-06-16 Taiho Pharmaceutical Co Ltd Condensed-indan derivative and pharmaceutically acceptable salts thereof
US6268392B1 (en) * 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US5717100A (en) * 1995-10-06 1998-02-10 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
US6083949A (en) * 1995-10-06 2000-07-04 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
ZA97175B (en) * 1996-01-11 1997-11-04 Smithkline Beecham Corp Novel substituted imidazole compounds.
BR9809451A (pt) * 1997-05-22 2000-06-20 Searle & Co Pirazóis substituìdos com 3(5)-heteroarila como inibidores de quinase p38.
US6087496A (en) * 1998-05-22 2000-07-11 G. D. Searle & Co. Substituted pyrazoles suitable as p38 kinase inhibitors
WO1998052941A1 (en) * 1997-05-22 1998-11-26 G.D. Searle And Co. PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS
US6514977B1 (en) * 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
US6093742A (en) * 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
US6130235A (en) * 1998-05-22 2000-10-10 Scios Inc. Compounds and methods to treat cardiac failure and other disorders
CA2348885A1 (en) * 1998-11-06 2000-05-18 G.D. Searle & Co. Combination therapy of angiotensin converting enzyme inhibitor and aldosterone antagonist for reducing morbidity and mortality from cardiovascular disease
US6509361B1 (en) * 1999-05-12 2003-01-21 Pharmacia Corporation 1,5-Diaryl substituted pyrazoles as p38 kinase inhibitors
WO2003026662A1 (en) * 2001-09-25 2003-04-03 Pharmacia Corporation Solid-state forms of n-(2-hydroxyacetyl)-5-(4-piperidyl)-4-(4-pyrimidinyl)-3-(4-chlorophenyl)pyrazole
CN1321644C (zh) * 2001-09-25 2007-06-20 法玛西雅公司 制备取代的吡唑的方法
WO2003104223A1 (en) * 2002-06-05 2003-12-18 Pharmacia Corporation Pyrazole-derivatives as p38 kinase inhibitors

Also Published As

Publication number Publication date
WO2004075852A2 (en) 2004-09-10
TW200500361A (en) 2005-01-01
US20040167197A1 (en) 2004-08-26
WO2004075857A2 (en) 2004-09-10
WO2004075857A3 (en) 2005-08-18
TW200508226A (en) 2005-03-01
US20050203072A1 (en) 2005-09-15
WO2004075852A3 (en) 2005-07-28

Similar Documents

Publication Publication Date Title
CL2004000366A1 (es) USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA.
CL2007000601A1 (es) Compuestos derivados de heterobiciclos pirazolicos, inhibidores de la actividad de proteina tiroxina quinasa; composicion farmaceutica que comprende dichos compuestos; y uso de los compuestos en el tratamiento de una enfermedad hiperproliferativa.
EA200701790A1 (ru) Твёрдый фармацевтический дозированный состав
CL2009001936A1 (es) Compuestos derivados de piridazina, inhibidores de 11beta-hsd1; composicion farmaceutica; procedimiento de preparacion; y uso en el tratamiento de la diabetes, obesidad, dislipidemia, trastornos de ingestion de comida e hipertension (divisional de solicitud 1720-2006).
CR7583A (es) Nueva sal formiato de o-desmetil venlafaxina
RS52110B (en) DIPEPTIDIL PEPTIDASE INHIBITORS FOR TREATMENT OF DIABETES
ECSP066392A (es)
EA200100934A1 (ru) Применение ингибиторов cyp2d6 в комбинированных способах лечения
ATE451369T1 (de) Piperidinopyrimidindipeptidylpeptidaseinhibitor n zur behandlung von diabetes
SV2006002174A (es) Composicion de anticuerpo her2
CO5600999A2 (es) Composiciones farmaceuticas que comprenden inhibidores de valsartan y endopeptidasa neutra
PA8513601A1 (es) Composiciones farmaceuticas de inhibidores de la glucogenofosforilasa
TNSN06370A1 (fr) Derives de pyrimidine pour le traitement d'une croissance cellulaire anormale
BRPI0507652A (pt) composições farmacêuticas compreendendo um derivado de benzoidiazepina e um inibidor da proeìna de fusão de rsv
ATE541848T1 (de) Diaryl-purin, azapurine und deazapurine als nichtnukleoside reverse-transkriptase-inhibitoren zur behandlung von hiv
CO5660275A2 (es) Composicion que comprende un inhibidor de pde4 y un inhibidor de pde5
NO20071871L (no) Fosfoindoler som HIV-inhibitorer.
DK1296972T3 (da) Arylmethylamin-derivater til anvendelse som tryptaseinhibitorer
HRP20050510A2 (en) Microbicide substances
PA8586801A1 (es) Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
AR041713A1 (es) Una composicoin farmaceutica de duracion prolongada
DOP2000000022A (es) Combinacion de inhibidores de mtp e inhibidores de hmg-coa reductasa y su uso en medicametos.
RS52945B (en) PHARMACEUTICAL FORMULATIONS AND THEIR APPLICATION IN THE TREATMENT OF WOMEN SEXUAL DYSFUNCTION
CL2004001421A1 (es) Composicion farmaceutica que comprende un compuesto derivado de 1,4-dipiperidin-4-il-piperazina; y su uso para la prevencion y/o tratamiento del dolor.
AR046853A1 (es) Mezclas insecticidas que contienen triflumuron con actividad sinergica