CL2004000284A1 - Compuestos derivados de heterociclos biciclicos; composicion farmaceutica; procedimiento de preparacion; y uso para tratar tumores benignos o malignos, enfermedades de las vias respiratorias, del tracto gastrointestinal, conductos biliares, vesicula - Google Patents
Compuestos derivados de heterociclos biciclicos; composicion farmaceutica; procedimiento de preparacion; y uso para tratar tumores benignos o malignos, enfermedades de las vias respiratorias, del tracto gastrointestinal, conductos biliares, vesiculaInfo
- Publication number
- CL2004000284A1 CL2004000284A1 CL200400284A CL2004000284A CL2004000284A1 CL 2004000284 A1 CL2004000284 A1 CL 2004000284A1 CL 200400284 A CL200400284 A CL 200400284A CL 2004000284 A CL2004000284 A CL 2004000284A CL 2004000284 A1 CL2004000284 A1 CL 2004000284A1
- Authority
- CL
- Chile
- Prior art keywords
- diseases
- heterocicles
- vesicula
- malignum
- bicycle
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
LA PRESENTE INVENCIO SE REFIERE A HETEROCICLOS BICICLICOS DE FORMULA GENERAL EN LA QUE Ra,Rb,Rc,Rd,Re Y X SE DEFINEN COMO EN LA REIVINDICACION 1, SUS TAUTOMEROS SUS ESTEROISOMEROS, SU MEZCLAS Y SUS SALES, EN PARTICULAR SUS SALES FISIOLOGICAMENTE COMPATIBLES CON ACIDCOS INORGANICOS U ORGANICOS, LOS CUALES POSEEN VALIOSAS PROPIEDADES FARMACOLOGICAS, EN PARTICULAR UN EFECTO INHIBIDOR SOBRE LA TRANSDUCCION DE SENAL PROPORCIONADA POR LA TIROSINAQUINASAS, SU USO PARA EL TRTAMIENTO DE ENFERMEDADES, EN PARTICULAR DE ENFERMEDADES TUMORALES, ASI COMO DE LA HIPERPLASIA BENIGNA DE LA PROSTATA (BHP) DE ENFERMEDADES DE LOS PULMONES Y DE LAS VIAS RESIRATORIAS Y SU PREPARACION.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10307165A DE10307165A1 (de) | 2003-02-20 | 2003-02-20 | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, ihre Verwendung und Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2004000284A1 true CL2004000284A1 (es) | 2005-01-14 |
Family
ID=32797568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL200400284A CL2004000284A1 (es) | 2003-02-20 | 2004-02-18 | Compuestos derivados de heterociclos biciclicos; composicion farmaceutica; procedimiento de preparacion; y uso para tratar tumores benignos o malignos, enfermedades de las vias respiratorias, del tracto gastrointestinal, conductos biliares, vesicula |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1597240B1 (es) |
| JP (1) | JP4468305B2 (es) |
| KR (1) | KR20050103230A (es) |
| CN (1) | CN1751033A (es) |
| AR (1) | AR043249A1 (es) |
| AT (1) | ATE407929T1 (es) |
| AU (1) | AU2004213129A1 (es) |
| BR (1) | BRPI0407709A (es) |
| CA (1) | CA2516426A1 (es) |
| CL (1) | CL2004000284A1 (es) |
| DE (2) | DE10307165A1 (es) |
| ES (1) | ES2314374T3 (es) |
| MX (1) | MXPA05008780A (es) |
| NZ (1) | NZ542402A (es) |
| PE (1) | PE20040953A1 (es) |
| RU (1) | RU2005128826A (es) |
| TW (1) | TW200505912A (es) |
| UY (1) | UY28191A1 (es) |
| WO (1) | WO2004074263A1 (es) |
| ZA (1) | ZA200506121B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU90901A (sh) | 1999-06-21 | 2004-07-15 | Boehringer Ingelheim Pharma Gmbh. & Co.Kg. | Biciklični heterocikli, lekovi koji sadrže ta jedinjenja, njihova primena i postupci za njihovo pripremanje |
| US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
| EP1957468A2 (en) * | 2005-09-06 | 2008-08-20 | T.K. Signal Ltd. | Polyalkylene glycol derivatives of 4 - (phenylamino)quinazolines useful as irreversible inhibitors of epidermal growth factor receptor tyrosine kinase |
| EP1948180B1 (en) | 2005-11-11 | 2013-03-13 | Boehringer Ingelheim International GmbH | Combination treatment of cancer comprising egfr/her2 inhibitors |
| WO2007054550A1 (en) * | 2005-11-11 | 2007-05-18 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
| ES2397181T3 (es) * | 2006-01-26 | 2013-03-05 | Boehringer Ingelheim International Gmbh | Procedimiento para preparar derivados de quinazolina sustituida con aminocrotonilamino |
| US8877764B2 (en) | 2006-09-18 | 2014-11-04 | Boehringer Ingelheim International Gmbh | Method for treating cancer harboring EGFR mutations |
| CN102711472B (zh) | 2009-07-02 | 2015-12-02 | 江苏康缘药业股份有限公司 | 含磷的喹唑啉化合物及其使用方法 |
| US9545381B2 (en) | 2009-07-06 | 2017-01-17 | Boehringer Ingelheim International Gmbh | Process for drying of BIBW2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient |
| CN102020639A (zh) * | 2009-09-14 | 2011-04-20 | 上海恒瑞医药有限公司 | 6-氨基喹唑啉或3-氰基喹啉类衍生物、其制备方法及其在医药上的应用 |
| WO2012027445A1 (en) | 2010-08-26 | 2012-03-01 | Boehringer Ingelheim International Gmbh | Methods of administering an egfr inhibitor |
| CN102675287A (zh) * | 2011-03-11 | 2012-09-19 | 江苏恒瑞医药股份有限公司 | (e)-n-[4-[[3-氯-4-(2-吡啶基甲氧基)苯基]氨基]-3-氰基-7-乙氧基-6-喹啉基]-3-[(2r)-1-甲基吡咯烷-2-基]丙-2-烯酰胺的可药用的盐、其制备方法及其在医药上的应用 |
| US8828391B2 (en) | 2011-05-17 | 2014-09-09 | Boehringer Ingelheim International Gmbh | Method for EGFR directed combination treatment of non-small cell lung cancer |
| WO2013135176A1 (zh) * | 2012-03-16 | 2013-09-19 | 苏州迈泰生物技术有限公司 | 氨基喹唑啉衍生物及其在制备抗恶性肿瘤药物中的用途 |
| US9388160B2 (en) | 2011-10-12 | 2016-07-12 | Teligene Ltd | Quinazoline derivatives as kinases inhibitors and methods of use thereof |
| US20150368230A1 (en) | 2013-02-01 | 2015-12-24 | Boehringer Ingelheim International Gmbh | Radiolabeled quinazoline derivatives |
| US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
| EP3402536A4 (en) | 2016-01-13 | 2019-07-03 | Hadasit Medical Research Services And Development Limited | RADIOACTIVELY MARKED ERLOTINIB ANALOGUES AND USES THEREOF |
| TWI808958B (zh) | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
| TWI820414B (zh) * | 2020-04-17 | 2023-11-01 | 大陸商北京賽特明強醫藥科技有限公司 | 喹唑啉類化合物、製備方法及其應用 |
| CN115806548B (zh) * | 2021-09-15 | 2024-10-11 | 甫康（上海）健康科技有限责任公司 | 含有egfr抑制剂的药物组合物及其制备方法和应用 |
| TWI847289B (zh) * | 2021-09-30 | 2024-07-01 | 大陸商北京賽特明強醫藥科技有限公司 | 喹唑啉類化合物、組合物及其應用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19911509A1 (de) * | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE10042060A1 (de) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE10063435A1 (de) * | 2000-12-20 | 2002-07-04 | Boehringer Ingelheim Pharma | Chinazolinderviate,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
-
2003
- 2003-02-20 DE DE10307165A patent/DE10307165A1/de not_active Withdrawn
-
2004
- 2004-02-14 WO PCT/EP2004/001398 patent/WO2004074263A1/de active IP Right Grant
- 2004-02-14 MX MXPA05008780A patent/MXPA05008780A/es not_active Application Discontinuation
- 2004-02-14 AT AT04711303T patent/ATE407929T1/de active
- 2004-02-14 ES ES04711303T patent/ES2314374T3/es not_active Expired - Lifetime
- 2004-02-14 EP EP04711303A patent/EP1597240B1/de not_active Expired - Lifetime
- 2004-02-14 KR KR1020057015218A patent/KR20050103230A/ko not_active Application Discontinuation
- 2004-02-14 NZ NZ542402A patent/NZ542402A/en unknown
- 2004-02-14 BR BRPI0407709-1A patent/BRPI0407709A/pt not_active IP Right Cessation
- 2004-02-14 AU AU2004213129A patent/AU2004213129A1/en not_active Abandoned
- 2004-02-14 CN CNA2004800047746A patent/CN1751033A/zh active Pending
- 2004-02-14 CA CA002516426A patent/CA2516426A1/en not_active Abandoned
- 2004-02-14 DE DE502004008024T patent/DE502004008024D1/de not_active Expired - Lifetime
- 2004-02-14 RU RU2005128826/04A patent/RU2005128826A/ru not_active Application Discontinuation
- 2004-02-14 JP JP2005518423A patent/JP4468305B2/ja not_active Expired - Fee Related
- 2004-02-18 PE PE2004000166A patent/PE20040953A1/es not_active Application Discontinuation
- 2004-02-18 TW TW093103966A patent/TW200505912A/zh unknown
- 2004-02-18 UY UY28191A patent/UY28191A1/es not_active Application Discontinuation
- 2004-02-18 CL CL200400284A patent/CL2004000284A1/es unknown
- 2004-02-20 AR ARP040100540A patent/AR043249A1/es unknown
-
2005
- 2005-08-01 ZA ZA200506121A patent/ZA200506121B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200506121B (en) | 2006-11-29 |
| RU2005128826A (ru) | 2006-08-27 |
| TW200505912A (en) | 2005-02-16 |
| JP4468305B2 (ja) | 2010-05-26 |
| CA2516426A1 (en) | 2004-09-02 |
| AU2004213129A1 (en) | 2004-09-02 |
| JP2006515005A (ja) | 2006-05-18 |
| UY28191A1 (es) | 2004-09-30 |
| DE502004008024D1 (de) | 2008-10-23 |
| NZ542402A (en) | 2008-09-26 |
| MXPA05008780A (es) | 2005-10-18 |
| DE10307165A1 (de) | 2004-09-02 |
| ATE407929T1 (de) | 2008-09-15 |
| KR20050103230A (ko) | 2005-10-27 |
| CN1751033A (zh) | 2006-03-22 |
| AR043249A1 (es) | 2005-07-20 |
| BRPI0407709A (pt) | 2006-02-14 |
| EP1597240B1 (de) | 2008-09-10 |
| ES2314374T3 (es) | 2009-03-16 |
| EP1597240A1 (de) | 2005-11-23 |
| PE20040953A1 (es) | 2005-01-20 |
| WO2004074263A1 (de) | 2004-09-02 |
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