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CA3083741A1 - Polytherapie et prophylaxie contre des infections du tractus genital - Google Patents

Polytherapie et prophylaxie contre des infections du tractus genital Download PDF

Info

Publication number
CA3083741A1
CA3083741A1 CA3083741A CA3083741A CA3083741A1 CA 3083741 A1 CA3083741 A1 CA 3083741A1 CA 3083741 A CA3083741 A CA 3083741A CA 3083741 A CA3083741 A CA 3083741A CA 3083741 A1 CA3083741 A1 CA 3083741A1
Authority
CA
Canada
Prior art keywords
mice
omv
gonorrhoeae
infection
blank
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3083741A
Other languages
English (en)
Inventor
Michael W. Russell
Yingru LIU
Nejat K. Egilmez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of the State University of New York
Original Assignee
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/824,700 external-priority patent/US20180071379A1/en
Priority claimed from US16/138,526 external-priority patent/US20190008941A1/en
Application filed by Research Foundation of the State University of New York filed Critical Research Foundation of the State University of New York
Publication of CA3083741A1 publication Critical patent/CA3083741A1/fr
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/208IL-12
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/095Neisseria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • A61K2039/543Mucosal route intranasal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons
    • A61K2039/55527Interleukins
    • A61K2039/55538IL-12

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne une méthode pour traiter et réduire la récurrence d'infections du tractus génital telles que des infections gonococciques. La méthode comprend l'application locale d'IL-12 incorporée dans des microsphères polymères. L'invention concerne également une méthode pour réduire l'incidence d'infections du tractus génital provoquées par N. gonorrhoeae par l'administration de préparations de vésicules de membrane externe de N. gonorrhoeae et d'IL-12 incorporée dans des microsphères polymères.
CA3083741A 2017-11-28 2018-11-27 Polytherapie et prophylaxie contre des infections du tractus genital Pending CA3083741A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15/824,700 2017-11-28
US15/824,700 US20180071379A1 (en) 2012-05-29 2017-11-28 Combined therapy and prophylaxis for genital tract infections
US16/138,526 US20190008941A1 (en) 2012-05-29 2018-09-21 Combined therapy and prophylaxis for genital tract infections
US16/138,526 2018-09-21
PCT/US2018/062590 WO2019108528A1 (fr) 2017-11-28 2018-11-27 Polythérapie et prophylaxie contre des infections du tractus génital

Publications (1)

Publication Number Publication Date
CA3083741A1 true CA3083741A1 (fr) 2019-06-19

Family

ID=66665780

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3083741A Pending CA3083741A1 (fr) 2017-11-28 2018-11-27 Polytherapie et prophylaxie contre des infections du tractus genital

Country Status (7)

Country Link
EP (1) EP3716995A4 (fr)
JP (1) JP2021504478A (fr)
CN (1) CN111698998A (fr)
AU (1) AU2018375133A1 (fr)
CA (1) CA3083741A1 (fr)
MX (1) MX2020007237A (fr)
WO (1) WO2019108528A1 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2281570A3 (fr) * 2000-01-17 2012-05-09 Novartis Vaccines and Diagnostics S.r.l. Vaccin OMV contre le méningocoque contenant des vésicules membranaires
US7892567B2 (en) * 2007-10-01 2011-02-22 Board Of Regents, The University Of Texas System Methods and compositions for immunization against chlamydial infection and disease
WO2013181224A1 (fr) * 2012-05-29 2013-12-05 The Research Foundation For The State University Of New York Thérapie combinée et prophylaxie pour les infections du tractus génital

Also Published As

Publication number Publication date
EP3716995A1 (fr) 2020-10-07
AU2018375133A1 (en) 2020-06-18
MX2020007237A (es) 2020-09-25
CN111698998A (zh) 2020-09-22
JP2021504478A (ja) 2021-02-15
EP3716995A4 (fr) 2021-08-25
WO2019108528A1 (fr) 2019-06-06

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Effective date: 20231020