CA2900110A1 - Epitopes de proteine f du virus respiratoire syncytial - Google Patents
Epitopes de proteine f du virus respiratoire syncytial Download PDFInfo
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- CA2900110A1 CA2900110A1 CA2900110A CA2900110A CA2900110A1 CA 2900110 A1 CA2900110 A1 CA 2900110A1 CA 2900110 A CA2900110 A CA 2900110A CA 2900110 A CA2900110 A CA 2900110A CA 2900110 A1 CA2900110 A1 CA 2900110A1
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- protein
- rsv
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- epitope
- amino acids
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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Abstract
Le virus respiratoire syncytial est un virus de rhume commun appartenant à la famille des paramixovirus. Le VRS est virulent, facilement transmissible et constitue la cause la plus courante de maladie des voies respiratoires inférieures chez les enfants de moins de 2 ans. Jusqu'à 98 % des enfants recevant des soins de jour vont être infectés en une seule saison de VRS. Entre 0,5 % et 3,2 % des enfants ayant contracté d'une infection par le VRS doivent être hospitalisés. Environ 90 000 admissions à l'hôpital et 4500 décès par an ont été rapportés aux Etats Unis. Les facteurs de risque majeurs pour l'hospitalisation due au VRS sont la naissance prématurée, une maladie pulmonaire chronique, une maladie cardiaque congénitale, un système immunitaire affaibli et un âge inférieur à 6 semaines chez des enfants par ailleurs sains.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361759664P | 2013-02-01 | 2013-02-01 | |
| US61/759,664 | 2013-02-01 | ||
| US201361783380P | 2013-03-14 | 2013-03-14 | |
| US61/783,380 | 2013-03-14 | ||
| PCT/US2014/014054 WO2014121021A1 (fr) | 2013-02-01 | 2014-01-31 | Épitopes de protéine f du virus respiratoire syncytial |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2900110A1 true CA2900110A1 (fr) | 2014-08-07 |
Family
ID=51262966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2900110A Abandoned CA2900110A1 (fr) | 2013-02-01 | 2014-01-31 | Epitopes de proteine f du virus respiratoire syncytial |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10016496B2 (fr) |
| EP (1) | EP2950886B1 (fr) |
| JP (1) | JP6450688B2 (fr) |
| CN (1) | CN105073196B (fr) |
| AU (1) | AU2014212268B2 (fr) |
| CA (1) | CA2900110A1 (fr) |
| CY (1) | CY1122937T1 (fr) |
| DK (1) | DK2950886T3 (fr) |
| ES (1) | ES2778899T3 (fr) |
| HR (1) | HRP20200404T1 (fr) |
| LT (1) | LT2950886T (fr) |
| PL (1) | PL2950886T3 (fr) |
| PT (1) | PT2950886T (fr) |
| RS (1) | RS60056B1 (fr) |
| SI (1) | SI2950886T1 (fr) |
| WO (1) | WO2014121021A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1997830A1 (fr) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | Molécules à liaison spécifiques RSV et leur moyen de fabrication |
| TWI659968B (zh) | 2013-03-14 | 2019-05-21 | 再生元醫藥公司 | 針對呼吸道融合病毒ｆ蛋白質的人類抗體及其使用方法 |
| EP3741390A1 (fr) | 2014-01-15 | 2020-11-25 | Medlmmune, LLC | Anticorps spécifique du rsv et parties fonctionnelles de ceux-ci |
| JO3555B1 (ar) | 2015-10-29 | 2020-07-05 | Merck Sharp & Dohme | جسم مضاد يبطل فعالية فيروس الالتهاب الرئوي البشري |
| EP3529272A2 (fr) * | 2016-10-21 | 2019-08-28 | Adimab, LLC | Anticorps contre le virus respiratoire syncytial et leurs méthodes de génération et d'utilisation |
| MX2019004448A (es) | 2016-10-21 | 2019-08-14 | Adimab Llc | Anticuerpos anti-virus respiratorio sincitial y metodos de generacion y uso de estos. |
| CA3040893A1 (fr) * | 2016-10-21 | 2018-04-26 | Adimab, Llc | Anticorps anti-virus respiratoire syncytial, et leurs procedes de generation et d'utilisation |
| TWI683826B (zh) * | 2016-11-22 | 2020-02-01 | 國立臺灣大學 | 重組ｒｓｖ抗原 |
| TW202228779A (zh) | 2017-03-01 | 2022-08-01 | 英商梅迪繆思有限公司 | 抗rsv單株抗體配製物 |
| US12024553B2 (en) | 2019-04-30 | 2024-07-02 | Medimmune Limited | Dosage regimens for and compositions including anti-RSV antibodies |
| CN111208307B (zh) * | 2020-04-21 | 2020-07-17 | 上海普铭生物科技有限公司 | 一种与参照分子具有相同或不同的靶蛋白结合的分子的筛选方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| AU2001263443A1 (en) * | 2000-05-25 | 2001-12-03 | Med Immune, Inc. | F-protein epitope-based vaccine for respiratory syncytial virus infection |
| EP1997830A1 (fr) * | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | Molécules à liaison spécifiques RSV et leur moyen de fabrication |
| CA2721246A1 (fr) | 2008-04-18 | 2009-10-22 | Vaxinnate Corporation | Mutants par deletion de la flagelline et procedes d'utilisation |
| EP2408477A4 (fr) | 2009-03-16 | 2013-03-27 | Sanofi Pasteur Biologics Llc | Vecteurs de vaccin anti-flavivirus à réplication déficiente contre un virus syncytial respiratoire |
| US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
| CN102712692B (zh) | 2009-10-06 | 2014-12-31 | 医学免疫有限公司 | Rsv-特异性结合分子 |
| EP2496609A4 (fr) * | 2009-11-03 | 2013-05-08 | Ligocyte Pharmaceuticals Inc | Particules de type viral (vlp) chimériques à base de gag de polypeptide rsv-f et de lentivirus ou alpharétrovirus |
| WO2012089231A1 (fr) | 2010-12-30 | 2012-07-05 | Okairòs Ag | Vaccins contre les paramyxovirus |
| US9738689B2 (en) | 2013-03-13 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| SI2970398T1 (sl) | 2013-03-13 | 2024-09-30 | The United States of America, as represented by the Secretary, Deparment of Health and Human Services | Prefuzijski proteini RSV in njihova uporaba |
| US9060975B2 (en) | 2013-03-14 | 2015-06-23 | Mucosis Bv | Heat-stable respiratory syncytial virus F protein oligomers and their use in immunological compositions |
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2014
- 2014-01-31 DK DK14746750.0T patent/DK2950886T3/da active
- 2014-01-31 CA CA2900110A patent/CA2900110A1/fr not_active Abandoned
- 2014-01-31 AU AU2014212268A patent/AU2014212268B2/en active Active
- 2014-01-31 WO PCT/US2014/014054 patent/WO2014121021A1/fr active Application Filing
- 2014-01-31 US US14/764,635 patent/US10016496B2/en active Active
- 2014-01-31 EP EP14746750.0A patent/EP2950886B1/fr active Active
- 2014-01-31 CN CN201480007046.4A patent/CN105073196B/zh active Active
- 2014-01-31 PL PL14746750T patent/PL2950886T3/pl unknown
- 2014-01-31 LT LTEP14746750.0T patent/LT2950886T/lt unknown
- 2014-01-31 SI SI201431530T patent/SI2950886T1/sl unknown
- 2014-01-31 RS RS20200305A patent/RS60056B1/sr unknown
- 2014-01-31 ES ES14746750T patent/ES2778899T3/es active Active
- 2014-01-31 JP JP2015556154A patent/JP6450688B2/ja active Active
- 2014-01-31 PT PT147467500T patent/PT2950886T/pt unknown
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2020
- 2020-03-12 HR HRP20200404TT patent/HRP20200404T1/hr unknown
- 2020-03-18 CY CY20201100248T patent/CY1122937T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2778899T3 (es) | 2020-08-12 |
| JP2016508503A (ja) | 2016-03-22 |
| SI2950886T1 (sl) | 2020-06-30 |
| JP6450688B2 (ja) | 2019-01-09 |
| CY1122937T1 (el) | 2020-10-14 |
| PL2950886T3 (pl) | 2020-06-01 |
| AU2014212268B2 (en) | 2018-07-19 |
| HRP20200404T1 (hr) | 2020-06-12 |
| PT2950886T (pt) | 2020-03-26 |
| CN105073196B (zh) | 2020-04-07 |
| EP2950886A1 (fr) | 2015-12-09 |
| LT2950886T (lt) | 2020-07-10 |
| CN105073196A (zh) | 2015-11-18 |
| EP2950886A4 (fr) | 2016-09-07 |
| RS60056B1 (sr) | 2020-04-30 |
| AU2014212268A1 (en) | 2015-08-20 |
| WO2014121021A1 (fr) | 2014-08-07 |
| DK2950886T3 (da) | 2020-03-23 |
| EP2950886B1 (fr) | 2019-12-18 |
| US10016496B2 (en) | 2018-07-10 |
| US20150366960A1 (en) | 2015-12-24 |
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