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CA2894918A1 - Structure d'accepteur pour greffe cdr - Google Patents

Structure d'accepteur pour greffe cdr Download PDF

Info

Publication number
CA2894918A1
CA2894918A1 CA2894918A CA2894918A CA2894918A1 CA 2894918 A1 CA2894918 A1 CA 2894918A1 CA 2894918 A CA2894918 A CA 2894918A CA 2894918 A CA2894918 A CA 2894918A CA 2894918 A1 CA2894918 A1 CA 2894918A1
Authority
CA
Canada
Prior art keywords
immunobinder
framework
antibody
heavy chain
acceptor framework
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2894918A
Other languages
English (en)
Inventor
Dominik Escher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esbatech a Novartis Co LLC
Original Assignee
Esbatech a Novartis Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esbatech a Novartis Co LLC filed Critical Esbatech a Novartis Co LLC
Publication of CA2894918A1 publication Critical patent/CA2894918A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2894918A 2013-02-15 2013-02-15 Structure d'accepteur pour greffe cdr Abandoned CA2894918A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2013/053039 WO2014124677A1 (fr) 2013-02-15 2013-02-15 Structure d'accepteur pour greffe cdr

Publications (1)

Publication Number Publication Date
CA2894918A1 true CA2894918A1 (fr) 2014-08-21

Family

ID=47716049

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2894918A Abandoned CA2894918A1 (fr) 2013-02-15 2013-02-15 Structure d'accepteur pour greffe cdr

Country Status (8)

Country Link
EP (1) EP2956478A1 (fr)
JP (1) JP2016506974A (fr)
CN (1) CN104884470A (fr)
AU (1) AU2013378628A1 (fr)
CA (1) CA2894918A1 (fr)
HK (1) HK1217960A1 (fr)
RU (1) RU2015139095A (fr)
WO (1) WO2014124677A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10125198B2 (en) 2015-04-17 2018-11-13 Distributed Bio, Inc. Method for mass humanization of non-human antibodies
CN108473987B (zh) * 2016-01-08 2024-01-02 马可讯治疗有限公司 具有改变的多样性支架结构域的结合成员

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4704362A (en) 1977-11-08 1987-11-03 Genentech, Inc. Recombinant cloning vehicle microbial polypeptide expression
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
EP0279582A3 (fr) 1987-02-17 1989-10-18 Pharming B.V. Séquences d'ADN pour diriger des protéines vers les glandes mammaires afin d'être sécrétées efficacement
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5633076A (en) 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
CA2126967A1 (fr) 1992-11-04 1994-05-11 Anna M. Wu Nouvelle construction d'anticorps
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
US6905668B1 (en) 1998-09-25 2005-06-14 Tokyo Gas Company Limited Diagnostic agents for pancreatic exocrine function
EP1479694B1 (fr) 1999-12-28 2016-10-26 ESBATech, an Alcon Biomedical Research Unit LLC Anticorps simple chaine ScFv avec des structures définies (régions d'encadrement) stable dans un environnement réducteur
WO2002002781A1 (fr) 2000-06-30 2002-01-10 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Proteines de fusion heterodimeres
EP1506236B1 (fr) 2002-05-22 2013-01-23 ESBATech - a Novartis Company LLC Infrastructures immunoglobuliniques faisant preuve de stabilit accrue en environnement intracellulaire, et proc d s d'identification correspondants
AU2003264009A1 (en) 2002-08-15 2004-03-03 Epitomics, Inc. Humanized rabbit antibodies
AU2003259718A1 (en) 2003-08-07 2005-03-07 Epitomics, Inc. Methods for humanizing rabbit monoclonal antibodies
US7429487B2 (en) 2005-07-05 2008-09-30 Epitomics, Inc. Fusion partner for production of monoclonal rabbit antibodies
CA2652392C (fr) * 2006-05-19 2017-10-10 Alder Biopharmaceuticals, Inc. Procede de culture permettant d'obtenir une population clonee de lymphocytes b specifiques d'antigene
WO2008144753A2 (fr) * 2007-05-21 2008-11-27 Alder Biopharmaceuticals, Inc. Anticorps anti-tnf alpha et leur utilisation
TWI501976B (zh) 2007-05-21 2015-10-01 Alder Biopharmaceuticals Inc 抗ＴＮＦ－α之抗體及其用途
ES2861592T3 (es) * 2008-06-25 2021-10-06 Novartis Ag Anticuerpos estables y solubles que inhiben el TNF
PT3241843T (pt) * 2008-06-25 2021-09-10 Novartis Ag Otimização da solubilidade de imunoligantes
KR101956059B1 (ko) * 2008-06-25 2019-03-08 에스바테크 - 어 노바티스 컴파니 엘엘씨 보편적 항체 프레임워크를 사용한 래빗 항체의 인간화
US8399624B1 (en) * 2009-06-25 2013-03-19 Esbatech, An Alcon Biomedical Research Unit Llc Acceptor framework for CDR grafting

Also Published As

Publication number Publication date
EP2956478A1 (fr) 2015-12-23
AU2013378628A1 (en) 2015-06-11
RU2015139095A (ru) 2017-03-21
JP2016506974A (ja) 2016-03-07
WO2014124677A1 (fr) 2014-08-21
CN104884470A (zh) 2015-09-02
HK1217960A1 (zh) 2017-01-27

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20190215