CA2780547C - Spiro-oxindole mdm2 antagonists - Google Patents

Spiro-oxindole mdm2 antagonists Download PDF

Info

Publication number: CA2780547C
Authority: CA; Canada
Prior art keywords: optionally substituted; group; hydrogen; alkyl; compound
Prior art date: 2009-11-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA2780547A

Other languages

English (en)

French (fr)

Other versions

CA2780547A1 (en

Inventor

Shaomeng Wang

Shanghai Yu

Wei Sun

Sanjeev Kumar

Duxin Sun

Peng Zou

Yujun Zhao

Donna Mceachern

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Michigan

Original Assignee

University of Michigan

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-11-12

Filing date

2010-11-10

Publication date

2015-02-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43974649&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2780547(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-11-10 Application filed by University of Michigan filed Critical University of Michigan

2011-05-19 Publication of CA2780547A1 publication Critical patent/CA2780547A1/en

2015-02-03 Application granted granted Critical

2015-02-03 Publication of CA2780547C publication Critical patent/CA2780547C/en

Status Expired - Fee Related legal-status Critical Current

2030-11-10 Anticipated expiration legal-status Critical

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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Publication number	Publication date
WO2011060049A3 (en)	2011-10-20
ZA201203323B (en)	2013-01-30
US9079913B2 (en)	2015-07-14
AR079026A1 (es)	2011-12-21
IL219706A (en)	2016-07-31
AU2010319595A1 (en)	2012-06-28
PE20121282A1 (es)	2012-10-12
IL219706A0 (en)	2012-07-31
NZ600430A (en)	2014-06-27
TWI508967B (zh)	2015-11-21
MA33815B1 (fr)	2012-12-03
US8877796B2 (en)	2014-11-04
WO2011060049A2 (en)	2011-05-19
CL2012001250A1 (es)	2012-11-30
US20110112052A1 (en)	2011-05-12
KR20120099462A (ko)	2012-09-10
BR112012011317A2 (pt)	2019-09-24
TW201129570A (en)	2011-09-01
RU2012124056A (ru)	2013-12-20
ECSP12011943A (es)	2012-07-31
UY33029A (es)	2011-06-30
CN102712650A (zh)	2012-10-03
CR20120313A (es)	2012-07-24
EP2499145A4 (de)	2013-07-10
NI201200083A (es)	2012-10-29
CN102712650B (zh)	2015-05-20
DOP2012000131A (es)	2012-09-30
UA107814C2 (uk)	2015-02-25
MX2012005507A (es)	2012-07-03
TN2012000161A1 (en)	2013-12-12
US20130296303A1 (en)	2013-11-07
CO6501131A2 (es)	2012-08-15
US20140378680A1 (en)	2014-12-25
CN104876938A (zh)	2015-09-02
EP2499145A2 (de)	2012-09-19
AU2010319595B2 (en)	2015-09-17
JP2013510860A (ja)	2013-03-28
GT201200147A (es)	2014-08-26
US8518984B2 (en)	2013-08-27
RU2553269C2 (ru)	2015-06-10
CA2780547A1 (en)	2011-05-19
EP2499145B1 (de)	2016-01-27

Publication	Publication Date	Title
CA2780547C (en)	2015-02-03	Spiro-oxindole mdm2 antagonists
AU2011326395B2 (en)	2016-01-07	Spiro-oxindole MDM2 antagonists
EP2707372B1 (de)	2016-12-21	Spiro-oxindol-mdm2-antagonisten
CA2945527C (en)	2022-05-17	Mdm2 inhibitors and therapeutic methods using the same
US20230041761A1 (en)	2023-02-09	Small molecule modulators of sigma-1 and sigma-2 receptors and uses thereof
EP4427812A2 (de)	2024-09-11	Substituierte bicyclische und tetracyclische chinone und zugehörige verfahren zur verwendung
OA16409A (en)	2015-10-07	Spiro-oxindole MDM2 antagonists.
NZ617580B2 (en)	2015-11-03	Spiro-oxindole mdm2 antagonists

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