[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

CA2666570A1 - Manufacturing method of radioactive molybdenum, manufacturing apparatus and radioactive molybdenum manufactured thereby - Google Patents

Manufacturing method of radioactive molybdenum, manufacturing apparatus and radioactive molybdenum manufactured thereby Download PDF

Info

Publication number
CA2666570A1
CA2666570A1 CA002666570A CA2666570A CA2666570A1 CA 2666570 A1 CA2666570 A1 CA 2666570A1 CA 002666570 A CA002666570 A CA 002666570A CA 2666570 A CA2666570 A CA 2666570A CA 2666570 A1 CA2666570 A1 CA 2666570A1
Authority
CA
Canada
Prior art keywords
solution
water
nuclear reactor
dissolved
natural isotopic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002666570A
Other languages
French (fr)
Other versions
CA2666570C (en
Inventor
Etsuo Ishitsuka
Katsuyoshi Tatenuma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KAKEN Inc
Japan Atomic Energy Agency
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2666570A1 publication Critical patent/CA2666570A1/en
Application granted granted Critical
Publication of CA2666570C publication Critical patent/CA2666570C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/02—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes in nuclear reactors
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001—Recovery of specific isotopes from irradiated targets
    • G21G2001/0036—Molybdenum

Landscapes

  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plasma & Fusion (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Manufacture And Refinement Of Metals (AREA)
  • Monitoring And Testing Of Nuclear Reactors (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

An efficient process for producing radioactive molybdenum 99Mo being a parent nuclide of radioactive technetium (99mTc) as a radioactive diagnostic agent, in which uranium is not used as a raw material. Efficient production of 99Mo is carried out by irradiating with neutron an aqueous solution of Mo having an Mo compound dissolved in water in an irradiation capsule installed in a nuclear reactor core so as to generate 99Mo through 98Mo(n,.gamma.) reaction and recovering the aqueous solution of Mo continuously or batchwise.

Claims (5)

  1. [Claim 1]

    A method of manufacturing radioactive molybdenum comprising the steps of:
    irradiating neutrons in a nuclear reactor to Mo solution in which Mo compound containing 98Mo of the natural isotopic ratio is dissolved in water, or Mo solution in which 98Mo is concentrated more than the natural isotopic ratio is dissolved in water to produce 99Mo in the Mo solution by the radioactivation of 98Mo; and collecting the Mo solution to obtain 99Mo.
  2. [Claim 2]

    A method of manufacturing radioactive molybdenum comprising the steps of:
    circulating or feeding Mo solution in which Mo compound containing 98Mo of the natural isotopic ratio is dissolved in water, or Mo solution in which 98Mo is concentrated more than the natural isotopic ratio is dissolved in water inside of a nuclear reactor by using a pump to produce 99Mo in said Mo solution by radioactivating 98Mo with neutrons in the nuclear reactor, and collecting said Mo solution in continuous or batch processing to obtain 99Mo.
  3. [Claim 3] (Deleted)
  4. [Claim 4]

    The method of manufacturing 99Mo according to claim 1 or 2, which comprises the steps of irradiating neutrons in a nuclear reactor to Mo solution in which either Mo compound containing 98Mo of the natural isotopic ratio or Mo compound in which 98Mo is concentrated more than the natural isotopic ratio is dissolved in water, the method further comprises the steps of:
    extracting continuously or periodically hydrogen and oxygen gases generated by the radiolysis of water when neutrons are irradiated to said Mo solution in the nuclear reactor; and purging the hydrogen and oxygen with inert gas to dispose of them.
  5. [Claim 5]

    The method of manufacturing 99Mo according to claim 1 or 2, which comprises the steps of irradiating neutrons in a nuclear reactor to Mo solution in which either Mo compound containing 98Mo of the natural isotopic ratio or Mo compound in which 98Mo is concentrated more than the natural isotopic ratio is dissolved in water, the method further comprises the steps of:
    extracting continuously or periodically hydrogen and oxygen gases generated by the radiolysis of water when neutrons are irradiated to said Mo solution in the nuclear reactor;
    collecting after reuniting the hydrogen and oxygen with catalyst to return to water; and collecting to remove hydrogen and oxygen obtained by decomposing in radiation the water in which the Mo compound is dissolved.
CA2666570A 2006-10-20 2007-10-19 Manufacturing method of radioactive molybdenum, manufacturing apparatus and radioactive molybdenum manufactured thereby Expired - Fee Related CA2666570C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006-286159 2006-10-20
JP2006286159A JP4618732B2 (en) 2006-10-20 2006-10-20 Method and apparatus for manufacturing radioactive molybdenum
PCT/JP2007/070863 WO2008047946A1 (en) 2006-10-20 2007-10-19 Process for producing radioactive molybdenum, apparatus therefor and radioactive molybdenum produced by the process

Publications (2)

Publication Number Publication Date
CA2666570A1 true CA2666570A1 (en) 2008-04-24
CA2666570C CA2666570C (en) 2011-11-15

Family

ID=39314153

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2666570A Expired - Fee Related CA2666570C (en) 2006-10-20 2007-10-19 Manufacturing method of radioactive molybdenum, manufacturing apparatus and radioactive molybdenum manufactured thereby

Country Status (5)

Country Link
EP (1) EP2104113B1 (en)
JP (1) JP4618732B2 (en)
AT (1) ATE541297T1 (en)
CA (1) CA2666570C (en)
WO (1) WO2008047946A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106128539A (en) * 2016-08-30 2016-11-16 中广核研究院有限公司 A kind of system utilizing pressurized-water reactor nuclear power plant to produce medical short-lived phase radioactive source

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2294582T3 (en) 2008-05-02 2019-02-28 Shine Medical Technologies, Inc. Device and method for producing medical isotopes
EP2131369A1 (en) * 2008-06-06 2009-12-09 Technische Universiteit Delft A process for the production of no-carrier added 99Mo
CN101685680B (en) * 2008-09-27 2011-11-09 中国核动力研究设计院 Uniform inner heat source simulator of medical isotope production solution reactor
JP5569834B2 (en) * 2009-01-30 2014-08-13 独立行政法人日本原子力研究開発機構 Method for producing high density, high purity (n, γ) 99Mo
US8699651B2 (en) * 2009-04-15 2014-04-15 Ge-Hitachi Nuclear Energy Americas Llc Method and system for simultaneous irradiation and elution capsule
JP5427483B2 (en) 2009-06-19 2014-02-26 株式会社化研 Concentration, elution recovery method, and system of radiotechnetium as a raw material for radiopharmaceuticals and their labeled compounds
JP5403605B2 (en) * 2009-06-29 2014-01-29 独立行政法人日本原子力研究開発機構 Radiation irradiation equipment
JP5598900B2 (en) * 2009-11-20 2014-10-01 独立行政法人日本原子力研究開発機構 High purity 99mTc concentration method and concentration apparatus
WO2012003009A2 (en) 2010-01-28 2012-01-05 Shine Medical Technologies, Inc. Segmented reaction chamber for radioisotope production
DE102010006433B4 (en) * 2010-02-01 2012-03-29 Siemens Aktiengesellschaft Method and device for producing two different radioactive isotopes
DE102010006435B3 (en) * 2010-02-01 2011-07-21 Siemens Aktiengesellschaft, 80333 Method and apparatus for the production of 99mTc
PL2599087T3 (en) * 2010-07-29 2019-03-29 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Isotope production target
WO2012039036A1 (en) * 2010-09-22 2012-03-29 独立行政法人放射線医学総合研究所 Process and device for production of radionuclide using accelerator
KR101138445B1 (en) * 2011-03-04 2012-04-26 한국원자력연구원 A method for preparing low enriched and plate shaped uranium target with high density, and low enriched uranium target with high density prepared by the method
US10734126B2 (en) 2011-04-28 2020-08-04 SHINE Medical Technologies, LLC Methods of separating medical isotopes from uranium solutions
JP5916082B2 (en) * 2011-12-23 2016-05-11 株式会社化研 99mTc recovery method and 99mTc recovery device
JP5916083B2 (en) * 2011-12-23 2016-05-11 株式会社化研 99mTc recovery device
JP5916084B2 (en) * 2011-12-23 2016-05-11 株式会社化研 Purified Mo solution preparation method for preparation and purified Mo solution preparation apparatus for preparation
RU2490737C1 (en) * 2012-03-29 2013-08-20 Федеральное государственное бюджетное учреждение "Национальный исследовательский центр "Курчатовский институт" Method for obtaining molybdenum-99 radioisotope
WO2013187974A2 (en) 2012-04-05 2013-12-19 Shine Medical Technologies, Inc. Aqueous assembly and control method
EP2929541B1 (en) * 2012-12-10 2017-07-19 Ge-Hitachi Nuclear Energy Americas LLC Systems and methods for harvesting and storing materials produced in a nuclear reactor
RU2578039C1 (en) * 2014-12-18 2016-03-20 Федеральное государственное бюджетное учреждение "Национальный исследовательский центр "Курчатовский институт" Method of producing nanostructured target for production of molybdenum-99 radioisotope
RU2588594C1 (en) * 2015-06-15 2016-07-10 Российская Федерация, от имени которой выступает Государственная корпорация по атомной энергии "Росатом" Method of producing nanostructured target for producing molybdenum-99 radioisotopes
RU2666552C1 (en) * 2017-12-19 2018-09-11 Федеральное государственное бюджетное учреждение "Национальный исследовательский центр "Курчатовский институт" Method of producing nanostructured target for production of molybdenum-99
RU2688196C9 (en) * 2018-07-02 2019-07-09 Акционерное общество "Радиевый институт имени В.Г. Хлопина" The method of producing radioisotope molybdenum-99
RU2690692C1 (en) * 2018-11-21 2019-06-05 Федеральное государственное бюджетное учреждение "Национальный исследовательский центр "Курчатовский институт" METHOD OF PRODUCING NANOSTRUCTURED TARGET FOR PRODUCTION OF RADONUCLIDE Mo-99
JP7194637B2 (en) * 2019-05-09 2022-12-22 株式会社日立製作所 Radionuclide production device and radionuclide production method
RU2735646C1 (en) * 2020-05-15 2020-11-05 Акционерное Общество "Производственное Объединение "Электрохимический завод" (АО "ПО ЭХЗ") Method of producing nanostructured target for production of radionuclide molybdenum-99
JP2022069253A (en) * 2020-10-23 2022-05-11 三菱重工業株式会社 Production management device, production management method and production management program of radioisotope
CN114121330B (en) * 2021-11-11 2024-05-14 中国核动力研究设计院 Molybdenum technetium generator, preparation method and device

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6057040B2 (en) * 1978-08-02 1985-12-12 日本原子力研究所 Method for producing molybdenum-99 using molybdenum trioxide pellets
US4990787A (en) * 1989-09-29 1991-02-05 Neorx Corporation Radionuclide generator system and method for its preparation and use
US5596611A (en) * 1992-12-08 1997-01-21 The Babcock & Wilcox Company Medical isotope production reactor
JP2857349B2 (en) 1995-05-22 1999-02-17 日本原子力研究所 Mo adsorbent for 99Mo-99mTc generator and method for producing the same
JP2862837B2 (en) 1996-07-16 1999-03-03 日本原子力研究所 Mo adsorbent for 99Mo-99mTc generator and method for producing the same
US6337055B1 (en) * 2000-01-21 2002-01-08 Tci Incorporated Inorganic sorbent for molybdenum-99 extraction from irradiated uranium solutions and its method of use
JP4994589B2 (en) * 2004-11-08 2012-08-08 住友重機械工業株式会社 Target for radioisotope production

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106128539A (en) * 2016-08-30 2016-11-16 中广核研究院有限公司 A kind of system utilizing pressurized-water reactor nuclear power plant to produce medical short-lived phase radioactive source

Also Published As

Publication number Publication date
EP2104113B1 (en) 2012-01-11
CA2666570C (en) 2011-11-15
EP2104113A4 (en) 2010-09-15
JP2008102078A (en) 2008-05-01
WO2008047946A1 (en) 2008-04-24
ATE541297T1 (en) 2012-01-15
JP4618732B2 (en) 2011-01-26
EP2104113A1 (en) 2009-09-23

Similar Documents

Publication Publication Date Title
CA2666570A1 (en) Manufacturing method of radioactive molybdenum, manufacturing apparatus and radioactive molybdenum manufactured thereby
JP5461435B2 (en) Method and apparatus for producing radioisotopes or treating nuclear waste
JP5427483B2 (en) Concentration, elution recovery method, and system of radiotechnetium as a raw material for radiopharmaceuticals and their labeled compounds
CN111485123B (en) Separation from large-amount and low-specific-activity Mo solution99mTc device and method
AU2009255830A1 (en) A process for the production of no-carrier added 99Mo
NL2011311B1 (en) Extracting method of radioactive 99Mo from low-enriched uranium target.
JP2013035714A (en) Method for producing technetium-99m solution having high concentration and high radioactivity
Ball et al. Present status of the use of LEU in aqueous reactors to produce Mo-99
RU2688196C9 (en) The method of producing radioisotope molybdenum-99
CN116377255A (en) Method for separating molybdenum-99 from alpha particle irradiated zirconium target
RU2332735C1 (en) Method of production of carrier-free radionuclide palladium-103
Cols et al. Mo-99 from low-enriched uranium
RU2418606C1 (en) Method of producing radiopharmaceutical preparation with palladium-103
JP2001074891A (en) Device and method for manufacturing radioactive isotope
Rosenbaum et al. Process for separating fission product molybdenum from an irradiated target material.[thermal chromatography]
Van Abel et al. Design of a Commercial Scale Accelerator Driven Subcritical Aqueous Assembly
JPH1048390A (en) Method for extinguishing radioactivity of radioactive iodine and neutron irradiation device therefor
Kim et al. Development of Silver-exchanged Adsorbents for the Removal of Fission Iodine from Alkaline Dissolution
Tsukada et al. Generation of Medical Radioisotopes with Accelerator Neutrons
Kolar et al. Making of fission {sup 99} Mo from LEU silicide (s): A radiochemists' view
JP2006248821A (en) Hydrogen production method by radiation-induced catalytic reaction using high-level radioactive waste as radiation source

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20151019