CA2531692A1 - Utilisation de porphobilinogene synthase hexamere comme cible pour la mise au point d'antibiotiques et d'herbicides - Google Patents

Utilisation de porphobilinogene synthase hexamere comme cible pour la mise au point d'antibiotiques et d'herbicides Download PDF

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Publication number: CA2531692A1
Authority: CA; Canada
Prior art keywords: composition; multimeric; pbgs; porphobilinogen synthase; protein
Prior art date: 2003-07-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002531692A

Other languages

English (en)

Inventor

Eileen K. Jaffe

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Fox Chase Cancer Center

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-07

Filing date

2004-07-07

Publication date

2005-01-27

2004-07-07 Application filed by Individual filed Critical Individual

2005-01-27 Publication of CA2531692A1 publication Critical patent/CA2531692A1/fr

Status Abandoned legal-status Critical Current

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/04—Nitro compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Cosmetics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

CA002531692A 2003-07-07 2004-07-07 Utilisation de porphobilinogene synthase hexamere comme cible pour la mise au point d'antibiotiques et d'herbicides Abandoned CA2531692A1 (fr)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US48525303P	2003-07-07	2003-07-07
US60/485,253		2003-07-07
US57731204P	2004-06-04	2004-06-04
US60/577,312		2004-06-04
PCT/US2004/021722 WO2005007817A2 (fr)	2003-07-07	2004-07-07	Utilisation de porphobilinogene synthase hexamere comme cible pour la mise au point d'antibiotiques et d'herbicides

Publications (1)

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CA2531692A1 true CA2531692A1 (fr)	2005-01-27

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CA002531692A Abandoned CA2531692A1 (fr)	2003-07-07	2004-07-07	Utilisation de porphobilinogene synthase hexamere comme cible pour la mise au point d'antibiotiques et d'herbicides

Country Status (6)

Country	Link
EP (1)	EP1648429A4 (fr)
JP (1)	JP2007529995A (fr)
AU (1)	AU2004257208B2 (fr)
CA (1)	CA2531692A1 (fr)
IL (1)	IL173016A (fr)
WO (1)	WO2005007817A2 (fr)

Families Citing this family (2)

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Publication number	Priority date	Publication date	Assignee	Title
US8153410B2 (en)	2003-07-07	2012-04-10	Fox Chase Cancer Center	Alternate morpheein forms of allosteric proteins as a target for the development of bioactive molecules
US20060162014A1 (en) *	2003-07-07	2006-07-20	Jaffe Eileen K	Alternate morpheeins of allosteric proteins as a target for the development of bioactive molecules

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WO1999059606A1 (fr) *	1998-05-16	1999-11-25	Mogam Biotechnology Research Institute	Emploi de l'acide romarinique et/ou de ses derives immunosuppresseur et/ou inhibiteur des processus induits par le sh2
JP4112730B2 (ja) *	1999-02-22	2008-07-02	オリザ油化株式会社	口腔用抗菌剤

2004
- 2004-07-07 CA CA002531692A patent/CA2531692A1/fr not_active Abandoned
- 2004-07-07 JP JP2006518868A patent/JP2007529995A/ja active Pending
- 2004-07-07 WO PCT/US2004/021722 patent/WO2005007817A2/fr active Application Filing
- 2004-07-07 AU AU2004257208A patent/AU2004257208B2/en not_active Ceased
- 2004-07-07 EP EP04786044A patent/EP1648429A4/fr not_active Ceased
2006
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Also Published As

Publication number	Publication date
IL173016A (en)	2012-03-29
JP2007529995A (ja)	2007-11-01
IL173016A0 (en)	2006-06-11
WO2005007817A2 (fr)	2005-01-27
EP1648429A2 (fr)	2006-04-26
WO2005007817A3 (fr)	2005-11-03
EP1648429A4 (fr)	2009-09-02
AU2004257208A1 (en)	2005-01-27
AU2004257208B2 (en)	2010-02-25

Publication	Publication Date	Title
US8153410B2 (en)	2012-04-10	Alternate morpheein forms of allosteric proteins as a target for the development of bioactive molecules
Amorim Franco et al.	2017	Bacterial branched-chain amino acid biosynthesis: structures, mechanisms, and drugability
Laflamme et al.	2001	Molecular and biochemical analysis of a Madagascar periwinkle root-specific minovincinine-19-hydroxy-O-acetyltransferase
US6613553B1 (en)	2003-09-02	Enoyl reductases and methods of use thereof
Lu et al.	2005	Fatty acid synthesis as a target for antimalarial drug discovery
WO1999024586A1 (fr)	1999-05-20	Hydroxy-phenyl pyruvate dioxygenase chimere, sequence d'adn et obtention de plantes contenant un tel gene, tolerantes aux herbicides
US20110207816A1 (en)	2011-08-25	Alternate morpheeins of allosteric proteins as a target for the development of bioactive molecules
CA2341412A1 (fr)	2000-03-09	Heparinases a conception rationnelle derivees de l'heparinase i et ii
JP6665281B2 (ja)	2020-03-13	安定性が増加されたヒト繊維芽細胞成長因子−２変異体及びその用途
RU2652605C2 (ru)	2018-04-27	Блокада воспалительных протеаз тета-дефензинами
Supuran	2009	Carbonic anhydrases as drug targets—general presentation
AU2004257208B2 (en)	2010-02-25	Hexameric porphobilinogen synthase as a target for the development of antibiotics and herbicides
WO2005007817A9 (fr)	2006-04-06	Utilisation de porphobilinogene synthase hexamere comme cible pour la mise au point d'antibiotiques et d'herbicides
US20240335476A1 (en)	2024-10-10	Systems and methods for the treatment of hemoglobinopathies
Moorefield et al.	2023	Characterization of a family I inorganic pyrophosphatase from Legionella pneumophila Philadelphia 1
EP1069911A1 (fr)	2001-01-24	Nitroreductase nouvelle et usages therapeutiques associes
JP3355368B2 (ja)	2002-12-09	植物由来のエポキシド水解酵素をコードするｃＤＮＡを含むプラスミドベクターおよび形質転換体
CN113939586A (zh)	2022-01-14	治疗β-地中海贫血症的方法
Peters-Golden	2018	The chemical elucidation of slow-reacting substance: bronchospasm and beyond
RU2437934C1 (ru)	2011-12-27	СПОСОБ ПОЛУЧЕНИЯ ФРАКЦИИ ИЗ КЛЕТОК Escherichia coli, ОБЛАДАЮЩЕЙ ИНГИБИРУЮЩЕЙ ПРОТЕАЗЫ АКТИВНОСТЬЮ
CN1835739A (zh)	2006-09-20	六聚体胆色素原合成酶作为开发抗生素和除草剂的靶
EP2337850A2 (fr)	2011-06-29	Composés anti-protozoaires
Parker	1995	Production and purification of imidazole glycerol phosphate dehydratase from Escherichia coli and Cryptococcus neoformans: Comparative kinetic and metal binding studies
JPH10505747A (ja)	1998-06-09	ヒトのイノシトールモノホスファターゼｈ１
EP1003848A2 (fr)	2000-05-31	Procedes d'activation de genes inactifs et procedes de modification de la vitesse de developpement de cellules, de tissus, et d'organismes

Legal Events

Date	Code	Title	Description
2009-05-21	EEER	Examination request
2013-05-06	FZDE	Discontinued	Effective date: 20130311