CA2507142A1

CA2507142A1 - Apparatus, devices and methods for contraception, conception and pregnancy

Info

Publication number: CA2507142A1
Application number: CA 2507142
Authority: CA
Inventors: Mohammad Nadeem Qadir; Ehtisham Qadir Sheikh; Soban Qadir; Sheikh Hafeez Ullah; Saeeda Baigum; Zargham Qadir Sheikh; Seemien Saeeda; Waseem Qadir Sheikh; Sadaf Saeeda
Original assignee: Individual
Current assignee: Individual
Priority date: 2005-04-25
Filing date: 2005-04-25
Publication date: 2006-10-25
Also published as: KR20080034093A; CN101232848A; EP2083698A2; WO2006114004A2; AU2006239700A1; WO2006114004A3

Abstract

Apparatus and methods for user-friendly predicting controlling, monitoring, treating and managing contraception (no-pregnancy) and conception (pregnancy) with user's own choice and decision locally or remotely when to have pregnancy and when to not and also to monitor and predict the health of pregnancy. The present invention includes the implantable "Novel"
tubular implants, the implant delivering device and the smart remote-control device, suitable for teen-aged girl, married lady and mature women, which can be set for contraception or conception either through preprogrammed or through user selection remotely and acts as an implantable device for infertility treatment due to blocked, cut, broken, scarred, plaque, and or narrowed fallopian tubes and or opening or grafting of various vessels, ducts, and circulations paths including controlling and regulating their flow paths based on various measuring parameters thereof.

Claims

1. An implant device for placement in a mammalian vessel, tube or duct to regulate fluid flow through the vessel, tube or duct, the implant device comprising:
an elongate tubular housing dimensioned for placement coaxially within the lumen of the vessel, tube or duct;
a tubular conduit mounted within the housing, each end of which is sealed to a respective end of the housing to define a fluid passageway through the housing that is in fluid communication with the lumen of the vessel, tube or duct, and to define a hermetically or otherwise sealed circumferential space between the conduit and the housing;
a valve mounted inline with the conduit and being operable for regulating the fluid flow through the passageway;
a source of mechanical energy mounted within the circumferential space and coupled to the valve for moving the valve in response to a control signal from controller; where source of mechanical energy means an actuator and or a motor, and controller means for providing a control signal to the source of mechanical energy in response to a stimulus that originates externally of the implant device.

2. The device as claimed in claim 1, further including a first source of electrical energy located within the circumferential space and being connected to the source of mechanical energy, and wherein the source of mechanical energy is an actuator or motor for converting electrical energy from the first source of electrical energy into mechanical energy to drive the valve.

3. The device as claimed in claim 2, wherein the first source of electrical energy comprises an inductive coil that translates an external electromagnetic energy into electrical energy for the actuator or motor.

4. The device as claimed in claim 2, wherein the first source of electrical energy comprises a nano-battery.

5. The device as claimed in claim 2, wherein the first source of electrical energy comprises a nano biothermal battery.

6. The device as claimed in any one of claims 3 to 5, further including a transceiver antenna for receiving and transmitting wireless data signals, and wherein the controller means comprises a control circuit connected to the antenna for receiving the data of the wireless signal and translating the data into a control signal to the actuator or motor for controlling the action of the actuator or motor to drive the valve.

7. The device as claimed in claim 6, wherein the actuator or motor is a tubular actuator or motor.

8. The device as claimed in any one of claims 6 and 7, wherein the control circuit is a flexible longitudinal electronic control circuit that is bendable to conform to the available space in the circumferential space in the housing.

9. The device as claimed in any one of claims 7 and 8, further including one or more sensors connected to the electronic control circuit for sensing environmental information within the vessel, tube or duct, and wherein the electronic control circuit includes preprogrammed instructions to measure and evaluate the environmental information and send a control signal to the actuator or motor based on the evaluation of the environmental information and or to transmit out.

10. The device as claimed in claim 9, wherein the sensors comprise, in various combinations, one or more sensors electrodes from the group consisting of biochemical sensors, electrophysiological sensors, physical sensors, Electrodes and physiological sensors.

11. The device as claimed in claim 10, wherein at least one of said sensors is mounted on the conduit within the fluid passageway.

12. The device as claimed in claim 11, wherein the sensors on the conduit are recessed into the conduit wall so as to not obstruct any of the fluid passageway.

13. The device as claimed in claim 9, wherein at least one of said sensor electrode is mounted on an outer surface of the housing which, in situ, contacts a portion of the wall of the vessel, tube or duct within which the device is implanted.

14. The device as claimed in claim 13, wherein the sensors on the surface of the housing are recessed into the wall of the housing so as not to interfere with the wall of the vessel, tube or duct within which the device is implanted.

15. A self-controlled implant device for placement in a mammalian vessel, tube or duct to regulate fluid flow through the vessel, tube or duct, the implant device comprising:
an elongate tubular housing dimensioned for placement coaxially within the lumen of the vessel, tube or duct;

a tubular conduit mounted within the housing, each end of which is sealed to a respective end of the housing to define a fluid passageway through the housing that is in fluid communication with the lumen of the vessel, tube or duct, and to define a hermetically or otherwise sealed circumferential space between the conduit and the housing;
a valve mounted inline with the conduit and being operable for regulating the fluid flow through the passageway;
an actuator or motor mounted within the circumferential space for providing mechanical energy to operate the said valve in response to a control signal;
one or more sensors on the housing or on the conduit for sensing environmental information within the vessel, tube or duct;
a electronic control circuit within the circumferential space connected to the sensors for receiving the environmental information, wherein the electronic control circuit includes preprogrammed instructions to evaluate the environmental information and send a control signal to the actuator or motor based on the evaluation of the environmental information; and a nano-battery mounted within the circumferential space for providing electrical energy to the electronic control circuit and actuator or motor.

16. The device as claimed in claim 15, wherein the control circuit is a flexible longitudinal electronic control circuit that is bendable to conform to the available space in the circumferential space in the housing.

17. The device as claimed in claim 16, wherein the actuator or motor comprises a tubular actuator or motor.

18. The device as claimed in claim 17, wherein the valve comprises a tubular diagonal bendable knife gate valve.

19. The device as claimed in claim 17, wherein the valve comprises a tubular U-channel bendable knife gate valve.

20. The device as claimed in claim 17, wherein the valve comprises a tubular double-symmetrical pinching gate valve.

21. The device as claimed in claim 17, wherein the valve comprises a tubular balloon gate valve.

22. The device as claimed in any one of claims 18 - 21, wherein the sensors comprise, in various combinations, one or more sensors from the group consisting of biochemical sensors, electrophysiological sensors, physical sensors and physiological sensors.

23. An electromagnetically controlled implant device for placement in a mammalian vessel, tube or duct to regulate fluid flow through the vessel, tube or duct, the implant device comprising:
an elongate tubular housing dimensioned for placement coaxially within the lumen of the vessel, tube or duct;
a tubular conduit mounted within the housing, each end of which is sealed to a respective end of the housing to define a fluid passageway through the housing that is in fluid communication with the lumen of the vessel, tube or duct, and to define a hermetically or otherwise sealed circumferential space between the conduit and the housing;
a valve mounted inline with the conduit and being operable for regulating the fluid flow through the passageway;

an electronic actuator or motor mounted within the circumferential space for providing mechanical energy to operate the valve in response to a control signal;
an inductive coil that translates an external electromagnetic energy into electrical energy for the actuator or motor; and controller means for providing a control signal to the actuator or motor in response to a stimulus that originates externally of the implant device.

24. The device as claimed in claim 23, further including a transceiver antenna for receiving and transmitting wireless data signals, and wherein the controller means comprises a control circuit connected to the antenna for receiving the data of the wireless signal and translating the data into a control signal to the actuator or motor for controlling the action of the actuator or motor.

25. The device as claimed in claim 24, wherein the actuator or motor comprises a tubular actuator or motor.

26. The device as claimed in claim 25, wherein the electronic control circuit is a flexible longitudinal electronic control circuit that is bendable to conform to the available space in the circumferential space in the housing.

27. The device as claimed in claim 26, wherein the valve comprises a tubular diagonal bendable knife gate valve.

28. The device as claimed in claim 26, wherein the valve comprises a tubular U-channel bendable knife gate valve.

29. The device as claimed in claim 26, wherein the valve comprises a tubular double-symmetrical pinching gate valve.

30. The device as claimed in claim 26, wherein the valve comprises a tubular balloon gate valve.

31. The device as claimed in any one of claims 27 - 30, further including one or more sensors connected to the electronic control circuit for sensing environmental information vessel, tube or duct and transmitting the environmental information to the electronic control circuit, and wherein the electronic control circuit includes preprogrammed instructions to evaluate the environmental information and send a control signal to the actuator or motor based on the evaluation of the environmental information.

32. The device as claimed in claim 31, wherein the sensors comprise, in various combinations, one or more sensors from the group consisting of biochemical sensors, electrophysiological sensors, physical sensors and physiological sensors.

33. The device as claimed in claim 32, wherein at least one of said sensors is mounted on the conduit within the fluid passageway.

34. The device as claimed in claim 33, wherein the sensors on the conduit are recessed into the conduit wall so as to not obstruct any of the fluid passageway.

35. The device as claimed in claim 32, wherein at least one of said sensors is mounted on a surface of the housing which, in situ, contacts a portion of the wall of the vessel, tube or duct within which the device is implanted.

36. The device as claimed in claim 35, wherein the sensors on the surface of the housing are recessed into the wall of the housing so as not to interfere with the wall of the vessel, tube or duct within which the device is implanted.

37. A contraceptive implant for placement in the fallopian tubes of a mammal, the implant comprising:
an elongate tubular housing dimensioned for placement coaxially within the lumen of the fallopian tube;
a tubular conduit mounted within the housing, each end of which is sealed to a respective end of the housing to define a fluid passageway through the housing that is in fluid communication with the lumen of the fallopian tube, and to define a hermetically or otherwise sealed circumferential space between the conduit and the housing;
a valve mounted inline with the conduit and being operable for regulating the fluid flow through the passageway;
a source of mechanical energy mounted within the circumferential space and coupled to the valve for moving the valve in response to a control signal; and controller means for providing a control signal to the source of mechanical energy in response to a stimulus that originates externally of the implant device.

38. The device as claimed in claim 37, further including a first source of electrical energy located within the circumferential space and being connected to the source of mechanical energy, and wherein the source of mechanical energy is an electronic actuator or motor for converting electrical energy from the first source of electrical energy into mechanical energy to drive the valve.

39. The device as claimed in claim 38, wherein the first source of electrical energy comprises and inductive coil that translates an external wireless signal into electrical energy for the actuator.

40. The device as claimed in claim 38, wherein the first source of electrical energy comprises a nano-battery.

41. The device as claimed in claim 38, wherein the first source of electrical energy comprises a nano biothermal battery.

42. The device as claimed in any one of claims 39 to 41, further including a transceiver antenna for receiving and transmitting wireless data signals, and wherein the controller means comprises a control circuit connected to the antenna for receiving the data of the wireless signal and translating the data into a control signal to the actuator or motor for controlling the action of the actuator or motor.

43. The device as claimed in claim 42, wherein the actuator or motor comprises a tubular actuator or motor.

44. The device as claimed in any one of claims 42 and 43, wherein the control circuit is a flexible longitudinal electronic control circuit that is bendable to conform to the available space in the circumferential space in the housing.

45. The device as claimed in any one of claims 43 and 44, further including one or more sensors connected to the electronic control circuit for sensing environmental information within the fallopian tube and wherein the electronic control circuit includes preprogrammed instructions to evaluate the environmental information and send a control signal to the actuator or motor based on the measurement and evaluation of the environmental information.

46. The device as claimed in claim 45, wherein the sensors comprise, in various combinations, one or more sensors from the group consisting of biochemical sensors, electrophysiological sensors, physical sensors and physiological sensors.

47. The device as claimed in claim 46, wherein at least one of said sensors is mounted on the conduit within the fluid passageway.

48. The device as claimed in claim 47, wherein the sensors on the conduit are recessed into the conduit wall so as to not obstruct any of the fluid passageway.

49. The device as claimed in claim 46, wherein at least one of said sensors is mounted on a surface of the housing which, in situ, contacts a portion of the wall of the fallopian tube within which the device is implanted.

50. The device as claimed in claim 49, wherein the sensors on the surface of the housing are recessed into the wall of the housing so as not to interfere with the wall of the vessel, tube or duct within which the device is implanted.

51. A implant for placement in the urethra of a mammal to control the flow of urine out of the bladder, the implant comprising:
an elongate tubular housing dimensioned for placement coaxially within the lumen of the urethra;
a tubular conduit mounted within the housing, each end of which is sealed to a respective end of the housing to define a fluid passageway through the housing that is in fluid communication with the lumen of the urethra, and to define a hermetically or otherwise sealed circumferential space between the conduit and the housing;

a valve mounted inline with the conduit and being operable for regulating the urine flow through the passageway;
a source of mechanical energy mounted within the circumferential space and coupled to the valve for moving the valve in response to a control signal; and controller means for providing a control signal to the source of mechanical energy in response to a stimulus that originates externally of the implant device.

52. The device as claimed in claim 51, further including a first source of electrical energy located within the circumferential space and being connected to the source of mechanical energy, and wherein the source of mechanical energy is an electronic actuator or motor for converting electrical energy from the first source of electrical energy into mechanical energy to drive the valve.

53. The device as claimed in claim 52, wherein the first source of electrical energy comprises and inductive coil that translates an external wireless signal into electrical energy for the actuator or motor.

54. The device as claimed in claim 52, wherein the first source of electrical energy comprises a nano-battery.

55. The device as claimed in claim 52, wherein the first source of electrical energy comprises a nano biothermal battery.

56. The device as claimed in any one of claims 53 to 55, further including a transceiver antenna for receiving and transmitting wireless data signals, and wherein the controller means comprises a control circuit connected to the antenna for receiving the data of the wireless signal and translating the data into a control signal to the actuator or motor for controlling the action of the actuator or motor.

57. The device as claimed in claim 56, wherein the actuator or motor comprises a tubular actuator or motor.

58. The device as claimed in any one of claims 56 and 57, wherein the control circuit is a flexible longitudinal electronic control circuit that is bendable to conform to the available space in the circumferential space in the housing.

59. The device as claimed in any one of claims 57 and 58, further including one or more pressure sensors connected to the electronic control circuit for sensing the pressure of the urine in the bladder and transmitting the pressure information to the electronic control circuit, and wherein the electronic control circuit includes preprogrammed instructions to evaluate the pressure information and send a control signal to the actuator based on the evaluation of the pressure information.

60. The device as claimed in claim 59, further including one or more flow sensors connected to the electronic control circuit for sensing the flow of urine in the urethra and transmitting the flow information to the electronic control circuit, and wherein the electronic control circuit includes preprogrammed instructions to evaluate the flow information and send a control signal to the actuator based on the evaluation of the flow information.

61. The device as claimed in claim 60, further including one or more pH
sensors connected to the electronic control circuit for sensing the pH of urine in the urethra and transmitting the pH information to the electronic control circuit, and wherein the electronic control circuit includes preprogrammed instructions to evaluate the pH information and send a control signal to the actuator based on the evaluation of the pH information.

62. A remote controlled contraceptive implant for placement anywhere between tail of epididymis and ductus deferens of a male mammal to control the flow of spermatozoa out of the testes, the implant comprising:
an elongate tubular housing dimensioned for placement coaxially within the lumen of the tail of epididymis and ductus deferens;
a tubular conduit mounted within the housing, each end of which is sealed to a respective end of the housing to define a fluid passageway through the housing that is in fluid communication with the lumen of the urethra, and to define a hermetically or otherwise sealed circumferential space between the conduit and the housing;
a valve mounted inline with the conduit and being operable for regulating the sperm flow through the passageway;
a source of mechanical energy mounted within the circumferential space and coupled to the valve for moving the valve in response to a control signal; and controller means for providing a control signal to the source of mechanical energy in response to a stimulus that originates externally of the implant device.

63. The device as claimed in claim 62, further including a first source of electrical energy located within the circumferential space and being connected to the source of mechanical energy, and wherein the source of mechanical energy is an electronic actuator or motor for converting electrical energy from the first source of electrical energy into mechanical energy to drive the valve.

64. The device as claimed in claim 63, wherein the first source of electrical energy comprises and inductive coil that translates an external wireless signal into electrical energy for the actuator or motor.

65. The device as claimed in claim 63, wherein the first source of electrical energy comprises a nano-battery.

66. The device as claimed in claim 63, wherein the first source of electrical energy comprises a nano biothermal battery.

67. The device as claimed in any one of claims 63 to 66, further including a transceiver antenna for receiving and transmitting wireless data signals, and wherein the controller means comprises a control circuit connected to the antenna for receiving the data of the wireless signal and translating the data into a control signal to the actuator or motor for controlling the action of the actuator or motor.

68. The device as claimed in claim 67, wherein the actuator or motor comprises a tubular actuator or motor.

69. The device as claimed in any one of claims 67 and 68, wherein the control circuit is a flexible longitudinal electronic control circuit that is bendable to conform to the available space in the circumferential space in the housing.

70. A valve for use in an implant device for placement in a mammalian vessel, tube or duct to regulate fluid flow therethrough, the valve comprising:
a first tubular conduit having a first end;

a second tubular conduit axially aligned with the first tubular conduit and having a second end located near the first end;
a housing between the conduits and sealed to the first and second ends, and defining an internal chamber that is in fluid communication with the first and second conduits such that the conduits and the chamber define a fluid flow path, and wherein the internal chamber defines a pathway that intersects the fluid flow path;
an elongate planar bendable blade movably mounted within the pathway and being slidable between a closed position in which the blade interferes with the fluid flow path, and an open position in which the blade does not interfere with the fluid flow path; and an actuator or motor connected to the blade to move the blade between the open and closed positions in response to a control signal.

71. The device as claimed in claim 70 wherein a portion of the pathway diagonally intersects the fluid flow path.

72. The device as claimed in claim 71 wherein the chamber in the housing comprises a first planar portion that diagonally intersects the conduit, and a second planar portion that is generally parallel with the conduit, wherein the blade in the closed position is located within the first and second planar portions, and in the open position is located within the second planar portion, and wherein the blade is capable of bending as it is moved through the first and second planar portions.

73. The device as claimed in claim 72, wherein a portion of the pathway perpendicularly intersects the fluid flow path.

74. The device as claimed in claim 73 wherein the chamber in the housing comprises:

a first planar portion that is generally parallel to the conduit;
a second planar portion that is perpendicular to the first planar portion and which perpendicularly intersects the conduit; and a third planar portion that is perpendicular to the second planar portion and is generally parallel with the conduit, wherein the blade in the open position is located within the first planar portion, and in the closed position is located within the first, second and third planar portions, and wherein the blade is capable of bending as it is moved through the first, second and third planar portions.

75. The device as claimed in any one of claims 70 - 74, wherein the actuator or motor is a tubular actuator or motor mounted around the second conduit.

76. The device as claimed in claim 75, wherein the actuator comprises:
a stationary inner tubular stator mounted around the second conduit; and an outer tubular actuating electrode movably mounted around the inner tubular stator and being connected to the blade, wherein the outer tubular actuating electrode moves in relation to the tubular stator in response to electrical energy provided to the actuator.

77. The device as claimed in claim 76, wherein the inner tubular stator and outer tubular actuating electrode are comprised of piezoelectric material that responds to the charge of the electrical energy being provided to cause the outer tubular actuating electrode to selectively move in direction (left or right depending on the polarity of said electrical energy) along the inner tubular stator.

78. The device as claimed in claim 77, further including a plurality of contact switches positioned longitudinally between the inner tubular stator and the outer tubular actuating electrode for controlling the distance of motion of the outer tubular actuating electrode in relation to the inner tubular stator.

79. A valve for use in an implant device for placement in a mammalian vessel, tube or duct to regulate fluid flow therethrough, the valve comprising:
a first tubular conduit, defining a fluid flow path, and having a deformable flexible tubular portion;
a plurality of pinching arms connected to the conduit and positioned adjacent the flexible tubular portion, the arms being movable between a closed position in which the arms pinch the flexible tubular portion to interfere with the fluid flow path, and an open position in which the arms do not pinch the flexible tubular portion to allow unimpeded fluid flow;
and an actuator connected to the arms to move the arms between the open and closed positions in response to a control signal.

80. A valve for use in an implant device for placement in a mammalian vessel, tube or duct to regulate fluid flow therethrough, the valve comprising:
a first tubular conduit defining a fluid flow path;
a balloon connected to the conduit and being in physical communication with the fluid flow path, wherein the balloon in its deflated state does not interfere with the fluid flow path, and wherein the balloon is inflatable such that it is capable of blocking the fluid flow path in its inflated state;

an inflation fluid conduit connected to the balloon for supplying an inflation fluid for inflating the balloon;
a compressible and expandable inflation fluid reservoir connected to the inflation fluid conduit for storing the inflation fluid;
an actuator connected to the inflation fluid reservoir for selectively compressing or expanding the inflation fluid reservoir in response to a control signal, thereby selectively inflating or deflating the balloon to regulate the fluid flow through the conduit.

81. The device as claimed in any one of claims 80, wherein the actuator is a tubular actuator mounted around the conduit adjacent the inflation fluid reservoir.

82. The device as claimed in claim 81, wherein the actuator comprises:
a stationary inner tubular stator mounted around the conduit; and an outer tubular actuating electrode movably mounted around the inner tubular stator and being connected to the inflation fluid reservoir, wherein the outer tubular actuating electrode moves in relation to the tubular stator in response to electrical energy provided to the actuator to selectively compress or expand the inflation fluid reservoir.

83. The device as claimed in claim 82, wherein the inner tubular stator and outer tubular actuating electrodes are comprised of piezoelectric material that responds to the charge of the electrical energy being provided to cause the outer tubular actuating electrode to selectively move in one direction along the inner tubular stator.

84. The device as claimed in claim 83, further including a plurality of contact switches positioned longitudinally between the inner tubular stator and the outer tubular actuating electrode for controlling the distance of motion of the outer tubular actuating electrode in relation to the inner tubular stator.

85. A method of predicting pre-ovulation in a female human subject, which subject has experienced the onset of menstruation in her menstrual cycle, the method comprising the steps of:
a) sensing invasively one or more of the properties selected from the group consisting of:
i) concentration of estradiol or Estrogen in the fluid;
ii) concentration of sodium (Na+) and chloride (Cl-) ions in the fluid;
iii) concentration of calcium (Ca2+) and potassium (K+) ions in the fluid;
iv) pH in the fluid;
v) membrane potential in the cells or tissues;
vi) conductivity in the cells or tissues; and vii) capacitance in the cells or tissues of a Fallopian tube of the female subject at least on a daily basis;
b) generating output signals indicative of the levels of the properties sensed in step (a); and c) monitoring the output signals from the onset of menstruation to identify:
i) in the case of concentration of estradiol or estrogen, a steady increase in concentration of estradiol or estrogen;
ii) in the case of concentration of sodium (Na+) and chloride (Cl-) ions, a steady increase in concentration of sodium (Na+) and chloride (Cl-) ions;
iii) in the case of concentration of calcium (Ca2+) and potassium (K+) ions, a slight rise in concentration of calcium (Ca2+) and potassium (K+) ions;
iv) in the case of pH, a steady decrease in pH;
v) in the case of membrane potential, an increase in membrane potential;
vi) in the case of conductivity, an increase in conductivity; and vii) in the case of capacitance, an increase in capacitance;
wherein the properties identified, either alone or in combination, indicate that the female human is approaching the ovulation phase of a menstrual cycle.

86. The method as in claim 85, further comprising the step of comparing the levels indicated in step (b) with mean values of corresponding properties obtained in at least one previous menstrual cycle of the female human in identifying the changes listed in (c).

87. The method as in claim 86 wherein the levels indicated in step (c) occur after the tenth day from menstruation.

88. A method of predicting ovulation in a female human subject, which subject has experienced the onset of menstruation in her menstrual cycle, the method comprising the steps of:
a. sensing invasively one or more of the properties selected from the group consisting of:
i. temperature;
ii. concentration of estradiol or estrogen in the fluid;
iii. concentration of luteinizing hormone in the fluid;
iv. concentration of sodium (Na+) and chloride (Cl-) ions in the fluid;
v. concentration of calcium (Ca2+) and potassium (K+) ions in the fluid;
vi. pH in the fluid;
vii. membrane potential in the cells or tissues;
viii. conductivity in the cells or tissues; and ix. capacitance in the cells or tissues of a Fallopian tube of the female subject at least on a daily basis;
b. generating output signals indicative of the levels of the properties sensed in step (a);
and c. monitoring the output signals to identify:
i. in the case of temperature, a rise in temperature from the levels at pre-ovulation ii. in the case of concentration of estradiol or estrogen, a steady decrease in concentration of estradiol or estrogen;
iii. in the case of concentration of luteinizing hormone, a peak in concentration of luteinizing hormone;
iv. in the case of concentration of sodium (Na+) and chloride (Cl-) ions, a sharp decline in concentration of sodium (Na+) and chloride (Cl-) ions from the levels at pre-ovulation;

v. in the case of concentration of calcium (Ca2+) and potassium (K+) ions, an increase in concentration of calcium (Ca2+) and potassium (K+) ions from the levels at pre-ovulation;
vi. in the case of pH, a significant rise in pH from the levels at pre-ovulation;
vii. in the case of membrane potential, a sharp rise in membrane potential from the levels at pre-ovulation;
viii. in the case of conductivity, a sharp rise in conductivity from the levels at pre-ovulation; and ix. in the case of capacitance, a sharp rise in capacitance from the levels at pre-ovulation;
wherein the properties identified, either alone or in combination, indicate that the female human is in the ovulation phase of a menstrual cycle.

89. The method as in claim 88, further comprising the step of comparing the levels indicated in step (b) with mean values of corresponding properties obtained in at least one previous menstrual cycle of the female human in identifying the changes listed in (c).

90. A method of predicting if no fertilization of an egg occurred post-ovulation in a female human subject, which subject has experienced the onset of menstruation in her menstrual cycle, the method comprising the steps of:
a. sensing invasively one or more of the properties selected from the group consisting of:
i. temperature;
ii. concentration of progesterone in the fluid;
iii. concentration of calcium (Ca2+) and potassium (K+) ions in the fluid;
iv. pH in the fluid;
v. membrane potential in the cells or tissues;
vi. conductivity in the cells or tissues; and vii. capacitance in the cells or tissues of a Fallopian tube of the female subject at least on a daily basis;
b. generating output signals indicative of the levels of the properties sensed in step (a);
c. determining the levels of the properties sensed in step (a) at ovulation;
and d. monitoring the output signals after ovulation to identify:

i. in the case of temperature, a decline in temperature from the levels at ovulation;
ii. in the case of concentration of progesterone, an increase, then a peak, followed by a steady decline in concentration of progesterone from the levels at ovulation;
iii. in the case of concentration of calcium (Ca2+) and potassium (K+) ions, a decline in concentration of calcium (Ca2+) and potassium (K+) ions from the levels at ovulation;
iv. in the case of pH, a decline in pH from the levels at ovulation;
v. in the case of membrane potential, a decline in membrane potential from the levels at ovulation;
vi. in the case of conductivity, a decline in conductivity from the levels at ovulation; and vii. in the case of capacitance, a decline in capacitance from the levels at ovulation;
wherein the properties identified, either alone or in combination, indicate that fertilization has not occurred in the female human.

91. The method as in claim 90, further comprising the step of comparing the levels indicated in step (b) with mean values of corresponding properties obtained in at least one previous menstrual cycle of the female human in identifying the changes listed in (c).

92. A method of predicting if fertilization of an egg occurred after ovulation in a female human subject, which subject has experienced the onset of menstruation in her menstrual cycle, the method comprising the steps of:
a. sensing invasively one or more of the properties selected from the group consisting of:
i. temperature;
ii. concentration of progesterone in the fluid;
iii. concentration of calcium (Ca2+) and potassium (K+) ions in the fluid;
iv. pH in the fluid;
v. conductivity in the cells or tissues; and vi. capacitance in the cells or tissues of a Fallopian tube of the female subject at least on a daily basis;
b. generating output signals indicative of the levels of the properties sensed in step (a);
c. determining the levels of the properties sensed in step (a) at ovulation;
and d. monitoring the output signals after ovulation to identify:
i. in the case of temperature, an increase in temperature from the levels at ovulation;
ii. in the case of concentration of progesterone, a steady increase in concentration of progesterone from the levels at ovulation;
iii. in the case of concentration of calcium (Ca2+) and potassium (K+) ions, an increase in concentration of calcium (Ca2+) and potassium (K+) ions from the levels at ovulation;
iv. in the case of pH, an increase in pH from the levels at ovulation;
v. in the case of conductivity, an increase in conductivity; and vi. in the case of capacitance, an increase in capacitance from the levels at ovulation;
wherein the properties identified, either alone or in combination, are indicative that fertilization has occurred in the female human.

93. The method as in claim 92, further comprising the step of determining the presence of sperm in the Fallopian tube wherein the presence of sperm in conjunction with the levels identified in (d) supports the indication that fertilization has occurred, and the absence of sperm indicates that no fertilization has occurred.

94. A method of predicting if a normal pregnancy is taking place after fertilization of an egg in a female human subject, the method comprising the steps of:
a. sensing invasively one or more of the properties selected from the group consisting of:
i. temperature;
ii. concentration of progesterone in the fluid;
iii. concentration of calcium (Ca2+) and potassium (K+) ions in the fluid;
iv. pH in the fluid;
v. conductivity in the cells or tissues; and vi. capacitance in the cells or tissues of a Fallopian tube of the female subject at least on a daily basis;
b. generating output signals indicative of the levels of the properties sensed in step (a);
c. determining the levels of the properties sensed in step (a) at fertilization; and d. monitoring the output signals after fertilization to identify:
i. in the case of temperature, a stabilization in temperature near the levels at fertilization;
ii. in the case of concentration of progesterone, a steady increase in concentration of progesterone from the levels at fertilization;
iii. in the case of concentration of calcium (Ca2+) and potassium (K+) ions, a stabilization in concentration of calcium (Ca2+) and potassium (K+) ions near the levels at fertilization;
iv. in the case of pH, a stabilization in pH near the levels at fertilization;
v. in the case of conductivity, a stabilization in conductivity near the levels at fertilization; and vi. in the case of capacitance, a stabilization in capacitance near the levels at fertilization;
wherein the properties identified, either alone or in combination, indicate that a normal pregnancy is taking place in the female human.

95. A method of predicting if an abnormal pregnancy is taking place after fertilization of an egg in a female human subject, the method comprising the steps of:
a. sensing one or more of the properties selected from the group consisting of:
i. temperature;
ii. concentration of progesterone in the fluid;
iii. concentration of sodium (Na+) and chloride (Cl-) ions in the fluid;
iv. concentration of calcium (Ca2+) and potassium (K+) ions in the fluid;
v. membrane potential in the cells or tissues;
vi. conductivity in the cells or tissues; and vii. capacitance in the cells or tissues of a Fallopian tube of the female subject at least on a daily basis;
b. generating output signals indicative of the levels of the properties sensed in step (a);
c. determining the levels of the properties sensed in step (a) at fertilization; and d. monitoring the output signals after fertilization to identify:

i. in the case of temperature, a fluctuation in temperature from the levels at fertilization;
ii. in the case of concentration of progesterone, a fluctuation in concentration of progesterone from the levels at fertilization;
iii. in the case of concentration of sodium (Na+) and chloride (Cl-) ions, a fluctuation in concentration of sodium (Na+) and chloride (Cl-) ions from the levels at fertilization;
iv. in the case of concentration of calcium (Ca2+) and potassium (K+) ions, a fluctuation in concentration of potassium (K+) ions and calcium (Ca2+) ions from the levels at fertilization;
v. in the case of membrane potential, a fluctuation in membrane potential from the levels at fertilization;
vi. in the case of conductivity, a fluctuation in conductivity from the levels at fertilization; and vii. in the case of capacitance, a fluctuation in capacitance from the levels at fertilization;
wherein the properties identified, either alone or in combination, indicate that an abnormal pregnancy is possibly taking place in the female human.

96. The method as claimed in any one of claims 85 - 95 wherein the step of sensing is carried out by one or more sensors and electrodes on a device that is implanted in a Fallopian tube of the female human subject.

97. The method as claimed in claim 96 wherein said device comprises a device as claimed in any one of the preceding claims.

98. A method of predicting pre-ovulation in a female human subject, which subject has experienced the onset of menstruation in her menstrual cycle, the method comprising the steps of:
d) sensing invasively one or more of the properties selected from the group consisting of:
i) concentration of estradiol or estrogen in the fluid;
ii) concentration of sodium (Na+) and chloride (Cl-) ions in a fluid;
iii) concentration of calcium (Ca2+) and potassium (K+) ions in the fluid;

iv) pH in the fluid;
v) membrane potential in the cells or tissues;
vi) conductivity in the cells or tissues; and vii) capacitance in the cells or tissues of a reproductive organ of the female subject at least on a daily basis;
e) generating output signals indicative of the levels of the properties sensed in step (a); and f) monitoring the output signals from the onset of menstruation to identify:
i) the case of concentration of estradiol or estrogen, a steady increase in concentration of estradiol or estrogen;
ii) in the case of concentration of sodium (Na+) and chloride (Cl-) ions, a steady increase in concentration of sodium (Na+) and chloride (Cl-) ions;
iii) in the case of concentration of calcium (Ca2+) and potassium (K+) ions, a slight rise in concentration of calcium (Ca2+) and potassium (K+) ions;
iv) in the case of pH, a steady decrease in pH;
v) in the case of membrane potential, an increase in membrane potential;
vi) in the case of conductivity, an increase in conductivity; and vii) in the case of capacitance, an increase in capacitance;
wherein the properties identified, either alone or in combination, indicate that the female human is approaching the ovulation phase of a menstrual cycle.

99. The method as in claim 98, further comprising the step of comparing the levels indicated in step (b) with mean values of corresponding properties obtained in at least one previous menstrual cycle of the female human in identifying the changes listed in (c).

100. The method as in claim 99 wherein the levels indicated in step (c) occur after the tenth or more days from menstruation.

101. A method of predicting ovulation in a female human subject, which subject has experienced the onset of menstruation in her menstrual cycle, the method comprising the steps of:
a. sensing invasively one or more of the properties selected from the group consisting of:
i. temperature;

ii. concentration of estradiol or estrogen in the fluid;
iii. concentration of luteinizing hormone in the fluid;
iv. concentration of sodium (Na+) and chloride (Cl-) ions in a fluid;
v. concentration of calcium (Ca2+) and potassium (K+) ions in the fluid;
vi. pH in the fluid;
vii. membrane potential in the cells or tissues;
viii. conductivity in the cells or tissues; and ix. capacitance in the cells or tissues of a reproductive organ of the female subject at least on a daily basis;
b. generating output signals indicative of the levels of the properties sensed in step (a);
and c. monitoring the output signals to identify:
i. in the case of temperature, a rise in temperature from the levels at pre-ovulation;
ii. in the case of concentration of estradiol or estrogen, a steady decrease in concentration of estradiol or estrogen;
iii. in the case of concentration of luteinizing hormone, a peak in concentration of luteinizing hormone;
iv. in the case of concentration of sodium (Na+) and chloride (Cl-) ions, a sharp decline in concentration of sodium (Na+) . and chloride (Cl-) ions from the levels at pre-ovulation;
v. in the case of concentration of calcium (Ca2+) and potassium (K+) ions, an increase in concentration of calcium (Ca2+) and potassium (K+) ions from the levels at pre-ovulation;
vi. in the case of pH, a significant rise in pH from the levels at pre-ovulation;
vii. in the case of membrane potential, a sharp rise in membrane potential from the levels at pre-ovulation;
viii. in the case of conductivity, a sharp rise in conductivity from the levels at pre-ovulation; and ix. in the case of capacitance, a sharp rise in capacitance from the levels at pre-ovulation;
wherein the properties identified, either alone or in combination, indicate that the female human is in the ovulation phase of a menstrual cycle.

102. The method as in claim 101, further comprising the step of comparing the levels indicated in step (b) with mean values of corresponding properties obtained in at least one previous menstrual cycle of the female human in identifying the changes listed in (c).

103. A method of predicting if no fertilization of an egg occurred post-ovulation in a female human subject, which subject has experienced the onset of menstruation in her menstrual cycle, the method comprising the steps of:
a. sensing invasively one or more of the properties selected from the group consisting of:
i. temperature;
ii. concentration of progesterone in the fluid;
iii. concentration of calcium (Ca2+) and potassium (K+) ions in a fluid;
iv. pH in the fluid;
v. membrane potential in the cells or tissues;
vi. conductivity in the cells or tissues; and vii. capacitance in the cells or tissues of a reproductive organ of the female subject at least on a daily basis;
b. generating output signals indicative of the levels of the properties sensed in step (a);
c. determining the levels of the properties sensed in step (a) at ovulation;
and d. monitoring the output signals after ovulation to identify:
i. in the case of temperature, a decline in temperature from the levels at ovulation;
ii. in the case of concentration of progesterone, an increase, then a peak, followed by a steady decline in concentration of progesterone from the levels at ovulation;
iii. in the case of concentration of calcium (Ca2+) and potassium (K+) ions, a decline in concentration of calcium (Ca2+) and potassium (K+) ions from the levels at ovulation;
iv. in the case of pH, a decline in pH from the levels at ovulation;
v. in the case of membrane potential, a decline in membrane potential from the levels at ovulation;

vi. in the case of conductivity, a decline in conductivity from the levels at ovulation; and vii. in the case of capacitance, a decline in capacitance from the levels at ovulation;
wherein the properties identified, either alone or in combination, indicate that fertilization has not occurred in the female human.

104. The method as in claim 103, further comprising the step of comparing the levels indicated in step (b) with mean values of corresponding properties obtained in at least one previous menstrual cycle of the female human in identifying the changes listed in (c).

105. A method of predicting if fertilization of an egg occurred after ovulation in a female human subject, which subject has experienced the onset of menstruation in her menstrual cycle, the method comprising the steps of:
a. sensing invasively one or more of the properties selected from the group consisting of:
i. temperature;
ii. concentration of progesterone in the fluid;
iii. concentration of calcium (Ca2+) and potassium (K+) ions in a fluid;
iv. pH in the fluid;
v. conductivity in the cells or tissues; and vi. capacitance in the cells or tissues of a reproductive organ of the female subject at least on a daily basis;
b. generating output signals indicative of the levels of the properties sensed in step (a);
c. determining the levels of the properties sensed in step (a) at ovulation;
and d. monitoring the output signals after ovulation to identify:
i. in the case of temperature, an increase in temperature from the levels at ovulation;
ii. in the case of concentration of progesterone, a steady increase in concentration of progesterone from the levels at ovulation;
iii. in the case of concentration of calcium (Ca2+) and potassium (K+) ions, an increase in concentration of calcium (Ca2+) and potassium (K+) ions from the levels at ovulation;

iv. in the case of pH, an increase in pH from the levels at ovulation;
v. in the case of conductivity, an increase in conductivity; and vi. in the case of capacitance, an increase in capacitance from the levels at ovulation;
wherein the properties identified, either alone or in combination, indicate that fertilization has occurred in the female human.

106. The method as in claim 105 further comprising the step of determining the presence of sperm in the Fallopian tube wherein the presence of sperm in conjunction with the levels identified in (d) supports the indication that fertilization has occurred, and the absence of sperm indicates that no fertilization has occurred.

107. A method of predicting if a normal pregnancy is taking place after fertilization of an egg in a female human subject, the method comprising the steps of:
a. sensing invasively one or more of the properties selected from the group consisting of:
i. temperature;
ii. concentration of progesterone in the fluid;
iii. concentration of calcium (Ca2+) and potassium (K+) ions in a fluid;
iv. pH in the fluid;
v. conductivity in the cells or tissues; and vi. capacitance in the cells or tissues of a reproductive organ of the female subject at least on a daily basis;
b. generating output signals indicative of the levels of the properties sensed in step (a);
c. determining the levels of the properties sensed in step (a) at fertilization; and d. monitoring the output signals after fertilization to identify:
i. in the case of temperature, a stabilization in temperature near the levels at fertilization;
ii. in the case of concentration of progesterone, an steady increase in concentration of progesterone from the levels at fertilization;
iii. in the case of concentration of calcium (Ca2+) and potassium (K+) ions, a stabilization in concentration of calcium (Ca2+) and potassium (K+) ions near the levels at fertilization;

iv. in the case of pH, a stabilization in pH near the levels at fertilization;
v. in the case of conductivity, a stabilization in conductivity near the levels at fertilization; and vi. in the case of capacitance, a stabilization in capacitance near the levels at fertilization;
wherein the properties identified, either alone or in combination, indicate that a normal pregnancy is taking place in the female human.

108. A method of predicting if an abnormal pregnancy is taking place after fertilization of an egg in a female human subject, the method comprising the steps of:
a. sensing invasively one or more of the properties selected from the group consisting of:
i. temperature;
ii. concentration of progesterone in the fluid;
iii. concentration of sodium (Na+) and chloride (Cl-) ions in a fluid;
iv. concentration of calcium (Ca2+) and potassium (K+) ions in the fluid;
v. membrane potential in the cells or tissues;
vi. conductivity in the cells or tissues; and vii. capacitance in the cells or tissues of a reproductive organ of the female subject at least on a daily basis;
b. generating output signals indicative of the levels of the properties sensed in step (a);
c. determining the levels of the properties sensed in step (a) at fertilization; and d. monitoring the output signals after fertilization to identify:
i. in the case of temperature, a fluctuation in temperature from the levels at fertilization;
ii. in the case of concentration of progesterone, a fluctuation in concentration of progesterone from the levels at fertilization;
iii. in the case of concentration of sodium (Na+) and chloride (Cl-) ions, a fluctuation in concentration of sodium (Na+) and chloride (Cl-) ions from the levels at fertilization;
iv. in the case of concentration of calcium (Ca2+) and potassium (K+) ions, a fluctuation in concentration of potassium (K+) ions and calcium (Ca2+) ions from the levels at fertilization;

v. in the case of membrane potential, a fluctuation in membrane potential;
vi. in the case of conductivity, a fluctuation in conductivity from the levels at fertilization; and vii. in the case of capacitance, a fluctuation in capacitance from the levels at fertilization;
wherein the properties identified, either alone or in combination, indicate that an abnormal pregnancy is possibly taking place in the female human.

109. The method as claimed in any one of claims 98 - 108 wherein the step of sensing is carried out by one or more sensors and electrodes on a device that is implanted in a vessel, tube, duct or cavity of the female human subject.

110. The method as claimed in claim 109 wherein said device comprises a device as claimed in any one of the preceding claims.

111. An implant device for placement in a mammalian vessel to regulate fluid flow and pressure through the vessel, the implant device comprising:
an. elongate tubular housing dimensioned for placement coaxially within the lumen of the vessel;
a tubular conduit mounted within the housing, each end of which is sealed to a respective end of the housing to define a fluid passageway through the housing that is in fluid communication with the lumen of the vessel, and to define a hermetically or otherwise sealed circumferential space between the conduit and the housing;
a valve mounted inline with the conduit and being operable for regulating the fluid flow and pressure through the passageway;
one or more sensors on the housing or on the conduit for sensing environmental information within the vessel;

one or more electrodes on the outer housing surface for stimulating contacted vessel's luminal wall or endothelial cells within the vessel;
a source of mechanical energy mounted within the circumferential space and coupled to the valve for moving the valve in response to a control signal from controller; where source of mechanical energy means an actuator and or a motor, and controller means for providing a control signal to the source of mechanical energy in response to a stimulus that originates externally of the implant device; and controller further means for sensing and measuring environmental information and sending stimulating voltage and current to electrodes at the outer wall of the implant device.

112. The device as claimed in claim 111, further including a first source of electrical energy located within the circumferential space and being connected to the source of mechanical energy, and wherein the source of mechanical energy is an actuator or motor for converting electrical energy from the first source of electrical energy into mechanical energy to drive the valve.

113. The device as claimed in claim 112, wherein the first source of electrical energy comprises an inductive coil that translates an external electromagnetic energy into electrical energy for the actuator or motor.

114. The device as claimed in claim 112, wherein the first source of electrical energy comprises a nano-battery.

115. The device as claimed in claim 112, wherein the first source of electrical energy comprises a nano biothermal battery.

116. The device as claimed in any one of claims 113 to 115, further including a transceiver antenna for receiving and transmitting wireless data signals, and wherein the controller means comprises a control circuit connected to the antenna for receiving the data of the wireless signal and translating the data into a control signal to the actuator or motor for controlling the action of the actuator or motor to drive the valve and for sensing and measuring environmental information and sending stimulating voltage and current to electrodes at the outer wall of the implant device; wherein intensity of stimulating voltage and current controlled by either internal environmental information and in response to a stimulus that originates externally of the implants device.

117. The device as claimed in claim 6, wherein the actuator or motor is a tubular actuator or motor.

118. The device as claimed in any one of claims 6 and 7, wherein the control circuit is a flexible longitudinal electronic control circuit that is bendable to conform to the available space in the circumferential space in the housing.

119. The device as claimed in any one of claims 117 and 118, further including one or more sensors and electrodes connected to the electronic control circuit for sensing environmental information within the vessel and wherein the electronic control circuit includes preprogrammed instructions to measure and evaluate the environmental information and send a control signal to the actuator or motor based on the evaluation of the environmental information and or to transmit out and sending stimulating voltage and current to said electrodes at the outer wall of the implant device; wherein device sends stimulating voltage and current to electrodes at the outer wall of the implant device and intensity of stimulating voltage and current controlled by said control circuit based on either~~~~~~~~

internal environmental information and in response to a stimulus that originates externally of the implants device

120. The device as claimed in claim 119, wherein the sensors comprise, in various combinations, one or more sensors from the group consisting of biochemical sensors, electrophysiological sensors, physical sensors and physiological sensors.

121. The device as claimed in claim 120, wherein at least one of said sensors is mounted on the conduit within the fluid passageway.

122. The device as claimed in claim 121, wherein the sensors on the conduit are recessed into the conduit wall so as to not obstruct any of the fluid passageway.

123. The device as claimed in claim 119, wherein at least one of said sensors is mounted on a surface of the housing which, in situ, contacts a portion of the wall of the vessel.

124. The device as claimed in claim 119, wherein at least one or more electrodes are mounted on the outer wall of the implant device so as to make physical interconnection with implant device wall and internal luminal wall of the vessel.

125. An implant device for placement in a mammalian vessel, duct or tube to regulate fluid flow and pressure through the vessel, duct or tube dilation and constriction, the implant device comprising:
an elongate tubular housing dimensioned for placement coaxially within the lumen of the vessel;
a tubular conduit mounted within the housing, each end of which is sealed to a respective end of the housing to define a fluid passageway through the housing that is in fluid communication with the lumen of the vessel, duct or tube and to define a hermetically or otherwise sealed circumferential space between the conduit and the housing;
one or more sensors on the housing or on the conduit for sensing environmental information within the vessel;
one or more electrodes on the outer housing surface for stimulating contacted vessel's, duct's or tube's luminal wall or endothelial cells;
controller means for sensing and measuring environmental information and sending stimulating voltage and current to electrodes at the outer wall of the implant device.

126. The device as claimed in claim 125, further including a first source of electrical energy located within the circumferential space and being connected to the control circuit.

127. The device as claimed in claim 126, wherein the first source of electrical energy comprises an inductive coil that translates an external electromagnetic energy into electrical energy for the actuator or motor.

128. The device as claimed in claim 127, wherein the first source of electrical energy comprises a nano-battery.

129. The device as claimed in claim 126, wherein the first source of electrical energy comprises a nano biothermal battery.

130. The device as claimed in any one of claims 126 to 129, further including a transceiver antenna for receiving and transmitting wireless data signals, and wherein the controller means comprises a control circuit connected to the antenna for receiving the data of the wireless signal and translating the data into a control signal to stimulating electrodes and for sensing and measuring environmental information and sending stimulating voltage and current to electrodes at the outer wall of the implant device; wherein intensity of stimulating voltage and current controlled by internal environmental information and in response to a stimulus that originates externally of the implants device.

131. The device as claimed in any one of claims 125 and 126, wherein the control circuit is a flexible longitudinal electronic control circuit that is bendable to conform to the available space in the circumferential space in the housing.

132. The device as claimed in any one of claims 125 and 126, further including one or more sensors and electrodes connected to the electronic control circuit for sensing environmental information within the vessel, duct or tube and wherein the electronic control circuit includes preprogrammed instructions to measure and evaluate the environmental information and sending stimulating voltage and current to said electrodes at the outer wall of the implant device; wherein device sends stimulating voltage and current to electrodes at the outer wall of the implant device and intensity of stimulating voltage and current controlled by said control circuit based on either internal environmental information and in response to a stimulus that originates externally of the implants device

133. The device as claimed in claim 132, wherein the sensors comprise, in various combinations, one or more sensors from the group consisting of biochemical sensors, electrophysiological sensors, electrodes, physical sensors and physiological sensors.

134. The device as claimed in claim 133, wherein at least one of said sensors is mounted on the conduit within the fluid passageway.

135. The device as claimed in claim 134, wherein the sensors on the conduit are recessed into the conduit wall so as to not obstruct any of the fluid passageway.

136. The device as claimed in claim 119, wherein at least one of said sensors is mounted on a surface of the housing which, in situ, contacts a portion of the wall of the vessel.

137. The device as claimed in claim 119, wherein at least one or more electrodes are mounted on the outer wall of the implant device so as to make physical interconnection with implant device wall and internal luminal wall of the vessel, duct or tube.

138. The device as claimed in claim 132 and 125, wherein stimulating voltage and current is in Direct Current.

139. The device as claimed in claim 132 and 125, wherein stimulating voltage and current is in any form of Alternating Current.

140. The device as claimed in claim 132 and 125, wherein stimulating voltage and current is in any form of Pulsating Current.

141. The device as claimed in claim 125, wherein a valve mounted inline with the conduit and being operable as secondary assisting for regulating the fluid flow through the passageway along with stimulating dilation and or constriction of vessel, duct or tube.