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CA2463113A1 - Device for medicine delivery by intraocular iontophoresis or electroporation - Google Patents

Device for medicine delivery by intraocular iontophoresis or electroporation Download PDF

Info

Publication number
CA2463113A1
CA2463113A1 CA002463113A CA2463113A CA2463113A1 CA 2463113 A1 CA2463113 A1 CA 2463113A1 CA 002463113 A CA002463113 A CA 002463113A CA 2463113 A CA2463113 A CA 2463113A CA 2463113 A1 CA2463113 A1 CA 2463113A1
Authority
CA
Canada
Prior art keywords
electroporation
reservoir
iontophoresis
tank
probe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002463113A
Other languages
French (fr)
Other versions
CA2463113C (en
Inventor
Francine Behar
Pierre Roy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EyeGate Pharma SAS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2463113A1 publication Critical patent/CA2463113A1/en
Application granted granted Critical
Publication of CA2463113C publication Critical patent/CA2463113C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention concerns a device for ocular delivery of an active principle by peroperative intraocular iontophoresis or electroporation comprising a reservoir (7) for receiving a solution comprising the active principle, means for diffusing (8, 6) the active principle connected to the reservoir, means for injecting (4) the solution into the reservoir, and means (5) for exerting suction of the content of the reservoir during an injection of the solution therein by the injection means.

Claims (16)

1. Dispositif d'application oculaire d'un principe actif par iontophorèse ou électroporation intraoculaire peropératoire comprenant un réservoir (7) apte à
recevoir une solution comprenant le principe actif, des moyens de diffusion (8,6;106;206;306;406,307;507) du principe actif connectés au réservoir, caractérisé en ce qu'il comporte en outre des moyens d'injection (4) de la solution dans le réservoir, ainsi que des moyens (5) aptes à exercer une aspiration d'un contenu du réservoir pendant une injection de la solution dans celui-ci par les moyens d'injection. 1. Device for ocular application of an active principle by iontophoresis or intraocular electroporation intraoperatively comprising a reservoir (7) capable of receive a solution comprising the active ingredient, means of diffusion (8.6; 106; 206; 306; 406.307; 507) of the active ingredient connected to the reservoir, characterized in that it further comprises means (4) for injecting the solution in the tank, as well as means (5) suitable for suctioning contents from the reservoir during an injection of the solution into it by the means of injection. 2. Dispositif selon la revendication 1, caractérisé en ce qu'il comporte un tube d'injection (4) et un tube d'aspiration (5) s'étendant l'un dans l'autre et aptes à
être raccordés au réservoir. 2. Device according to claim 1, characterized in what it includes an injection tube (4) and a tube suction (5) extending one inside the other and suitable for be connected to the tank. 3. Dispositif selon la revendication 1 ou 2, caractérisé
en ce que les moyens de diffusion sont disposés à une extrémité distale (7) d'une sonde (9). 3. Device according to claim 1 or 2, characterized in that the means of diffusion are arranged at a distal end (7) of a probe (9). 4. Dispositif selon la revendication 3, caractérisé en ce que le réservoir est disposé à l'extrémité distale. 4. Device according to claim 3, characterized in that the reservoir is disposed at the distal end. 5. Dispositif selon l'une des revendications 1 à 4, caractérisé en ce qu'il comporte un tube d'injection (4) et un tube d'aspiration (5) s'étendant à l'intérieur d'une sonde (9). 5. Device according to one of claims 1 to 4, characterized in that it comprises an injection tube (4) and a suction tube (5) extending inside a probe (9). 6. Dispositif selon l'une des revendications 3 à 5, caractérisé en ce que l'extrémité distale de la sonde forme un angle (.alpha.) par rapport à la direction selon laquelle la sonde s'étend principalement. 6. Device according to one of claims 3 to 5, characterized in that the distal end of the probe forms an angle (.alpha.) relative to the direction according to which the probe mainly extends. 7. Dispositif selon la revendication 6, caractérisé en ce que l'angle est compris entre 90° et 170°. 7. Device according to claim 6, characterized in what the angle is between 90 ° and 170 °. 8. Dispositif selon la revendication 7, caractérisé en ce que l'angle est de l'ordre de 135°. 8. Device according to claim 7, characterized in what the angle is around 135 °. 9. Dispositif selon l'une des revendications 1 à 8, caractérisé en ce qu'une électrode de iontophorèse ou d'électroporation (8) s'étend dans une sonde (9). 9. Device according to one of claims 1 to 8, characterized in that an iontophoresis electrode or electroporation (8) extends into a probe (9). 10. Dispositif selon l'une des revendications 1 à 9, caractérisé en ce que les moyens de diffusion comportent une paroi poreuse (6;106;306) apte à laisser passer le principe actif, en particulier sous l'effet d'un courant de iontophorèse ou d'électroporation. 10. Device according to one of claims 1 to 9, characterized in that the means of diffusion include a porous wall (6; 106; 306) capable of letting the active ingredient, in particular under the effect of a current iontophoresis or electroporation. 11. Dispositif selon l'une des revendications 1 à 9, caractérisé en ce que le réservoir présente une paroi comportant au moins un orifice de diffusion (107;406). 11. Device according to one of claims 1 to 9, characterized in that the tank has a wall comprising at least one diffusion orifice (107; 406). 12. Dispositif selon la revendication 11, caractérisé en ce que l'orifice (406) est recouvert par une membrane perméable ou semi-perméable (407) apte à laisser passer le principe actif, en particulier sous l'effet d'un courant de iontophorèse ou d'électroporation. 12. Device according to claim 11, characterized in that the orifice (406) is covered by a membrane permeable or semi-permeable (407) able to pass the active ingredient, in particular under the effect of a iontophoresis or electroporation current. 13. Dispositif selon la revendication 11 ou 12, caractérisé en ce que l'orifice latéral est bouché du coté du réservoir par un bouchon (507) en matériau absorbant apte à laisser passer le principe actif, en particulier sous l'effet d'un courant de iontophorèse ou d'électroporation. 13. Device according to claim 11 or 12, characterized in that the lateral opening is blocked from the side of the tank by a cap (507) of material absorbent capable of letting the active principle pass, particularly under the effect of an iontophoresis current or electroporation. 14. Dispositif selon l'une des revendications 1 à 13, caractérisé en ce qu'il comporte en outre une fibre optique (10) apte à être reliée à une source lumineuse et agencée de sorte à éclairer l'environnement des moyens de diffusion, notamment des cellules cibles à
traiter. 14. Device according to one of claims 1 to 13, characterized in that it further comprises a fiber optic (10) capable of being connected to a light source and arranged so as to illuminate the environment of means of dissemination, including target cells to treat. 15. Dispositif selon la revendication 14, caractérisé en ce qu'il comprend une deuxième fibre optique (11) apte à
être reliée à une caméra et agencée de sorte à
enregistrer des images de l'environnement des moyens de diffusion, notamment des cellules cibles à traiter. 15. Device according to claim 14, characterized in what it includes a second optical fiber (11) capable of be connected to a camera and arranged so that record images of the environment means of diffusion, in particular of the target cells to be treated. 16. Sonde pour l'application oculaire d'un principe actif par iontophorèse ou électroporation intraoculaire comportant un réservoir apte à recevoir une solution comprenant le principe actif, des moyens de diffusion du principe actif connectés au réservoir, caractérisé en ce qu'il comporte en outre un tube d'infection de la solution dans le réservoir et un tube d'aspiration d'un contenu du réservoir. 16. Probe for the ocular application of a principle active by iontophoresis or intraocular electroporation comprising a reservoir capable of receiving a solution including the active ingredient, means of disseminating the active ingredient connected to the reservoir, characterized in that it also includes a tube of infection of the solution in the tank and a suction tube of a contents of the tank.
CA2463113A 2001-10-12 2002-10-11 Device for medicine delivery by intraocular iontophoresis or electroporation Expired - Fee Related CA2463113C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0113177 2001-10-12
FR0113177A FR2830767B1 (en) 2001-10-12 2001-10-12 DEVICE FOR DELIVERING DRUGS BY IONTOPHORESIS OR INTROCULAR ELECTROPORATION
PCT/FR2002/003473 WO2003043689A1 (en) 2001-10-12 2002-10-11 Device for medicine delivery by intraocular iontophoresis or electroporation

Publications (2)

Publication Number Publication Date
CA2463113A1 true CA2463113A1 (en) 2003-05-30
CA2463113C CA2463113C (en) 2010-12-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2463113A Expired - Fee Related CA2463113C (en) 2001-10-12 2002-10-11 Device for medicine delivery by intraocular iontophoresis or electroporation

Country Status (16)

Country Link
US (1) US7684857B2 (en)
EP (1) EP1434623B1 (en)
JP (1) JP4234010B2 (en)
KR (1) KR20040048951A (en)
AT (1) ATE390168T1 (en)
AU (1) AU2002360111A1 (en)
BR (1) BR0213245A (en)
CA (1) CA2463113C (en)
DE (1) DE60225822T2 (en)
DK (1) DK1434623T3 (en)
ES (1) ES2305337T3 (en)
FR (1) FR2830767B1 (en)
IL (2) IL161292A0 (en)
MX (1) MXPA04003437A (en)
PT (1) PT1434623E (en)
WO (1) WO2003043689A1 (en)

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ES2305337T3 (en) 2008-11-01
FR2830767B1 (en) 2004-03-12
AU2002360111A1 (en) 2003-06-10
WO2003043689A1 (en) 2003-05-30
DE60225822D1 (en) 2008-05-08
EP1434623A1 (en) 2004-07-07
ATE390168T1 (en) 2008-04-15
BR0213245A (en) 2004-09-28
KR20040048951A (en) 2004-06-10
MXPA04003437A (en) 2005-02-17
DE60225822T2 (en) 2009-04-16
CA2463113C (en) 2010-12-21
IL161292A0 (en) 2004-09-27
JP2005518229A (en) 2005-06-23
PT1434623E (en) 2008-07-07
FR2830767A1 (en) 2003-04-18
JP4234010B2 (en) 2009-03-04
EP1434623B1 (en) 2008-03-26
US20050049541A1 (en) 2005-03-03
US7684857B2 (en) 2010-03-23
DK1434623T3 (en) 2010-01-25
IL161292A (en) 2009-02-11

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