CA2445749C - Dyeing agents for keratin fibers, containing n-heteroarylmethyl-m-phenylenediamine deritaves, as well as new n-heteroarylmethyl-m-phenylenediamine derivatives - Google Patents
Dyeing agents for keratin fibers, containing n-heteroarylmethyl-m-phenylenediamine deritaves, as well as new n-heteroarylmethyl-m-phenylenediamine derivatives Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
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Abstract
Dyeing agents for keratin fibers, containing N-heteroarylmethyl-m-phenylenediamine derivatives of general formula (I) or the salts thereof (see formula I) and new N-heteroarylmethyl-m-phenylenediamine derivatives.
Description
DESCRIPTION
DYEING AGENTS FOR KERATIN FIBERS, CONTAINING N-HETEROARYLMETHYL-m-PHENYLENEDIAMINE DERIVATIVES, AS WELL AS NEW N-HETEROARYLMETHYL-m-PHENYLENEDIAMINE DERIVATIVES
The present invention relates to agents for oxidative dyeing of keratin fibers, particularly human hair, based on a developer/coupler combination which contains an N-heteroarylmethyl-m-phenylenediamine derivative as the coupler, and to new N-heteroaryimethyl-m-phenylenediamine derivatives.
In the area of keratin fiber dyeing, particularly hair dyeing, oxidation dyes have attained substantial importance. In this case, the coloration is produced by reaction of certain developers with certain couplers in the presence of an appropriate oxidant.
Suitable developers are, in particular, 2,5-diaminotoluene, 2,5-diaminophenylethyl alcohol, p-aminophenol, 1,4-diaminobenzene and 4,5-diamino-l-(2-hydroxyethyl)-pyrazole, and suitable couplers are, for example, resorcinol, 2-methylresorcinol, 1-naphthol, 3-aminophenol, m-phenylenediamine, 2-amino-4-(2'-hydroxyethyl)amino-anisole, 1,3-diamino-4-(2'-hydroxyethoxy)benzene and 2,4-diamino-5-fluorotoluene.
The oxidation dyes used for dyeing human hair must meet numerous requirements in addition to that of being able to produce colorations of the desired intensity. For example, these dyes must be harmless from a toxicological and dermatological standpoint, and the hair colorations obtained must have good light fastness, resistance to permanent waving, acid fastness and rubbing fastness. In any case, however, in the absence of exposure to light, rubbing and chemicals, such colorations must remain stable over a period of at least 4 to 6 weeks. Moreover, by combining appropriate developers and couplers, it must be possible to create a wide range of different color shades.
Attempts have already been made to improve the properties of m-phenylenediamines by introduction of substituents. In this regard, the reader is referred to German Unexamined Patent Application DE 29 34 330 which, among other things, describes special N-substituted m-phenylenediamines as couplers. With the currently known -dyeing agents, however; it is not possible to meet the requirements placed on dyeing agents in all respects.
Hence, the need continued to exist for novel couplers that would meet the aforesaid requirements to a particularly high degree.
We have now found that intense, stable violet to dark-blue color shades can be obtained by use of special N-heteroarylmethyl=m-phenylenediamine derivatives of general formula (I).
Hence, the object of the present invention is an agent for oxidative dyeing of keratin fibers, for example wool, furs, feathers or hair, particularly human hair, which agent is based on a developer-coupler combination characterized by the fact that it contains as the coupler at least one N-heteroarylmethyl-m-phenylenediamine derivative of formula (I) or a salt thereof with an organic or inorganic acid V Xr X5 ' = . X
RN H
R'1 N.IH
H
wherein X5 denotes sulfur, nitrogen, oxygen, C-R6 or N-R5;
X6 denotes sulfur, nitrogen, oxygen, C-R7 or N-R5;
X7 denotes sulfur, nitrogen, oxygen, C-R8 or N-R5;
R1 denotes hydrogen, a C,-C4:alkyl group, a C,-C4 hydroxyalkoxy group or C,-C4-hydroxyalkyl group;
R2 and R3 can be equal or different and independently of each other denote hydrogen or a C,-C6-alkyl group;
DYEING AGENTS FOR KERATIN FIBERS, CONTAINING N-HETEROARYLMETHYL-m-PHENYLENEDIAMINE DERIVATIVES, AS WELL AS NEW N-HETEROARYLMETHYL-m-PHENYLENEDIAMINE DERIVATIVES
The present invention relates to agents for oxidative dyeing of keratin fibers, particularly human hair, based on a developer/coupler combination which contains an N-heteroarylmethyl-m-phenylenediamine derivative as the coupler, and to new N-heteroaryimethyl-m-phenylenediamine derivatives.
In the area of keratin fiber dyeing, particularly hair dyeing, oxidation dyes have attained substantial importance. In this case, the coloration is produced by reaction of certain developers with certain couplers in the presence of an appropriate oxidant.
Suitable developers are, in particular, 2,5-diaminotoluene, 2,5-diaminophenylethyl alcohol, p-aminophenol, 1,4-diaminobenzene and 4,5-diamino-l-(2-hydroxyethyl)-pyrazole, and suitable couplers are, for example, resorcinol, 2-methylresorcinol, 1-naphthol, 3-aminophenol, m-phenylenediamine, 2-amino-4-(2'-hydroxyethyl)amino-anisole, 1,3-diamino-4-(2'-hydroxyethoxy)benzene and 2,4-diamino-5-fluorotoluene.
The oxidation dyes used for dyeing human hair must meet numerous requirements in addition to that of being able to produce colorations of the desired intensity. For example, these dyes must be harmless from a toxicological and dermatological standpoint, and the hair colorations obtained must have good light fastness, resistance to permanent waving, acid fastness and rubbing fastness. In any case, however, in the absence of exposure to light, rubbing and chemicals, such colorations must remain stable over a period of at least 4 to 6 weeks. Moreover, by combining appropriate developers and couplers, it must be possible to create a wide range of different color shades.
Attempts have already been made to improve the properties of m-phenylenediamines by introduction of substituents. In this regard, the reader is referred to German Unexamined Patent Application DE 29 34 330 which, among other things, describes special N-substituted m-phenylenediamines as couplers. With the currently known -dyeing agents, however; it is not possible to meet the requirements placed on dyeing agents in all respects.
Hence, the need continued to exist for novel couplers that would meet the aforesaid requirements to a particularly high degree.
We have now found that intense, stable violet to dark-blue color shades can be obtained by use of special N-heteroarylmethyl=m-phenylenediamine derivatives of general formula (I).
Hence, the object of the present invention is an agent for oxidative dyeing of keratin fibers, for example wool, furs, feathers or hair, particularly human hair, which agent is based on a developer-coupler combination characterized by the fact that it contains as the coupler at least one N-heteroarylmethyl-m-phenylenediamine derivative of formula (I) or a salt thereof with an organic or inorganic acid V Xr X5 ' = . X
RN H
R'1 N.IH
H
wherein X5 denotes sulfur, nitrogen, oxygen, C-R6 or N-R5;
X6 denotes sulfur, nitrogen, oxygen, C-R7 or N-R5;
X7 denotes sulfur, nitrogen, oxygen, C-R8 or N-R5;
R1 denotes hydrogen, a C,-C4:alkyl group, a C,-C4 hydroxyalkoxy group or C,-C4-hydroxyalkyl group;
R2 and R3 can be equal or different and independently of each other denote hydrogen or a C,-C6-alkyl group;
R4, R6, R7, R8 can be equal or different and independently of each other denote hydrogen, a halogen atom (F, Cl, Br, 1), a cyano group, a C,-C4-alkoxy group, a C,-Cs-alkyl group, a Cl-C4-alky! thioether group, a mercapto group, a nitro group, an amino group, a C,-C4 alkylamino group, a d"(C,-C4)-alkylamino group, a di(C,-C4 hydroxyalkyl)amino group, a C,-C4-hydroxyalkylamino group, a trifluoromethyl group, a -C(O)CH3- group, a -C(O)CF3group, an -Si(CH3)3 group, a C,-C4-hydroxyalkyl group or a C3 C4 dihydroxyalkyi group; and R5 denotes hydrogen, a C,-Cs-alkyl group, a C2-C4 hydroxyalkyl group, a phenyl group or an acetyl group; at least one and at the most two of the X5 to X7 groups denoting respectively C-R6 or C-R7 or C-R8 and at the most one of the X5 to X7 groups denoting sulfur, oxygen or N-R5.
Noteworthy among the compounds of formula (1) are, for example:
N-thiophen-3-ylmethyl-1,3-diaminobenzene, N-furan-3-ylmethyl-1,3-diaminoben-zene, N-(1H-imidazol-2-ylmethyl)-1,3-diaminobenzene, N-(1H-pyrol-2-ylmethyl)-1,3-diaminobenzene, N-thiophen-2-ylmethyl-1,3-diaminobenzene, N-thiazol-2-yl-methyl-1,3-diaminobenzene, N-(5-nitrothiophen-2-ylmethyl)-1,3-diaminobenzene, N-(3-methylthiophen-2-y(methyl)-1,3-diaminobenzene, N-(2-methylthiophen-3-ylmethyl)-1,3-diaminobenzene, N-(4-methylthiophen-3-ylmethyl)-1,3-diaminobenzene, N-(5-meth-ylthiophen-2-ylmethyl)-1,3-diaminobenzene, N-(3-chlorothiophen-2-ylmethyl)-1,3-di-aminobenzene, N-(4-methylthiophen-2-ylmethyl)-1,3-diaminobenzene, N-(4-chloro-thiophen-2-ylmethyl)-1,3-diaminobenzene, N-(5-methylthiophen-2-ylmethyl)-1,3-diami-nobenzene, N-(5-chlorothiophen-2-ylmethyl)-1,3-diaminobenzene, 2-{4-amino-2-[(furan-2-ylmethyl)amino]phenoxy}ethanol, 2={4-amino-2-[(thiophen-3-ylmethyi)amino]phenoxy)ethanol, 2-{4-amino-2-[(thiophen-2-ylmethyl)amino]phenoxy}ethanol, 2-(4-amino-2-[(1 H-imidazol-2-ylmethyl)amino]phenoxy}ethanol, 2-{4-amino-2-[(furan-3-ylmethyl)amino]phenoxy}ethanol, 2-{4-amino-2-[(1 H-pyrol-2-ylmethyl)amino]phenoxy}ethanol, 2-{4-amino-2-[(3-methylthiophen-2-yimethyl)amino]phenoxy}ethanol, 2-{4-amino-2-[(3-chlorothiophen-2-ylmethyl)amino]phenoxy}ethanol, 2-{4-amino-2-[(4-methylthiophen-2-ylmethyl)amino]phenoxy}ethanol, 2-{4-amino-2-[(4-chlorothiophen-2-ylmethyl)amino]phenoxy}ethanol, 2-{4-amino-2-[(5-chlorothiophen-2-ylmethyl)amino]phenoxy}ethanol, 2-14 -amino-2-[(5-methylthiophen-2-ylrriethyl)amino]phenoxy}ethanol, 2-{4-amino-2-[(2-methylthiophen-3-ylrnethyl)aminolphenoxy}ethanol, 2-{4-amino-2-[(2-chlorothiophen-3-ylmethyl)amino]phenoxy}ethanolj 2-{4amino-2-[(4-methylthiophen-3-ylmethyl)amino]phenoxy}ethanol, 2-{4-amirio-2-[(4-chlorothiophen=3-ylmethyl)amino]phenoxy}ethanol, 2-{4-amino-2-[ (5-methylthiophen-3-ylmethyl)amino]phenoxy}ethanol, 2-[4-a mino-2-[ (5-chlorothiophen-3-ylmethyl)amino]phenoxy}etha noi 2-{ 2-amin.o-4-[ (furan-2-ylmethyl)amino]phenoxy}ethanol, 2-{2-amino-4-[(thiophen-3-yimethyl)aminojphenoxy}ethanol, 2-{2=amino-4-[(thiophen-2-ylmethyl)aminolphenoxy}ethanol, 2-{2-amino-4-[(1 H-imidazol-2-ylmethyl)amino]phenoxy}ethanol and 2-{2-amino-4-[(furan-3-ylmethyl)amino]phenoxy}ethanol.
Preferred compounds of formula (I) are those wherein (i) R1 denotes hydrogen or ;q hydroxyalkoxy group and R2 and R3 or R2, R3 and R4 denote hydrogen; or (ii) RI
denotes hydrogen or a hydroxyalkoxy group and the R2 and R3 groups or the R2, and R4 groups denote hydrogen, X5 denotes sulfur or oxygen, 'X6 denotes nitrogen or C-R7 and X7 denotes C-R8, with at least one of the R7 and R8 groups denoting hydrogen; or (iii) R1 denotes hydrogen or a hydroxyalkoxy group, the R2 and R3 groups or the R2, R3 and R4 groups denote hydrogen, X7 denotes sulfur or oxygen, X5 denotes C-R6 and X6 denotes C-R7, with at least one of the R6 and R7 groups denoting hydrogen; or (iv) Ri denotes hydrogen or a hydroxyalkoxy group, the.
R2 and R3 groups or the R2, R3 and R4 groups denote hydrogeri, X6 denotes sulfur or oxygen, X5 denotes C=R6 and X7 denotes C-R8, with at least one of the R6 and groups denoting hydrogen.
Particularly preferred are the following N-heteroarylmethyl-m-phenylenediamine derivatives of formula (I): N-thiophen-3-ylmethyi=l,3-diaminobenzene, N-furan-3-ylmethyl-1,3-diaminobenzene, N-furan-2-y1methyl-1,3-diarninobenzene, N-thio-phen-2-ylmethyl-1,3-diamiriobenzene, 2-(4-amino-2-[(thiophen-3-ylmethyl)amino]phen-oxy)ethanol, 2-{4-amino-2-1(thiophen-2-ylmethyl)aminolphenoxy}ethanol, 2-{4-ami-no-2-[(furan-3-ylmethyi)amino)phenoxy}ethanol, 2-{4-amino-2-[(furan-2-yimethyl)-arriino)phenoxy}ethanol,2-(2-amino-4-[(thiophen-2-yimethyi)amino]phenoxy)ethanol and 2-(2-amino-4-[(furan-2-ylmethyi)amino]phenoxy}ethanol or the salts thereof.
The compounds of formula (I) can be used as the free bases as well as in the form of their physiologically tolerated salts with inorganic or organic acids, for example hydrochloric acid, sulfuric acid, phosphoric acid, acetic acid, propionic acid, lactic acid or citric acid.
The colorant of the invention contains the N-heteroarylmethyl-m-phenylenediamine derivatives of formula (I) in a total amount from about 0.005 to 20 wt.%, an amount of about 0.01 to 5 wt.% and especially 0.1 to 2.5 wt.% being preferred. ~
Suitable developers are all those developers that are known to be used with, and are appropriate for, such colorants, for example 1,4-diaminobenzene (p-phenylene-diamine), 1,4-diamino-2-methylbenzene (p-toluylenediamine), 1,4-diamino-2,6-di-methylbenzene, 1,4-diamino-3,5-diethyibenzene, 1,4-diamino-2,5-dimethylbenzene, 1,4-diamino-2,3-dimethylbenzene, 2-chloro-1,4-diaminobenzene, 1,4-diamino-2-(thiophen-2-y!)benzene, 1,4-diamino-2-(thiophen-3-yl)benzene, 1,4-diamino-2-(pyri-din-3-yl)benzene, 2,5-diaminobiphenyl; 1,4-diamino-2-methoxymethylbenzene, 1,4-diamino-2-aminomethylbenzene, 1,4-diamino-2-hydroxymethylbenzene, 1,4-diamino-(2-hydroxyethoxy) benzene, 1-(2,5-diaminophenyl)ethanol, 2-[2-(acetylamino)eth-oxy]-1,4-diaminobenzene, 4-phenylaminoaniline, 4-dimethylaminoaniline, 4-diethyl-aminoaniline, 4-dipropylaminoaniline, 4-[ethyl-(2-hydroxyethyl)amino]aniline, 4-[di(2-hyd roxyethyl)a mino]aniline, 4-[di (2-hydroxyethyl)amino]-2-methylani(ine, 4-[(2-meth-oxyethyl)amino]aniline, 4-[(3-hydroxypropyl)amino]aniline, 4-[(2,3-dihydroxypropyl)-amino]aniline, 1,4-diamino-2-(2-hydroxyethyl)benzene, 1,4-diamino-2-(1-methyleth-yl)benzene, 1,3-bis-[(4-aminophenyi)(2-hydroxyethyl)amino]-2-propanol, 1,4-bis-[(4-aminophenyl)amino]butane,1,8-bis-(2,5-diaminophenoxy)-3,6-dioxaoctane,4-amino-phenol, 4-amino-3-methylphenol, 4-amino-3-(hydroxymethyl)phenol, 4-amino-3-flu-orophenol, 4-methylaminophenol, 4-amino-2-(aminomethyl)phenol, 4-amino-2-(hy-droxymethyl)phenol, 4-amino-2-fluorophenol, 4-amino-2-[(2-hydroxyethyl)amino]-methyiphenol, 4-amino-2-methylphenol, 4-amino-2-(methoxymethyl)phenol, 4-amino-2-(2-hydroxyethyl)phenol, 5-aminosalicylic acid, 2,5-diaminopyridine, 2,4,5,6-tetraaminopyrimidine, 2,5,6-triamino-4-(1 H)-pyrimidone, 4,5-diamino-l-(2-hydroxyethyl)-1H-pyrazole, 4,5-diamino-l-(1-methylethyl)-1H-pyrazole, 41 5-diamino-l-[(4-methylphenyl)methyl]-1 H-pyrazole, 1-[(4-chlorophenyl)methyl]-4,5-diamino-pyrazole, 4,5-diamino-l-methyl-1 H-pyrazole, 4,5-diamino-3-methyl-l-methyl-1 H-py-razole, 2-aminophenol, 2-amino-6-methylphenol and 2-amino-5-methylphenol.
Moreover, the colorant of the invention can optionaily-a(so contain other known couplers, for example -2,6-diaminopyridine, 2-amino-4-[(2-hydroxyethyl)amino]ani-sole, 2,4-diamino-1-fluoro-5-methylbenzene, 2,4-diamino-l-methoxy-5-methylben-xene, 2,4-diamino-1-ethoxy-5-methylbenzene, 2,4-diamino-l-(2=hydroxyethoxy)-5-methylbenzene, 2,4-di[(2-hydroxyethyl)amino]-1,5-dimethoxybenzene, 2,3-diamino-6-methoxypyridine, 3-amino-6-methoxy-2-(methylamino)pyr-idine, 2,6-diamino-3,5-.
dimethoxypyridine, 3,5-diamino-2,6-dimethoXypyridirie, 1a3-diaminobenzene, 2,4-di-amino-1-(2-hydroxyethoxy)benzene, 2,4-diamino-1,5-di(2-hydroxyethoxy)benzene, 1-(2-aminoethoxy)-2,4-diaminobenzene, 2=amino-1-(2-hydroxyethoxy)-4-methylamirlo-benzene, 2,4-diar.ninophenoxyacetic acid, 3-[di(2-hydroxyethyl)amino]aniline, 4-ami-no-2-di[(2-hydroxyethyl)amino]-1-ethoxybenzene, 5-methyl-2-(1-methylethyl)phen-ol, 3-[(2-hydroxyethyi)aminolaniline, 3-[(2-aminoethy()amino]aniline, 1,3-di(2,4-dia-minophenoxy)propane, di(2,4-diaminophenoxy)methane, 1,3~-diamino-2,4-dimeth-oxybenzene, 2,6-bis-(2-hydroxyethyl)aminotoluene, 4-hydroxyindole, 3-dimethylamino-phenol, 3-diethylaminophenol,.5-amino=2-methylphenol., 5-amino-4-fluoro-2-methyl-phenol, 5-amino-4-methoxy-2-methylphenol,.5-amino-4-ethoxy-2-rnethylphenol, 3-ami-no-2,4-dichlorophenol, 5-amino-2,4-dichlorophenol, 3-amino-2-methylphenol; 3-amino-2-chloro-6-methylphenol, 3-aminophenol, 2-[(3-hydroxyphenyl)aminolacetamide, 5-[(2-hydroxyethyl)aminol-2-methyiphenol, 3-1(2-hydroxyethyi)eminolphenol, 3-[(2-methoxyethyl)aminolphenol, 5-amino-2-ethylphenol, 2-(4-amino-2-hydroxyphenoxy)-ethanol, 5-[(3-hydroxypropyl)amino]-2-methylphenol, 3-j(2,3-dihydroxypropyl)ami-no]-2-methylphenol, 3-[(2-hydroxyethyl)aminoj-2-methyiphenoi, 2-amino-3-hydroxy-pyridine, 5-amino-4-chloro-2-methyiphenol, 1-naphthoi, 1,5-dihydroxynaphthalene, 1,7-dihydroxynaphthaiene, 2,3-dihydroxynaphthalene, 2,7-dihydroxynaphthalene, methyl-1 -napFithQl acetate, 1,3-dihydroxybenzene, 1-chloro-2,4-dihydroxybenzene, 2-chloro-1,3-dihydroxybenzene, 1,2-dichloro-3,5-dihydroxy-4=methylbenzene,.
1,5-dichloro-2,4-dihydroxybenzene,1,3-dihydroxy-2-methylbenzene, 3,4-methylenedi-oxyphenoi, 3,4-methylenedioxyaniiine, 5-[(2-hydroxyethyi)amino]-1,3-benzodioxoie, 6-bromo-'1-hydroxy-3,4-methyfenedioxybenzene, 3,4-diaminobenzoic acid; 3,4-di-hydro-6-hydroxy-1,4(2H)benzoxazine, 6-amino-3,4-dihydro-1,4(2H)-benzoxazine, 3-methyl-l-phenyl-5-pyrazolone, 5,6-dihydroxyindole, 5,6-dihydroxyindoline, 5=hy-'"droXyindole, 6-hydroxyindole, 7-hydroxyindole and 2,3-indolinedione.
The couplers and developers can be present In the colorant of the invention -either .individually or in admbcture with one another, the total arimount of each of the couplers and developers In the colorant of the invention being about 0.005 to 20. wt,g6 preferably about 0.01 to 5.0 wt. % and particularly 0.1 to 2.5 wt. % (based on the total amount of 'colorant). The total amount of the developer-coupler combination coritained in the colorant described herein is preferably about 0.01 to 20 wt.
fa, an -amount of about 0.02 to 10 wt.%. and especially 0.2 to 6_wt. % being particularly preferred. In general, the developer and the coupler are used in approximateiy equimolar amounts. In this respect, it is not disadvantageous, however, if the developer is present in a certain excess or deficiency [for example in a (coupier:deveiopee) ratio of i: 2 to 1: 0.51.
Moreover, the colorant of the invention can also contain other dye components, for exarnple 6-amino-2-methylphenol and 2-amino-5-methylphenol, as well as common anionic, cationic, amphoteric or nonionic direct dyes, for example triphenylmethane dyes such as 4-[(4'-aminophenyl)-(4'-imino-2",5"-cyciohexadien-1 "-yiidene)methyl]-2-methylaminobenzene monohydrochloride (Color Index [C.I.] 42 510) and 4-[(4'-arnino-3'-methylphenyl)-(4"-imino-3"-methyl-2", 5 "-cyciohexad ien-1 "-ylidene)rnethyl]-2-methyiaminobenzene monohydrochioride (C.I. 42 520), aromatic nitro dyes such as 4-(2'-hydroxyethyl)aminonitrotoluene, 2-amino-4,6-dinitrophenol, - 2-amino-5-(2'-hydroxyethyi)aminonitrobenzene, 2-chloro-6-(ethyiamino)-4-nitrophenoi, 4-chioro-N-(2-hydroxyethyl)-2~nitroaniline, 5-chloro-2-hydroxy-4-nitroaniline, 2-amino-4-chloro-6-nitrophenol and 1-(2'-ureidoethyl)amino-4-nitrobenzene, azo dyes such as sodium 6-[(4'-amiriophenyl)azol-5-hydroxynaphthalene-1-suifonate (C.I. 14 805) and disperse dyes, for example 1,4-diaminoanthraquinone and 1,4,5,8-tetraaminoanthraquinone.
The colorants of the invention can contain the aforesaid dye components in an amount from about 0.1 to 4 wt.%
The couplers and developers as well as the other dye components, provided they are bases, can, of course, also be used in the form of their physiologically tolerated salts with organic or inorganic acids, for example hydrochloric acid or sulfuric acid, or - if they contain aromatic OH groups - In the form of their salts with bases, for example as alkali metal phenoxides.
Moreover, If the colorants of the invention are to be used for coloring hair, they can also contain other common cosmetic additives, for example antioxidants such as ascorbic acid, 'thiogiycoiic acid or sodium suifite, as well as perfume oils, comptexing agents; wetting agents, emulsifiers, thickeners and hair-care agents.
-The colorant of the invention can be in the form of, for example, a solution, particularly an aqueous or aqueous-alcoholic solution. A particularly preferred formulation form, however, is a cream, gel or emulsion. Such a composition consists of a mixture of the dye components and the usual additives employed for such compositions.
Common additives to solutions, creams, emulsions or gels are, for example solvents such as water, lower aliphatic alcohols, for example ethanol, propanol or isopropanol, glycerol or glycols such as 1,2-propylene glycol, moreover wetting agents or emulsifiers from the classes of anionic, cationic, amphoteric or nonionic surface-active agents, for example fatty alcohol sulfates, ethoxylated fatty alcohol sulfates, alkylsulfonates, alkylbenzenesulfonates, alkyltrimethylammonium salts, alkylbeta- -ines, ethoxylated fatty alcohols, ethoxylated nonylphenols, fatty acid alkanolamides and ethoxylated fatty esters, furthermore thickeners such as the higher fatty alcohols, starch, cellulose derivatives, petrolatum, paraffin oil and fatty acids, also hair-care agents such as cationic resins, lanolin derivatives, cholesterol, pantothenic acid and betaine. The said constituents are used in amounts commonly employed for such purposes, for example the wetting agents and emulsifiers at a concentration of about 0.5 to 30 wt. %, the thickeners in an amount from about 0.1 to 25 wt. % and the hair-care agents at a concentration from about 0.1 to 5 wt.%.
The ready-to-use hair colorant of the invention is prepared by mixing the colorant with an oxidant just before use.
Suitable oxidants are primarily hydrogen peroxide or its products of addition to urea, melamine, sodium borate or sodium carbonate in the form of a 1 to 12% and preferably 3 to 6% aqueous solution. The weight ratio of hair colorant to oxidant in this case is preferably from 5 : 1 to 1: 3 and particularly from 1 : 1 to 1 :
2. Higher amounts of oxidant are used especially with higher concentrations of hair colorant or when stronger bleaching of the hair is wanted at the same time. In principle, however, atmospheric oxygen can be used in place of the aforesaid oxidants to oxidize the dyes.
buring the mixing of the dye (the pH of which is approximately 6 to 11.5) with the oxidant, which most frequently is adjusted to an acidic pH (approximately 2 to 6.5), the pH of the ready-to-use hair colorant of the invention assumes a value which depends on the amount of alkali in the dye and of acid in the oxidant as well as on the mixing ratio. Depending on the composition, the colorant of the invention can be weakly acidic, neutral or alkaline and in the ready-to-use form can have a pH
of about 3 to 11.5 and preferably about 6 to 10. The adjustment to a basic pH is preferably made with ammonia, but it can also be made with an organic amine, for example with 2-amino-2-methyl-l-propanol,tris(hydroxymethyl)aminomethane, monoethanolamine and triethanolamine, or with an inorganic base such as sodium hydroxide and potassium hydroxide. The adjustment to an acidic pH can be made with an inorganic or organic acid, for example phosphoric, acetic, lactic, ascorbic, citric or tartaric acid.
Then, depending on the hair fullness, an amount of this mixture sufficient for the hair treatment, usually about 60 to 200 grams, is applied to the hair, and the mixture is allowed to act on the hair at about 15 to 50 C and preferably at 30 to 40 C, for about 10 to 45 min and preferably for 30 min after which the hair is rinsed with water and dried. Optionally, following this rinsing the hair is washed with a shampoo and optionally post-rinsed with a weak organic acid, for example citric acid or tartaric acid.
The hair is then dried.
The colorants of the invention containing an N-heteroarylmethyl-m-phenylenediamine derivative of formula (I) as coupler give hair colorations of excellent color stability, particularly in terms of light fastness, wash fastness and rubbing fastness.
As far as the dyeing properties are concerned, the hair colorants of the invention provide a wide range of different color shades from blond to brown, purple, violet and even blue and black, depending on the kind and composition of the dye components used, the achievable violet to dark-blue shades being particularly noteworthy. The color shades are characterized by their unusual color intensity. The very good coloring properties of the hair colorant of the present patent application also manifest themselves particularly in that this colorant makes it possible to dye gray hair, previously not damaged chemically, without any problems and with good covering power.
- The N-heteroarylmethyl-m-phenylenediamine derivatives of formula (I) of the invention can be prepared by known methods of synthesis, for example by'the methods described in the practical examples given hereinbelow.
The N-heteroarylmethyl-m-phenylenediamine derivatives of formula (I) are highly.
water-soluble and give colorations of high color intensity and excellent color stability, particularly in terms of light fastness, wash fastness and rubbing fastness.
Moreover, they have excellent storage stability, particularly as constituents of the oxidation colorants described herein.
Hence, another object of the present invention are N-heteroarylmethyl-m-phenylenediamine derivatives of general formula (II) or the water-soluble salts thereof with organic or inorganic acids x7 R2~N
/ NH
H (11) wherein X5 denotes sulfur, nitrogen, oxygen, C-R6 or N-R5;
X6 denotes sulfur, nitrogen, oxygen, C-R7 or N-R5;
X7 denotes sulfur, nitrogen, oxygen, C-R8 or N-R5;
R1 denotes hydrogen, a C,-C4-alky! group, a C,-C4-hydroxyalkoxy group or a C,-hydroxyalkyl group;
R2 and R3 can be equal or different and independently of each other denote hydrogen or a Cl-Cs-alkyl group;
R4, R6, R7, R8 can be equal or different and independently of each other denote hydrogen, a halogen atom (F, Cl, Br, I), a cyano group, a C,-C4 alkoxy group, a Cl-CB
a(kyl group, a C,-C4-alkyl thioether group, a mercapto group, a nitro group, an amino group, a C,-C4-alkylamino group, a di(C,-C4)-alkylamino group, a di(C,-C4 hydroxyalkyl)amino group, a C,-C4 hydroxyalkylamino group, a trif(uoromethyl group, a -C(O)CH3- group, a -C(O)CF3 group, an -Si(CH3)3 group, a C,-C4 hydroxyaikyl group or a C3-C4 dihydroxyalkyl group; and R5 denotes hydrogen, a C,-C6-alkyl group, a C2-C4 hydroxyalkyl group, a phenyl group or an acetyl group; at least one and at the most two of the X5 to X7 groups denoting respectively C-R6 or. C-R7 or C-R8 and at the most one of the X5 to X7 groups denoting sulfur, oxygen or N-R5; ~
provided that at least one of the R9, R2, R3, R4 , R6, R7 and R8 groups does not denote hydrogen when X5 or X6 denotes sulfur.
The following examples illustrate the object of the invention in greater detail withoat limiting its scope.
EXAMPLES
Example 1: Synthesis of N-heteroarylmethyl-1,3-diaminobenzenes A. Synthesis of tert.butyl (3-aminophenyllcarbamate A solution of 11 g (50 mmol) of ditert.butyl dicarbonate in 30 mL of methylene chloride was. added dropwise to a solution of 10.8 g (100 mmol) of 1,3-phenylenediamine in 100 mL of methylene chloride/NaOH (4%) 1: 1. The reaction mixture was allowed to agitate 8 hours after which 5 g of ditert.butyl dicarbonate was added to it. The reaction mixture was then allowed to agitate for an additional 12 hours at room temperature. The organic phase was washed with a saturated aqueous sodium chloride solution, dried over sodium sulfate and filtered, and the filtrate was evaporated. The resulting crude product was purified on silica gel with hexane/ethyl acetate (1 : 1). This gave 6.2 g (30% of the theoretical) of tert.butyl (3=amino-phenyl)carbamate.
'H-NMR (300 MHz; CDCI,): d= 7.06 (t, 1 H); 6.99 (br s, 1 H); 6.44 (br s, 2H);
6.56 (d, 1H); 6.39 (m; 2H); 3.68 (br, 2H); 1.53 (s, 9H).
B. Synthesis of N-heteroarylmethyl-1,3-diaminobenzenes 0.031 g (0.15 mmol) of tert.butyl (3-aminophenyl)carbamate from step 1A and 0.1 mmol of the appropriate aldehyde were dissolved in methanol (dried over molecular sieve). 10 mg of molecular sieve was added, and the reaction mixture was allowed to agitate for 7 hours. Then, 0.3 mL of a borane-tetrahydrofuran complex solution (1 M in tetrahydrofuran) was added at 0 C, and the reaction mixture was allowed to agitate for one hour at room temperature. At the end of the reaction, the reaction mixture was poured into water and extracted with ethyl acetate. The organic phase was dried with magnesium sulfate, the solvent was distilled off in a rotary evaporator and the residue was purified on silica gel with petroleum ether/ethyl acetate (1 1).
The resulting product in 4 mL of ethanol and 1.5 mL of a 2.9-molar ethanofic hydrochloric acid solution was heated to 50 C. The resulting precipitate was filtered off, washed twice with 1-mL portions of ethanol and then dried.
a. N-Thiophen-2-ylmethyl-1,3-diaminobenzene hydrochloride Aldehyde derivative used: thiophene-2-carbaidehyde Mass spectrum: MH' 203 (100) b. N-Thiophen-3-ylmethvl-1,3-diaminobenzene hydrochloride Aldehyde derivative used: thiophene-3-carbaidehyde Mass spectrum: MH+ 205 (100) c. N-Furan-2-ylmethXl-1,3-diaminobenzene hydrochloride Aldehyde derivative used: furan-2-carbaldehyde Mass spectrum: MH+ 189 (100) d. N-Furan-3-yimethyl-1,3-diaminobenzene hydrochloride Aldehyde derivative used: furan-3-carbaldehyde Mass spectrum: MH+ 189 (100) e. N-(1 H-Imidazol-2-yfinethyl)-1.3-diaminobenzene hydrochloride Aldehyde derivative used: imidazole-2-carbaidehyde Mass spectrum: MH 189 (100) f. N-Thiazol-2-Ylmethyl-1,3-diaminobenzene hydrochloride Aldehyde derivative used: thiazole-2-carbaldehyde Mass spectrum: MH 242 (100) g. N-(5-Nitrothiophen-2-ylmethy!)-1,3-diaminobenzene hydrochloride Aldehyde derivative used: 5-nitrothiophene-2-carbaidehyde Mass spectrum: MH+ 250 (20) Example 2 Synthesis of 2-{4-amino-2-[(N-heteroarylmethyl)amino]-phenoxy}ethanois A. Synthesis of tert.butvl f3-amino-4=(2-hydroxyethoxy)phenvllcarbamate A solution of 16.8 g of NaHC03 in 100 mL of water was added dropwise to a solution of 10.7 g (100 mmo.l) of 2-(2,4-diaminophenoxy) ethanol in 300 mL of acetonitrile.
Then,- 22 g (100 mmol) of ditert.butyl dicarbonate was added, and the reaction mixture was allowed to agitate for 6 hours. At the end of the reaction, the reaction mixture was poured into 100 mL of dichloromethane, and the organic phase was extracted with dilute hydrochloric acid. The aqueous phase was rendered alkaline with a 2N sodium hydroxide solution and then extracted with dichloromethane. The organic phase was dried over sodium sulfate and the solvent was distilled off in a rotary evaporator. This gave 10.3 g (38% of the theoretical) of tert.butyl [3-amino-4-(2-hydroxyethoxy)phenyl]carbamate.
'H-NMR (300 MHz. CDCI,): d= 7.26 {br s, 1 H); 6.95 (d, 1 H); 6.72 (d, 1 H);
6.34 (s, 1 H); 4.77 (m, 2H); 3.9 (m, 2H); 1.50 (s, 9H).
B. Synthesis of 2-{4-amino-2-L(N-heteroarvimethyl)aminolphenoxy}ethanols 0.031 '-g (0.15 mmol) of tert:butyi [3-amino-4-(2-hydroxyethoxy)phenyi]carbamate from Example 2A and 0.1 mmol of the appropriate aldehyde were dissolved in methanol (dried over molecular sieve). 10 mg of molecular sieve was added, and the reaction mixture was allowed to agitate for 7 hours. Then, 0.3 mL of a borane-tetrahydrofuran complex solution (1 M in tetrahydrofuran) was added at 0 C, and the reaction mixture was allowed to agitate for one hour at room temperature. At the end of the reaction, the reaction mixture was poured into water and extracted with ethyl acetate. The organic phase was dried with magnesium sulfate. 'The solvent was distilled off In a rotary evaporator, and the residue was purified on silica gel with petroieum ether/ethyi acetate (1 : 1). The resulting product in 4 mL of ethanol and 1.5 nmL of a 2.9-moiar ethanolic hydrochloric acid solution was heated to 50 C. The precipitate was filtered off, washed twice with 1 -mL portions of ethanol and then dried.
a. 2-{4-Amino-2-((thioghen-2-ylmethyl)aminolphenoxy}ethanol hydrochloride Aldehyde derivative used: thiophene-2-carbaldehyde Mass spectrum: MH+ 265 (100) b. 2-{4-Amino-2-((furan-2-ylmethyl)aminolphenoxy}ethanol hydrochloride Aldehyde derivative used: furan-2-carbaldehyde Mass spectrum: MH+ 249 (100) ~
c. 2-{4-Amino-2-((thiophen-3-vimethyl)aminolphenoxy}ethanol hydrochloride Aldehyde derivative used: thiophene-3-carbaldehyde Mass spectrum: MH+ 265 (20) d. 2-{4-Amino-2-f (1 H-imidazol-2-ylmethyl)aminolphenoxy}ethanol hydrochloride Aldehyde derivative used: imidazole-2-carba(dehyde Mass spectrum: MH+ 249 (10) e. 2-{4-Amino-2-((furan-3-ylmethyl)aminolphenoxy}ethanol hydrochloride Aidehyde derivative used: furan-3-carbaidehyde Mass spectrum: MH+ 249 (20) Examples 3 to 14 Hair Colorants Hair colorant solutions having the following composition were prepared:
1.25 mmol of coupler of formula (I) as per Table 1 1.25 mmol of developer as per Table 1 1.0 g of potassium oleate (8% aqueous solution) 1.0 g of ammonia (22% aqueous solution) 1.0 g of ethanol 0.3 g of ascorbic acid to 100.0 g water Just before use, 50 g of the foregoing coloring solution was mixed with 50 g of a 6%
aqueous hydrogen peroxide solution. The mixture was then applied to bleached hair.
After an exposure time of 30 min at 40 C, the hair was rinsed with water, washed with a commercial shampoo and dried. The resulting color shades are presented in Table 1.
Example Coupler Coupler [sic - Translator] ~
No. of formula (I) I. II. Ill. IV:
1,4-Di- 2,5-Diamino- 2,5-Diamino- 4,5-Diamino-l-amino- toluene phenyletha- (2'-hydroxyeth-benzene sulfate nol sulfate yl)pyrazole sulfate 3 As per Ex. la dark blue dark blue dark blue violet 4 As per Ex. 1b dark blue dark blue dark blue violet As per Ex. 1 c dark blue dark blue dark blue violet 6 As per Ex. 1d dark blue dark blue dark blue violet 7 As per Ex. 1 e blue blue blue violet 8 As per Ex. 1f blue blue blue violet 9 As per Ex. 1 g blue gray-blue gray-blue bright violet As per Ex. 2a dark blue dark blue dark blue violet 11 As per Ex. 2b dark blue dark blue dark blue violet TABLE 1 - Continuation 12 As per Ex. 2c dark blue dark blue dark blue violet 13 As per Ex. 2d dark blue dark blue dark blue violet 14 As per Ex. 2e dark blue dark blue dark blue violet ~
Examples 15 to 39 Hair Colorants Hair colorant solutions of the following composition were prepared:
X g of N-heteroarylmethyl-1,3-diaminobenzene [coupler K1 to K4 of formula (I) as per Table 3]
U g of developer E8 to E15 as per Table 2 Y g of coupler K11 to K36 as per Table 3 Z g of 6-chloro-2-ethylamino-4-nitrophenol (D2) 10.0 g of potassium oleate (8% aqueous solution) 10.0 g of ammonia (22% aqueous solution) 10.0 g of ethanol 0.3 g of ascorbic acid to 100.0 g water Just before use, 30 g of the foregoing coloring solution was mixed with 30 g of a 6%
aqueous solution of hydrogen peroxide. The mixture was then applied to bleached hair. After an exposure time of 30 min at 40 C, the hair was rinsed with water,.
washed with a commercial shampoo and dried. Table 4 shows the coloring results.
Examples 39 to 62: Hair Colorants Dye carriers in cream form and having the following composition were prepared:
X g of N-heteroarylmethyl-1,3-diaminobenzene (coupler Ki to K4 of formula (I) as per Table 3) U g of developer E8 to E15 as per Table. 2 Y g of coupler K11 to K36 as per Table 3 Z g of 6-chloro-2-ethylamino-4-nitrophenol (D2) 15.0 g of cetyl alcohol 0.3 g of ascorbic acid 3.5 g of sodium lauryl alcohol diethylene glycol ether sulfate, 28%
aqueous solution 3.0 g of ammonia, 22% aqueous solution 0.3 g of sodium sulfite, anhydrous to 100 g water Just before use, 30 g of the foregoing coloring cream was mixed with 30 g of a 6%
solution of hydrogen peroxide. The mixture was then applied to the hair. After an exposure time of 30 min at 40 C, the hair was rinsed with water, washed with a commercial shampoo and dried. The coloring results are presented in Table 5.
TABLE 2 - Developers E8 1,4-diaminobenzene E9 2,5-diaminophenylethanol sulfate E10 3-methyl-4-aminophenol Ei i 4-amino-2-aminomethylphenol.2 HCI
E12 4-aminophenol E13 N,N-bis(2'-hydroxyethyl)-p-phenylenediamine sulfate E14 4,5-diamino-1=(2'-hydroxyethyl)pyrazole sulfate E15 2,5-diaminotoluene sulfate TABLE 3 - Couplers K1 N-thiophen-2-ylmethyl-1,3-diaminobenzene.HCI
K2 N-furan-2-ylmethyl-1,3-diaminobenzene.HCI
K3 2-{4-amino-2-[(thiophen-2-ylmethyl)amino]-phenoxy}ethanol.HCI
K4 2-{4-amino-2-((furan-2-ylmethyl)amino]-phenoxy}ethanol.HCI
K11 1,3-diaminobenzene K12 2-amino-4-(2'-hydroxyethyl)aminoanisole sulfate K13 1,3-diamino-4-(2'-hydroxyethoxy)benzene sulfate K14 2,4-diamino-5-fluorotoluene sulfate K15 3-amino-2-methylamino-6-methoxypyridine K16 3, 5-diamino-2, 6-dimethoxypyridine.2 HCI
K17 2,4-diamino-5-ethoxytoluene sulfate K18 N-(3-dimethylamino)phenylurea K19 1,3-bis(2,4-diaminophenoxy)propane. 4 HCI
K21 3-aminophenol K22 5-amino-2-methylphenol K23 3-amino-2-chloro-6-methylphenol K24 5-amino-4-fluoro-2-methylphenol sulfate K25. 1-naphthol K26 1-acetoxy-2-methyinaphthalene K31 1,3-dihydroxybenzene K32 2-methyl-1,3-dihydroxybenzene K33 1 -chloro-2,4-dihydroxybenzene K34 4-(2'-hydroxyethyl)amino- 1,2-methylenedioxy-benzene.HCI
K35 3,4-methylenedioxyphenol K36 2-amino-5-methylphenol TABLE 4 - Hair Colorants Example No. 15 116 117 )18 119 120 Dyes (Dyes in grams) KI 0,1 0,12 0,05 0,07 0,10 0,12 E8 0,30 E9 0,25 0,30 E15 0,25 - 0,30 0,25 K12 0,05 K1'3 0,05 `
K31 0,20 0,15 0,20 0,10 K32 0,20 0,10 0,10 K33 0f,20 K21 0,05 K22 0;05 K23 0,05 0,10 0,10 0,10 Dyeing result blond blond blond blond blond blond TABLE 4 - Continuation Example No. 21 122 123 124 25 26 .. ~
Dyes (Dyes in gramsj K2 0,10 0,12 0,05 0,07 0,10 0,12 E8 0,30 E9 0,25 0;30 E15 0,25 0,30 0125 K12 0,05-K13 0,05 K31 0;20 0,15 - 0,20 0;1U --K32 0,20 0,1 o 0;10 ' K33 0,20 K21 0,05 K22 0,05 K23 0,05 0,10 0,10 0:,10.
Dyeing result blond blond blond blond blond blond TABLE 4 - Continuation : Example No. 27 128 J29 J3131 132 Dyes (Dyes in grams) K3 0,10 0,12 0,05 0,07 0,10 0,12 E8 0,30 E9 0,25 0,30 E15 0,25 0,30 0,25 K12 0,05 K13 0,05 K31 0,20 0,15 0,20 0,10 K32 0,20 0,10 0,10 K33 0,20 K21 0,05 K22 0,05 K23 0,05 0,10 0,10 0,10 Dyeing result blond blond blond blond blond blond TABLE 4 - Continuation Example No. 33 34 135 136 137 [38 Dyes (Dyes in grams) K4 0,1 0,12 0,05 0,07 0,10 0,12 E8 0,30 E9 0,25 0,30 E15 0,25 0,30 0,25 K13 o-~ 05 K31 0,20 0,1_5 0;20 0,10. -K32 0,20 0,10 0,10 K33 0,20 K21 0,05 K22 0,05 K23 0,05 0,10 0,10 0,10 Dyeing result blond blond biond blond biond blond ' TABLE 5 - Hair Colorants Example No. 39 140 141 142 143 144 Dyes (Dyes in grams) K1 0,60 1,30 1,15 0,15 0,15 0,15 E8 1,50 E13 1,60 0,70 E1 5 1,80 0,70 0,70 K12 0,60 K31 .111.0 1,10 1,10 0,40 0,40 0,40 D2 0,10 0,10 0,10 K2.3 0,05 0,10 0,10 0,10 Dyeing result :black black black brown (brown brown TABLE 5 - Continuation Example No. 45 f46 47 148 49 150 Dyes (Dyes in grams) K2 0,60 1,30 1,15 0,15 0,15 0,15 E8 1,50 .
E13 1,60 0,70 E15 1;80 0,70 0,70 K12 0,60 K31 1,10 1,10 1,10 0,40 . 0,40 0,40 .
D2 0;~0. 0;fi0.- 01,10 K23 0,05 0,10 0,10 0,10 Dyeing result black black black brown' ~ brown -brown TABLE 5 - Continuation Example No. 51 152 53 54 55 156 Dyes (Dyes in grams) -K3. 0,60 1,30 1,15 0,15 0,15 0,15 E8 1,50 E13 1,60 0,70 E15 1,80 0,70 0,70 K12 0,60 K31 1,10 1,10 1,10 0,40 0,40 0,40 0 . 2' 0,10 0,10 0,10 K23 0,05 0,10 0,10 0,10 Dyeing result black black black brown brown brown >} .
TABLE 5 - Continuation Example No. 57 158 j59 160 161 162 . Dyes (Dyes in grams) K4 0,60 1,30 1,15 0,15 0,15 0,15 E8 1,50 E13 1,60 0;70 E15 1,80 0,70 0,70 K12 0,60 K31 1,10 1,10 1,10 0,40 0,40 ' 0;40 ..:
D2 0,10 0,10: 0110 K23 0,05 0,10 0,10 0;10 Dyeing result Vack black black ' brown brown brown ..~
Noteworthy among the compounds of formula (1) are, for example:
N-thiophen-3-ylmethyl-1,3-diaminobenzene, N-furan-3-ylmethyl-1,3-diaminoben-zene, N-(1H-imidazol-2-ylmethyl)-1,3-diaminobenzene, N-(1H-pyrol-2-ylmethyl)-1,3-diaminobenzene, N-thiophen-2-ylmethyl-1,3-diaminobenzene, N-thiazol-2-yl-methyl-1,3-diaminobenzene, N-(5-nitrothiophen-2-ylmethyl)-1,3-diaminobenzene, N-(3-methylthiophen-2-y(methyl)-1,3-diaminobenzene, N-(2-methylthiophen-3-ylmethyl)-1,3-diaminobenzene, N-(4-methylthiophen-3-ylmethyl)-1,3-diaminobenzene, N-(5-meth-ylthiophen-2-ylmethyl)-1,3-diaminobenzene, N-(3-chlorothiophen-2-ylmethyl)-1,3-di-aminobenzene, N-(4-methylthiophen-2-ylmethyl)-1,3-diaminobenzene, N-(4-chloro-thiophen-2-ylmethyl)-1,3-diaminobenzene, N-(5-methylthiophen-2-ylmethyl)-1,3-diami-nobenzene, N-(5-chlorothiophen-2-ylmethyl)-1,3-diaminobenzene, 2-{4-amino-2-[(furan-2-ylmethyl)amino]phenoxy}ethanol, 2={4-amino-2-[(thiophen-3-ylmethyi)amino]phenoxy)ethanol, 2-{4-amino-2-[(thiophen-2-ylmethyl)amino]phenoxy}ethanol, 2-(4-amino-2-[(1 H-imidazol-2-ylmethyl)amino]phenoxy}ethanol, 2-{4-amino-2-[(furan-3-ylmethyl)amino]phenoxy}ethanol, 2-{4-amino-2-[(1 H-pyrol-2-ylmethyl)amino]phenoxy}ethanol, 2-{4-amino-2-[(3-methylthiophen-2-yimethyl)amino]phenoxy}ethanol, 2-{4-amino-2-[(3-chlorothiophen-2-ylmethyl)amino]phenoxy}ethanol, 2-{4-amino-2-[(4-methylthiophen-2-ylmethyl)amino]phenoxy}ethanol, 2-{4-amino-2-[(4-chlorothiophen-2-ylmethyl)amino]phenoxy}ethanol, 2-{4-amino-2-[(5-chlorothiophen-2-ylmethyl)amino]phenoxy}ethanol, 2-14 -amino-2-[(5-methylthiophen-2-ylrriethyl)amino]phenoxy}ethanol, 2-{4-amino-2-[(2-methylthiophen-3-ylrnethyl)aminolphenoxy}ethanol, 2-{4-amino-2-[(2-chlorothiophen-3-ylmethyl)amino]phenoxy}ethanolj 2-{4amino-2-[(4-methylthiophen-3-ylmethyl)amino]phenoxy}ethanol, 2-{4-amirio-2-[(4-chlorothiophen=3-ylmethyl)amino]phenoxy}ethanol, 2-{4-amino-2-[ (5-methylthiophen-3-ylmethyl)amino]phenoxy}ethanol, 2-[4-a mino-2-[ (5-chlorothiophen-3-ylmethyl)amino]phenoxy}etha noi 2-{ 2-amin.o-4-[ (furan-2-ylmethyl)amino]phenoxy}ethanol, 2-{2-amino-4-[(thiophen-3-yimethyl)aminojphenoxy}ethanol, 2-{2=amino-4-[(thiophen-2-ylmethyl)aminolphenoxy}ethanol, 2-{2-amino-4-[(1 H-imidazol-2-ylmethyl)amino]phenoxy}ethanol and 2-{2-amino-4-[(furan-3-ylmethyl)amino]phenoxy}ethanol.
Preferred compounds of formula (I) are those wherein (i) R1 denotes hydrogen or ;q hydroxyalkoxy group and R2 and R3 or R2, R3 and R4 denote hydrogen; or (ii) RI
denotes hydrogen or a hydroxyalkoxy group and the R2 and R3 groups or the R2, and R4 groups denote hydrogen, X5 denotes sulfur or oxygen, 'X6 denotes nitrogen or C-R7 and X7 denotes C-R8, with at least one of the R7 and R8 groups denoting hydrogen; or (iii) R1 denotes hydrogen or a hydroxyalkoxy group, the R2 and R3 groups or the R2, R3 and R4 groups denote hydrogen, X7 denotes sulfur or oxygen, X5 denotes C-R6 and X6 denotes C-R7, with at least one of the R6 and R7 groups denoting hydrogen; or (iv) Ri denotes hydrogen or a hydroxyalkoxy group, the.
R2 and R3 groups or the R2, R3 and R4 groups denote hydrogeri, X6 denotes sulfur or oxygen, X5 denotes C=R6 and X7 denotes C-R8, with at least one of the R6 and groups denoting hydrogen.
Particularly preferred are the following N-heteroarylmethyl-m-phenylenediamine derivatives of formula (I): N-thiophen-3-ylmethyi=l,3-diaminobenzene, N-furan-3-ylmethyl-1,3-diaminobenzene, N-furan-2-y1methyl-1,3-diarninobenzene, N-thio-phen-2-ylmethyl-1,3-diamiriobenzene, 2-(4-amino-2-[(thiophen-3-ylmethyl)amino]phen-oxy)ethanol, 2-{4-amino-2-1(thiophen-2-ylmethyl)aminolphenoxy}ethanol, 2-{4-ami-no-2-[(furan-3-ylmethyi)amino)phenoxy}ethanol, 2-{4-amino-2-[(furan-2-yimethyl)-arriino)phenoxy}ethanol,2-(2-amino-4-[(thiophen-2-yimethyi)amino]phenoxy)ethanol and 2-(2-amino-4-[(furan-2-ylmethyi)amino]phenoxy}ethanol or the salts thereof.
The compounds of formula (I) can be used as the free bases as well as in the form of their physiologically tolerated salts with inorganic or organic acids, for example hydrochloric acid, sulfuric acid, phosphoric acid, acetic acid, propionic acid, lactic acid or citric acid.
The colorant of the invention contains the N-heteroarylmethyl-m-phenylenediamine derivatives of formula (I) in a total amount from about 0.005 to 20 wt.%, an amount of about 0.01 to 5 wt.% and especially 0.1 to 2.5 wt.% being preferred. ~
Suitable developers are all those developers that are known to be used with, and are appropriate for, such colorants, for example 1,4-diaminobenzene (p-phenylene-diamine), 1,4-diamino-2-methylbenzene (p-toluylenediamine), 1,4-diamino-2,6-di-methylbenzene, 1,4-diamino-3,5-diethyibenzene, 1,4-diamino-2,5-dimethylbenzene, 1,4-diamino-2,3-dimethylbenzene, 2-chloro-1,4-diaminobenzene, 1,4-diamino-2-(thiophen-2-y!)benzene, 1,4-diamino-2-(thiophen-3-yl)benzene, 1,4-diamino-2-(pyri-din-3-yl)benzene, 2,5-diaminobiphenyl; 1,4-diamino-2-methoxymethylbenzene, 1,4-diamino-2-aminomethylbenzene, 1,4-diamino-2-hydroxymethylbenzene, 1,4-diamino-(2-hydroxyethoxy) benzene, 1-(2,5-diaminophenyl)ethanol, 2-[2-(acetylamino)eth-oxy]-1,4-diaminobenzene, 4-phenylaminoaniline, 4-dimethylaminoaniline, 4-diethyl-aminoaniline, 4-dipropylaminoaniline, 4-[ethyl-(2-hydroxyethyl)amino]aniline, 4-[di(2-hyd roxyethyl)a mino]aniline, 4-[di (2-hydroxyethyl)amino]-2-methylani(ine, 4-[(2-meth-oxyethyl)amino]aniline, 4-[(3-hydroxypropyl)amino]aniline, 4-[(2,3-dihydroxypropyl)-amino]aniline, 1,4-diamino-2-(2-hydroxyethyl)benzene, 1,4-diamino-2-(1-methyleth-yl)benzene, 1,3-bis-[(4-aminophenyi)(2-hydroxyethyl)amino]-2-propanol, 1,4-bis-[(4-aminophenyl)amino]butane,1,8-bis-(2,5-diaminophenoxy)-3,6-dioxaoctane,4-amino-phenol, 4-amino-3-methylphenol, 4-amino-3-(hydroxymethyl)phenol, 4-amino-3-flu-orophenol, 4-methylaminophenol, 4-amino-2-(aminomethyl)phenol, 4-amino-2-(hy-droxymethyl)phenol, 4-amino-2-fluorophenol, 4-amino-2-[(2-hydroxyethyl)amino]-methyiphenol, 4-amino-2-methylphenol, 4-amino-2-(methoxymethyl)phenol, 4-amino-2-(2-hydroxyethyl)phenol, 5-aminosalicylic acid, 2,5-diaminopyridine, 2,4,5,6-tetraaminopyrimidine, 2,5,6-triamino-4-(1 H)-pyrimidone, 4,5-diamino-l-(2-hydroxyethyl)-1H-pyrazole, 4,5-diamino-l-(1-methylethyl)-1H-pyrazole, 41 5-diamino-l-[(4-methylphenyl)methyl]-1 H-pyrazole, 1-[(4-chlorophenyl)methyl]-4,5-diamino-pyrazole, 4,5-diamino-l-methyl-1 H-pyrazole, 4,5-diamino-3-methyl-l-methyl-1 H-py-razole, 2-aminophenol, 2-amino-6-methylphenol and 2-amino-5-methylphenol.
Moreover, the colorant of the invention can optionaily-a(so contain other known couplers, for example -2,6-diaminopyridine, 2-amino-4-[(2-hydroxyethyl)amino]ani-sole, 2,4-diamino-1-fluoro-5-methylbenzene, 2,4-diamino-l-methoxy-5-methylben-xene, 2,4-diamino-1-ethoxy-5-methylbenzene, 2,4-diamino-l-(2=hydroxyethoxy)-5-methylbenzene, 2,4-di[(2-hydroxyethyl)amino]-1,5-dimethoxybenzene, 2,3-diamino-6-methoxypyridine, 3-amino-6-methoxy-2-(methylamino)pyr-idine, 2,6-diamino-3,5-.
dimethoxypyridine, 3,5-diamino-2,6-dimethoXypyridirie, 1a3-diaminobenzene, 2,4-di-amino-1-(2-hydroxyethoxy)benzene, 2,4-diamino-1,5-di(2-hydroxyethoxy)benzene, 1-(2-aminoethoxy)-2,4-diaminobenzene, 2=amino-1-(2-hydroxyethoxy)-4-methylamirlo-benzene, 2,4-diar.ninophenoxyacetic acid, 3-[di(2-hydroxyethyl)amino]aniline, 4-ami-no-2-di[(2-hydroxyethyl)amino]-1-ethoxybenzene, 5-methyl-2-(1-methylethyl)phen-ol, 3-[(2-hydroxyethyi)aminolaniline, 3-[(2-aminoethy()amino]aniline, 1,3-di(2,4-dia-minophenoxy)propane, di(2,4-diaminophenoxy)methane, 1,3~-diamino-2,4-dimeth-oxybenzene, 2,6-bis-(2-hydroxyethyl)aminotoluene, 4-hydroxyindole, 3-dimethylamino-phenol, 3-diethylaminophenol,.5-amino=2-methylphenol., 5-amino-4-fluoro-2-methyl-phenol, 5-amino-4-methoxy-2-methylphenol,.5-amino-4-ethoxy-2-rnethylphenol, 3-ami-no-2,4-dichlorophenol, 5-amino-2,4-dichlorophenol, 3-amino-2-methylphenol; 3-amino-2-chloro-6-methylphenol, 3-aminophenol, 2-[(3-hydroxyphenyl)aminolacetamide, 5-[(2-hydroxyethyl)aminol-2-methyiphenol, 3-1(2-hydroxyethyi)eminolphenol, 3-[(2-methoxyethyl)aminolphenol, 5-amino-2-ethylphenol, 2-(4-amino-2-hydroxyphenoxy)-ethanol, 5-[(3-hydroxypropyl)amino]-2-methylphenol, 3-j(2,3-dihydroxypropyl)ami-no]-2-methylphenol, 3-[(2-hydroxyethyl)aminoj-2-methyiphenoi, 2-amino-3-hydroxy-pyridine, 5-amino-4-chloro-2-methyiphenol, 1-naphthoi, 1,5-dihydroxynaphthalene, 1,7-dihydroxynaphthaiene, 2,3-dihydroxynaphthalene, 2,7-dihydroxynaphthalene, methyl-1 -napFithQl acetate, 1,3-dihydroxybenzene, 1-chloro-2,4-dihydroxybenzene, 2-chloro-1,3-dihydroxybenzene, 1,2-dichloro-3,5-dihydroxy-4=methylbenzene,.
1,5-dichloro-2,4-dihydroxybenzene,1,3-dihydroxy-2-methylbenzene, 3,4-methylenedi-oxyphenoi, 3,4-methylenedioxyaniiine, 5-[(2-hydroxyethyi)amino]-1,3-benzodioxoie, 6-bromo-'1-hydroxy-3,4-methyfenedioxybenzene, 3,4-diaminobenzoic acid; 3,4-di-hydro-6-hydroxy-1,4(2H)benzoxazine, 6-amino-3,4-dihydro-1,4(2H)-benzoxazine, 3-methyl-l-phenyl-5-pyrazolone, 5,6-dihydroxyindole, 5,6-dihydroxyindoline, 5=hy-'"droXyindole, 6-hydroxyindole, 7-hydroxyindole and 2,3-indolinedione.
The couplers and developers can be present In the colorant of the invention -either .individually or in admbcture with one another, the total arimount of each of the couplers and developers In the colorant of the invention being about 0.005 to 20. wt,g6 preferably about 0.01 to 5.0 wt. % and particularly 0.1 to 2.5 wt. % (based on the total amount of 'colorant). The total amount of the developer-coupler combination coritained in the colorant described herein is preferably about 0.01 to 20 wt.
fa, an -amount of about 0.02 to 10 wt.%. and especially 0.2 to 6_wt. % being particularly preferred. In general, the developer and the coupler are used in approximateiy equimolar amounts. In this respect, it is not disadvantageous, however, if the developer is present in a certain excess or deficiency [for example in a (coupier:deveiopee) ratio of i: 2 to 1: 0.51.
Moreover, the colorant of the invention can also contain other dye components, for exarnple 6-amino-2-methylphenol and 2-amino-5-methylphenol, as well as common anionic, cationic, amphoteric or nonionic direct dyes, for example triphenylmethane dyes such as 4-[(4'-aminophenyl)-(4'-imino-2",5"-cyciohexadien-1 "-yiidene)methyl]-2-methylaminobenzene monohydrochloride (Color Index [C.I.] 42 510) and 4-[(4'-arnino-3'-methylphenyl)-(4"-imino-3"-methyl-2", 5 "-cyciohexad ien-1 "-ylidene)rnethyl]-2-methyiaminobenzene monohydrochioride (C.I. 42 520), aromatic nitro dyes such as 4-(2'-hydroxyethyl)aminonitrotoluene, 2-amino-4,6-dinitrophenol, - 2-amino-5-(2'-hydroxyethyi)aminonitrobenzene, 2-chloro-6-(ethyiamino)-4-nitrophenoi, 4-chioro-N-(2-hydroxyethyl)-2~nitroaniline, 5-chloro-2-hydroxy-4-nitroaniline, 2-amino-4-chloro-6-nitrophenol and 1-(2'-ureidoethyl)amino-4-nitrobenzene, azo dyes such as sodium 6-[(4'-amiriophenyl)azol-5-hydroxynaphthalene-1-suifonate (C.I. 14 805) and disperse dyes, for example 1,4-diaminoanthraquinone and 1,4,5,8-tetraaminoanthraquinone.
The colorants of the invention can contain the aforesaid dye components in an amount from about 0.1 to 4 wt.%
The couplers and developers as well as the other dye components, provided they are bases, can, of course, also be used in the form of their physiologically tolerated salts with organic or inorganic acids, for example hydrochloric acid or sulfuric acid, or - if they contain aromatic OH groups - In the form of their salts with bases, for example as alkali metal phenoxides.
Moreover, If the colorants of the invention are to be used for coloring hair, they can also contain other common cosmetic additives, for example antioxidants such as ascorbic acid, 'thiogiycoiic acid or sodium suifite, as well as perfume oils, comptexing agents; wetting agents, emulsifiers, thickeners and hair-care agents.
-The colorant of the invention can be in the form of, for example, a solution, particularly an aqueous or aqueous-alcoholic solution. A particularly preferred formulation form, however, is a cream, gel or emulsion. Such a composition consists of a mixture of the dye components and the usual additives employed for such compositions.
Common additives to solutions, creams, emulsions or gels are, for example solvents such as water, lower aliphatic alcohols, for example ethanol, propanol or isopropanol, glycerol or glycols such as 1,2-propylene glycol, moreover wetting agents or emulsifiers from the classes of anionic, cationic, amphoteric or nonionic surface-active agents, for example fatty alcohol sulfates, ethoxylated fatty alcohol sulfates, alkylsulfonates, alkylbenzenesulfonates, alkyltrimethylammonium salts, alkylbeta- -ines, ethoxylated fatty alcohols, ethoxylated nonylphenols, fatty acid alkanolamides and ethoxylated fatty esters, furthermore thickeners such as the higher fatty alcohols, starch, cellulose derivatives, petrolatum, paraffin oil and fatty acids, also hair-care agents such as cationic resins, lanolin derivatives, cholesterol, pantothenic acid and betaine. The said constituents are used in amounts commonly employed for such purposes, for example the wetting agents and emulsifiers at a concentration of about 0.5 to 30 wt. %, the thickeners in an amount from about 0.1 to 25 wt. % and the hair-care agents at a concentration from about 0.1 to 5 wt.%.
The ready-to-use hair colorant of the invention is prepared by mixing the colorant with an oxidant just before use.
Suitable oxidants are primarily hydrogen peroxide or its products of addition to urea, melamine, sodium borate or sodium carbonate in the form of a 1 to 12% and preferably 3 to 6% aqueous solution. The weight ratio of hair colorant to oxidant in this case is preferably from 5 : 1 to 1: 3 and particularly from 1 : 1 to 1 :
2. Higher amounts of oxidant are used especially with higher concentrations of hair colorant or when stronger bleaching of the hair is wanted at the same time. In principle, however, atmospheric oxygen can be used in place of the aforesaid oxidants to oxidize the dyes.
buring the mixing of the dye (the pH of which is approximately 6 to 11.5) with the oxidant, which most frequently is adjusted to an acidic pH (approximately 2 to 6.5), the pH of the ready-to-use hair colorant of the invention assumes a value which depends on the amount of alkali in the dye and of acid in the oxidant as well as on the mixing ratio. Depending on the composition, the colorant of the invention can be weakly acidic, neutral or alkaline and in the ready-to-use form can have a pH
of about 3 to 11.5 and preferably about 6 to 10. The adjustment to a basic pH is preferably made with ammonia, but it can also be made with an organic amine, for example with 2-amino-2-methyl-l-propanol,tris(hydroxymethyl)aminomethane, monoethanolamine and triethanolamine, or with an inorganic base such as sodium hydroxide and potassium hydroxide. The adjustment to an acidic pH can be made with an inorganic or organic acid, for example phosphoric, acetic, lactic, ascorbic, citric or tartaric acid.
Then, depending on the hair fullness, an amount of this mixture sufficient for the hair treatment, usually about 60 to 200 grams, is applied to the hair, and the mixture is allowed to act on the hair at about 15 to 50 C and preferably at 30 to 40 C, for about 10 to 45 min and preferably for 30 min after which the hair is rinsed with water and dried. Optionally, following this rinsing the hair is washed with a shampoo and optionally post-rinsed with a weak organic acid, for example citric acid or tartaric acid.
The hair is then dried.
The colorants of the invention containing an N-heteroarylmethyl-m-phenylenediamine derivative of formula (I) as coupler give hair colorations of excellent color stability, particularly in terms of light fastness, wash fastness and rubbing fastness.
As far as the dyeing properties are concerned, the hair colorants of the invention provide a wide range of different color shades from blond to brown, purple, violet and even blue and black, depending on the kind and composition of the dye components used, the achievable violet to dark-blue shades being particularly noteworthy. The color shades are characterized by their unusual color intensity. The very good coloring properties of the hair colorant of the present patent application also manifest themselves particularly in that this colorant makes it possible to dye gray hair, previously not damaged chemically, without any problems and with good covering power.
- The N-heteroarylmethyl-m-phenylenediamine derivatives of formula (I) of the invention can be prepared by known methods of synthesis, for example by'the methods described in the practical examples given hereinbelow.
The N-heteroarylmethyl-m-phenylenediamine derivatives of formula (I) are highly.
water-soluble and give colorations of high color intensity and excellent color stability, particularly in terms of light fastness, wash fastness and rubbing fastness.
Moreover, they have excellent storage stability, particularly as constituents of the oxidation colorants described herein.
Hence, another object of the present invention are N-heteroarylmethyl-m-phenylenediamine derivatives of general formula (II) or the water-soluble salts thereof with organic or inorganic acids x7 R2~N
/ NH
H (11) wherein X5 denotes sulfur, nitrogen, oxygen, C-R6 or N-R5;
X6 denotes sulfur, nitrogen, oxygen, C-R7 or N-R5;
X7 denotes sulfur, nitrogen, oxygen, C-R8 or N-R5;
R1 denotes hydrogen, a C,-C4-alky! group, a C,-C4-hydroxyalkoxy group or a C,-hydroxyalkyl group;
R2 and R3 can be equal or different and independently of each other denote hydrogen or a Cl-Cs-alkyl group;
R4, R6, R7, R8 can be equal or different and independently of each other denote hydrogen, a halogen atom (F, Cl, Br, I), a cyano group, a C,-C4 alkoxy group, a Cl-CB
a(kyl group, a C,-C4-alkyl thioether group, a mercapto group, a nitro group, an amino group, a C,-C4-alkylamino group, a di(C,-C4)-alkylamino group, a di(C,-C4 hydroxyalkyl)amino group, a C,-C4 hydroxyalkylamino group, a trif(uoromethyl group, a -C(O)CH3- group, a -C(O)CF3 group, an -Si(CH3)3 group, a C,-C4 hydroxyaikyl group or a C3-C4 dihydroxyalkyl group; and R5 denotes hydrogen, a C,-C6-alkyl group, a C2-C4 hydroxyalkyl group, a phenyl group or an acetyl group; at least one and at the most two of the X5 to X7 groups denoting respectively C-R6 or. C-R7 or C-R8 and at the most one of the X5 to X7 groups denoting sulfur, oxygen or N-R5; ~
provided that at least one of the R9, R2, R3, R4 , R6, R7 and R8 groups does not denote hydrogen when X5 or X6 denotes sulfur.
The following examples illustrate the object of the invention in greater detail withoat limiting its scope.
EXAMPLES
Example 1: Synthesis of N-heteroarylmethyl-1,3-diaminobenzenes A. Synthesis of tert.butyl (3-aminophenyllcarbamate A solution of 11 g (50 mmol) of ditert.butyl dicarbonate in 30 mL of methylene chloride was. added dropwise to a solution of 10.8 g (100 mmol) of 1,3-phenylenediamine in 100 mL of methylene chloride/NaOH (4%) 1: 1. The reaction mixture was allowed to agitate 8 hours after which 5 g of ditert.butyl dicarbonate was added to it. The reaction mixture was then allowed to agitate for an additional 12 hours at room temperature. The organic phase was washed with a saturated aqueous sodium chloride solution, dried over sodium sulfate and filtered, and the filtrate was evaporated. The resulting crude product was purified on silica gel with hexane/ethyl acetate (1 : 1). This gave 6.2 g (30% of the theoretical) of tert.butyl (3=amino-phenyl)carbamate.
'H-NMR (300 MHz; CDCI,): d= 7.06 (t, 1 H); 6.99 (br s, 1 H); 6.44 (br s, 2H);
6.56 (d, 1H); 6.39 (m; 2H); 3.68 (br, 2H); 1.53 (s, 9H).
B. Synthesis of N-heteroarylmethyl-1,3-diaminobenzenes 0.031 g (0.15 mmol) of tert.butyl (3-aminophenyl)carbamate from step 1A and 0.1 mmol of the appropriate aldehyde were dissolved in methanol (dried over molecular sieve). 10 mg of molecular sieve was added, and the reaction mixture was allowed to agitate for 7 hours. Then, 0.3 mL of a borane-tetrahydrofuran complex solution (1 M in tetrahydrofuran) was added at 0 C, and the reaction mixture was allowed to agitate for one hour at room temperature. At the end of the reaction, the reaction mixture was poured into water and extracted with ethyl acetate. The organic phase was dried with magnesium sulfate, the solvent was distilled off in a rotary evaporator and the residue was purified on silica gel with petroleum ether/ethyl acetate (1 1).
The resulting product in 4 mL of ethanol and 1.5 mL of a 2.9-molar ethanofic hydrochloric acid solution was heated to 50 C. The resulting precipitate was filtered off, washed twice with 1-mL portions of ethanol and then dried.
a. N-Thiophen-2-ylmethyl-1,3-diaminobenzene hydrochloride Aldehyde derivative used: thiophene-2-carbaidehyde Mass spectrum: MH' 203 (100) b. N-Thiophen-3-ylmethvl-1,3-diaminobenzene hydrochloride Aldehyde derivative used: thiophene-3-carbaidehyde Mass spectrum: MH+ 205 (100) c. N-Furan-2-ylmethXl-1,3-diaminobenzene hydrochloride Aldehyde derivative used: furan-2-carbaldehyde Mass spectrum: MH+ 189 (100) d. N-Furan-3-yimethyl-1,3-diaminobenzene hydrochloride Aldehyde derivative used: furan-3-carbaldehyde Mass spectrum: MH+ 189 (100) e. N-(1 H-Imidazol-2-yfinethyl)-1.3-diaminobenzene hydrochloride Aldehyde derivative used: imidazole-2-carbaidehyde Mass spectrum: MH 189 (100) f. N-Thiazol-2-Ylmethyl-1,3-diaminobenzene hydrochloride Aldehyde derivative used: thiazole-2-carbaldehyde Mass spectrum: MH 242 (100) g. N-(5-Nitrothiophen-2-ylmethy!)-1,3-diaminobenzene hydrochloride Aldehyde derivative used: 5-nitrothiophene-2-carbaidehyde Mass spectrum: MH+ 250 (20) Example 2 Synthesis of 2-{4-amino-2-[(N-heteroarylmethyl)amino]-phenoxy}ethanois A. Synthesis of tert.butvl f3-amino-4=(2-hydroxyethoxy)phenvllcarbamate A solution of 16.8 g of NaHC03 in 100 mL of water was added dropwise to a solution of 10.7 g (100 mmo.l) of 2-(2,4-diaminophenoxy) ethanol in 300 mL of acetonitrile.
Then,- 22 g (100 mmol) of ditert.butyl dicarbonate was added, and the reaction mixture was allowed to agitate for 6 hours. At the end of the reaction, the reaction mixture was poured into 100 mL of dichloromethane, and the organic phase was extracted with dilute hydrochloric acid. The aqueous phase was rendered alkaline with a 2N sodium hydroxide solution and then extracted with dichloromethane. The organic phase was dried over sodium sulfate and the solvent was distilled off in a rotary evaporator. This gave 10.3 g (38% of the theoretical) of tert.butyl [3-amino-4-(2-hydroxyethoxy)phenyl]carbamate.
'H-NMR (300 MHz. CDCI,): d= 7.26 {br s, 1 H); 6.95 (d, 1 H); 6.72 (d, 1 H);
6.34 (s, 1 H); 4.77 (m, 2H); 3.9 (m, 2H); 1.50 (s, 9H).
B. Synthesis of 2-{4-amino-2-L(N-heteroarvimethyl)aminolphenoxy}ethanols 0.031 '-g (0.15 mmol) of tert:butyi [3-amino-4-(2-hydroxyethoxy)phenyi]carbamate from Example 2A and 0.1 mmol of the appropriate aldehyde were dissolved in methanol (dried over molecular sieve). 10 mg of molecular sieve was added, and the reaction mixture was allowed to agitate for 7 hours. Then, 0.3 mL of a borane-tetrahydrofuran complex solution (1 M in tetrahydrofuran) was added at 0 C, and the reaction mixture was allowed to agitate for one hour at room temperature. At the end of the reaction, the reaction mixture was poured into water and extracted with ethyl acetate. The organic phase was dried with magnesium sulfate. 'The solvent was distilled off In a rotary evaporator, and the residue was purified on silica gel with petroieum ether/ethyi acetate (1 : 1). The resulting product in 4 mL of ethanol and 1.5 nmL of a 2.9-moiar ethanolic hydrochloric acid solution was heated to 50 C. The precipitate was filtered off, washed twice with 1 -mL portions of ethanol and then dried.
a. 2-{4-Amino-2-((thioghen-2-ylmethyl)aminolphenoxy}ethanol hydrochloride Aldehyde derivative used: thiophene-2-carbaldehyde Mass spectrum: MH+ 265 (100) b. 2-{4-Amino-2-((furan-2-ylmethyl)aminolphenoxy}ethanol hydrochloride Aldehyde derivative used: furan-2-carbaldehyde Mass spectrum: MH+ 249 (100) ~
c. 2-{4-Amino-2-((thiophen-3-vimethyl)aminolphenoxy}ethanol hydrochloride Aldehyde derivative used: thiophene-3-carbaldehyde Mass spectrum: MH+ 265 (20) d. 2-{4-Amino-2-f (1 H-imidazol-2-ylmethyl)aminolphenoxy}ethanol hydrochloride Aldehyde derivative used: imidazole-2-carba(dehyde Mass spectrum: MH+ 249 (10) e. 2-{4-Amino-2-((furan-3-ylmethyl)aminolphenoxy}ethanol hydrochloride Aidehyde derivative used: furan-3-carbaidehyde Mass spectrum: MH+ 249 (20) Examples 3 to 14 Hair Colorants Hair colorant solutions having the following composition were prepared:
1.25 mmol of coupler of formula (I) as per Table 1 1.25 mmol of developer as per Table 1 1.0 g of potassium oleate (8% aqueous solution) 1.0 g of ammonia (22% aqueous solution) 1.0 g of ethanol 0.3 g of ascorbic acid to 100.0 g water Just before use, 50 g of the foregoing coloring solution was mixed with 50 g of a 6%
aqueous hydrogen peroxide solution. The mixture was then applied to bleached hair.
After an exposure time of 30 min at 40 C, the hair was rinsed with water, washed with a commercial shampoo and dried. The resulting color shades are presented in Table 1.
Example Coupler Coupler [sic - Translator] ~
No. of formula (I) I. II. Ill. IV:
1,4-Di- 2,5-Diamino- 2,5-Diamino- 4,5-Diamino-l-amino- toluene phenyletha- (2'-hydroxyeth-benzene sulfate nol sulfate yl)pyrazole sulfate 3 As per Ex. la dark blue dark blue dark blue violet 4 As per Ex. 1b dark blue dark blue dark blue violet As per Ex. 1 c dark blue dark blue dark blue violet 6 As per Ex. 1d dark blue dark blue dark blue violet 7 As per Ex. 1 e blue blue blue violet 8 As per Ex. 1f blue blue blue violet 9 As per Ex. 1 g blue gray-blue gray-blue bright violet As per Ex. 2a dark blue dark blue dark blue violet 11 As per Ex. 2b dark blue dark blue dark blue violet TABLE 1 - Continuation 12 As per Ex. 2c dark blue dark blue dark blue violet 13 As per Ex. 2d dark blue dark blue dark blue violet 14 As per Ex. 2e dark blue dark blue dark blue violet ~
Examples 15 to 39 Hair Colorants Hair colorant solutions of the following composition were prepared:
X g of N-heteroarylmethyl-1,3-diaminobenzene [coupler K1 to K4 of formula (I) as per Table 3]
U g of developer E8 to E15 as per Table 2 Y g of coupler K11 to K36 as per Table 3 Z g of 6-chloro-2-ethylamino-4-nitrophenol (D2) 10.0 g of potassium oleate (8% aqueous solution) 10.0 g of ammonia (22% aqueous solution) 10.0 g of ethanol 0.3 g of ascorbic acid to 100.0 g water Just before use, 30 g of the foregoing coloring solution was mixed with 30 g of a 6%
aqueous solution of hydrogen peroxide. The mixture was then applied to bleached hair. After an exposure time of 30 min at 40 C, the hair was rinsed with water,.
washed with a commercial shampoo and dried. Table 4 shows the coloring results.
Examples 39 to 62: Hair Colorants Dye carriers in cream form and having the following composition were prepared:
X g of N-heteroarylmethyl-1,3-diaminobenzene (coupler Ki to K4 of formula (I) as per Table 3) U g of developer E8 to E15 as per Table. 2 Y g of coupler K11 to K36 as per Table 3 Z g of 6-chloro-2-ethylamino-4-nitrophenol (D2) 15.0 g of cetyl alcohol 0.3 g of ascorbic acid 3.5 g of sodium lauryl alcohol diethylene glycol ether sulfate, 28%
aqueous solution 3.0 g of ammonia, 22% aqueous solution 0.3 g of sodium sulfite, anhydrous to 100 g water Just before use, 30 g of the foregoing coloring cream was mixed with 30 g of a 6%
solution of hydrogen peroxide. The mixture was then applied to the hair. After an exposure time of 30 min at 40 C, the hair was rinsed with water, washed with a commercial shampoo and dried. The coloring results are presented in Table 5.
TABLE 2 - Developers E8 1,4-diaminobenzene E9 2,5-diaminophenylethanol sulfate E10 3-methyl-4-aminophenol Ei i 4-amino-2-aminomethylphenol.2 HCI
E12 4-aminophenol E13 N,N-bis(2'-hydroxyethyl)-p-phenylenediamine sulfate E14 4,5-diamino-1=(2'-hydroxyethyl)pyrazole sulfate E15 2,5-diaminotoluene sulfate TABLE 3 - Couplers K1 N-thiophen-2-ylmethyl-1,3-diaminobenzene.HCI
K2 N-furan-2-ylmethyl-1,3-diaminobenzene.HCI
K3 2-{4-amino-2-[(thiophen-2-ylmethyl)amino]-phenoxy}ethanol.HCI
K4 2-{4-amino-2-((furan-2-ylmethyl)amino]-phenoxy}ethanol.HCI
K11 1,3-diaminobenzene K12 2-amino-4-(2'-hydroxyethyl)aminoanisole sulfate K13 1,3-diamino-4-(2'-hydroxyethoxy)benzene sulfate K14 2,4-diamino-5-fluorotoluene sulfate K15 3-amino-2-methylamino-6-methoxypyridine K16 3, 5-diamino-2, 6-dimethoxypyridine.2 HCI
K17 2,4-diamino-5-ethoxytoluene sulfate K18 N-(3-dimethylamino)phenylurea K19 1,3-bis(2,4-diaminophenoxy)propane. 4 HCI
K21 3-aminophenol K22 5-amino-2-methylphenol K23 3-amino-2-chloro-6-methylphenol K24 5-amino-4-fluoro-2-methylphenol sulfate K25. 1-naphthol K26 1-acetoxy-2-methyinaphthalene K31 1,3-dihydroxybenzene K32 2-methyl-1,3-dihydroxybenzene K33 1 -chloro-2,4-dihydroxybenzene K34 4-(2'-hydroxyethyl)amino- 1,2-methylenedioxy-benzene.HCI
K35 3,4-methylenedioxyphenol K36 2-amino-5-methylphenol TABLE 4 - Hair Colorants Example No. 15 116 117 )18 119 120 Dyes (Dyes in grams) KI 0,1 0,12 0,05 0,07 0,10 0,12 E8 0,30 E9 0,25 0,30 E15 0,25 - 0,30 0,25 K12 0,05 K1'3 0,05 `
K31 0,20 0,15 0,20 0,10 K32 0,20 0,10 0,10 K33 0f,20 K21 0,05 K22 0;05 K23 0,05 0,10 0,10 0,10 Dyeing result blond blond blond blond blond blond TABLE 4 - Continuation Example No. 21 122 123 124 25 26 .. ~
Dyes (Dyes in gramsj K2 0,10 0,12 0,05 0,07 0,10 0,12 E8 0,30 E9 0,25 0;30 E15 0,25 0,30 0125 K12 0,05-K13 0,05 K31 0;20 0,15 - 0,20 0;1U --K32 0,20 0,1 o 0;10 ' K33 0,20 K21 0,05 K22 0,05 K23 0,05 0,10 0,10 0:,10.
Dyeing result blond blond blond blond blond blond TABLE 4 - Continuation : Example No. 27 128 J29 J3131 132 Dyes (Dyes in grams) K3 0,10 0,12 0,05 0,07 0,10 0,12 E8 0,30 E9 0,25 0,30 E15 0,25 0,30 0,25 K12 0,05 K13 0,05 K31 0,20 0,15 0,20 0,10 K32 0,20 0,10 0,10 K33 0,20 K21 0,05 K22 0,05 K23 0,05 0,10 0,10 0,10 Dyeing result blond blond blond blond blond blond TABLE 4 - Continuation Example No. 33 34 135 136 137 [38 Dyes (Dyes in grams) K4 0,1 0,12 0,05 0,07 0,10 0,12 E8 0,30 E9 0,25 0,30 E15 0,25 0,30 0,25 K13 o-~ 05 K31 0,20 0,1_5 0;20 0,10. -K32 0,20 0,10 0,10 K33 0,20 K21 0,05 K22 0,05 K23 0,05 0,10 0,10 0,10 Dyeing result blond blond biond blond biond blond ' TABLE 5 - Hair Colorants Example No. 39 140 141 142 143 144 Dyes (Dyes in grams) K1 0,60 1,30 1,15 0,15 0,15 0,15 E8 1,50 E13 1,60 0,70 E1 5 1,80 0,70 0,70 K12 0,60 K31 .111.0 1,10 1,10 0,40 0,40 0,40 D2 0,10 0,10 0,10 K2.3 0,05 0,10 0,10 0,10 Dyeing result :black black black brown (brown brown TABLE 5 - Continuation Example No. 45 f46 47 148 49 150 Dyes (Dyes in grams) K2 0,60 1,30 1,15 0,15 0,15 0,15 E8 1,50 .
E13 1,60 0,70 E15 1;80 0,70 0,70 K12 0,60 K31 1,10 1,10 1,10 0,40 . 0,40 0,40 .
D2 0;~0. 0;fi0.- 01,10 K23 0,05 0,10 0,10 0,10 Dyeing result black black black brown' ~ brown -brown TABLE 5 - Continuation Example No. 51 152 53 54 55 156 Dyes (Dyes in grams) -K3. 0,60 1,30 1,15 0,15 0,15 0,15 E8 1,50 E13 1,60 0,70 E15 1,80 0,70 0,70 K12 0,60 K31 1,10 1,10 1,10 0,40 0,40 0,40 0 . 2' 0,10 0,10 0,10 K23 0,05 0,10 0,10 0,10 Dyeing result black black black brown brown brown >} .
TABLE 5 - Continuation Example No. 57 158 j59 160 161 162 . Dyes (Dyes in grams) K4 0,60 1,30 1,15 0,15 0,15 0,15 E8 1,50 E13 1,60 0;70 E15 1,80 0,70 0,70 K12 0,60 K31 1,10 1,10 1,10 0,40 0,40 ' 0;40 ..:
D2 0,10 0,10: 0110 K23 0,05 0,10 0,10 0;10 Dyeing result Vack black black ' brown brown brown ..~
Claims (14)
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A colorant for oxidative dyeing of keratin fibers, based on a developer-coupler combination, characterized in that it contains as coupler at least one N-heteroarylmethyl-m-phenylenediamine derivative of formula (I) or a salt thereof with an organic or inorganic acid wherein X5 denotes sulfur, nitrogen, oxygen, C-R6 or N-R5;
X6 denotes sulfur, nitrogen, oxygen, C-R7 or N-R5;
X7 denotes sulfur, nitrogen, oxygen, C-R8 or N-R5;
R1 denotes hydrogen, a C1-C4-alkyl group, a C1-C4-hydroxyalkoxy group or C1-C4-hydroxyalkyl group;
R2 and R3 can be equal or different and independently of each other denote hydrogen or a C1-C6-alkyl group;
R4, R6, R7, R8 can be equal or different and independently of each other denote hydrogen, a halogen atom, a cyano group, a C1-C4-alkoxy group, a C1-C6-alkyl group, a C1-C4-alkyl thioether group, a mercapto group, a nitro group, an amino group, a C1-C4-alkylamino group, a di(C1-C4)-alkylamino group, a di(C1-C4-hydroxyalkyl)amino group, a C1-C4-hydroxyalkylamino group, a trifluoromethyl group, a -C(O)CH3-group, a -C(O)CF3,group, an -Si(CH3)3 group, a C1-C4-hydroxyalkyl group or a C3-C4 dihydroxyalkyl group; and R5 denotes hydrogen, a C1-C6-alkyl group, a C2-C4-hydroxyalkyl group, a phenyl group or an acetyl group; at least one and at the most two of the X5 to X7 groups denoting respectively C-R6 or C-R7 or C-R8 and at the most one of the X5 to X7 groups denoting sulfur, oxygen or N-R5.
X6 denotes sulfur, nitrogen, oxygen, C-R7 or N-R5;
X7 denotes sulfur, nitrogen, oxygen, C-R8 or N-R5;
R1 denotes hydrogen, a C1-C4-alkyl group, a C1-C4-hydroxyalkoxy group or C1-C4-hydroxyalkyl group;
R2 and R3 can be equal or different and independently of each other denote hydrogen or a C1-C6-alkyl group;
R4, R6, R7, R8 can be equal or different and independently of each other denote hydrogen, a halogen atom, a cyano group, a C1-C4-alkoxy group, a C1-C6-alkyl group, a C1-C4-alkyl thioether group, a mercapto group, a nitro group, an amino group, a C1-C4-alkylamino group, a di(C1-C4)-alkylamino group, a di(C1-C4-hydroxyalkyl)amino group, a C1-C4-hydroxyalkylamino group, a trifluoromethyl group, a -C(O)CH3-group, a -C(O)CF3,group, an -Si(CH3)3 group, a C1-C4-hydroxyalkyl group or a C3-C4 dihydroxyalkyl group; and R5 denotes hydrogen, a C1-C6-alkyl group, a C2-C4-hydroxyalkyl group, a phenyl group or an acetyl group; at least one and at the most two of the X5 to X7 groups denoting respectively C-R6 or C-R7 or C-R8 and at the most one of the X5 to X7 groups denoting sulfur, oxygen or N-R5.
2. The colorant according to Claim 1, characterized in that R1 denotes hydrogen or a hydroxyalkoxy group and the R2 and R3 groups or the R2, R3 and R4 groups denote hydrogen.
3. The colorant according to Claim 1 or 2, characterized in that R1 denotes hydrogen or a hydroxyalkoxy group, the R2 and R3 groups or the R2, R3 and R4 groups denote hydrogen, X5 denotes sulfur or oxygen, X6 denotes nitrogen or C-R7 and X7 denotes C-R8, and at least one of the R7 and R8 groups denotes hydrogen.
4. The colorant according to Claim 1 or 2, characterized in that R1 denotes hydrogen or a hydroxyalkoxy group, the R2 and R3 groups or the R2, R3 and R4 groups denote hydrogen, X7 denotes sulfur or oxygen, X5 denotes C-R6 and X6 denotes C-R7, and at least one of the R6 and R7 groups denotes hydrogen.
5. The colorant according to Claim 1 or 2, characterized in that R1 denotes hydrogen or a hydroxyalkoxy group, the R2 and R3 groups or the R2, R3 and R4 groups denote hydrogen, X6 denotes sulfur or oxygen, X5 denotes C-R6 and X7 denotes C-R8, and at least one of the R6 and R8 groups denotes hydrogen.
6. The colorant according to any one of Claims 1 to 5, characterized in that the N-heteroarylmethyl-m-phenylenediamine derivative of formula (I) is selected from among N-thiophen-3-ylmethyl-1,3-diaminobenzene, N-furan-3-ylmethyl-1,3-diaminobenzene, N-furan-2-ylmethyl-1,3-diaminobenzene, N-thiophen-2-ylmethyl-1,3-diaminobenzene, 2-{4-amino-2-[(thiophen-3-ylmethyl)amino]phenoxy}ethanol, 2-{4-amino-2-[(thiophen-2-ylmethyl)amino]phenoxy}ethanol, 2-{4-amino-2-[(furan-3-ylmethyl)amino]phenoxy}-ethanol, 2-{4-amino-2-[(furan-2-ylmethyl)amino]
phenoxy}ethanol, 2-{2-amino-4-[(thiophen-2-ylmethyl)amino]phenoxy}ethanol and 2-{2-amino-4-[(furan-2-ylmethyl)amino]phenoxy}ethanol or the salts thereof.
phenoxy}ethanol, 2-{2-amino-4-[(thiophen-2-ylmethyl)amino]phenoxy}ethanol and 2-{2-amino-4-[(furan-2-ylmethyl)amino]phenoxy}ethanol or the salts thereof.
7. The colorant according to any one of Claims 1 to 6, characterized in that it contains the N-heteroarylmethyl-m-phenylenediamine of formula (I) in an amount from 0.005 to 20 weight percent.
8. The colorant according to any one of Claims 1 to 7, characterized in that the developer is selected from the group consisting of 1,4-diaminobenzene, 1,4-diamino-2-methylbenzene, 1,4-diamino-2,6-dimethylbenzene, 1,4-diamino-3,5-diethylbenzene, 1,4-diamino-2,5-dimethylbenzene, 1,4-diamino-2,3-dimethylbenzene, 2-chloro-1,4-diaminobenzene, 1,4-diamino-2-(thiophen-2-yl)benzene, 1,4-diamino-2-(thiophen-3-yl)benzene, 1,4-diamino-2-(pyridin-3-yl)benzene, 2,5-diaminobiphenyl, 1,4-diamino-2-methoxymethylbenzene, 1,4-diamino-2-aminomethylbenzene, 1,4-diamino-2-hydroxymethylbenzene, 1,4-diamino-2-(2-hydroxyethoxy)benzene, 1-(2,5-diaminophenyl)ethanol, 2-[2-(acetylamino)ethoxy]-1,4-diaminobenzene, 4-phenylaminoaniline, 4-dimethylaminoaniline, 4-diethylaminoaniline, 4-dipropylaminoaniline, 4-[ethyl(2-hydroxyethyl)amino]aniline, 4-[di(2-hydroxyethyl)amino]aniline, 4-[di(2-hydroxyethyl)amino]-2-methylaniline, 4-[(2-methoxyethyl)amino]aniline, 4-[(3-hydroxypropyl)amino]-aniline, 4-[(2,3-dihydroxypropyl)amino]aniline, 1,4-diamino-2-(2-hydroxyethyl)benzene, 1,4-diamino-2-(1-methylethyl)benzene, 1,3-bis-[(4-aminophenyl)-(2-hydroxyethyl)amino]-2-propanol, 1,4-bis-[(4-aminophenyl)amino]butane, 1,8-bis-(2,5-diaminophenoxy)-3,6-dioxaoctane;
4-aminophenol, 4-amino-3-methyl phenol, 4-amino-3-(hydroxymethyl)phenol, 4-amino-3-fluorophenol, 4-methylaminophenol, 4-amino-2-(aminomethyl) phenol, 4-amino-2-(hydroxymethyl) phenol, 4-amino-2-fluorophenol, 4-amino-2-[(2-hydroxyethyl)amino]methylphenol, 4-amino-2-methylphenol, 4-amino-2-(methoxymethyl)phenol, 4-amino-2-(2-hydroxyethyl)phenol, 5-amino-salicylic acid, 2,5-diaminopyridine, 2,4,5,6-tetraaminopyrimidine, 2,5,6-triamino-4(1H)-pyrimidone, 4,5-diamino-1-(2-hydroxyethyl)-1H-pyrazole, 4,5-diamino-1-(1-methylethyl)-1H-pyrazole, 4,5-diamino-1-[(4-methylphenyl)methyl]-1H-pyrazole, 1-[(4-chlorophenyl)methyl]-4,5-diamino-1H-pyrazole, 4,5-diamino-1-methyl-1H-pyrazole, 4,5-diamino-3-methyl-1-methyl-1H-pyrazole, 2-aminophenol, 2-amino-6-methylphenol and 2-amino-5-methylphenol.
4-aminophenol, 4-amino-3-methyl phenol, 4-amino-3-(hydroxymethyl)phenol, 4-amino-3-fluorophenol, 4-methylaminophenol, 4-amino-2-(aminomethyl) phenol, 4-amino-2-(hydroxymethyl) phenol, 4-amino-2-fluorophenol, 4-amino-2-[(2-hydroxyethyl)amino]methylphenol, 4-amino-2-methylphenol, 4-amino-2-(methoxymethyl)phenol, 4-amino-2-(2-hydroxyethyl)phenol, 5-amino-salicylic acid, 2,5-diaminopyridine, 2,4,5,6-tetraaminopyrimidine, 2,5,6-triamino-4(1H)-pyrimidone, 4,5-diamino-1-(2-hydroxyethyl)-1H-pyrazole, 4,5-diamino-1-(1-methylethyl)-1H-pyrazole, 4,5-diamino-1-[(4-methylphenyl)methyl]-1H-pyrazole, 1-[(4-chlorophenyl)methyl]-4,5-diamino-1H-pyrazole, 4,5-diamino-1-methyl-1H-pyrazole, 4,5-diamino-3-methyl-1-methyl-1H-pyrazole, 2-aminophenol, 2-amino-6-methylphenol and 2-amino-5-methylphenol.
9. The colorant according to any one of Claims 1 to 8, characterized in that it also contains at least one additional coupler and/or direct dye.
10. The colorant according to any one of Claims 1 to 9, characterized in that it contains each of the developers and couplers in a total amount of 0.005 to 20 wt.%, based on the total amount of said colorant.
11. The colorant according to any one of Claims 1 to 10, characterized in that before use it is mixed with an oxidant in a weight ratio of 5 : 1 to 1 : 3 to prepare a ready-to-use oxidative colorant.
12. The colorant according to Claim 11, characterized in that the ready-to-use oxidative colorant has a pH of 3 to 11.5.
13. The colorant according to any one of Claims 1 to 12, characterized in that it is a hair colorant.
14. N-Heteroarylmethyl-m-phenylenediamine derivatives of general formula (II) or water-soluble salts thereof with organic or inorganic acids wherein X5 denotes sulfur, nitrogen, oxygen, C-R6 or N-R5;
X6 denotes sulfur, nitrogen, oxygen, C-R7 or N-R5;
X7 denotes sulfur, nitrogen, oxygen, C-R8 or N-R5;
R1 denotes hydrogen, a C1-C4-alkyl group, a C1-C4-hydroxyalkoxy group or C1-C4-hydroxyalkyl group;
R2 and R3 can be equal or different and independently of each other denote hydrogen or a C1-C6-alkyl group;
R4, R6, R7, R8 can be equal or different and independently of each other denote hydrogen, a halogen atom, a cyano group, a C1-C4-alkoxy group, a C1-C6-alkyl group, a C1-C4-alkyl thioether group, a mercapto group, a nitro group, an amino group, a C1-C4-alkylamino group, a di(C1-C4)-alkylamino group, a di(C1-C4-hydroxyalkyl)amino group, a C1-C4-hydroxyalkylamino group, a trifluoromethyl group, a -C(O)CH3 group, a -C(O)CF3 group, an -Si(CH3)3 group, a C1-C4-hydroxyalkyl group or a C3-C4 dihydroxyalkyl group; and R5 denotes hydrogen, a C1-C6-alkyl group, a C2-C4-hydroxyalkyl group, a phenyl group or an acetyl group; at least one and at the most two of the X5 to X7 group denoting respectively C-R6 or C-R7 or C-R8 and at the most one of the X5 to X7 groups denoting sulfur, oxygen or N-R5;
provided that at least one of the R1, R2, R3, R4, R6, R7 and R8 groups is other than hydrogen when X5 or X6 denotes sulfur.
X6 denotes sulfur, nitrogen, oxygen, C-R7 or N-R5;
X7 denotes sulfur, nitrogen, oxygen, C-R8 or N-R5;
R1 denotes hydrogen, a C1-C4-alkyl group, a C1-C4-hydroxyalkoxy group or C1-C4-hydroxyalkyl group;
R2 and R3 can be equal or different and independently of each other denote hydrogen or a C1-C6-alkyl group;
R4, R6, R7, R8 can be equal or different and independently of each other denote hydrogen, a halogen atom, a cyano group, a C1-C4-alkoxy group, a C1-C6-alkyl group, a C1-C4-alkyl thioether group, a mercapto group, a nitro group, an amino group, a C1-C4-alkylamino group, a di(C1-C4)-alkylamino group, a di(C1-C4-hydroxyalkyl)amino group, a C1-C4-hydroxyalkylamino group, a trifluoromethyl group, a -C(O)CH3 group, a -C(O)CF3 group, an -Si(CH3)3 group, a C1-C4-hydroxyalkyl group or a C3-C4 dihydroxyalkyl group; and R5 denotes hydrogen, a C1-C6-alkyl group, a C2-C4-hydroxyalkyl group, a phenyl group or an acetyl group; at least one and at the most two of the X5 to X7 group denoting respectively C-R6 or C-R7 or C-R8 and at the most one of the X5 to X7 groups denoting sulfur, oxygen or N-R5;
provided that at least one of the R1, R2, R3, R4, R6, R7 and R8 groups is other than hydrogen when X5 or X6 denotes sulfur.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10111936.4 | 2001-03-13 | ||
| DE10111936A DE10111936C1 (en) | 2001-03-13 | 2001-03-13 | Hair dyes containing N-heteroarylmethyl-m-phenylenediamine derivatives and new N-heteroarylmethyl-m-phenylenediamine derivatives |
| PCT/EP2001/012053 WO2002072568A1 (en) | 2001-03-13 | 2001-10-18 | N-heteroarylmethyl-m-phenylenediamine derivative-containing dyes for keratin fibers and novel n-heteroarylmethyl-m-phenylenediamine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2445749A1 CA2445749A1 (en) | 2002-09-19 |
| CA2445749C true CA2445749C (en) | 2009-12-22 |
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ID=7677220
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002445749A Expired - Fee Related CA2445749C (en) | 2001-03-13 | 2001-10-18 | Dyeing agents for keratin fibers, containing n-heteroarylmethyl-m-phenylenediamine deritaves, as well as new n-heteroarylmethyl-m-phenylenediamine derivatives |
Country Status (11)
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| US (1) | US6997961B2 (en) |
| EP (1) | EP1280791B1 (en) |
| JP (1) | JP4165809B2 (en) |
| AT (1) | ATE325112T1 (en) |
| AU (1) | AU2002221696B2 (en) |
| BR (1) | BR0110490B1 (en) |
| CA (1) | CA2445749C (en) |
| DE (2) | DE10111936C1 (en) |
| ES (1) | ES2263553T3 (en) |
| MX (1) | MXPA03008248A (en) |
| WO (1) | WO2002072568A1 (en) |
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| US7764130B2 (en) | 1999-01-22 | 2010-07-27 | Multigig Inc. | Electronic circuitry |
| DE10260820A1 (en) * | 2002-12-23 | 2004-07-01 | Henkel Kgaa | New coupler components |
| US7649098B2 (en) * | 2006-02-24 | 2010-01-19 | Lexicon Pharmaceuticals, Inc. | Imidazole-based compounds, compositions comprising them and methods of their use |
| TW200920355A (en) * | 2007-09-06 | 2009-05-16 | Lexicon Pharmaceuticals Inc | Compositions and methods for treating immunological and inflammatory diseases and disorders |
| US10312922B2 (en) | 2016-10-07 | 2019-06-04 | Analog Devices, Inc. | Apparatus and methods for rotary traveling wave oscillators |
| US10277233B2 (en) | 2016-10-07 | 2019-04-30 | Analog Devices, Inc. | Apparatus and methods for frequency tuning of rotary traveling wave oscillators |
| US11527992B2 (en) | 2019-09-19 | 2022-12-13 | Analog Devices International Unlimited Company | Rotary traveling wave oscillators with distributed stubs |
| US11264949B2 (en) | 2020-06-10 | 2022-03-01 | Analog Devices International Unlimited Company | Apparatus and methods for rotary traveling wave oscillators |
| US11539353B2 (en) | 2021-02-02 | 2022-12-27 | Analog Devices International Unlimited Company | RTWO-based frequency multiplier |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| FR2395021A1 (en) * | 1977-06-24 | 1979-01-19 | Oreal | PARAPHENYLENE DIAMINES AND TINCTORIAL COMPOSITIONS CONTAINING THEM |
| DE2934330A1 (en) * | 1979-08-24 | 1981-03-12 | Henkel KGaA, 4000 Düsseldorf | HAIR DYE. |
| EP0761214A3 (en) | 1995-07-21 | 1999-06-09 | Kao Corporation | N,N-disubstituted anilines or alkylamines as singlet oxygen quenchers, topical compositions comprising them |
| DE19812058C1 (en) * | 1998-03-19 | 1999-10-07 | Wella Ag | New 2-heterocyclyl-1,4-phenylenediamine derivatives |
| DE10111862C2 (en) * | 2001-03-13 | 2003-08-07 | Wella Ag | New diaminopyrazole derivatives and colorants containing these compounds |
-
2001
- 2001-03-13 DE DE10111936A patent/DE10111936C1/en not_active Expired - Fee Related
- 2001-10-18 BR BRPI0110490-0A patent/BR0110490B1/en not_active IP Right Cessation
- 2001-10-18 WO PCT/EP2001/012053 patent/WO2002072568A1/en active IP Right Grant
- 2001-10-18 JP JP2002571484A patent/JP4165809B2/en not_active Expired - Fee Related
- 2001-10-18 CA CA002445749A patent/CA2445749C/en not_active Expired - Fee Related
- 2001-10-18 MX MXPA03008248A patent/MXPA03008248A/en active IP Right Grant
- 2001-10-18 ES ES01273957T patent/ES2263553T3/en not_active Expired - Lifetime
- 2001-10-18 EP EP01273957A patent/EP1280791B1/en not_active Expired - Lifetime
- 2001-10-18 AU AU2002221696A patent/AU2002221696B2/en not_active Ceased
- 2001-10-18 DE DE50109698T patent/DE50109698D1/en not_active Expired - Lifetime
- 2001-10-18 AT AT01273957T patent/ATE325112T1/en not_active IP Right Cessation
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| Publication number | Publication date |
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| US20050081310A1 (en) | 2005-04-21 |
| DE10111936C1 (en) | 2002-10-02 |
| US6997961B2 (en) | 2006-02-14 |
| BR0110490A (en) | 2003-04-08 |
| JP2004518760A (en) | 2004-06-24 |
| JP4165809B2 (en) | 2008-10-15 |
| EP1280791B1 (en) | 2006-05-03 |
| MXPA03008248A (en) | 2004-07-23 |
| DE50109698D1 (en) | 2006-06-08 |
| ATE325112T1 (en) | 2006-06-15 |
| BR0110490B1 (en) | 2012-07-24 |
| ES2263553T3 (en) | 2006-12-16 |
| WO2002072568A1 (en) | 2002-09-19 |
| AU2002221696B2 (en) | 2006-06-29 |
| EP1280791A1 (en) | 2003-02-05 |
| CA2445749A1 (en) | 2002-09-19 |
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