[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

CA2445135A1 - Spectrometrie de masse a reduction de la charge effectuee a l'aide d'une forme d'onde specifiquement adaptee - Google Patents

Spectrometrie de masse a reduction de la charge effectuee a l'aide d'une forme d'onde specifiquement adaptee Download PDF

Info

Publication number
CA2445135A1
CA2445135A1 CA002445135A CA2445135A CA2445135A1 CA 2445135 A1 CA2445135 A1 CA 2445135A1 CA 002445135 A CA002445135 A CA 002445135A CA 2445135 A CA2445135 A CA 2445135A CA 2445135 A1 CA2445135 A1 CA 2445135A1
Authority
CA
Canada
Prior art keywords
mass
ion
ionized molecules
ion trap
ions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002445135A
Other languages
English (en)
Inventor
Scott Mcluckey
Fred E. Regnier
Noubar B. Afeyan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beyond Genomics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2445135A1 publication Critical patent/CA2445135A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/0077—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction specific reactions other than fragmentation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/426—Methods for controlling ions
    • H01J49/4265—Controlling the number of trapped ions; preventing space charge effects
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/426—Methods for controlling ions
    • H01J49/427—Ejection and selection methods
    • H01J49/428—Applying a notched broadband signal

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

Les procédés selon l'invention tirent parti du mouvement des ions dépendant du rapport masse-charge dans des pièges à ions électrodynamiques en synergie avec un processus d'affaiblissement de la charge. Dans un piège à ions électrodynamique, chaque rapport masse-charge est caractérisé par un ensemble unique de fréquences de mouvement. Par conséquent le fait de d'adapter spécifiquement le potentiel électrique variant dans le temps du piège à ions, permet de contrôler les ions qui sont autorisés à traverser ou ceux qui sont retenus dans le piège à ions et les ions qui vont être soumis à des réactions d'affaiblissement de la charge. Le contrôle de la rétention des ions et de l'affaiblissement de la charge sert à améliorer la vitesse de traitement des échantillons, la discrimination de la plage dynamique des masses et du signal dans la spectrométrie de masse d'ions à charges multiples.
CA002445135A 2001-04-23 2002-04-23 Spectrometrie de masse a reduction de la charge effectuee a l'aide d'une forme d'onde specifiquement adaptee Abandoned CA2445135A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/840,633 US6627875B2 (en) 2001-04-23 2001-04-23 Tailored waveform/charge reduction mass spectrometry
US09/840,633 2001-04-23
PCT/US2002/012563 WO2002086490A2 (fr) 2001-04-23 2002-04-23 Spectrometrie de masse a reduction de la charge effectuee a l'aide d'une forme d'onde specifiquement adaptee

Publications (1)

Publication Number Publication Date
CA2445135A1 true CA2445135A1 (fr) 2002-10-31

Family

ID=25282842

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002445135A Abandoned CA2445135A1 (fr) 2001-04-23 2002-04-23 Spectrometrie de masse a reduction de la charge effectuee a l'aide d'une forme d'onde specifiquement adaptee

Country Status (5)

Country Link
US (1) US6627875B2 (fr)
EP (1) EP1384071A2 (fr)
JP (1) JP2004526161A (fr)
CA (1) CA2445135A1 (fr)
WO (1) WO2002086490A2 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7041967B2 (en) * 2001-05-25 2006-05-09 Mds Inc. Method of mass spectrometry, to enhance separation of ions with different charges
JP3936908B2 (ja) * 2002-12-24 2007-06-27 株式会社日立ハイテクノロジーズ 質量分析装置及び質量分析方法
EP1723416B1 (fr) 2004-03-12 2010-09-01 University Of Virginia Patent Foundation Dissociation par transfert d'electrons pour analyse de sequence de biopolymeres
ES2558978T3 (es) * 2004-07-21 2016-02-09 Mevion Medical Systems, Inc. Generador de formas de ondas de radiofrecuencia programable para un sincrociclotrón
CN101073012A (zh) * 2004-10-08 2007-11-14 维吉尼亚大学专利基金会 氨基和羧基末端的同步序列分析
JP4523488B2 (ja) * 2005-05-27 2010-08-11 株式会社日立ハイテクノロジーズ 質量分析システムおよび質量分析方法
US7518108B2 (en) * 2005-11-10 2009-04-14 Wisconsin Alumni Research Foundation Electrospray ionization ion source with tunable charge reduction
US7759637B2 (en) 2006-06-30 2010-07-20 Dh Technologies Development Pte. Ltd Method for storing and reacting ions in a mass spectrometer
DE102007034232B4 (de) * 2007-07-23 2012-03-01 Bruker Daltonik Gmbh Dreidimensionale Hochfrequenz-Ionenfallen hoher Einfangeffizienz
US8581523B2 (en) * 2007-11-30 2013-11-12 Mevion Medical Systems, Inc. Interrupted particle source
US8334506B2 (en) 2007-12-10 2012-12-18 1St Detect Corporation End cap voltage control of ion traps
GB0806725D0 (en) * 2008-04-14 2008-05-14 Micromass Ltd Mass spectrometer
US7973277B2 (en) 2008-05-27 2011-07-05 1St Detect Corporation Driving a mass spectrometer ion trap or mass filter
GB0820308D0 (en) 2008-11-06 2008-12-17 Micromass Ltd Mass spectrometer
GB2476603B (en) * 2008-06-05 2013-01-09 Micromass Ltd Method of charge reduction of electron transfer dissociation product ions
US8373120B2 (en) * 2008-07-28 2013-02-12 Leco Corporation Method and apparatus for ion manipulation using mesh in a radio frequency field
DE102008059779B4 (de) * 2008-12-05 2012-03-29 Bruker Daltonik Gmbh Verfahren für die Elektronentransfer-Dissoziation in Massenspektrometern und Massenspektrometer mit einer vakuuminternen Elektronenanlagerungsionenquelle zur Herstellung von Radikal-Anionen für eine Elektronentransfer-Dissoziation von Biopolymeren
US9202680B2 (en) 2009-06-03 2015-12-01 Wayne State University Mass spectometry using laserspray ionization
US8440962B2 (en) 2009-09-08 2013-05-14 Dh Technologies Development Pte. Ltd. Targeted ion parking for quantitation
CA2814208A1 (fr) * 2010-10-13 2012-04-19 Purdue Research Foundation Spectrometrie de masse en tandem a l'aide de formes d'onde composites
CN103718270B (zh) 2011-05-05 2017-10-03 岛津研究实验室（欧洲）有限公司 操纵带电粒子的装置
JP5764433B2 (ja) * 2011-08-26 2015-08-19 株式会社日立ハイテクノロジーズ 質量分析装置及び質量分析方法
WO2013061145A1 (fr) * 2011-10-26 2013-05-02 Dh Technologies Development Pte. Ltd. Procédé et appareil d'interruption de réactions ion-ion
WO2013171494A2 (fr) 2012-05-18 2013-11-21 Micromass Uk Limited Procédé amélioré de spectrométrie de masse ms e
WO2015145124A1 (fr) 2014-03-24 2015-10-01 Micromass Uk Limited Procédé de génération d'ions à rapport masse/charge élevé par réduction de charge
US9837255B2 (en) 2014-07-18 2017-12-05 Thermo Finnigan Llc Methods for mass spectrometry of mixtures of protein or polypeptides using proton transfer reaction
US9925547B2 (en) * 2014-08-26 2018-03-27 Tsi, Incorporated Electrospray with soft X-ray neutralizer
JP2016225108A (ja) * 2015-05-29 2016-12-28 国立研究開発法人日本原子力研究開発機構 質量分析装置、イオン照射装置
EP3193174B1 (fr) 2016-01-14 2018-11-07 Thermo Finnigan LLC Procédés d'analyse spectrale descendante de masse multiplexé de mélanges de protéines ou de polypeptides
EP3193352A1 (fr) 2016-01-14 2017-07-19 Thermo Finnigan LLC Procédés de caractérisation basée sur la spectrométrie de masse de molécules biologiques
US10192730B2 (en) 2016-08-30 2019-01-29 Thermo Finnigan Llc Methods for operating electrostatic trap mass analyzers

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761545A (en) * 1986-05-23 1988-08-02 The Ohio State University Research Foundation Tailored excitation for trapped ion mass spectrometry
US5479012A (en) * 1992-05-29 1995-12-26 Varian Associates, Inc. Method of space charge control in an ion trap mass spectrometer
US5300772A (en) * 1992-07-31 1994-04-05 Varian Associates, Inc. Quadruple ion trap method having improved sensitivity
US5324939A (en) * 1993-05-28 1994-06-28 Finnigan Corporation Method and apparatus for ejecting unwanted ions in an ion trap mass spectrometer
US5526110A (en) * 1994-07-08 1996-06-11 Iowa State University Research Foundation, Inc. In situ calibration of inductively coupled plasma-atomic emission and mass spectroscopy
US5569917A (en) * 1995-05-19 1996-10-29 Varian Associates, Inc. Apparatus for and method of forming a parallel ion beam

Also Published As

Publication number Publication date
JP2004526161A (ja) 2004-08-26
WO2002086490A3 (fr) 2002-12-12
US6627875B2 (en) 2003-09-30
WO2002086490A2 (fr) 2002-10-31
EP1384071A2 (fr) 2004-01-28
US20020166958A1 (en) 2002-11-14

Similar Documents

Publication Publication Date Title
US6627875B2 (en) Tailored waveform/charge reduction mass spectrometry
US9337009B2 (en) Exponential scan mode for quadrupole mass spectrometers to generate super-resolved mass spectra
US9536717B2 (en) Multiple ion injection in mass spectrometry
US4771172A (en) Method of increasing the dynamic range and sensitivity of a quadrupole ion trap mass spectrometer operating in the chemical ionization mode
US6107623A (en) Methods and apparatus for tandem mass spectrometry
Prazeller et al. Proton transfer reaction ion trap mass spectrometer
EP0237268B1 (fr) Procédé d'analyse de masse d'un échantillon
US7582862B2 (en) Ion source for electron transfer dissociation and deprotonation
US8927928B2 (en) Method for operating a time-of-flight mass spectrometer with orthogonal ion pulsing
WO1995019041A1 (fr) Procede de commande de la charge spatiale pour ameliorer l'isolation d'ions dans un spectrometre de masse a piege a ions par echantillonnage dynamiquement adaptatif
Qian et al. A marriage made in MS
CA2597167C (fr) Spectrometrie de masse multiple a grande vitesse pour sequencage ionique
Payne et al. Tandem mass spectrometry in quadrupole ion trap and ion cyclotron resonance mass spectrometers
US6984820B2 (en) Method and apparatus for analyzing hydrocarbon streams
Nibbering Principles and applications of Fourier transform ion cyclotron resonance mass spectrometry. Plenary lecture
US7045777B2 (en) Combined chemical/biological agent mass spectrometer detector
AU2002307457A1 (en) Tailored waveform/charge reduction mass spectrometry
Zientek et al. Improved sensitivity for low abundance ions in glow discharge Fourier transform ion cyclotron resonance mass spectrometry following ion preselection in an external octopole ion guide
PAYNE et al. + 109 [4] MS/MS IN TRAPPING INSTRUMENTS
JPH0961401A (ja) 質量分析方法

Legal Events

Date Code Title Description
FZDE Discontinued