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CA2333854A1 - Stereo-isomeres d'oligonucleotides de type cpg et procedes connexes - Google Patents

Stereo-isomeres d'oligonucleotides de type cpg et procedes connexes Download PDF

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Publication number
CA2333854A1
CA2333854A1 CA002333854A CA2333854A CA2333854A1 CA 2333854 A1 CA2333854 A1 CA 2333854A1 CA 002333854 A CA002333854 A CA 002333854A CA 2333854 A CA2333854 A CA 2333854A CA 2333854 A1 CA2333854 A1 CA 2333854A1
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CA
Canada
Prior art keywords
nucleotides
composition
nucleic acid
subject
chirality
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002333854A
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English (en)
Inventor
Arthur M. Krieg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Iowa Research Foundation UIRF
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2333854A1 publication Critical patent/CA2333854A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Sachant que les interactions des acides nucléiques et des protéines peuvent être sélectives pour le stéréo-isomère R ou S ou bien qu'elles peuvent être stéréo-indépendantes, l'invention montre que le stéréo-isomère S d'oligonucléotide de type CpG renfermant de l'ADN est actif dans la médiation des effets immunostimulateurs de l'ADN de CpG. L'invention concerne des procédés relatifs à l'utilisation d'un stéréo-isomère pur ou d'ADN enrichi pour cette forme d'applications cliniques concernant l'ADN de CpG, à savoir par exemple: adjuvants de vaccin, immuno-activateurs pour la prévention ou le traitement de maladies rétrovirales, virales, parasitaires ou fongiques, ou bien immunothérapie pour le cancer, immunothérapie pour des maladies allergiques ou des états asthmatiques, etc. L'invention concerne également des procédés relatifs à l'utilisation d'ADN de stéréo-isomère R pour contrecarrer les effets imuno-stimulateurs de l'ADN de CpG. Ce type de stéréo-isomère est utile pour le traitement de maladies comme le syndrome septicémique, les maladies inflammatoires du tractus intestinal, le psoriasis, la gingivite, le lupus érythémateux aigu disséminé et autres maladies auto-immunes.
CA002333854A 1998-07-27 1999-07-27 Stereo-isomeres d'oligonucleotides de type cpg et procedes connexes Abandoned CA2333854A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9437098P 1998-07-27 1998-07-27
US60/094,370 1998-07-27
PCT/US1999/017100 WO2000006588A1 (fr) 1998-07-27 1999-07-27 STEREO-ISOMERES D'OLIGONUCLEOTIDES DE TYPE CpG ET PROCEDES CONNEXES

Publications (1)

Publication Number Publication Date
CA2333854A1 true CA2333854A1 (fr) 2000-02-10

Family

ID=22244765

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002333854A Abandoned CA2333854A1 (fr) 1998-07-27 1999-07-27 Stereo-isomeres d'oligonucleotides de type cpg et procedes connexes

Country Status (5)

Country Link
EP (1) EP1100807A1 (fr)
JP (1) JP2002521489A (fr)
AU (1) AU764532B2 (fr)
CA (1) CA2333854A1 (fr)
WO (1) WO2000006588A1 (fr)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
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US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
US6218371B1 (en) 1998-04-03 2001-04-17 University Of Iowa Research Foundation Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines
WO1999061056A2 (fr) 1998-05-22 1999-12-02 Loeb Health Research Institute At The Ottawa Hospital Methodes et produits permettant d'induire une immunite au niveau des muqueuses
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CA2194761C (fr) * 1994-07-15 2006-12-19 Arthur M. Krieg Oligonucleotides immunomodulateurs
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Publication number Publication date
AU764532B2 (en) 2003-08-21
JP2002521489A (ja) 2002-07-16
AU5323899A (en) 2000-02-21
EP1100807A1 (fr) 2001-05-23
WO2000006588B1 (fr) 2000-04-06
WO2000006588A1 (fr) 2000-02-10

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