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CA2318492C - Vecteurs de fourniture de genes comportant un tropisme tissulaire et destines a des cellules de muscles lisses et/ou des cellules endotheliales - Google Patents

Vecteurs de fourniture de genes comportant un tropisme tissulaire et destines a des cellules de muscles lisses et/ou des cellules endotheliales Download PDF

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Publication number
CA2318492C
CA2318492C CA2318492A CA2318492A CA2318492C CA 2318492 C CA2318492 C CA 2318492C CA 2318492 A CA2318492 A CA 2318492A CA 2318492 A CA2318492 A CA 2318492A CA 2318492 C CA2318492 C CA 2318492C
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CA
Canada
Prior art keywords
adenovirus
cells
fiber
subgroup
serotype
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2318492A
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English (en)
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CA2318492A1 (fr
Inventor
Menzo Jans Emco Havenga
Abraham Bout
Ronald Vogels
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Vaccines and Prevention BV
Original Assignee
Crucell Holand BV
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Publication of CA2318492A1 publication Critical patent/CA2318492A1/fr
Application granted granted Critical
Publication of CA2318492C publication Critical patent/CA2318492C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10345—Special targeting system for viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
    • C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
    • C12N2810/6018—Adenoviridae

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne un vecteur de fourniture d'acide nucléique comportant ou ayant comporté au moins un tropisme tissulaire et destiné à des cellules de muscles lisses et/ou des cellules endothéliales. Dans un aspect de la présente invention, ce vecteur de fourniture de gènes est une capside virale ou une partie fonctionnelle, un dérivé et/ou un analogue de cette capside virale. De préférence, la capside virale est une capside adénovirale. De préférence, l'adénovirus est un adénovirus du sous-groupe B, de préférence un adénovirus 16. De préférence, le tropisme tissulaire est compris dans au moins une partie de détermination de tropisme tissulaire d'une protéine fibreuse adénovirale ou un dérivé fonctionnel et/ou un analogue de cette protéine. L'invention concerne également des méthodes de traitement de maladies, de préférence de maladies cardiovasculaires.
CA2318492A 1998-11-20 1999-11-22 Vecteurs de fourniture de genes comportant un tropisme tissulaire et destines a des cellules de muscles lisses et/ou des cellules endotheliales Expired - Fee Related CA2318492C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98203921 1998-11-20
EP98203921.6 1998-11-20
PCT/NL1999/000717 WO2000031285A1 (fr) 1998-11-20 1999-11-22 Vecteurs de fourniture de genes comportant un tropisme tissulaire et destines a des cellules de muscles lisses et/ou des cellules endotheliales

Publications (2)

Publication Number Publication Date
CA2318492A1 CA2318492A1 (fr) 2000-06-02
CA2318492C true CA2318492C (fr) 2010-05-11

Family

ID=8234363

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2318492A Expired - Fee Related CA2318492C (fr) 1998-11-20 1999-11-22 Vecteurs de fourniture de genes comportant un tropisme tissulaire et destines a des cellules de muscles lisses et/ou des cellules endotheliales

Country Status (12)

Country Link
JP (1) JP4683682B2 (fr)
AT (1) ATE296894T1 (fr)
AU (1) AU770780B2 (fr)
CA (1) CA2318492C (fr)
DE (1) DE69925567T2 (fr)
ES (1) ES2244145T3 (fr)
IL (1) IL133032A (fr)
MX (1) MXPA99010682A (fr)
NO (1) NO995697L (fr)
NZ (1) NZ501214A (fr)
WO (1) WO2000031285A1 (fr)
ZA (1) ZA997213B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6929946B1 (en) 1998-11-20 2005-08-16 Crucell Holland B.V. Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells
ATE403006T1 (de) * 1999-03-04 2008-08-15 Crucell Holland Bv Verwendung eines adenovirusvektors zur transduktion von synovialen zellen
US6492169B1 (en) 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
CA2410665C (fr) 2000-05-31 2017-11-07 University Of Saskatchewan Adenovirus bovin modifie avec modification du tropisme
AU2002223556A1 (en) * 2000-09-20 2002-04-02 Crucell Holland B.V. Transduction of dendritic cells using adenoviral vectors
US6905678B2 (en) * 2001-07-07 2005-06-14 Crucell Holland B.V. Gene delivery vectors with cell type specificity for mesenchymal stem cells
EP1482052A1 (fr) * 2003-05-27 2004-12-01 Cytos Biotechnology AG Polypeptides modifiées pour cibler l'entrée des Adenovirus de sous-typ B dans une cellule
NZ759833A (en) 2017-05-26 2023-01-27 Epicentrx Inc Recombinant adenoviruses carrying transgenes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770442A (en) * 1995-02-21 1998-06-23 Cornell Research Foundation, Inc. Chimeric adenoviral fiber protein and methods of using same
US5994128A (en) * 1995-06-15 1999-11-30 Introgene B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy
CZ162398A3 (cs) * 1995-11-28 1998-10-14 Gen Vec, Inc. Vektory a způsoby pro genový přenos do buněk
US5877011A (en) * 1996-11-20 1999-03-02 Genzyme Corporation Chimeric adenoviral vectors
FR2758822B1 (fr) * 1997-01-30 1999-07-02 Centre Nat Rech Scient Utilisation d'un polypeptide a titre de recepteur cellulaire des adenovirus
FR2761689B1 (fr) * 1997-04-02 1999-06-25 Transgene Sa Fibre adenovirale modifiee et adenovirus cibles

Also Published As

Publication number Publication date
IL133032A (en) 2007-06-03
AU770780B2 (en) 2004-03-04
NZ501214A (en) 2002-02-01
WO2000031285A1 (fr) 2000-06-02
CA2318492A1 (fr) 2000-06-02
IL133032A0 (en) 2001-03-19
JP4683682B2 (ja) 2011-05-18
NO995697L (no) 2000-05-22
DE69925567D1 (de) 2005-07-07
ZA997213B (en) 2000-05-22
ATE296894T1 (de) 2005-06-15
MXPA99010682A (es) 2002-03-08
JP2000157289A (ja) 2000-06-13
DE69925567T2 (de) 2006-05-04
AU5960099A (en) 2000-05-25
ES2244145T3 (es) 2005-12-01
NO995697D0 (no) 1999-11-19

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