CA2391805A1 - Genes a expression differentielle associes a la surexpression de her-2/neu - Google Patents
Genes a expression differentielle associes a la surexpression de her-2/neu Download PDFInfo
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- CA2391805A1 CA2391805A1 CA002391805A CA2391805A CA2391805A1 CA 2391805 A1 CA2391805 A1 CA 2391805A1 CA 002391805 A CA002391805 A CA 002391805A CA 2391805 A CA2391805 A CA 2391805A CA 2391805 A1 CA2391805 A1 CA 2391805A1
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- 230000010473 stable expression Effects 0.000 description 1
- 230000037351 starvation Effects 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 108020003113 steroid hormone receptors Proteins 0.000 description 1
- VNOYUJKHFWYWIR-ITIYDSSPSA-N succinyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 VNOYUJKHFWYWIR-ITIYDSSPSA-N 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 108060008226 thioredoxin Proteins 0.000 description 1
- 229940094937 thioredoxin Drugs 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 229960002175 thyroglobulin Drugs 0.000 description 1
- 238000012090 tissue culture technique Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108091006106 transcriptional activators Proteins 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000010474 transient expression Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 102000027257 transmembrane receptors Human genes 0.000 description 1
- 108091008578 transmembrane receptors Proteins 0.000 description 1
- 108700004896 tripeptide FEG Proteins 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- 101150081616 trpB gene Proteins 0.000 description 1
- 101150111232 trpB-1 gene Proteins 0.000 description 1
- 108010015666 tryptophyl-leucyl-glutamic acid Proteins 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 231100000588 tumorigenic Toxicity 0.000 description 1
- 230000000381 tumorigenic effect Effects 0.000 description 1
- 238000000539 two dimensional gel electrophoresis Methods 0.000 description 1
- 238000003160 two-hybrid assay Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 108010051110 tyrosyl-lysine Proteins 0.000 description 1
- 108010020532 tyrosyl-proline Proteins 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
- 229940045145 uridine Drugs 0.000 description 1
- IBIDRSSEHFLGSD-UHFFFAOYSA-N valinyl-arginine Natural products CC(C)C(N)C(=O)NC(C(O)=O)CCCN=C(N)N IBIDRSSEHFLGSD-UHFFFAOYSA-N 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- QAOHCFGKCWTBGC-QHOAOGIMSA-N wybutosine Chemical compound C1=NC=2C(=O)N3C(CC[C@H](NC(=O)OC)C(=O)OC)=C(C)N=C3N(C)C=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O QAOHCFGKCWTBGC-QHOAOGIMSA-N 0.000 description 1
- QAOHCFGKCWTBGC-UHFFFAOYSA-N wybutosine Natural products C1=NC=2C(=O)N3C(CCC(NC(=O)OC)C(=O)OC)=C(C)N=C3N(C)C=2N1C1OC(CO)C(O)C1O QAOHCFGKCWTBGC-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La présente invention concerne des protéines humaines modulées par la surexpression de Her-2/neu (HOMPS), et des polynucléotides codant les polypeptides HOMPS. L'invention concerne également des protéines HOMPS renfermant des vecteurs d'expression et des cellules hôtes, des anticorps dirigés contre les protéines HOMPS et des méthodes de production de protéines HOMPS. En outre, l'invention concerne des méthodes permettant de générer, d'identifier et de manipuler lesdites protéines HOMPS.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15792399P | 1999-10-06 | 1999-10-06 | |
| US60/157,923 | 1999-10-06 | ||
| PCT/US2000/027649 WO2001025250A1 (fr) | 1999-10-06 | 2000-10-06 | Genes a expression differentielle associes a la surexpression de her-2/neu |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2391805A1 true CA2391805A1 (fr) | 2001-04-12 |
Family
ID=22565913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002391805A Abandoned CA2391805A1 (fr) | 1999-10-06 | 2000-10-06 | Genes a expression differentielle associes a la surexpression de her-2/neu |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1218394A4 (fr) |
| AU (1) | AU777096B2 (fr) |
| CA (1) | CA2391805A1 (fr) |
| WO (1) | WO2001025250A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005519624A (ja) | 2002-03-13 | 2005-07-07 | ジェノミック ヘルス， インコーポレイテッド | 生検腫瘍組織での遺伝子発現プロファイリング |
| US8008003B2 (en) | 2002-11-15 | 2011-08-30 | Genomic Health, Inc. | Gene expression profiling of EGFR positive cancer |
| US20040231909A1 (en) | 2003-01-15 | 2004-11-25 | Tai-Yang Luh | Motorized vehicle having forward and backward differential structure |
| ATE412779T1 (de) | 2003-02-20 | 2008-11-15 | Genomic Health Inc | Benutzung von intronischen rna sequenzen zur quantifizierung der genexpression |
| EP3470535B1 (fr) | 2003-06-24 | 2020-04-01 | Genomic Health, Inc. | Prédiction de probabilité de récurrence de cancer |
| ES2651849T3 (es) | 2003-07-10 | 2018-01-30 | Genomic Health, Inc. | Algoritmo del perfil de expresión y test para el pronóstico del cáncer |
| ES2360113T3 (es) | 2003-12-23 | 2011-06-01 | Genomic Health, Inc. | Amplificación universal de rna fragmentado. |
| EP1737980A2 (fr) | 2004-04-09 | 2007-01-03 | Fondazione IRCCS Istituto Nazionale dei Tumori | Marqueurs d'expression genique permettant de predire la reponse a la chimiotherapie |
| CA2585561C (fr) | 2004-11-05 | 2018-07-17 | Genomic Health, Inc. | Resultat de groupe esr1, pgr, bcl2 et scube2 comme indicateurs de pronostic de cancer du sein et de prediction de la reponse au traitement |
| DK1836629T3 (da) | 2004-11-05 | 2020-05-18 | Genomic Health Inc | Forudsigelse af respons på kemoterapi ved anvendelse af markører for genekspression |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1074617A3 (fr) * | 1999-07-29 | 2004-04-21 | Research Association for Biotechnology | Amorces pour la synthèse de cADN de pleine longueur et leur utilisation |
| AU7680300A (en) * | 1999-08-18 | 2001-03-13 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Human dna sequences |
-
2000
- 2000-10-06 CA CA002391805A patent/CA2391805A1/fr not_active Abandoned
- 2000-10-06 EP EP00973424A patent/EP1218394A4/fr not_active Withdrawn
- 2000-10-06 WO PCT/US2000/027649 patent/WO2001025250A1/fr not_active Application Discontinuation
- 2000-10-06 AU AU11929/01A patent/AU777096B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU777096B2 (en) | 2004-09-30 |
| EP1218394A4 (fr) | 2004-04-14 |
| AU1192901A (en) | 2001-05-10 |
| EP1218394A1 (fr) | 2002-07-03 |
| WO2001025250A1 (fr) | 2001-04-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |