CA2389662A1 - Pentraxine i et recepteur de pentraxine, inhibiteurs de ces proteines et compositions pharmaceutiques contenant ces composes - Google Patents
Pentraxine i et recepteur de pentraxine, inhibiteurs de ces proteines et compositions pharmaceutiques contenant ces composes Download PDFInfo
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- CA2389662A1 CA2389662A1 CA002389662A CA2389662A CA2389662A1 CA 2389662 A1 CA2389662 A1 CA 2389662A1 CA 002389662 A CA002389662 A CA 002389662A CA 2389662 A CA2389662 A CA 2389662A CA 2389662 A1 CA2389662 A1 CA 2389662A1
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- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La présente invention concerne des séquences d'acides nucléiques codant pour le récepteur humain de la pentraxine et pour des protéines connexes, ainsi qu'une composition pharmaceutique comprenant une quantité thérapeutiquement efficace de (a) pentraxine I ou du récepteur humain de pentraxine, (b) un variant non fonctionnel de la protéine de (a), (c) un anticorps de la protéine de (a) ou de (b), (d) une séquence d'acides nucléiques codant pour la protéine de (a) ou de (b), (e) une séquence d'ARN antisens caractérisée en ce qu'elle est complémentaire à une pentraxine I ou à un ARNm de récepteur humain de pentraxine et en ce qu'elle peut se lier sélectivement audit ARNm, ladite séquence étant capable d'inhiber la synthèse de pentraxine I ou du récepteur humain de pentraxine, ou (f) un ribozyme caractérisé en ce qu'il est complémentaire à une pentraxine ou à un ARNm de récepteur humain de pentraxine et en ce qu'il peut sélectivement se lier au dit ARNm et le scinder, ce qui mène à l'inhibition de la synthèse de pentraxine I ou du récepteur humain de pentraxine. L'invention concerne, en outre, l'utilisation des composés ci-dessus pour le traitement de troubles neuronaux ou pour assurer un effet neuroprotecteur. Ces composés sont aussi utiles pour détecter une maladie associée à un trouble neuronal basé sur une expression sans régulation de ces protéines ou sur la présence de pentraxine I/récepteur humain de pentraxine n'ayant aucune activité biologique ou une activité biologique éventuellement réduite.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99122666A EP1101820A1 (fr) | 1999-11-15 | 1999-11-15 | Pentraxin I et recepteur de la pentraxin, inhibiteurs de ces proteines et compositions pharmaceutiques comprenant ces composés |
| EP99122666.3 | 1999-11-15 | ||
| PCT/EP2000/011302 WO2001036626A2 (fr) | 1999-11-15 | 2000-11-15 | Pentraxine i et recepteur de pentraxine, inhibiteurs de ces proteines et compositions pharmaceutiques contenant ces composes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2389662A1 true CA2389662A1 (fr) | 2001-05-25 |
Family
ID=8239390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002389662A Abandoned CA2389662A1 (fr) | 1999-11-15 | 2000-11-15 | Pentraxine i et recepteur de pentraxine, inhibiteurs de ces proteines et compositions pharmaceutiques contenant ces composes |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP1101820A1 (fr) |
| JP (1) | JP2003514528A (fr) |
| AU (1) | AU1700801A (fr) |
| CA (1) | CA2389662A1 (fr) |
| WO (1) | WO2001036626A2 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1259818A2 (fr) * | 2000-02-24 | 2002-11-27 | Oxford GlycoSciences (UK) Limited | Diagnostic et traitement de la schizophrenie |
| US7927597B2 (en) | 2001-04-10 | 2011-04-19 | Agensys, Inc. | Methods to inhibit cell growth |
| CA2443123A1 (fr) | 2001-04-10 | 2002-10-24 | Agensys, Inc. | Acides nucleiques et proteines correspondantes utiles pour la detection et le traitement de divers cancers |
| AU2003223184A1 (en) | 2002-02-21 | 2003-09-09 | Fujisawa Pharmaceutical Co., Ltd. | Methods of preventing or treating brain ischemia or brain injury |
| ES2325779B1 (es) * | 2007-12-05 | 2010-07-06 | Consejo Superior De Investigaciones Cientificas | Elementos reguladores de la actividad de np1 utiles para la elaboracion de medicamentos para el tratamiento o prevencion de enfermedades humanas neurodegenerativas, medicamentos asi obtenidos y sus aplicaciones. |
| ES2352630B1 (es) * | 2009-07-14 | 2012-01-02 | Consejo Superior De Investigaciones Científicas (Csic) | Rna de interferencia utiles para la elaboracion de medicamentos para el tratamiento o prevencion de enfermedades humanas neurodegenerativas, medicamentos asi obtenidos y sus aplicaciones |
| ES2352925B1 (es) * | 2009-07-14 | 2012-01-02 | Consejo Superior De Investigaciones Cientificas (Csic) | Rna de interferencia útiles para la elaboración de medicamentos para el tratamiento o prevención de enfermedades humanas neurodegenerativas, medicamentos así obtenidos y sus aplicaciones. |
| US10222386B2 (en) | 2014-09-19 | 2019-03-05 | The Johns Hopkins University | Biomarkers of congnitive dysfunction |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5767252A (en) * | 1996-04-08 | 1998-06-16 | The Johns Hopkins University School Of Medicine | Neuronal cell growth factor, Narp |
-
1999
- 1999-11-15 EP EP99122666A patent/EP1101820A1/fr not_active Withdrawn
-
2000
- 2000-11-15 JP JP2001538505A patent/JP2003514528A/ja active Pending
- 2000-11-15 EP EP00979564A patent/EP1230356A2/fr not_active Withdrawn
- 2000-11-15 AU AU17008/01A patent/AU1700801A/en not_active Abandoned
- 2000-11-15 WO PCT/EP2000/011302 patent/WO2001036626A2/fr active Search and Examination
- 2000-11-15 CA CA002389662A patent/CA2389662A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003514528A (ja) | 2003-04-22 |
| WO2001036626A9 (fr) | 2002-09-12 |
| EP1101820A1 (fr) | 2001-05-23 |
| WO2001036626A2 (fr) | 2001-05-25 |
| EP1230356A2 (fr) | 2002-08-14 |
| AU1700801A (en) | 2001-05-30 |
| WO2001036626A3 (fr) | 2001-10-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |