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CA2382359A1 - Pharmaceutical preparation containing nanosol - Google Patents

Pharmaceutical preparation containing nanosol Download PDF

Info

Publication number
CA2382359A1
CA2382359A1 CA002382359A CA2382359A CA2382359A1 CA 2382359 A1 CA2382359 A1 CA 2382359A1 CA 002382359 A CA002382359 A CA 002382359A CA 2382359 A CA2382359 A CA 2382359A CA 2382359 A1 CA2382359 A1 CA 2382359A1
Authority
CA
Canada
Prior art keywords
pharmaceutical preparation
preparation containing
nanosol
production
active substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002382359A
Other languages
French (fr)
Other versions
CA2382359C (en
Inventor
Hans-Rainer Hoffmann
Bodo Asmussen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2382359A1 publication Critical patent/CA2382359A1/en
Application granted granted Critical
Publication of CA2382359C publication Critical patent/CA2382359C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • B01J13/0039—Post treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to solid pharmaceutical preparations comprising at least one at least partially charged active substance in the form of a nanosol wherein the active substance is bonded to an oppositely charged chitosan derivative, processes for their production, and their use for the production of medicinal products.
CA002382359A 1999-08-27 2000-08-14 Pharmaceutical preparation containing nanosol Expired - Fee Related CA2382359C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19940794A DE19940794A1 (en) 1999-08-27 1999-08-27 Pharmaceutical preparation
DE19940794.0 1999-08-27
PCT/EP2000/007904 WO2001015669A1 (en) 1999-08-27 2000-08-14 Pharmaceutical preparation containing nanosol

Publications (2)

Publication Number Publication Date
CA2382359A1 true CA2382359A1 (en) 2001-03-08
CA2382359C CA2382359C (en) 2008-03-18

Family

ID=7919871

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002382359A Expired - Fee Related CA2382359C (en) 1999-08-27 2000-08-14 Pharmaceutical preparation containing nanosol

Country Status (25)

Country Link
EP (1) EP1206253B1 (en)
JP (1) JP2003508423A (en)
KR (1) KR100624499B1 (en)
CN (1) CN1181815C (en)
AR (1) AR025392A1 (en)
AT (1) ATE279180T1 (en)
AU (1) AU779692B2 (en)
BR (1) BR0013563A (en)
CA (1) CA2382359C (en)
CZ (1) CZ301704B6 (en)
DE (2) DE19940794A1 (en)
DK (1) DK1206253T3 (en)
ES (1) ES2231265T3 (en)
HK (1) HK1047037B (en)
HU (1) HU227609B1 (en)
IL (2) IL148220A0 (en)
MX (1) MXPA02002048A (en)
NZ (1) NZ517541A (en)
PL (1) PL203860B1 (en)
PT (1) PT1206253E (en)
RU (1) RU2256440C2 (en)
TR (1) TR200200520T2 (en)
TW (1) TWI267384B (en)
WO (1) WO2001015669A1 (en)
ZA (1) ZA200201135B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100638041B1 (en) * 2003-12-24 2006-10-23 주식회사 삼양사 Nanoparticle composition for oral administration of water-soluble drug and preparation method thereof
KR100767336B1 (en) * 2006-04-19 2007-10-18 서평원 Chitin / chitosan-based functional organic-inorganic composite materials and preparation method thereof, and use of such composite materials
US9161901B2 (en) 2008-02-21 2015-10-20 University Of South Florida Nanoparticle targeted drug delivery to the lungs using extra-testicular Sertoli cells
UA90013C2 (en) 2008-03-19 2010-03-25 Давид Анатолійович Нога Pharmaceutical composition containing insulin and process for the preparation thereof
PL220269B1 (en) 2008-04-21 2015-09-30 Przedsiębiorstwo Produkcji Farmaceutycznej Hasco Lek Spółka Akcyjna Composite carrier of powdered medicines, method of production the medicine carrier and equipment for production of particles of composite carrier
DE102009024542A1 (en) * 2009-06-10 2010-12-16 Arivine Pharma Ag Compositions based on chitosan oligosaccharides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474989A (en) * 1988-11-11 1995-12-12 Kurita Water Industries, Ltd. Drug composition
DE4140195C2 (en) * 1991-12-05 1994-10-27 Alfatec Pharma Gmbh Pharmaceutical nanosol and process for its manufacture
US6184037B1 (en) * 1996-05-17 2001-02-06 Genemedicine, Inc. Chitosan related compositions and methods for delivery of nucleic acids and oligonucleotides into a cell
WO1997047323A2 (en) * 1996-06-11 1997-12-18 Zonagen, Inc. Chitosan drug delivery system
ES2114502B1 (en) * 1996-07-29 1999-07-01 Univ Santiago Compostela APPLICATION OF NANOPARTICLES BASED ON HYDROPHILIC POLYMERS AS PHARMACEUTICAL FORMS.
DE19845246A1 (en) * 1997-12-18 1999-06-24 Henkel Kgaa Vitamin E compositions
JP2002509117A (en) * 1998-01-16 2002-03-26 ザ・ジョーンズ・ホプキンス・ユニバーシティ Oral administration of nucleic acid vaccine by granular complex

Also Published As

Publication number Publication date
HU227609B1 (en) 2011-09-28
PT1206253E (en) 2005-02-28
CA2382359C (en) 2008-03-18
TR200200520T2 (en) 2002-06-21
AR025392A1 (en) 2002-11-27
BR0013563A (en) 2002-07-09
CZ2002653A3 (en) 2002-05-15
MXPA02002048A (en) 2002-08-20
WO2001015669A1 (en) 2001-03-08
ZA200201135B (en) 2002-08-28
AU779692B2 (en) 2005-02-03
ES2231265T3 (en) 2005-05-16
CN1181815C (en) 2004-12-29
HK1047037B (en) 2005-03-24
KR20020031416A (en) 2002-05-01
CN1370065A (en) 2002-09-18
PL203860B1 (en) 2009-11-30
EP1206253A1 (en) 2002-05-22
KR100624499B1 (en) 2006-09-18
RU2256440C2 (en) 2005-07-20
HK1047037A1 (en) 2003-02-07
ATE279180T1 (en) 2004-10-15
TWI267384B (en) 2006-12-01
IL148220A0 (en) 2002-09-12
JP2003508423A (en) 2003-03-04
CZ301704B6 (en) 2010-06-02
NZ517541A (en) 2002-08-28
EP1206253B1 (en) 2004-10-13
DE19940794A1 (en) 2001-03-01
AU7509400A (en) 2001-03-26
PL354572A1 (en) 2004-01-26
IL148220A (en) 2009-05-04
HUP0300345A2 (en) 2003-09-29
DK1206253T3 (en) 2005-01-31
DE50008259D1 (en) 2004-11-18
HUP0300345A3 (en) 2009-01-28

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Legal Events

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EEER Examination request
MKLA Lapsed

Effective date: 20130814