[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

CA2374751A1 - System, method, and device for non-invasive body fluid sampling and analysis - Google Patents

System, method, and device for non-invasive body fluid sampling and analysis Download PDF

Info

Publication number
CA2374751A1
CA2374751A1 CA002374751A CA2374751A CA2374751A1 CA 2374751 A1 CA2374751 A1 CA 2374751A1 CA 002374751 A CA002374751 A CA 002374751A CA 2374751 A CA2374751 A CA 2374751A CA 2374751 A1 CA2374751 A1 CA 2374751A1
Authority
CA
Canada
Prior art keywords
body fluid
area
receiver
biological membrane
membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002374751A
Other languages
French (fr)
Other versions
CA2374751C (en
Inventor
Linda Custer
Tuan A. Elstrom
Scott C. Kellogg
Joseph Kost
Nicholas F. Warner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Echo Therapeutics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2374751A1 publication Critical patent/CA2374751A1/en
Application granted granted Critical
Publication of CA2374751C publication Critical patent/CA2374751C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Surgery (AREA)
  • Optics & Photonics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

A system, method, and device for non-in-vasive body fluid sampling is provided. According to one embodiment of the present invention, the system includes a controller that controls the generation of ultrasound; an ultrasonic applicator that applies the ultrasound to an area of biological membrane; a receiver that contacts the area of biological membrane and receives body fluid through and out of the area of biological membrane; and a meter that interacts with the receiver and detects the presence of at least one analyte in the body fluid in the receiver. The receiver may include a membrane and a medium, such as a hydrogel, a fluid, or a liquid, that is contained in the membrane. According to one embodiment of the present invention, the method includes the steps of (1) identifying an area of biological membrane having a permeability level;
(2) increasing the permeability level of the area of biological membrane; (3) contacting the area of biological membrane with a receiver; (4) extracting body fluid through and out of the area of biological membrane; (5) providing an external force to enhance the body fluid extraction; (6) collecting the body fluid in the receiver; (7) analyzing the collected body fluid for the presence of at least one analyte;
and (8) providing the results of the step of analyzing the body fluid.
CA002374751A 2000-03-17 2001-03-16 System, method, and device for non-invasive body fluid sampling and analysis Expired - Fee Related CA2374751C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18997100P 2000-03-17 2000-03-17
US60/189,971 2000-03-17
PCT/US2001/008489 WO2001070330A2 (en) 2000-03-17 2001-03-16 Non-invasive body fluid sampling and analysis

Publications (2)

Publication Number Publication Date
CA2374751A1 true CA2374751A1 (en) 2001-09-27
CA2374751C CA2374751C (en) 2009-10-13

Family

ID=22699523

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002374751A Expired - Fee Related CA2374751C (en) 2000-03-17 2001-03-16 System, method, and device for non-invasive body fluid sampling and analysis

Country Status (5)

Country Link
EP (1) EP1225831A2 (en)
JP (2) JP2003527613A (en)
AU (1) AU781149B2 (en)
CA (1) CA2374751C (en)
WO (1) WO2001070330A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040171980A1 (en) 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
NZ512367A (en) * 2001-06-14 2005-05-27 Horticulture & Food Res Inst Non-invasive transudate extraction
US20060094944A1 (en) 2004-10-28 2006-05-04 Sontra Medical Corporation System and method for analyte sampling and analysis with error correction
JP5502279B2 (en) * 2004-10-28 2014-05-28 エコー セラピューティクス， インコーポレイテッド System and method for analyte sampling and analysis using hydrogels
JP2006167428A (en) * 2004-11-16 2006-06-29 Sysmex Corp Analyte extraction device, analyzer, analyte extraction method, and analysis method
US8343134B2 (en) 2006-06-13 2013-01-01 Ben Gurion University Of The Negev Research And Development Authority System and method for transfetal (amnion-chorion) membranes transport
JP5508861B2 (en) 2007-03-07 2014-06-04 エコー セラピューティクス， インコーポレイテッド Transcutaneous analyte monitoring system
BRPI0810969A2 (en) 2007-04-27 2015-01-27 Echo Therapeutics Inc SKIN PERMEATION DEVICE FOR ANALYTIC DETECTION OR TRANSDERMAL PHARMACEUTICAL RELEASE
JP2010266203A (en) * 2008-05-20 2010-11-25 Sony Corp Method and device for acquisition of biological information, and method and device for measurement of physiologically active substance
EP2322093B1 (en) * 2008-07-31 2018-01-10 Sysmex Corporation Method for assaying in vivo component and apparatus and collection member for assaying in vivo component
EP2376059A2 (en) * 2008-11-25 2011-10-19 B.G. Negev Technologies and Applications Ltd. Pharmaceutical composition and system for permeabilizing fetal membranes
JP5406646B2 (en) * 2009-09-16 2014-02-05 シスメックス株式会社 Tissue fluid collection kit and tissue fluid collection sheet used for tissue fluid collection method
CN103842020B (en) * 2011-10-05 2016-12-28 皇家飞利浦有限公司 Chemical examination for the delivery of ultrasonic mediation
KR102673720B1 (en) 2016-07-29 2024-06-07 삼성전자주식회사 Apparatus and method for estimating substance in blood
KR102638309B1 (en) 2016-10-26 2024-02-19 삼성전자주식회사 Wearable device, and method for health monitoring
KR102681121B1 (en) 2016-11-15 2024-07-02 삼성전자주식회사 Apparatus and method for measuring biological components
KR102658240B1 (en) 2016-11-17 2024-04-16 삼성전자주식회사 Apparatus and method for estimating biological information

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767402A (en) 1986-07-08 1988-08-30 Massachusetts Institute Of Technology Ultrasound enhancement of transdermal drug delivery
JP2907342B2 (en) 1988-01-29 1999-06-21 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア Ion infiltration non-invasive sampling or delivery device
US5139023A (en) * 1989-06-02 1992-08-18 Theratech Inc. Apparatus and method for noninvasive blood glucose monitoring
US5458140A (en) * 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
PT766578E (en) * 1994-06-24 2001-01-31 Cygnus Therapeutic Systems IONTOFORETIC SAMPLING DEVICE
CA2226176C (en) * 1995-07-12 2003-09-16 Cygnus, Inc. Hydrogel patch
US6002961A (en) 1995-07-25 1999-12-14 Massachusetts Institute Of Technology Transdermal protein delivery using low-frequency sonophoresis
DE69624668T2 (en) * 1995-07-25 2003-08-28 Massachusetts Institute Of Technology, Cambridge IMPROVED TRANSDERMAL TRANSPORTATION USING ULTRASOUND
US5947921A (en) 1995-12-18 1999-09-07 Massachusetts Institute Of Technology Chemical and physical enhancers and ultrasound for transdermal drug delivery
US5735273A (en) * 1995-09-12 1998-04-07 Cygnus, Inc. Chemical signal-impermeable mask
US6009343A (en) * 1996-02-23 1999-12-28 Abbott Laboratories Enhanced transdermal transport of fluid using vacuum
US5895362A (en) * 1996-02-23 1999-04-20 Abbott Laboratories Transdermal transport using ultrasonic standing waves
CA2253549C (en) * 1996-06-18 2005-10-25 Alza Corporation Device for enhancing transdermal agent delivery or sampling
WO1998000194A2 (en) * 1996-06-28 1998-01-08 Sontra Medical, L.P. Ultrasound enhancement of transdermal transport
CA2317777C (en) 1998-01-08 2005-05-03 Sontra Medical, Inc. Sonophoretic enhanced transdermal transport
EP1053041A4 (en) * 1998-01-12 2001-02-07 Georgia Tech Res Inst Assessment and control of acoustic tissue effects
CA2265119C (en) * 1998-03-13 2002-12-03 Cygnus, Inc. Biosensor, iontophoretic sampling system, and methods of use thereof
DE69902229T2 (en) * 1998-05-13 2003-02-20 Cygnus, Inc. COLLECTING DEVICES FOR TRANSDERMAL SAMPLING SYSTEMS
CA2338292A1 (en) * 1998-07-21 2000-02-03 Jonathan A. Eppstein Fluid management in a continuous fluid collection and sensor device
WO2000035351A1 (en) 1998-12-18 2000-06-22 Sontra Medical, Inc. Method and apparatus for producing homogenous cavitation to enhance transdermal transport

Also Published As

Publication number Publication date
AU781149B2 (en) 2005-05-05
CA2374751C (en) 2009-10-13
JP2012068263A (en) 2012-04-05
WO2001070330A3 (en) 2002-05-23
WO2001070330A2 (en) 2001-09-27
AU4580901A (en) 2001-10-03
JP2003527613A (en) 2003-09-16
EP1225831A2 (en) 2002-07-31

Similar Documents

Publication Publication Date Title
CA2374751A1 (en) System, method, and device for non-invasive body fluid sampling and analysis
WO2003008933A3 (en) Test strip for a lateral flow assay
WO2002082040A3 (en) A 'one-device' system for testing constituents in fluids
WO2002100254A3 (en) Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
WO2006091426A3 (en) Methods and apparatus for extracting and analyzing a bodily fluid
WO1998024366A3 (en) Method and apparatus for obtaining blood for diagnostic tests
EP1579814A3 (en) Methods and apparatus for sampling and analyzing body fluid
CA2321690A1 (en) Disposable apparatus for performing blood cell counts
GB2322699A (en) Methods and devices for determination of an analyte in body fluid
WO2003087775A3 (en) Monitoring blood substances using self-sampled tears
WO2005085796A3 (en) System and method for integrating fluids and reagents in self-contained cartridges containing sensor elements
WO2005085855A3 (en) System and method for integrating fluids and reagents in self-contained cartridges containing sensor elements and reagent delivery systems
ATE371497T1 (en) SAMPLE COLLECTOR AND TEST APPARATUS
EP1266608A3 (en) Biological fluid sampling and analyte measurement devices and methods
WO2003095974A3 (en) Collection assembly
CA2448905A1 (en) Blood sampling apparatus and method
BR9912333A (en) System to continuously monitor a characteristic of a biological fluid extracted from an organism and a process to extract a biological fluid from a biological membrane of an organism and continuously monitor a characteristic of it.
WO2005008216A3 (en) Sanitary fluid collection, application and storage device and methods of use of same
RU2005104830A (en) PHYSIOLOGICAL LIQUID TAKE-UP SYSTEMS AND CONTROL CONTAINED IN ANALYT
WO2002084224A3 (en) Perfusion sensitive biopsy extractor
CA2435550A1 (en) System for monitoring the concentration of analytes in body fluids
ATE286675T1 (en) DEVICE FOR SAMPLING INTERSTITIAL FLUID FOR DIAGNOSTIC TESTS
MX9604108A (en) Integrated system for biological fluid constituent analysis.
WO2002084266A3 (en) Biological measurement system
DE60110785D1 (en) DEVICE FOR PERFORMING DIAGNOSTIC TESTS OF THE BLOOD

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20190318