CA2362320A1 - Gene de la calvitie chez l'homme, proteine et utilisations associees - Google Patents
Gene de la calvitie chez l'homme, proteine et utilisations associees Download PDFInfo
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- CA2362320A1 CA2362320A1 CA002362320A CA2362320A CA2362320A1 CA 2362320 A1 CA2362320 A1 CA 2362320A1 CA 002362320 A CA002362320 A CA 002362320A CA 2362320 A CA2362320 A CA 2362320A CA 2362320 A1 CA2362320 A1 CA 2362320A1
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- 229940001584 sodium metabisulfite Drugs 0.000 description 1
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- 239000012064 sodium phosphate buffer Substances 0.000 description 1
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- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
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- 108090000721 thyroid hormone receptors Proteins 0.000 description 1
- 229940034208 thyroxine Drugs 0.000 description 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
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- PYHOFAHZHOBVGV-UHFFFAOYSA-N triazane Chemical compound NNN PYHOFAHZHOBVGV-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
- A61Q7/02—Preparations for inhibiting or slowing hair growth
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/86—Products or compounds obtained by genetic engineering
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Cette invention concerne un acide nucléique isolé qui code une protéine de calvitie humaine du type sauvage ou mutant, ainsi qu'une protéine isolée de calvitie humaine du type sauvage ou mutant. Cette invention concerne également des procédés permettant d'isoler un acide nucléique codant une protéine liée à la calvitie humaine du type sauvage dans un échantillon contenant de l'acide nucléique, des procédés permettant d'identifier un composé qui est capable d'accroître ou d'inhiber l'expression d'une protéine de calvitie humaine, des procédés permettant d'identifier un composé de liaison qui est capable de former un complexe avec une protéine de calvitie humaine, et des procédés permettant d'identifier un composé inhibiteur qui est capable d'entraver la capacité d'une protéine de calvitie humaine de former un complexe avec le composé de liaison. Cette invention concerne également un animal transgénique, des compositions pharmaceutiques et des procédés de traitement de la calvitie chez l'homme.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7304398P | 1998-01-29 | 1998-01-29 | |
| US60/073,043 | 1998-01-29 | ||
| PCT/US1999/002128 WO1999038965A1 (fr) | 1998-01-29 | 1999-01-29 | Gene de la calvitie chez l'homme, proteine et utilisations associees |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2362320A1 true CA2362320A1 (fr) | 1999-08-05 |
Family
ID=22111367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002362320A Abandoned CA2362320A1 (fr) | 1998-01-29 | 1999-01-29 | Gene de la calvitie chez l'homme, proteine et utilisations associees |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1053315A4 (fr) |
| AU (1) | AU2572499A (fr) |
| CA (1) | CA2362320A1 (fr) |
| WO (1) | WO1999038965A1 (fr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6348348B1 (en) | 1998-04-07 | 2002-02-19 | The Carnegie Institution Of Washington | Human hairless gene and protein |
| GB0011269D0 (en) * | 2000-05-11 | 2000-06-28 | Univ Sheffield | Protein over expression |
| WO2002070743A2 (fr) * | 2001-03-07 | 2002-09-12 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Identification et utilisation d'inhibiteurs de la croissance pileuse |
| DE60238395D1 (de) | 2001-04-13 | 2011-01-05 | Univ Columbia | Ess-protein und verfahren zur verwendung davon |
| EP1399579A4 (fr) * | 2001-06-26 | 2006-04-19 | Anaderm Res Corp | Croissance de cheveux de mammifere induite par fkbp51/52 et cyp40 |
| US7169564B1 (en) | 2001-06-26 | 2007-01-30 | Anaderm Research Corporation | FKBP51/52 and CyP40-mediated mammalian hair growth |
| WO2006006948A2 (fr) | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | Methodes et compositions permettant de selectionner des arnsi presentant une fonctionnalite amelioree |
| US9719094B2 (en) | 2002-11-14 | 2017-08-01 | Thermo Fisher Scientific Inc. | RNAi targeting SEC61G |
| US9771586B2 (en) | 2002-11-14 | 2017-09-26 | Thermo Fisher Scientific Inc. | RNAi targeting ZNF205 |
| US7612196B2 (en) | 2002-11-14 | 2009-11-03 | Dharmacon, Inc. | siRNA targeting cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B) |
| US10011836B2 (en) | 2002-11-14 | 2018-07-03 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
| US9839649B2 (en) | 2002-11-14 | 2017-12-12 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
| US9879266B2 (en) | 2002-11-14 | 2018-01-30 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
| US9719092B2 (en) | 2002-11-14 | 2017-08-01 | Thermo Fisher Scientific Inc. | RNAi targeting CNTD2 |
| US9228186B2 (en) | 2002-11-14 | 2016-01-05 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
| AU2003295600A1 (en) | 2002-11-14 | 2004-06-15 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
| US20050106141A1 (en) * | 2003-11-13 | 2005-05-19 | The Procter & Gamble Company | Hairless protein-interacting partner complexes and methods thereof for the beautification and/or improvement of mammalian skin |
| US8168600B2 (en) | 2004-04-23 | 2012-05-01 | Isis Pharmaceuticals, Inc. | Compositions and methods for topical delivery of oligonucleotides |
| EP1747022A4 (fr) | 2004-04-23 | 2010-03-31 | Univ Columbia | Inhibition d'un arnm associe a une proteine du gene hairless (sans poil) |
| WO2014022655A1 (fr) * | 2012-08-01 | 2014-02-06 | The Trustees Of Columbia University In The City Of New York | Méthodes de régulation de troubles de la croissance des cheveux |
| EP2735303A1 (fr) * | 2012-11-23 | 2014-05-28 | Pilosciences | Procédés et compositions pour la croissance des cheveux |
| WO2019161805A1 (fr) * | 2018-02-26 | 2019-08-29 | Biocytogen Jiangsu Co., Ltd. | Animal non humain hr inactivé |
| CN113717975B (zh) * | 2021-09-01 | 2023-09-26 | 中国农业大学 | 一种与猪无毛性状相关的miRNA标志物及其应用 |
-
1999
- 1999-01-29 CA CA002362320A patent/CA2362320A1/fr not_active Abandoned
- 1999-01-29 AU AU25724/99A patent/AU2572499A/en not_active Abandoned
- 1999-01-29 WO PCT/US1999/002128 patent/WO1999038965A1/fr not_active Application Discontinuation
- 1999-01-29 EP EP99905596A patent/EP1053315A4/fr active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2572499A (en) | 1999-08-16 |
| EP1053315A1 (fr) | 2000-11-22 |
| EP1053315A4 (fr) | 2003-07-30 |
| WO1999038965A1 (fr) | 1999-08-05 |
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Legal Events
| Date | Code | Title | Description |
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| FZDE | Discontinued |