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CA2346068A1 - Nouvelle population de lymphocytes exprimant mo2 intracellulaire - Google Patents

Nouvelle population de lymphocytes exprimant mo2 intracellulaire Download PDF

Info

Publication number
CA2346068A1
CA2346068A1 CA002346068A CA2346068A CA2346068A1 CA 2346068 A1 CA2346068 A1 CA 2346068A1 CA 002346068 A CA002346068 A CA 002346068A CA 2346068 A CA2346068 A CA 2346068A CA 2346068 A1 CA2346068 A1 CA 2346068A1
Authority
CA
Canada
Prior art keywords
cells
antigen
level
expression
mabs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002346068A
Other languages
English (en)
Inventor
Boris Tartakovsky
Israel Yust
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tel-Aviv Medical Center Research & Development Fund
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2346068A1 publication Critical patent/CA2346068A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Cette invention a trait à une nouvelle population de lymphocytes exprimant à l'extérieur de la cellule un antigène reconnu par des MAb MO2 mais n'exprimant pas cet antigène sur leur surface. Ces cellules sont dénommées <=cellules MO2?+¿>=. Le taux de cellules MO2?+¿ est plus élevé dans des prélèvements sanguins de sujets atteints de diverses infections, notamment d'infection par le VIH, par rapport au taux présenté par des sujets sains. Ces cellules s'avèrent donc des plus utiles s'agissant de diagnostiquer une probabilité élevée de l'existence de cette infection. La connaissance du taux de cellules MO2?+¿ dans le sang d'un sujet est également utile pour déterminer l'efficacité de différents traitements anti-infectieux.
CA002346068A 1998-10-04 1999-10-04 Nouvelle population de lymphocytes exprimant mo2 intracellulaire Abandoned CA2346068A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL126452 1998-10-04
IL12645298A IL126452A (en) 1998-10-04 1998-10-04 Population of mo2+ lymphocyte cells and their use in detection methods
PCT/IL1999/000524 WO2000020562A1 (fr) 1998-10-04 1999-10-04 Nouvelle population de lymphocytes exprimant mo2 intracellulaire

Publications (1)

Publication Number Publication Date
CA2346068A1 true CA2346068A1 (fr) 2000-04-13

Family

ID=11072010

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002346068A Abandoned CA2346068A1 (fr) 1998-10-04 1999-10-04 Nouvelle population de lymphocytes exprimant mo2 intracellulaire

Country Status (6)

Country Link
EP (1) EP1121418A1 (fr)
JP (1) JP2002526105A (fr)
AU (1) AU5997199A (fr)
CA (1) CA2346068A1 (fr)
IL (1) IL126452A (fr)
WO (1) WO2000020562A1 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5415874A (en) * 1989-10-31 1995-05-16 The Board Of Trustees Of The Leland Stanford Junior University Natural killer cell lines and clones with antigen specificity
WO1996032418A1 (fr) * 1995-04-13 1996-10-17 Laboratoires Om S.A. Anticorps anti-cd14 utilises dans l'induction de la secretion il-10

Also Published As

Publication number Publication date
WO2000020562A1 (fr) 2000-04-13
AU5997199A (en) 2000-04-26
IL126452A0 (en) 1999-08-17
JP2002526105A (ja) 2002-08-20
IL126452A (en) 2005-03-20
EP1121418A1 (fr) 2001-08-08

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Legal Events

Date Code Title Description
FZDE Discontinued