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CA2232138A1 - Antagonistes du recepteur adrenergique alpha 1b - Google Patents

Antagonistes du recepteur adrenergique alpha 1b Download PDF

Info

Publication number
CA2232138A1
CA2232138A1 CA002232138A CA2232138A CA2232138A1 CA 2232138 A1 CA2232138 A1 CA 2232138A1 CA 002232138 A CA002232138 A CA 002232138A CA 2232138 A CA2232138 A CA 2232138A CA 2232138 A1 CA2232138 A1 CA 2232138A1
Authority
CA
Canada
Prior art keywords
adrenergic receptor
compound
alpha
human alpha
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002232138A
Other languages
English (en)
Inventor
William C. Lumma
Michael A. Patane
Mark G. Bock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9604288.2A external-priority patent/GB9604288D0/en
Application filed by Individual filed Critical Individual
Publication of CA2232138A1 publication Critical patent/CA2232138A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention concerne certains composés nouveaux et dérivés de ces composés, leur synthèse, et leur utilisation en tant qu'antagonistes du récepteur adrénergique alpha 1b. Ces composés présentent une affinité submicromolaire pour le sous-type humain du récepteur adrénergique alpha 1b tout en présentant une affinité au moins cinq fois inférieure pour les sous-types humains du récepteur adrénergique alpha 1d et alpha 1a et pour de nombreux autres récepteurs humains couplés à des protéines G. Ces composés sont notamment utilisés dans le traitement de l'hypertension. Plus spécifiquement, ces composés diminuent de façon sélective la pression artérielle sans, par exemple, affecter sensiblement la pression urétrale.
CA002232138A 1995-09-29 1996-09-24 Antagonistes du recepteur adrenergique alpha 1b Abandoned CA2232138A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US450195P 1995-09-29 1995-09-29
US60/004,501 1995-09-29
GB9604288.2 1996-02-29
GBGB9604288.2A GB9604288D0 (en) 1996-02-29 1996-02-29 Alpha 1b adrenergic receptor antagonists

Publications (1)

Publication Number Publication Date
CA2232138A1 true CA2232138A1 (fr) 1997-04-03

Family

ID=26308827

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002232138A Abandoned CA2232138A1 (fr) 1995-09-29 1996-09-24 Antagonistes du recepteur adrenergique alpha 1b

Country Status (4)

Country Link
EP (1) EP0853479A4 (fr)
JP (1) JPH11512710A (fr)
CA (1) CA2232138A1 (fr)
WO (1) WO1997011698A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1312310B1 (it) * 1999-05-07 2002-04-15 Recordati Ind Chimica E Farma Uso di antagonisti selettivi del recettore adrenergico a 1b per ilmiglioramento della disfunzione sessuale
KR100602929B1 (ko) 2000-08-31 2006-07-20 에프. 호프만-라 로슈 아게 알파-1 아드레날린성 길항제로서 퀴나졸린 유도체
EP1802775B1 (fr) 2004-09-14 2010-05-26 The Regents of the University of Colorado Procédé de traitement faisant intervenir du bucindolol fondé sur le ciblage génétique
WO2014079155A1 (fr) * 2012-11-26 2014-05-30 辽宁贝雷生物制药有限公司 Utilisation d'hétérocycles azotés pentagonaux de type pipérazine et des dérivés de pipéridine
WO2018005552A1 (fr) 2016-06-27 2018-01-04 Achillion Pharmaceuticals, Inc. Composés de quinazoline et d'indole destinés au traitement de troubles médicaux

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4026894A (en) * 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
US4101548A (en) * 1977-02-22 1978-07-18 Bristol-Myers Company 1,2,3-Thiadiazole amides
JPS5793977A (en) * 1980-11-26 1982-06-11 Sankyo Co Ltd Acylaminoquinazoline derivative and its preparation
GB2171977A (en) * 1985-03-05 1986-09-10 Emi Plc Thorn Gripper

Also Published As

Publication number Publication date
JPH11512710A (ja) 1999-11-02
EP0853479A1 (fr) 1998-07-22
WO1997011698A1 (fr) 1997-04-03
EP0853479A4 (fr) 2001-04-11

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Legal Events

Date Code Title Description
FZDE Dead