CA2217883C - A device for detecting components in exhaled air - Google Patents
A device for detecting components in exhaled air Download PDFInfo
- Publication number
- CA2217883C CA2217883C CA002217883A CA2217883A CA2217883C CA 2217883 C CA2217883 C CA 2217883C CA 002217883 A CA002217883 A CA 002217883A CA 2217883 A CA2217883 A CA 2217883A CA 2217883 C CA2217883 C CA 2217883C
- Authority
- CA
- Canada
- Prior art keywords
- plate
- carbon dioxide
- air
- exhalation air
- components
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000002745 absorbent Effects 0.000 claims abstract description 13
- 239000002250 absorbent Substances 0.000 claims abstract description 13
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 38
- 239000000463 material Substances 0.000 claims description 22
- 239000001569 carbon dioxide Substances 0.000 claims description 19
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 19
- 239000012528 membrane Substances 0.000 claims description 6
- 241000590002 Helicobacter pylori Species 0.000 claims description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 3
- 229940037467 helicobacter pylori Drugs 0.000 claims description 3
- 239000011358 absorbing material Substances 0.000 claims description 2
- 239000012084 conversion product Substances 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- 150000001447 alkali salts Chemical class 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 229910052744 lithium Inorganic materials 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 238000000034 method Methods 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
- 239000004202 carbamide Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 230000002285 radioactive effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- HUAUNKAZQWMVFY-UHFFFAOYSA-M sodium;oxocalcium;hydroxide Chemical compound [OH-].[Na+].[Ca]=O HUAUNKAZQWMVFY-UHFFFAOYSA-M 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000011111 cardboard Substances 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 238000005048 flame photometry Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000011087 paperboard Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Measuring devices for evaluating the respiratory organs
- A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Measuring devices for evaluating the respiratory organs
- A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
- A61B5/0836—Measuring rate of CO2 production
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- Physiology (AREA)
- Medical Informatics (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
A device for detecting one or more components in exhalation air includes a tubular element into whose one end exhalation air is introduced and at whose other end there is attached an absorbent plate which absorbs the component(s ), wherein the plate can be detached for determination of the components in a measuring apparatus.
Description
W 0~'32-~2 PCT/SE96/00~74 A DEVICE FOR ~ ~U~N1! IN ~x~r-~n AIR
The present invention relates to a device for detecting one or more components in exhaled air, and particularly for detecting the presence of pathogenic bacteria Helicobacter pylori in stomach and intestinal tracts of hllm~n beings.
R~ 701~ND OF THE lNV~N.LlON
Gaseous components can be analyzed in various ways, such as by gas chromatography, flame photometry and spectrophotome-try, for instance. These methods, however, require the use of expensive equipment and are much too advanced in many cases. Simpler, alternative methods are those in which the gas is absorbed by a material and the presence or absence of a gaseous component indicated with the aid of a colour indicator. Examples in this respect are the blow tubes used to indicate the presence of alcohol in ~h~l ~tion air. The~e devices have the drawback of not being constructed for separate measurements on the absorbent material.
Certain conditions and illnesses can be indicated by analyz-ing exhalation air. For instance, stomach ulcers are caused mainly by the pathogenic bacteria Helicobacter pylori. A
method has been described for indicating the presence of this bacteria and has been applied in clinical research for a number of years. According to this method, patients are to swallow an isotope-labelled, preferably radioactive, urea preparation. ~elicobacter pylori present in the gastric and intestinal tract will break the urea down to carbon dioxide, among other materials. This carbon dioxide is then transported to the lungs through the normal physiology of the body, where it is exhaled together with the carbon dioxide that has been formed in r~m~; n; ng body organs. Because the carbon dioxide that is formed by the bacteria is labelled, the amount of carbon dioxide exhaled can be measured by causing the patient to blow the exhalation air through a tube and down into a liquid which absorbs carbon dioxide. This liquid is then ex~mined with the aid of appropriate measuring instruments, for instance a scintillator counter, to indicate i~otope labelled components in the exhaled carbon dioxide as a sign of the presence of ~elicobacter pylori.
The aforesaid method is relatively complicated and time-consuming. In addition, it requires the use of expensive and bulky apparatus. Furthermore, no product for carrying out this method is actually available commercially.
OBJECTS OF ~1~ lNV~ ON
The object of the present invention is to provide apparatus for use in detecting one or more components in exhalation air. The apparatus shall be producible at low costs and shall also satisfy requirem~nts of long-term storability and reproducibility of test results. Another object is also to obviate the complex handling of liquids and the use of space-consuming analysis instruments.
These objects are fulfilled by the present invention, whichrelates to a device which consists of a tubular element, which may be rigid or soft as a plastic bag and through which air is conducted. A nozzle is formed on one end of the tube.
The opposite end of the tube is fitted with a plate, which may either be an airtight plate or a porous membrane. The plate is attached to the tube in a m~nne~ which will enable it to be readily ~e,l,oved therefrom. The plate fitting may either have the form of a screw device or snap-coupling, or may simply comprise adhesive tape. A dry, absorbent material has been mounted on or incorporated in the plate. This absorbent material is adapted solely to absorb a specific amount of desired gaseous component. A colour indicator in the absorbent substance indicates when the m~; mllm amount of gaseous component has been absorbed. When an airtight plate is used, the outer edge of the plate is perforated so as to allow air to pass out and therewith enable air to flow r through the tube.
The patient blows exhalation air through the nozzle and causes said air to flow across or through the plate. The plate can be separated from the tube when the plate becomes saturated. The plate is then analyzed in an appropriate measuring in~trument, to indicate the presence or absence of components in question.
In a preferred embodiment, the present invention is used to indicate the presence of isotope labelled carbon dioxide in ~hA1~tion air, and in particular to indicate the presence of radioactive carbon dioxide formed as a conversion product of the bacteria Helicobacter pylori. To this end, the plate has mounted thereon or incorporates a c~hon dioxide absorb-ing material. A patient ~m;n;stered with radioactive labelled urea is asked to blow through the inventive device.
Carbon dioxide, including radioactively labelled carbon dioxide, is absorbed on the plate. The plate is then removed from the device and analyzed with regard to radioactivity in an appropriate measuring device, to indicate the presence of the bacterium Helicobacter pylori.
The present invention thus provides a simple device for use in indicating the presence or absence of ~ori~ nts in exhalation air.
BRIEF DESCRIPTION OF THE DRAWINGS
Figure 1 is a perspective view of an inventive device.
Figure 2a is a view from above of a further embodiment of the inventive device.
Figure 2b is a side view of the embodiment shown in Figure 2a.
W 096~2062 PCT/~ Jo~74 DE~ATT~n DESCRIPTION OF ~ E FIG ~ ES
Figure 1 illustrates primarily the embodiment in which a porous membrane is used and the air shall be caused to flow through the plate. The device is comprised of a tubular element 1 provided with a nozzle 2 at one end. An absorbent plate 3 is fitted detachably to the opposite end. When an airtight plate is used in this embodiment, the outer edge of the plate will be perforated with holes 4, so as to enable air to flow through the device. These perforations are excluded when a porous membrane is used.
Figures 2a and 2b show two views of one embo~;m~nt of the device suitable when an airtight plate is used. The reference signs used in the Figures correspond to those used in Figure 1. The broken line in Figure 2b indicates that the whole of the upper part of the device including the plate can be separated from the lower part and introduced into a measuring instrument. When a porous membrane is used, the device is not provided with perforations 4.
When using the device, a patient exhales through the nozzle 2. The ~xh~lAtion air then passes through the tubular element 1, and flows through the plate 3, or across the plate 3, and out through the holes 4. The tube is constructed to ensure m-~;mllm contact between the air flow and the absorbent plate.
Subsequent to having absorbed a mA~;mllm amount of gaseous component, as indicated by the colour indicator, the plate is detached from the tubular element and introduced in a measuring instrument for indication of a desired component.
Alternatively, the whole of the upper part, including the plate, is detached from the rem~;n~r of the device and introduced into the measuring instrument.
The device may be made from any suitable material, preferably cardboard, paperboard or plastic of different kinds. Examples of plastics that can be used are polyethylene, polystyrene W 096~2062 ' PCTISE96/00474 or PVC. It is appropriate that the device can be sterilized by radiation or heat. The absorbent material will vary in dependence on the component to be indicated. Examples of carbon dioxide absorbent materials are sodium hydroxide and soda lime. The colour reaction on the plate that signal~ when the plate is saturated can be achieved with the use of commercially available soda lime as a colour indicator. Part of the device beneath or above the absorbent material will preferably be transparent, so that the colour reaction can be observed. Cor.,~ol~ents that are to be detected may, for instance, be labelled or marked by means of isotopes. The measuring instrument used to detect labelled components will vary in accordance with labelling. For instance, radioactively labelled components can be indicated with a Geiger Muller tube. From the aspect of mechanical strength, the device will preferably be packed in an airtight bag in a durable environment, for instance in a nitrogen gas environment when a carbon dioxide absorbent material is used.
The device may conveniently be adapted for one-time use only, for hygienic reasons.
The present invention relates to a device for detecting one or more components in exhaled air, and particularly for detecting the presence of pathogenic bacteria Helicobacter pylori in stomach and intestinal tracts of hllm~n beings.
R~ 701~ND OF THE lNV~N.LlON
Gaseous components can be analyzed in various ways, such as by gas chromatography, flame photometry and spectrophotome-try, for instance. These methods, however, require the use of expensive equipment and are much too advanced in many cases. Simpler, alternative methods are those in which the gas is absorbed by a material and the presence or absence of a gaseous component indicated with the aid of a colour indicator. Examples in this respect are the blow tubes used to indicate the presence of alcohol in ~h~l ~tion air. The~e devices have the drawback of not being constructed for separate measurements on the absorbent material.
Certain conditions and illnesses can be indicated by analyz-ing exhalation air. For instance, stomach ulcers are caused mainly by the pathogenic bacteria Helicobacter pylori. A
method has been described for indicating the presence of this bacteria and has been applied in clinical research for a number of years. According to this method, patients are to swallow an isotope-labelled, preferably radioactive, urea preparation. ~elicobacter pylori present in the gastric and intestinal tract will break the urea down to carbon dioxide, among other materials. This carbon dioxide is then transported to the lungs through the normal physiology of the body, where it is exhaled together with the carbon dioxide that has been formed in r~m~; n; ng body organs. Because the carbon dioxide that is formed by the bacteria is labelled, the amount of carbon dioxide exhaled can be measured by causing the patient to blow the exhalation air through a tube and down into a liquid which absorbs carbon dioxide. This liquid is then ex~mined with the aid of appropriate measuring instruments, for instance a scintillator counter, to indicate i~otope labelled components in the exhaled carbon dioxide as a sign of the presence of ~elicobacter pylori.
The aforesaid method is relatively complicated and time-consuming. In addition, it requires the use of expensive and bulky apparatus. Furthermore, no product for carrying out this method is actually available commercially.
OBJECTS OF ~1~ lNV~ ON
The object of the present invention is to provide apparatus for use in detecting one or more components in exhalation air. The apparatus shall be producible at low costs and shall also satisfy requirem~nts of long-term storability and reproducibility of test results. Another object is also to obviate the complex handling of liquids and the use of space-consuming analysis instruments.
These objects are fulfilled by the present invention, whichrelates to a device which consists of a tubular element, which may be rigid or soft as a plastic bag and through which air is conducted. A nozzle is formed on one end of the tube.
The opposite end of the tube is fitted with a plate, which may either be an airtight plate or a porous membrane. The plate is attached to the tube in a m~nne~ which will enable it to be readily ~e,l,oved therefrom. The plate fitting may either have the form of a screw device or snap-coupling, or may simply comprise adhesive tape. A dry, absorbent material has been mounted on or incorporated in the plate. This absorbent material is adapted solely to absorb a specific amount of desired gaseous component. A colour indicator in the absorbent substance indicates when the m~; mllm amount of gaseous component has been absorbed. When an airtight plate is used, the outer edge of the plate is perforated so as to allow air to pass out and therewith enable air to flow r through the tube.
The patient blows exhalation air through the nozzle and causes said air to flow across or through the plate. The plate can be separated from the tube when the plate becomes saturated. The plate is then analyzed in an appropriate measuring in~trument, to indicate the presence or absence of components in question.
In a preferred embodiment, the present invention is used to indicate the presence of isotope labelled carbon dioxide in ~hA1~tion air, and in particular to indicate the presence of radioactive carbon dioxide formed as a conversion product of the bacteria Helicobacter pylori. To this end, the plate has mounted thereon or incorporates a c~hon dioxide absorb-ing material. A patient ~m;n;stered with radioactive labelled urea is asked to blow through the inventive device.
Carbon dioxide, including radioactively labelled carbon dioxide, is absorbed on the plate. The plate is then removed from the device and analyzed with regard to radioactivity in an appropriate measuring device, to indicate the presence of the bacterium Helicobacter pylori.
The present invention thus provides a simple device for use in indicating the presence or absence of ~ori~ nts in exhalation air.
BRIEF DESCRIPTION OF THE DRAWINGS
Figure 1 is a perspective view of an inventive device.
Figure 2a is a view from above of a further embodiment of the inventive device.
Figure 2b is a side view of the embodiment shown in Figure 2a.
W 096~2062 PCT/~ Jo~74 DE~ATT~n DESCRIPTION OF ~ E FIG ~ ES
Figure 1 illustrates primarily the embodiment in which a porous membrane is used and the air shall be caused to flow through the plate. The device is comprised of a tubular element 1 provided with a nozzle 2 at one end. An absorbent plate 3 is fitted detachably to the opposite end. When an airtight plate is used in this embodiment, the outer edge of the plate will be perforated with holes 4, so as to enable air to flow through the device. These perforations are excluded when a porous membrane is used.
Figures 2a and 2b show two views of one embo~;m~nt of the device suitable when an airtight plate is used. The reference signs used in the Figures correspond to those used in Figure 1. The broken line in Figure 2b indicates that the whole of the upper part of the device including the plate can be separated from the lower part and introduced into a measuring instrument. When a porous membrane is used, the device is not provided with perforations 4.
When using the device, a patient exhales through the nozzle 2. The ~xh~lAtion air then passes through the tubular element 1, and flows through the plate 3, or across the plate 3, and out through the holes 4. The tube is constructed to ensure m-~;mllm contact between the air flow and the absorbent plate.
Subsequent to having absorbed a mA~;mllm amount of gaseous component, as indicated by the colour indicator, the plate is detached from the tubular element and introduced in a measuring instrument for indication of a desired component.
Alternatively, the whole of the upper part, including the plate, is detached from the rem~;n~r of the device and introduced into the measuring instrument.
The device may be made from any suitable material, preferably cardboard, paperboard or plastic of different kinds. Examples of plastics that can be used are polyethylene, polystyrene W 096~2062 ' PCTISE96/00474 or PVC. It is appropriate that the device can be sterilized by radiation or heat. The absorbent material will vary in dependence on the component to be indicated. Examples of carbon dioxide absorbent materials are sodium hydroxide and soda lime. The colour reaction on the plate that signal~ when the plate is saturated can be achieved with the use of commercially available soda lime as a colour indicator. Part of the device beneath or above the absorbent material will preferably be transparent, so that the colour reaction can be observed. Cor.,~ol~ents that are to be detected may, for instance, be labelled or marked by means of isotopes. The measuring instrument used to detect labelled components will vary in accordance with labelling. For instance, radioactively labelled components can be indicated with a Geiger Muller tube. From the aspect of mechanical strength, the device will preferably be packed in an airtight bag in a durable environment, for instance in a nitrogen gas environment when a carbon dioxide absorbent material is used.
The device may conveniently be adapted for one-time use only, for hygienic reasons.
Claims (9)
1. A device for use in detecting one or more components in exhalation air, comprising a tubular element through which exhalation air is conducted and at one end of which the exhalation air is introduced, and characterized in that at the other end of the tubular element is provided a plate having mounted thereon or incorporating therein a material that will absorb one or more of said components, said one or more components being brought into contact with said plate and said material when exhaling into the device, and that said plate is detachable for determining said one or more components in a measuring apparatus.
2. A device according to claim 1, characterized in that the material is mounted on the surface of an airtight plate and in that exhalation air is brought into contact with said material by causing the air to flow across said plate.
3. A device according to claim 1, characterized in that the plate has the form of a porous membrane that has absorbent material mounted thereon or incorporated therein; and in that exhalation air is brought into contact with said material by causing said air to flow through the membrane.
4. A device according to any one of claims 1-3, characterized in that said material is a carbon dioxide absorbing material.
5. A device according to any one of claims 1-4, characterized in that the absorbent material includes a colour indicator.
6. A device according to any one of claims 1-5 for indicating carbon dioxide formed as a conversion product from Helicobacter pylori in the gastro-intestinal tract.
7. A device for use in detecting carbon dioxide in exhalation air, comprising a tubular element through which exhalation air containing said carbon dioxide is conducted after having been introduced at one end, said tubular element being provided at the other end with a plate having mounted thereon or incorporating therein a material for absorption of said carbon dioxide brought into contact with said plate and said material when exhaling into said device, said plate being detachable for insertion into a measuring apparatus separate from the aforesaid device for determining whether any carbon dioxide is present in said exhalation air.
8. The device of claim 7, wherein said material comprises a hydroxide or basic salt of an element selected from the group consisting of sodium, lithium, magnesium and calcium.
9. The device of claims 7 and 8, wherein said material for absorption includes a colour indicator.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9501351-2 | 1995-04-11 | ||
| SE9501351A SE505335C2 (en) | 1995-04-11 | 1995-04-11 | Device for detecting components in exhaled air |
| PCT/SE1996/000474 WO1996032062A1 (en) | 1995-04-11 | 1996-04-11 | A device for detecting components in exhaled air |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2217883A1 CA2217883A1 (en) | 1996-10-17 |
| CA2217883C true CA2217883C (en) | 2001-08-07 |
Family
ID=20397933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002217883A Expired - Fee Related CA2217883C (en) | 1995-04-11 | 1996-04-11 | A device for detecting components in exhaled air |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0959764A1 (en) |
| JP (1) | JPH11503527A (en) |
| KR (1) | KR19980703695A (en) |
| CN (1) | CN1180997A (en) |
| AU (1) | AU693344B2 (en) |
| CA (1) | CA2217883C (en) |
| CZ (1) | CZ289458B6 (en) |
| HU (1) | HU219755B (en) |
| NO (1) | NO974692L (en) |
| PL (1) | PL185366B1 (en) |
| RU (1) | RU2143844C1 (en) |
| SE (1) | SE505335C2 (en) |
| WO (1) | WO1996032062A1 (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9604519D0 (en) | 1996-12-09 | 1996-12-09 | Noster System Ab | Device for capturing and determining carbon dioxide and methods for its use |
| SE510922C2 (en) | 1997-11-20 | 1999-07-12 | Studsvik Instr Ab | Apparatus and method for measuring low-energy sample radiation |
| GB2381580A (en) * | 2001-10-30 | 2003-05-07 | Sentec Ltd | Sample collection |
| GB2427687B (en) | 2005-06-25 | 2009-12-09 | Sensam Ltd | Breath sampling device |
| CN102338757A (en) * | 2010-07-26 | 2012-02-01 | 深圳市中核海得威生物科技有限公司 | Helicobacter pylori 14C detection device and method |
| CN104640502B (en) * | 2012-09-20 | 2017-09-12 | 皇家飞利浦有限公司 | Low dead band liquid trap |
| KR20160067582A (en) | 2014-12-04 | 2016-06-14 | 동아대학교 산학협력단 | Valve including a tube for flow control |
| CN105547969A (en) * | 2015-12-23 | 2016-05-04 | 深圳职业技术学院 | Helicobacter pylori tester |
| CN106053387B (en) * | 2016-06-29 | 2019-04-23 | 南京青辰光电科技有限公司 | A kind of exhaled gas detection method and device |
| JP6419999B1 (en) * | 2018-02-01 | 2018-11-07 | 靖 高島 | Intake device |
| CN110243811B (en) * | 2019-04-30 | 2023-05-16 | 广州超威生物科技有限公司 | Method for evaluating release rate of chlorine dioxide |
| CN111044547A (en) * | 2019-12-31 | 2020-04-21 | 深圳市福瑞康科技有限公司 | Absorber, gas collecting card, respiration detection equipment, preparation method and application |
| CN112345635A (en) * | 2020-10-28 | 2021-02-09 | 上海交通大学 | Stomach illness diagnostic system based on exhaled gas volatile organic compound analysis |
| CN114137039B (en) * | 2021-11-25 | 2024-01-09 | 西安交通大学 | Gas storage bag integrated with wireless passive ammonia sensor tag and preparation method thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3233462A1 (en) * | 1982-09-09 | 1984-04-12 | Drägerwerk AG, 2400 Lübeck | MOUTHPIECE FOR A BREATH ALCOHOL MEASURING DEVICE |
| SU1720002A1 (en) * | 1989-01-18 | 1992-03-15 | Медико-Инженерный Центр Профилактики Заболеваний Органов Дыхания "Аэрозоль" | Method for examining patients with fat and carbohydrate metabolism disorders and device for controlling the exhaled air |
| US4947861A (en) * | 1989-05-01 | 1990-08-14 | Hamilton Lyle H | Noninvasive diagnosis of gastritis and duodenitis |
| US5171535A (en) * | 1990-10-12 | 1992-12-15 | Wayne Lamont | Breath alcohol tester |
-
1995
- 1995-04-11 SE SE9501351A patent/SE505335C2/en not_active IP Right Cessation
-
1996
- 1996-04-11 CA CA002217883A patent/CA2217883C/en not_active Expired - Fee Related
- 1996-04-11 AU AU53523/96A patent/AU693344B2/en not_active Ceased
- 1996-04-11 CZ CZ19973228A patent/CZ289458B6/en not_active IP Right Cessation
- 1996-04-11 RU RU97118330/14A patent/RU2143844C1/en not_active IP Right Cessation
- 1996-04-11 EP EP96910283A patent/EP0959764A1/en not_active Withdrawn
- 1996-04-11 JP JP8530960A patent/JPH11503527A/en active Pending
- 1996-04-11 KR KR1019970707095A patent/KR19980703695A/en not_active Application Discontinuation
- 1996-04-11 WO PCT/SE1996/000474 patent/WO1996032062A1/en not_active Application Discontinuation
- 1996-04-11 HU HU9802039A patent/HU219755B/en not_active IP Right Cessation
- 1996-04-11 CN CN96193244A patent/CN1180997A/en active Pending
-
1997
- 1997-10-09 PL PL96322738A patent/PL185366B1/en unknown
- 1997-10-10 NO NO974692A patent/NO974692L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO974692D0 (en) | 1997-10-10 |
| HUP9802039A3 (en) | 1999-04-28 |
| WO1996032062A1 (en) | 1996-10-17 |
| MX9707786A (en) | 1998-06-28 |
| PL322738A1 (en) | 1998-02-16 |
| KR19980703695A (en) | 1998-12-05 |
| NO974692L (en) | 1997-10-10 |
| RU2143844C1 (en) | 2000-01-10 |
| HU219755B (en) | 2001-07-30 |
| CZ322897A3 (en) | 1998-03-18 |
| JPH11503527A (en) | 1999-03-26 |
| AU693344B2 (en) | 1998-06-25 |
| SE9501351L (en) | 1996-10-12 |
| CN1180997A (en) | 1998-05-06 |
| EP0959764A1 (en) | 1999-12-01 |
| CA2217883A1 (en) | 1996-10-17 |
| SE505335C2 (en) | 1997-08-11 |
| SE9501351D0 (en) | 1995-04-11 |
| PL185366B1 (en) | 2003-04-30 |
| CZ289458B6 (en) | 2002-01-16 |
| AU5352396A (en) | 1996-10-30 |
| HUP9802039A2 (en) | 1998-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |