CA2202348A1 - Indole derivatives as 5ht1-like agonists - Google Patents
Indole derivatives as 5ht1-like agonistsInfo
- Publication number
- CA2202348A1 CA2202348A1 CA 2202348 CA2202348A CA2202348A1 CA 2202348 A1 CA2202348 A1 CA 2202348A1 CA 2202348 CA2202348 CA 2202348 CA 2202348 A CA2202348 A CA 2202348A CA 2202348 A1 CA2202348 A1 CA 2202348A1
- Authority
- CA
- Canada
- Prior art keywords
- agonists
- alkyl
- pharmaceutically acceptable
- indole derivatives
- headache
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000556 agonist Substances 0.000 title abstract 2
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000001845 4 membered carbocyclic group Chemical group 0.000 abstract 1
- 125000001054 5 membered carbocyclic group Chemical group 0.000 abstract 1
- 206010009094 Chronic paroxysmal hemicrania Diseases 0.000 abstract 1
- 208000006561 Cluster Headache Diseases 0.000 abstract 1
- 206010019233 Headaches Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 208000018912 cluster headache syndrome Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 231100000869 headache Toxicity 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 208000007777 paroxysmal Hemicrania Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 208000019553 vascular disease Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compounds of formula (I), pharmaceutically acceptable salts thereof, and pharmaceutically acceptable solvates (including hydrates) of either entity, wherein R1 is (a) R2 is R3R4C(OH)A; V is C=O or CH2; W is O or NR5; R3 and R4 are each independently selected from H and C1-C4 alkyl; or, together with the carbon atom to which they are attached, form a 4- or 5-membered carbocyclic ring; R5 is H, benzyl, C1-C5 alkanoyl or SO2(C1-C4)alkyl; A is C2-C3 alkylene;
m is 0 or 1; and n is 0 or 1; with the provisos that when n is 1 and V is C=O
then W is NH, and when n is 1 and V is CH2 then W is O; are selective 5-HT1-like agonists useful in the treatment of, inter alia, migraine, cluster headache, chronic paroxysmal hemicrania and headache associated with vascular disorders.
m is 0 or 1; and n is 0 or 1; with the provisos that when n is 1 and V is C=O
then W is NH, and when n is 1 and V is CH2 then W is O; are selective 5-HT1-like agonists useful in the treatment of, inter alia, migraine, cluster headache, chronic paroxysmal hemicrania and headache associated with vascular disorders.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9420503A GB9420503D0 (en) | 1994-10-11 | 1994-10-11 | Therapeutic agents |
| GB9420503.6 | 1994-10-11 | ||
| PCT/EP1995/003884 WO1996011195A1 (en) | 1994-10-11 | 1995-09-29 | Indole derivatives as 5ht1-like agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2202348A1 true CA2202348A1 (en) | 1996-04-18 |
| CA2202348C CA2202348C (en) | 2000-05-09 |
Family
ID=29421791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2202348 Expired - Fee Related CA2202348C (en) | 1994-10-11 | 1995-09-29 | Indole derivatives as 5ht1-like agonists |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2202348C (en) |
-
1995
- 1995-09-29 CA CA 2202348 patent/CA2202348C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2202348C (en) | 2000-05-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |