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CA2289945A1 - Proteine 3 de decouplage d'origine humaine - Google Patents

Proteine 3 de decouplage d'origine humaine Download PDF

Info

Publication number
CA2289945A1
CA2289945A1 CA002289945A CA2289945A CA2289945A1 CA 2289945 A1 CA2289945 A1 CA 2289945A1 CA 002289945 A CA002289945 A CA 002289945A CA 2289945 A CA2289945 A CA 2289945A CA 2289945 A1 CA2289945 A1 CA 2289945A1
Authority
CA
Canada
Prior art keywords
protein
ucp3
host cell
expression vector
uncoupling protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002289945A
Other languages
English (en)
Inventor
Qingyun Liu
Fang Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9716886.8A external-priority patent/GB9716886D0/en
Application filed by Individual filed Critical Individual
Publication of CA2289945A1 publication Critical patent/CA2289945A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention concerne une molécule d'acide nucléique isolé codant une nouvelle protéine de découplage d'origine humaine (UCP3), des vecteurs d'expression recombinants s'y rapportant, des cellules hôtes recombinantes, ainsi que des formes globalement purifiées de la protéine UCP3. L'acide nucléique isolé et les protéines décrits dans cette invention sont utiles lors de procédés qui visent à identifier les composés modulant les dépenses d'énergie et la régulation du poids du corps, et qui permettent combattre des maladies telles que l'obésité et le diabètes ainsi que l'hypermétabolisme associé à une mitochondrie. Les acides nucléiques isolés décrits dans la présente invention peuvent en outre être utilisés comme agents potentiels de thérapie génique chez un mammifère hôte, y compris chez les êtres humains.
CA002289945A 1997-05-20 1998-05-19 Proteine 3 de decouplage d'origine humaine Abandoned CA2289945A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US4717997P 1997-05-20 1997-05-20
US60/047,179 1997-05-20
GB9716886.8 1997-08-08
GBGB9716886.8A GB9716886D0 (en) 1997-08-08 1997-08-08 Human uncoupling protein 3
US6914197P 1997-12-09 1997-12-09
US60/069,141 1997-12-09
PCT/US1998/010215 WO1998052958A1 (fr) 1997-05-20 1998-05-19 Proteine 3 de decouplage d'origine humaine

Publications (1)

Publication Number Publication Date
CA2289945A1 true CA2289945A1 (fr) 1998-11-26

Family

ID=27268968

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002289945A Abandoned CA2289945A1 (fr) 1997-05-20 1998-05-19 Proteine 3 de decouplage d'origine humaine

Country Status (4)

Country Link
EP (1) EP1012155A4 (fr)
JP (1) JP2002502240A (fr)
CA (1) CA2289945A1 (fr)
WO (1) WO1998052958A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6620594B1 (en) 1997-05-07 2003-09-16 Novartis Ag Uncoupling protein homologue: UCP 3
JP4709383B2 (ja) 1998-09-22 2011-06-22 ジェネンテック， インコーポレイテッド Ｕｃｐ４
JP2002533062A (ja) 1998-11-30 2002-10-08 ジェネンテック・インコーポレーテッド Ｕｃｐ５
US7342102B2 (en) 1998-11-30 2008-03-11 Genentech, Inc. Uncoupling protein 5 (UCP5)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2247799A1 (fr) * 1997-03-05 1998-09-11 Smithkline Beecham P.L.C. Polynucleotides et polypeptides appartenant a la famille des proteines non liantes
US6620594B1 (en) * 1997-05-07 2003-09-16 Novartis Ag Uncoupling protein homologue: UCP 3

Also Published As

Publication number Publication date
JP2002502240A (ja) 2002-01-22
EP1012155A1 (fr) 2000-06-28
WO1998052958A1 (fr) 1998-11-26
EP1012155A4 (fr) 2002-11-04

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Legal Events

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FZDE Dead