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CA2289719A1 - Lieur chlorure pour syntheses organiques en phase solide - Google Patents

Lieur chlorure pour syntheses organiques en phase solide Download PDF

Info

Publication number
CA2289719A1
CA2289719A1 CA002289719A CA2289719A CA2289719A1 CA 2289719 A1 CA2289719 A1 CA 2289719A1 CA 002289719 A CA002289719 A CA 002289719A CA 2289719 A CA2289719 A CA 2289719A CA 2289719 A1 CA2289719 A1 CA 2289719A1
Authority
CA
Canada
Prior art keywords
resin
bound
linker
chloride
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002289719A
Other languages
English (en)
Inventor
Ravi S. Garigipati
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2289719A1 publication Critical patent/CA2289719A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/18—Introducing halogen atoms or halogen-containing groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

Abstract

L'invention a trait à un lieur utile dans des synthèses en phase solide, à la préparation et à des procédés d'utilisation de celui-ci. Le lieur consiste essentiellement en un noyau phénylique substitué par un alcoxy portant un chlorure benzylique éventuellement substitué. Des constituants synthétiques portant un nucléophile approprié peuvent déplacer l'atome de chlore et former une liaison covalente par rapport au support.
CA002289719A 1997-05-08 1998-05-08 Lieur chlorure pour syntheses organiques en phase solide Abandoned CA2289719A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4597097P 1997-05-08 1997-05-08
US60/045,970 1997-05-08
PCT/US1998/009485 WO1998050438A1 (fr) 1997-05-08 1998-05-08 Lieur chlorure pour syntheses organiques en phase solide

Publications (1)

Publication Number Publication Date
CA2289719A1 true CA2289719A1 (fr) 1998-11-12

Family

ID=21940842

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002289719A Abandoned CA2289719A1 (fr) 1997-05-08 1998-05-08 Lieur chlorure pour syntheses organiques en phase solide

Country Status (4)

Country Link
EP (1) EP0981554A4 (fr)
JP (1) JP2001525866A (fr)
CA (1) CA2289719A1 (fr)
WO (1) WO1998050438A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100282819B1 (ko) 1998-08-20 2001-03-02 김충섭 조합화학합성에 유용한 신규 할로겐화 왕레진

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3716501A (en) * 1971-03-08 1973-02-13 Dow Chemical Co Stable carbonium ion resins and method of preparation
EP0687691B1 (fr) * 1990-08-31 1998-10-07 Regents Of The University Of Minnesota Résines pour la synthèse de peptides en phase solide
AU668347B2 (en) * 1990-11-21 1996-05-02 Torrey Pines Institute For Molecular Studies Synthesis of equimolar multiple oligomer mixtures, especially of oligopeptide mixtures
US5268423A (en) * 1992-02-28 1993-12-07 New York University Method for preparation of peptide synthesis resins and peptide synthesis resins
GB9502225D0 (en) * 1995-02-04 1995-03-22 Zeneca Ltd Method

Also Published As

Publication number Publication date
JP2001525866A (ja) 2001-12-11
EP0981554A1 (fr) 2000-03-01
WO1998050438A1 (fr) 1998-11-12
EP0981554A4 (fr) 2005-11-09

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Legal Events

Date Code Title Description
FZDE Discontinued