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CA2177578C - Inhibiteurs non steroides pour le traitement de l'elevation de la pression intraoculaire - Google Patents

Inhibiteurs non steroides pour le traitement de l'elevation de la pression intraoculaire Download PDF

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Publication number
CA2177578C
CA2177578C CA002177578A CA2177578A CA2177578C CA 2177578 C CA2177578 C CA 2177578C CA 002177578 A CA002177578 A CA 002177578A CA 2177578 A CA2177578 A CA 2177578A CA 2177578 C CA2177578 C CA 2177578C
Authority
CA
Canada
Prior art keywords
steroidal
medicament
composition
intraocular pressure
cyclooxygenase inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002177578A
Other languages
English (en)
Other versions
CA2177578A1 (fr
Inventor
Jon R. Polansky
Ernest Bloom
Donald J. Fauss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/171,448 external-priority patent/US5474985A/en
Application filed by University of California filed Critical University of California
Publication of CA2177578A1 publication Critical patent/CA2177578A1/fr
Application granted granted Critical
Publication of CA2177578C publication Critical patent/CA2177578C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Méthodes et compositions de prévention et de traitement des pressions intraoculaires élevées à caractère non inflammatoire associées à des stéroïdes administrés ou endogènes consistant à administrer à un mammifère une préparation contenant (a) une dose à efficacité ophtalmologique d'un inhibiteur non stéroïde de la cyclooxygénase et (b) un excipient pharmacocompatible, pour réduire ou prévenir l'élévation de la pression intraoculaire et/ou l'induction de marqueurs de protéines due à une exposition chronique aux glucocorticoïdes.
CA002177578A 1993-12-22 1994-12-08 Inhibiteurs non steroides pour le traitement de l'elevation de la pression intraoculaire Expired - Fee Related CA2177578C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/171,448 US5474985A (en) 1993-12-22 1993-12-22 Preventing and treating elevated intraocular pressure associated with administered or endogenous steroids using non-steroidal cyclooxygenase inhibitors
US08/171,448 1993-12-22
PCT/US1994/014068 WO1995017178A1 (fr) 1993-12-22 1994-12-08 Inhibiteurs non steroides pour le traitement de l'elevation de la pression intraoculaire

Publications (2)

Publication Number Publication Date
CA2177578A1 CA2177578A1 (fr) 1995-06-29
CA2177578C true CA2177578C (fr) 2007-04-03

Family

ID=37951685

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002177578A Expired - Fee Related CA2177578C (fr) 1993-12-22 1994-12-08 Inhibiteurs non steroides pour le traitement de l'elevation de la pression intraoculaire

Country Status (1)

Country Link
CA (1) CA2177578C (fr)

Also Published As

Publication number Publication date
CA2177578A1 (fr) 1995-06-29

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