CA2169066A1 - Phenoxyphenyl Cyclopentenyl Hydroxyureas - Google Patents
Phenoxyphenyl Cyclopentenyl HydroxyureasInfo
- Publication number
- CA2169066A1 CA2169066A1 CA2169066A CA2169066A CA2169066A1 CA 2169066 A1 CA2169066 A1 CA 2169066A1 CA 2169066 A CA2169066 A CA 2169066A CA 2169066 A CA2169066 A CA 2169066A CA 2169066 A1 CA2169066 A1 CA 2169066A1
- Authority
- CA
- Canada
- Prior art keywords
- pct
- date
- above compounds
- hydroxyureas
- phenoxyphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Polyurethanes Or Polyureas (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
PCT No. PCT/JP94/01349 Sec. 371 Date May 24, 1996 Sec. 102(e) Date May 24, 1996 PCT Filed Aug. 15, 1994 PCT Pub. No. WO95/05360 PCT Pub. Date Feb. 23, 1995The invention relates to compounds of the formula <IMAGE> and to pharmaceutically acceptable salts thereof, wherein R1 is hydrogen, fluoro, or chloro, and R2 is hydrogen or methyl. The above compounds are lipoxygenase inhibitors. The invention also relates to pharmaceutical compositions containing the above compounds, and to methods of treating inflammatory and allergic conditions by administering the above compounds.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP205,453/1993 | 1993-08-19 | ||
| JP20545393 | 1993-08-19 | ||
| PCT/JP1994/001349 WO1995005360A1 (en) | 1993-08-19 | 1994-08-15 | Phenoxyphenyl cyclopentenyl hydroxyureas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2169066A1 true CA2169066A1 (en) | 1995-02-23 |
| CA2169066C CA2169066C (en) | 1999-06-22 |
Family
ID=16507136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002169066A Expired - Fee Related CA2169066C (en) | 1993-08-19 | 1994-08-15 | Phenoxyphenyl cyclopentenyl hydroxyureas |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5792882A (en) |
| EP (1) | EP0720598B1 (en) |
| JP (1) | JP2794343B2 (en) |
| KR (1) | KR0170623B1 (en) |
| CN (1) | CN1077568C (en) |
| AT (1) | ATE171939T1 (en) |
| AU (1) | AU674776B2 (en) |
| BR (1) | BR9407314A (en) |
| CA (1) | CA2169066C (en) |
| CO (1) | CO4230229A1 (en) |
| CZ (1) | CZ288358B6 (en) |
| DE (1) | DE69413831T2 (en) |
| DK (1) | DK0720598T3 (en) |
| EC (1) | ECSP941144A (en) |
| EG (1) | EG20530A (en) |
| ES (1) | ES2121218T3 (en) |
| FI (1) | FI114466B (en) |
| IL (1) | IL110628A (en) |
| MY (1) | MY111140A (en) |
| NO (1) | NO305595B1 (en) |
| NZ (1) | NZ269849A (en) |
| PE (1) | PE57194A1 (en) |
| PL (1) | PL176223B1 (en) |
| RU (1) | RU2125987C1 (en) |
| TW (2) | TW448144B (en) |
| WO (1) | WO1995005360A1 (en) |
| ZA (1) | ZA946253B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9606635A (en) * | 1994-06-27 | 1997-12-31 | Cytomed Inc | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders. |
| EP0790981B1 (en) * | 1994-11-10 | 1999-09-08 | Pfizer Inc. | Aryloxycycloalkenyl and aryloxyiminocycloalkenylhydroxyureas as 5-lipoxygenase inhibitors |
| WO1996016054A1 (en) * | 1994-11-18 | 1996-05-30 | Pfizer Pharmaceuticals Inc. | Cycloalkenyl-n-hydroxyureas |
| EP1741424B1 (en) | 1997-08-11 | 2018-10-03 | Pfizer Products Inc. | Solid pharmaceutical dispersions with enhanced bioavailabilty |
| US6121323A (en) * | 1997-12-03 | 2000-09-19 | 3M Innovative Properties Company | Bishydroxyureas |
| DE602005025934D1 (en) * | 2004-12-02 | 2011-02-24 | Amorepacific Corp | THE PRODUCTION OF TNF-ALPHA INHIBITING 2-CYCLOPENEN-1-ONOXY DERIVATIVES |
| KR101567571B1 (en) | 2007-12-03 | 2015-11-11 | (주)아모레퍼시픽 | Cosmetic composition for body slimming containing 2-cyclopentene-1-one oxime derivatives |
| CN105237530A (en) | 2009-04-03 | 2016-01-13 | 豪夫迈罗氏公司 | Propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide compositions and uses thereof |
| US8512464B2 (en) * | 2009-12-02 | 2013-08-20 | 3M Innovative Properties Company | Functionalized zirconia nanoparticles and high index films made therefrom |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ222168A (en) * | 1986-10-20 | 1991-05-28 | Oncogene Science Inc | Tumour growth inhibiting protein related to tgf-#b#1 and tgf-#b#2, preparation by genetic engineering methods, antibodies and pharmaceutical compositions |
| EP0384594B1 (en) * | 1989-02-03 | 1993-10-27 | The Wellcome Foundation Limited | Anti-inflammatory aryl derivatives |
| US5120752A (en) * | 1989-12-28 | 1992-06-09 | Abbott Laboratories | Cyclopropyl derivative lipoxygenase inhibitors |
| GB9025514D0 (en) * | 1990-11-23 | 1991-01-09 | Wellcome Found | Anti-inflammatory compounds |
| JP3007138B2 (en) * | 1990-11-27 | 2000-02-07 | ファイザー製薬株式会社 | Novel hydroxamic acid and N-hydroxyurea derivatives and compositions thereof |
| JPH06256285A (en) * | 1990-12-11 | 1994-09-13 | Pfizer Pharmaceut Co Ltd | Hydroxamic acid derivative and its use |
| JPH05163229A (en) * | 1991-12-13 | 1993-06-29 | Pfizer Pharmaceut Co Ltd | New cyclopropyl derivative |
| JPH05294921A (en) * | 1992-04-17 | 1993-11-09 | Pfizer Pharmaceut Co Ltd | New phenyl-substituted cycloalkylurea derivative and composition |
-
1994
- 1994-07-25 TW TW089116268A patent/TW448144B/en active
- 1994-07-25 TW TW083106784A patent/TW418089B/en not_active IP Right Cessation
- 1994-08-11 IL IL11062894A patent/IL110628A/en not_active IP Right Cessation
- 1994-08-11 PE PE1994248312A patent/PE57194A1/en not_active Application Discontinuation
- 1994-08-15 EP EP94922374A patent/EP0720598B1/en not_active Expired - Lifetime
- 1994-08-15 CN CN94193117A patent/CN1077568C/en not_active Expired - Fee Related
- 1994-08-15 WO PCT/JP1994/001349 patent/WO1995005360A1/en active IP Right Grant
- 1994-08-15 CZ CZ1996483A patent/CZ288358B6/en not_active IP Right Cessation
- 1994-08-15 ES ES94922374T patent/ES2121218T3/en not_active Expired - Lifetime
- 1994-08-15 NZ NZ269849A patent/NZ269849A/en unknown
- 1994-08-15 AU AU73509/94A patent/AU674776B2/en not_active Ceased
- 1994-08-15 BR BR9407314A patent/BR9407314A/en not_active Application Discontinuation
- 1994-08-15 JP JP7506862A patent/JP2794343B2/en not_active Expired - Fee Related
- 1994-08-15 RU RU96105400A patent/RU2125987C1/en not_active IP Right Cessation
- 1994-08-15 MY MYPI94002132A patent/MY111140A/en unknown
- 1994-08-15 KR KR1019960700828A patent/KR0170623B1/en not_active IP Right Cessation
- 1994-08-15 DK DK94922374T patent/DK0720598T3/en active
- 1994-08-15 US US08/591,634 patent/US5792882A/en not_active Expired - Fee Related
- 1994-08-15 CA CA002169066A patent/CA2169066C/en not_active Expired - Fee Related
- 1994-08-15 AT AT94922374T patent/ATE171939T1/en not_active IP Right Cessation
- 1994-08-15 DE DE69413831T patent/DE69413831T2/en not_active Expired - Fee Related
- 1994-08-17 EC EC1994001144A patent/ECSP941144A/en unknown
- 1994-08-17 EG EG50694A patent/EG20530A/en active
- 1994-08-18 ZA ZA946253A patent/ZA946253B/en unknown
- 1994-08-18 FI FI943799A patent/FI114466B/en not_active IP Right Cessation
- 1994-08-19 CO CO94036772A patent/CO4230229A1/en unknown
-
1996
- 1996-02-16 NO NO960631A patent/NO305595B1/en not_active IP Right Cessation
- 1996-02-16 PL PL94313037A patent/PL176223B1/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69522947D1 (en) | Phenylxanthin-derivate | |
| FI943948A (en) | Heterocyclic carbonic acid derivatives | |
| AU3345595A (en) | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | |
| FI932229A (en) | AZABICYCLISKA BRYGGDERIVAT | |
| CA2169066A1 (en) | Phenoxyphenyl Cyclopentenyl Hydroxyureas | |
| NO308654B1 (en) | Amide derivatives, processes and intermediates for their preparation, their use and pharmaceutical compositions containing them | |
| PL324012A1 (en) | N-hydroxyureas as antiinflammatory agents |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |