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CA2023012A1 - 4-substituted 17.beta.-(cyclopropylamino)androst-5-en-3.beta.-ol and related compounds useful as c17-20 lyase inhibitors - Google Patents

4-substituted 17.beta.-(cyclopropylamino)androst-5-en-3.beta.-ol and related compounds useful as c17-20 lyase inhibitors

Info

Publication number
CA2023012A1
CA2023012A1 CA002023012A CA2023012A CA2023012A1 CA 2023012 A1 CA2023012 A1 CA 2023012A1 CA 002023012 A CA002023012 A CA 002023012A CA 2023012 A CA2023012 A CA 2023012A CA 2023012 A1 CA2023012 A1 CA 2023012A1
Authority
CA
Canada
Prior art keywords
beta
androst
cyclopropylamino
substituted
related compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002023012A
Other languages
French (fr)
Other versions
CA2023012C (en
Inventor
Michael R. Angelastro
Thomas R. Blohm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Canada Inc filed Critical Merrell Dow Pharmaceuticals Canada Inc
Publication of CA2023012A1 publication Critical patent/CA2023012A1/en
Application granted granted Critical
Publication of CA2023012C publication Critical patent/CA2023012C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

This invention is directed to 4-substituted 17.beta.-(cyclopropylamino)androst-5-en-3.beta.-ol and related compounds and also to a method for using such compounds in the treatment of androgen-dependent disorders. The compounds are prepared by the hydride reduction of an appropriate steroidal imine or enamine.
CA002023012A 1989-08-15 1990-08-09 4-substituted 17.beta.-(cyclopropylamino)androst-5-en-3.beta.-ol and related compounds useful as c17-20 lyase inhibitors Expired - Fee Related CA2023012C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/394,025 US4966898A (en) 1989-08-15 1989-08-15 4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
US394,025 1989-08-15

Publications (2)

Publication Number Publication Date
CA2023012A1 true CA2023012A1 (en) 1991-02-16
CA2023012C CA2023012C (en) 2001-07-03

Family

ID=23557240

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002023012A Expired - Fee Related CA2023012C (en) 1989-08-15 1990-08-09 4-substituted 17.beta.-(cyclopropylamino)androst-5-en-3.beta.-ol and related compounds useful as c17-20 lyase inhibitors

Country Status (20)

Country Link
US (1) US4966898A (en)
EP (1) EP0413270B1 (en)
JP (1) JP2879703B2 (en)
KR (1) KR910004649A (en)
CN (1) CN1050196A (en)
AT (1) ATE137761T1 (en)
AU (1) AU628209B2 (en)
CA (1) CA2023012C (en)
DD (1) DD299650A5 (en)
DE (1) DE69026881T2 (en)
ES (1) ES2088928T3 (en)
FI (1) FI95804C (en)
HU (1) HUT55029A (en)
IE (1) IE72516B1 (en)
IL (1) IL95358A (en)
NO (1) NO903564L (en)
NZ (1) NZ234856A (en)
PH (1) PH27098A (en)
PT (1) PT94993B (en)
ZA (1) ZA906308B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4966897A (en) * 1989-08-15 1990-10-30 Merrell Dow Pharmaceuticals Inc. 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
KR100235135B1 (en) * 1992-03-31 2000-01-15 말콤 카터 17-substituted steroids useful in cancer treatment
US5604213A (en) * 1992-03-31 1997-02-18 British Technology Group Limited 17-substituted steroids useful in cancer treatment
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US6365597B1 (en) 1996-02-14 2002-04-02 Aventis Pharmaceuticals Inc. 4-aza steroids
IL152696A0 (en) * 2000-06-09 2003-06-24 Bayer Cropscience Sa Process for the preparation of pesticidal compounds
EP1681290B9 (en) 2000-11-17 2013-06-19 Takeda Pharmaceutical Company Limited Imidazole derivatives, production method thereof and use thereof
US6960586B2 (en) 2000-11-20 2005-11-01 Takeda Pharmaceutical Company Limited Imidazole derivatives, process for their preparation and their use
EP1348706B1 (en) 2000-12-08 2009-08-19 Takeda Pharmaceutical Company Limited Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
SI2445903T1 (en) 2009-06-26 2014-07-31 Novartis Ag 1,3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17
JP2011098893A (en) * 2009-11-04 2011-05-19 Sumitomo Chemical Co Ltd Use of compound for inhibiting biosynthesis of testosterone and the same compound
MX345788B (en) 2010-08-04 2017-02-15 Pellficure Pharmaceuticals Inc * Combination therapy for the treatment of prostate carcinoma.
WO2012035078A1 (en) 2010-09-16 2012-03-22 Novartis Ag 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS
EP2702052B1 (en) 2011-04-28 2017-10-18 Novartis AG 17alpha-hydroxylase/c17,20-lyase inhibitors
WO2014158875A1 (en) 2013-03-14 2014-10-02 Pellficure Pharmaceuticals Inc. Novel therapy for prostate carcinoma
CA2960750A1 (en) 2014-09-12 2016-03-17 Pellficure Pharmaceuticals, Inc. Compositions and methods for treatment of prostate carcinoma
KR20240115925A (en) 2016-07-29 2024-07-26 얀센 파마슈티카 엔브이 Methods of treating prostate cancer
WO2018080933A1 (en) 2016-10-24 2018-05-03 Pellficure Pharmaceuticals Inc. Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3107254A (en) * 1960-10-05 1963-10-15 Upjohn Co 17beta-dialkylamino-17-cyanosteroids and their 17alpha-alkyl, alkylene and alkyne derivatives
US3097200A (en) * 1962-01-03 1963-07-09 Syntex Corp 17-aminoandrostanes
NL302932A (en) * 1962-12-31
NZ224288A (en) * 1987-04-22 1989-12-21 Merrell Dow Pharma 17b-(cyclopropylamino)androst-5-en-3b-ol and related compounds and methods using these for treatment of non-humans
US4966897A (en) * 1989-08-15 1990-10-30 Merrell Dow Pharmaceuticals Inc. 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors

Also Published As

Publication number Publication date
FI904035A0 (en) 1990-08-15
NO903564D0 (en) 1990-08-14
NZ234856A (en) 1992-08-26
CA2023012C (en) 2001-07-03
CN1050196A (en) 1991-03-27
HUT55029A (en) 1991-04-29
JP2879703B2 (en) 1999-04-05
EP0413270A3 (en) 1992-05-20
IE902942A1 (en) 1991-02-27
FI95804B (en) 1995-12-15
NO903564L (en) 1991-02-18
AU628209B2 (en) 1992-09-10
KR910004649A (en) 1991-03-29
IE72516B1 (en) 1997-04-23
FI95804C (en) 1996-03-25
DE69026881D1 (en) 1996-06-13
JPH0383998A (en) 1991-04-09
PT94993A (en) 1991-04-18
DE69026881T2 (en) 1996-09-12
ZA906308B (en) 1991-06-26
PH27098A (en) 1993-02-26
EP0413270B1 (en) 1996-05-08
HU905004D0 (en) 1991-01-28
AU6087790A (en) 1991-02-21
EP0413270A2 (en) 1991-02-20
IL95358A (en) 1995-03-30
ATE137761T1 (en) 1996-05-15
US4966898A (en) 1990-10-30
PT94993B (en) 1997-07-31
IL95358A0 (en) 1991-06-30
ES2088928T3 (en) 1996-10-01
DD299650A5 (en) 1992-04-30

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed
MKLA Lapsed

Effective date: 20040809