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CA2017636A1 - Derivative of tissue-type plasminogen activator - Google Patents

Derivative of tissue-type plasminogen activator

Info

Publication number
CA2017636A1
CA2017636A1 CA2017636A CA2017636A CA2017636A1 CA 2017636 A1 CA2017636 A1 CA 2017636A1 CA 2017636 A CA2017636 A CA 2017636A CA 2017636 A CA2017636 A CA 2017636A CA 2017636 A1 CA2017636 A1 CA 2017636A1
Authority
CA
Canada
Prior art keywords
derivative
plasminogen activator
tissue
type plasminogen
glycosylated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2017636A
Other languages
French (fr)
Other versions
CA2017636C (en
Inventor
Anne Stern
Ulrich Kohnert
Rainer Rudolph
Stephan Fischer
Ulrich Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of CA2017636A1 publication Critical patent/CA2017636A1/en
Application granted granted Critical
Publication of CA2017636C publication Critical patent/CA2017636C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Luminescent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The tissue plasminogen activator (t-PA) derivative is not glycosylated and has the following amino-acid sequence: <IMAGE>
CA002017636A 1989-05-31 1990-05-28 Derivative of tissue-type plasminogen activator Expired - Fee Related CA2017636C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3917781 1989-05-31
DEP3917781.5 1989-05-31
DEP3923339.1 1989-07-14
DE3923339A DE3923339A1 (en) 1989-05-31 1989-07-14 FABRIC PLASMINOGEN ACTIVATOR DERIVATIVE

Publications (2)

Publication Number Publication Date
CA2017636A1 true CA2017636A1 (en) 1990-11-30
CA2017636C CA2017636C (en) 2000-05-02

Family

ID=25881452

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002017636A Expired - Fee Related CA2017636C (en) 1989-05-31 1990-05-28 Derivative of tissue-type plasminogen activator

Country Status (17)

Country Link
EP (1) EP0400545B1 (en)
JP (1) JPH0327286A (en)
AT (1) ATE119940T1 (en)
AU (1) AU623781B2 (en)
CA (1) CA2017636C (en)
CZ (1) CZ282035B6 (en)
DD (1) DD300109A5 (en)
DE (2) DE3923339A1 (en)
ES (1) ES2070210T3 (en)
FI (1) FI101475B (en)
HU (1) HU216870B (en)
IE (1) IE66006B1 (en)
IL (1) IL94539A (en)
NO (1) NO902405L (en)
NZ (1) NZ233796A (en)
PT (1) PT94227B (en)
ZA (1) ZA904089B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3942144A1 (en) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh STABILIZATION OF K1K2P PRO
AU2660397A (en) * 1996-04-05 1997-10-29 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA833174B (en) * 1982-05-05 1984-08-29 Genentech Inc Human tissue plasminogen activator
FR2594845B1 (en) * 1986-02-21 1989-12-01 Genetica MICROBIOLOGICAL PREPARATION OF THE HUMAN PLASMINOGEN TISSUE ACTIVATOR (T-PA) AND CONVERSION OF THE ENZYME SO OBTAINED IN ITS ACTIVE FORM
DE3643158A1 (en) * 1986-04-21 1987-11-19 Boehringer Mannheim Gmbh TISSUE PLASMINOGEN ACTIVATOR (TPA) DERIVATIVE AND ITS PRODUCTION
FI100106B (en) * 1986-12-05 1997-09-30 Novartis Ag A process for the preparation of a plasminogen single-stranded recombinant activator
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of tissue plasminogen activator comprising only the kringle 2 and protease domain dna encoding the same processes for the preparation thereof and pharmaceutical compositions containing the same
US5094953A (en) * 1988-03-21 1992-03-10 Genentech, Inc. Human tissue plasminogen activator variants
DE3903581A1 (en) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh FABRIC PLASMINOGEN ACTIVATOR DERIVATIVE

Also Published As

Publication number Publication date
IE66006B1 (en) 1995-11-29
JPH0327286A (en) 1991-02-05
CZ267690A3 (en) 1997-04-16
PT94227B (en) 1997-01-31
DE3923339A1 (en) 1990-12-06
FI902700A0 (en) 1990-05-30
CZ282035B6 (en) 1997-04-16
HU216870B (en) 1999-09-28
HU903267D0 (en) 1990-10-28
AU623781B2 (en) 1992-05-21
FI101475B1 (en) 1998-06-30
AU5600990A (en) 1990-12-06
IL94539A0 (en) 1991-03-10
HUT54734A (en) 1991-03-28
IL94539A (en) 1996-08-04
IE901848L (en) 1990-11-30
ZA904089B (en) 1991-03-27
ES2070210T3 (en) 1995-06-01
NO902405D0 (en) 1990-05-30
ATE119940T1 (en) 1995-04-15
CA2017636C (en) 2000-05-02
DD300109A5 (en) 1992-05-21
DE59008693D1 (en) 1995-04-20
NO902405L (en) 1990-12-03
EP0400545B1 (en) 1995-03-15
EP0400545A1 (en) 1990-12-05
PT94227A (en) 1991-02-08
NZ233796A (en) 1992-07-28
FI101475B (en) 1998-06-30

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed